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Fusion gene ID: 23203 |
FusionGeneSummary for MYO9B_DDA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO9B_DDA1 | Fusion gene ID: 23203 | Hgene | Tgene | Gene symbol | MYO9B | DDA1 | Gene ID | 4650 | 79016 |
| Gene name | myosin IXB | DET1 and DDB1 associated 1 | |
| Synonyms | CELIAC4|MYR5 | C19orf58|PCIA1 | |
| Cytomap | 19p13.11 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-IXbmyosin-IXbunconventional myosin-9b | DET1- and DDB1-associated protein 1PCIA-1cross-immune reaction antigen PCIA1placenta cross-immune reaction antigen 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q13459 | Q9BW61 | |
| Ensembl transtripts involved in fusion gene | ENST00000595618, ENST00000594824, ENST00000397274, ENST00000593411, | ENST00000359866, | |
| Fusion gene scores | * DoF score | 13 X 8 X 7=728 | 1 X 1 X 1=1 |
| # samples | 13 | 1 | |
| ** MAII score | log2(13/728*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MYO9B [Title/Abstract] AND DDA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYO9B | GO:0030048 | actin filament-based movement | 9490638 |
| Hgene | MYO9B | GO:0032011 | ARF protein signal transduction | 15644318 |
| Hgene | MYO9B | GO:0035385 | Roundabout signaling pathway | 26529257 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0FJ-01A | MYO9B | chr19 | 17213367 | + | DDA1 | chr19 | 17424832 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000595618 | ENST00000359866 | MYO9B | chr19 | 17213367 | + | DDA1 | chr19 | 17424832 | + |
| In-frame | ENST00000594824 | ENST00000359866 | MYO9B | chr19 | 17213367 | + | DDA1 | chr19 | 17424832 | + |
| In-frame | ENST00000397274 | ENST00000359866 | MYO9B | chr19 | 17213367 | + | DDA1 | chr19 | 17424832 | + |
| 3UTR-3CDS | ENST00000593411 | ENST00000359866 | MYO9B | chr19 | 17213367 | + | DDA1 | chr19 | 17424832 | + |
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FusionProtFeatures for MYO9B_DDA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO9B | DDA1 |
| Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Binds actin with high affinity both in the absence and presence ofATP and its mechanochemical activity is inhibited by calcium ions(PubMed:9490638). Also acts as a GTPase activator for RHOA(PubMed:9490638, PubMed:26529257). Plays a role in the regulationof cell migration via its role as RHOA GTPase activator. This isregulated by its interaction with the SLIT2 receptor ROBO1;interaction with ROBO1 impairs interaction with RHOA andsubsequent activation of RHOA GTPase activity, and thereby leadsto increased levels of active, GTP-bound RHOA (PubMed:26529257).{ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. | May be involved in ubiquitination and subsequentproteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction withCUL4A and WD repeat proteins. {ECO:0000269|PubMed:17452440}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 15_114 | 280 | 2189 | Domain | Ras-associating |
| Hgene | MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 15_114 | 280 | 2458 | Domain | Ras-associating |
| Hgene | MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 239_246 | 280 | 2189 | Nucleotide binding | ATP |
| Hgene | MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 239_246 | 280 | 2458 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1046_1071 | 280 | 2189 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1880_1901 | 280 | 2189 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1959_1989 | 280 | 2189 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1046_1071 | 280 | 2458 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1880_1901 | 280 | 2458 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1959_1989 | 280 | 2458 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1001_1023 | 280 | 2189 | Domain | IQ 3 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1024_1053 | 280 | 2189 | Domain | IQ 4 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 146_953 | 280 | 2189 | Domain | Myosin motor |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1703_1888 | 280 | 2189 | Domain | Rho-GAP |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 957_977 | 280 | 2189 | Domain | IQ 1 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 979_1000 | 280 | 2189 | Domain | IQ 2 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1001_1023 | 280 | 2458 | Domain | IQ 3 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1024_1053 | 280 | 2458 | Domain | IQ 4 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 146_953 | 280 | 2458 | Domain | Myosin motor |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1703_1888 | 280 | 2458 | Domain | Rho-GAP |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 957_977 | 280 | 2458 | Domain | IQ 1 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 979_1000 | 280 | 2458 | Domain | IQ 2 |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1045_2157 | 280 | 2189 | Region | Tail |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 844_855 | 280 | 2189 | Region | Actin-binding |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 940_1044 | 280 | 2189 | Region | Neck or regulatory domain |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1045_2157 | 280 | 2458 | Region | Tail |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 844_855 | 280 | 2458 | Region | Actin-binding |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 940_1044 | 280 | 2458 | Region | Neck or regulatory domain |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1632_1681 | 280 | 2189 | Zinc finger | Phorbol-ester/DAG-type |
| Hgene | >MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1632_1681 | 280 | 2458 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for MYO9B_DDA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MYO9B_ENST00000595618_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_382aa MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG >In-frame_MYO9B_ENST00000594824_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_382aa MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG >In-frame_MYO9B_ENST00000397274_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_382aa MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MYO9B_ENST00000595618_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_1146nt ATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGC CAGGCCTCGTGCCGCGTGACTGCCACCAAGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACC AAATGTTATGTGCTGGTGGAGGTCAAAGAGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTA TGGCCCCGGCGGGCACAGGACGAGCACCCTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTAC GTGCATATGCAGCTGGTGGCGCAGGCCACAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGAC CTGTGTAACCTCCCCGAGCTAACCGAGGGCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGG AGCATCCTGGTGGCCATCAACCCCTTTAAGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAG CTGGAGCCACACGTCTTCGCGCTGGCCGACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAG AGCGGCTCCGGCAAGACCCAGAGCACCAACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGG ACCATCCTGGGTGCTGGCCCTGTGCTGGAGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCG GACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAG ACAAACATCCTCCTGCGCTACCTGCATCAGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGC >In-frame_MYO9B_ENST00000594824_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_1146nt ATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGC CAGGCCTCGTGCCGCGTGACTGCCACCAAGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACC AAATGTTATGTGCTGGTGGAGGTCAAAGAGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTA TGGCCCCGGCGGGCACAGGACGAGCACCCTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTAC GTGCATATGCAGCTGGTGGCGCAGGCCACAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGAC CTGTGTAACCTCCCCGAGCTAACCGAGGGCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGG AGCATCCTGGTGGCCATCAACCCCTTTAAGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAG CTGGAGCCACACGTCTTCGCGCTGGCCGACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAG AGCGGCTCCGGCAAGACCCAGAGCACCAACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGG ACCATCCTGGGTGCTGGCCCTGTGCTGGAGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCG GACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAG ACAAACATCCTCCTGCGCTACCTGCATCAGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGC >In-frame_MYO9B_ENST00000397274_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_1146nt ATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGC CAGGCCTCGTGCCGCGTGACTGCCACCAAGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACC AAATGTTATGTGCTGGTGGAGGTCAAAGAGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTA TGGCCCCGGCGGGCACAGGACGAGCACCCTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTAC GTGCATATGCAGCTGGTGGCGCAGGCCACAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGAC CTGTGTAACCTCCCCGAGCTAACCGAGGGCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGG AGCATCCTGGTGGCCATCAACCCCTTTAAGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAG CTGGAGCCACACGTCTTCGCGCTGGCCGACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAG AGCGGCTCCGGCAAGACCCAGAGCACCAACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGG ACCATCCTGGGTGCTGGCCCTGTGCTGGAGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCG GACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAG ACAAACATCCTCCTGCGCTACCTGCATCAGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MYO9B_ENST00000595618_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_4943nt CGGGGCGGAGCGGCTCGAGCAGCGGCGGGCTGGCAGGCGGTCGTCCGGCCGGGGACCCGGCCCGGGACCGGCGGCGCGCGGCGGCCGAGG CCAGCTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGG GCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCA AGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAG AGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACC CTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCA CAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGG GCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTA AGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCG ACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCA ACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGG AGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGAC GGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATC AGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGG CGCGGACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCAC CCGCCTGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAG GAGCCGATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTG ATGTTGGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTC TCCAGAGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTA CCAGGACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCA TGCCCAGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACT AGTGCGTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAG CCCCTGGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGC TTGCTGAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCC TGAGAGACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCG CAGAGATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCG GTCTTGCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATG GCCGCTCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGT TTGTGGCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCT TTTGTTTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCC TCGACCTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTT TGAGATGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATT CTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTT GTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCC TGGCTAATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCT TCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTG GGATGGTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCC TGTGTCAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGAC CAGGCCCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGG TCACAGGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTG GGGAGTCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAA GGCCAGGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTG GCTGGGGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCC CTCCTTTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGG CACACACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCC CTTTACCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCA CAGCCTCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACA CATTTGTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTG ATGTCTGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCAC AAGTCGGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGAT GTTCCAGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGC CTGTGCACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATC TGGGCCGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGC CTGTACCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCT >In-frame_MYO9B_ENST00000594824_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_4938nt CGGAGCGGCTCGAGCAGCGGCGGGCTGGCAGGCGGTCGTCCGGCCGGGGACCCGGCCCGGGACCGGCGGCGCGCGGCGGCCGAGGCCAGC TCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGC CGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCAAGGAC AGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAGAGTCG GGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACCCTCAG GAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCACAGCC ACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGGGCAAC CTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTAAGTTC CTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCGACGTG GCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCAACTTC CTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGGAGGCA GATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCC TCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATCAGCAA TGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGGCGCGG ACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCACCCGCC TGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAGGAGCC GATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTGATGTT GGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTCTCCAG AGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTACCAGG ACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCATGCCC AGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACTAGTGC GTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAGCCCCT GGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGCTTGCT GAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCCTGAGA GACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCGCAGAG ATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCGGTCTT GCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATGGCCGC TCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGTTTGTG GCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCTTTTGT TTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCCTCGAC CTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTTTGAGA TGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCT ACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTTGTCAT GTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCCTGGCT AATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCTTCCTC AGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTGGGATG GTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCCTGTGT CAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGACCAGGC CCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGGTCACA GGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTGGGGAG TCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAAGGCCA GGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTGGCTGG GGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCCCTCCT TTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGGCACAC ACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCCCTTTA CCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCACAGCC TCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACACATTT GTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTGATGTC TGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCACAAGTC GGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGATGTTCC AGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGCCTGTG CACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATCTGGGC CGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGCCTGTA CCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCTCGGGC >In-frame_MYO9B_ENST00000397274_chr19_17213367_+_DDA1_ENST00000359866_chr19_17424832_+_4853nt CTAGCTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGG GCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCA AGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAG AGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACC CTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCA CAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGG GCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTA AGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCG ACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCA ACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGG AGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGAC GGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATC AGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGG CGCGGACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCAC CCGCCTGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAG GAGCCGATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTG ATGTTGGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTC TCCAGAGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTA CCAGGACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCA TGCCCAGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACT AGTGCGTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAG CCCCTGGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGC TTGCTGAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCC TGAGAGACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCG CAGAGATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCG GTCTTGCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATG GCCGCTCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGT TTGTGGCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCT TTTGTTTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCC TCGACCTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTT TGAGATGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATT CTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTT GTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCC TGGCTAATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCT TCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTG GGATGGTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCC TGTGTCAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGAC CAGGCCCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGG TCACAGGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTG GGGAGTCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAA GGCCAGGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTG GCTGGGGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCC CTCCTTTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGG CACACACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCC CTTTACCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCA CAGCCTCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACA CATTTGTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTG ATGTCTGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCAC AAGTCGGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGAT GTTCCAGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGC CTGTGCACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATC TGGGCCGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGC CTGTACCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCT |
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FusionGenePPI for MYO9B_DDA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MYO9B | LRRC41, CALM1, MYC, PKN2, GRK5, GPRASP2, CCDC8, HLA-DPA1, RBM33, SDF4, SKAP1, LCN15, NTRK1, HERC2, FOXG1, FOXL1, MCM2, DQX1, FAM131B, EID1, MOAP1, BPNT1, CDH5, IFT43, NEUROG3, DKK3, TMOD4, TRIM25 | DDA1 | COPS6, DDB1, CUL4A, AMBRA1, VPRBP, DCAF17, DDB2, DCAF11, ANKFY1, LTA4H, ASNS, FKBP4, LARS, PGK1, TARS, ECHS1, PA2G4, HADHA, SHMT2, ETFA, COPA, PRKDC, CBR1, FARSB, SRM, LAP3, DCAF5, WDTC1, SEPT9, NANS, ESD, CAND1, WARS, PRKAA1, IDH3A, MCM2, ALDH7A1, ADSL, ALDH9A1, NAMPT, GMPS, EIF5, COPB2, HADHB, TRPC4AP, ELAVL1, UBE2E3, DET1, COPS3, COPS5, RBX1, CUL4B, RFWD2, COPS2, COPS4, COPS7A, COPS7B, COPS8, PWP1, DCAF12, ERCC8, DCAF6, DCAF10, DTL, DCAF8, DCAF15, DCAF16, TOR1AIP2, TUBG1, AGTRAP, CMTM5, UBE2E1, UBE2E2, MRPS11, LNX2, LLGL2, WSB2, RFPL4B, CFAP20, DCAF7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MYO9B | chr19:17213367 | chr19:17424832 | ENST00000397274 | + | 1 | 39 | 1739_1744 | 280 | 2189 | RHOA |
| Hgene | MYO9B | chr19:17213367 | chr19:17424832 | ENST00000595618 | + | 2 | 40 | 1739_1744 | 280 | 2458 | RHOA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYO9B_DDA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYO9B_DDA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MYO9B | C0036341 | Schizophrenia | 3 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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