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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23252

FusionGeneSummary for N4BP1_GPATCH2

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP1_GPATCH2
Fusion gene ID: 23252
HgeneTgene
Gene symbol

N4BP1

GPATCH2

Gene ID

9683

55105

Gene nameNEDD4 binding protein 1G-patch domain containing 2
Synonyms-CT110|GPATC2|PPP1R30|Pfa1
Cytomap

16q12.1

1q41

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 1G patch domain-containing protein 2cancer/testis antigen 110protein phosphatase 1, regulatory subunit 30
Modification date2018052220180519
UniProtAcc

O75113

Q9NW75

Ensembl transtripts involved in fusion geneENST00000262384, ENST00000565423, 
ENST00000366935, ENST00000489246, 
ENST00000366934, 
Fusion gene scores* DoF score7 X 5 X 4=1404 X 4 X 3=48
# samples 95
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: N4BP1 [Title/Abstract] AND GPATCH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPATCH2

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A2QS-01AN4BP1chr16

48643686

-GPATCH2chr1

217793841

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000262384ENST00000366935N4BP1chr16

48643686

-GPATCH2chr1

217793841

-
5CDS-intronENST00000262384ENST00000489246N4BP1chr16

48643686

-GPATCH2chr1

217793841

-
5CDS-intronENST00000262384ENST00000366934N4BP1chr16

48643686

-GPATCH2chr1

217793841

-
intron-3CDSENST00000565423ENST00000366935N4BP1chr16

48643686

-GPATCH2chr1

217793841

-
intron-intronENST00000565423ENST00000489246N4BP1chr16

48643686

-GPATCH2chr1

217793841

-
intron-intronENST00000565423ENST00000366934N4BP1chr16

48643686

-GPATCH2chr1

217793841

-

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FusionProtFeatures for N4BP1_GPATCH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP1

O75113

GPATCH2

Q9NW75

Inhibitor of the E3 ubiquitin-protein ligase ITCH. Actsby interacting with the second WW domain of ITCH, leading tocompete with ITCH's substrates and impairing ubiquitination ofsubstrates (By similarity). {ECO:0000250}. Enhances the ATPase activity of DHX15 in vitro.{ECO:0000269|PubMed:19432882}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for N4BP1_GPATCH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for N4BP1_GPATCH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
N4BP1LSM1, ITCH, AZI2, UBC, CUL3, CDK6, FAM114A1, HYPK, CDH1GPATCH2CSNK2A2, PICK1, XPO1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for N4BP1_GPATCH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for N4BP1_GPATCH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource