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Fusion gene ID: 23217 |
FusionGeneSummary for MYOT_BOLA2 |
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Fusion gene information | Fusion gene name: MYOT_BOLA2 | Fusion gene ID: 23217 | Hgene | Tgene | Gene symbol | MYOT | BOLA2 | Gene ID | 9499 | 654483 |
Gene name | myotilin | bolA family member 2B | |
Synonyms | LGMD1|LGMD1A|MFM3|TTID|TTOD | BOLA2 | |
Cytomap | 5q31.2 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | myotilin57 kDa cytoskeletal proteinmyofibrillar titin-like Ig domains proteintitin immunoglobulin domain protein (myotilin) | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9UBF9 | Q9H3K6 | |
Ensembl transtripts involved in fusion gene | ENST00000239926, ENST00000421631, ENST00000509812, ENST00000515645, | ENST00000330978, | |
Fusion gene scores | * DoF score | 6 X 7 X 1=42 | 19 X 26 X 1=494 |
# samples | 9 | 28 | |
** MAII score | log2(9/42*10)=1.09953567355091 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MYOT [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB249980 | MYOT | chr5 | 137089701 | - | BOLA2 | chr16 | 29874174 | - | ||
ChiTaRS3.1 | AK310988 | MYOT | chr5 | 137089701 | - | BOLA2 | chr16 | 29874174 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000239926 | ENST00000330978 | MYOT | chr5 | 137089701 | - | BOLA2 | chr16 | 29874174 | - |
intron-intron | ENST00000421631 | ENST00000330978 | MYOT | chr5 | 137089701 | - | BOLA2 | chr16 | 29874174 | - |
intron-intron | ENST00000509812 | ENST00000330978 | MYOT | chr5 | 137089701 | - | BOLA2 | chr16 | 29874174 | - |
intron-intron | ENST00000515645 | ENST00000330978 | MYOT | chr5 | 137089701 | - | BOLA2 | chr16 | 29874174 | - |
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FusionProtFeatures for MYOT_BOLA2 |
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Hgene | Tgene |
MYOT | BOLA2 |
Component of a complex of multiple actin cross-linkingproteins. Involved in the control of myofibril assembly andstability at the Z lines in muscle cells.{ECO:0000269|PubMed:12499399}. | Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYOT_BOLA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYOT_BOLA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYOT_BOLA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYOT_BOLA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MYOT | C1834659 | Muscular dystrophy, limb-girdle, type 1A | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | MYOT | C0031117 | Peripheral Neuropathy | 1 | CTD_human;HPO |
Hgene | MYOT | C0151786 | Muscle Weakness | 1 | CTD_human |
Hgene | MYOT | C0878544 | Cardiomyopathies | 1 | CTD_human;HPO |
Hgene | MYOT | C1836607 | MYOTILINOPATHY | 1 | CTD_human |
Hgene | MYOT | C1866785 | Spheroid body myopathy | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | MYOT | C3714934 | MYOPATHY, MYOFIBRILLAR, 3 | 1 | ORPHANET;UNIPROT |