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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23233

FusionGeneSummary for MYRIP_S100A2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYRIP_S100A2
Fusion gene ID: 23233
HgeneTgene
Gene symbol

MYRIP

S100A2

Gene ID

25924

6273

Gene namemyosin VIIA and Rab interacting proteinS100 calcium binding protein A2
SynonymsSLAC2-C|SLAC2CCAN19|S100L
Cytomap

3p22.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionrab effector MyRIPSlp homologue lacking C2 domainsexophilin-8myosin-VIIa- and Rab-interacting proteinslp homolog lacking C2 domains csynaptotagmin-like protein homologue lacking C2 domains-csynaptotagmin-like protein lacking C2 domains Cprotein S100-A2
Modification date2018052320180519
UniProtAcc

Q8NFW9

P29034

Ensembl transtripts involved in fusion geneENST00000444716, ENST00000302541, 
ENST00000425621, ENST00000396217, 
ENST00000459828, ENST00000539167, 
ENST00000368708, ENST00000487430, 
ENST00000497140, ENST00000368710, 
ENST00000368709, ENST00000368707, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 2 X 5=50
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/50*10)=0
Context

PubMed: MYRIP [Title/Abstract] AND S100A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-10-0928-01AMYRIPchr3

40085762

+S100A2chr1

153536363

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000444716ENST00000368708MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000444716ENST00000487430MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-intronENST00000444716ENST00000497140MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000444716ENST00000368710MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000444716ENST00000368709MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000444716ENST00000368707MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000302541ENST00000368708MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000302541ENST00000487430MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-intronENST00000302541ENST00000497140MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000302541ENST00000368710MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000302541ENST00000368709MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000302541ENST00000368707MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000425621ENST00000368708MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000425621ENST00000487430MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-intronENST00000425621ENST00000497140MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000425621ENST00000368710MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000425621ENST00000368709MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000425621ENST00000368707MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000396217ENST00000368708MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000396217ENST00000487430MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-intronENST00000396217ENST00000497140MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000396217ENST00000368710MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000396217ENST00000368709MYRIPchr3

40085762

+S100A2chr1

153536363

-
5CDS-5UTRENST00000396217ENST00000368707MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000459828ENST00000368708MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000459828ENST00000487430MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-intronENST00000459828ENST00000497140MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000459828ENST00000368710MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000459828ENST00000368709MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000459828ENST00000368707MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000539167ENST00000368708MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000539167ENST00000487430MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-intronENST00000539167ENST00000497140MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000539167ENST00000368710MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000539167ENST00000368709MYRIPchr3

40085762

+S100A2chr1

153536363

-
intron-5UTRENST00000539167ENST00000368707MYRIPchr3

40085762

+S100A2chr1

153536363

-

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FusionProtFeatures for MYRIP_S100A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYRIP

Q8NFW9

S100A2

P29034

May function as calcium sensor and modulator,contributing to cellular calcium signaling. May function byinteracting with other proteins, such as TPR-containing proteins,and indirectly play a role in many physiological processes. Mayalso play a role in suppressing tumor cell growth.{ECO:0000269|PubMed:1372446, ECO:0000269|PubMed:22399290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYRIP_S100A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYRIP_S100A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYRIPRAB27A, C1orf216S100A2S100A2, MDM2, STUB1, ATF2, PPID, FKBP4, S100A1, S100B, HOPX, C17orf105, FOXP2, GMCL1, FAM60A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYRIP_S100A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneS100A2P29034DB00768OlopatadineProtein S100-A2small moleculeapproved
TgeneS100A2P29034DB01593ZincProtein S100-A2small moleculeapproved|investigational
TgeneS100A2P29034DB01373CalciumProtein S100-A2small moleculeapproved|nutraceutical

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RelatedDiseases for MYRIP_S100A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource