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Fusion gene ID: 23184 |
FusionGeneSummary for MYO6_MSR1 |
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Fusion gene information | Fusion gene name: MYO6_MSR1 | Fusion gene ID: 23184 | Hgene | Tgene | Gene symbol | MYO6 | MSR1 | Gene ID | 4646 | 4481 |
Gene name | myosin VI | macrophage scavenger receptor 1 | |
Synonyms | DFNA22|DFNB37|Myo6-007|Myo6-008 | CD204|SCARA1|SR-A|SR-AI|SR-AII|SR-AIII|SRA|phSR1|phSR2 | |
Cytomap | 6q14.1 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | unconventional myosin-VImyosin VI transcript variant 007myosin VI transcript variant 008unconventional myosin-6 | macrophage scavenger receptor types I and IImacrophage acetylated LDL receptor I and IImacrophage scavenger receptor type IIIscavenger receptor class A member 1 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q9UM54 | P21757 | |
Ensembl transtripts involved in fusion gene | ENST00000369981, ENST00000369985, ENST00000369977, ENST00000369975, ENST00000462633, | ENST00000350896, ENST00000262101, ENST00000445506, ENST00000355282, ENST00000518343, ENST00000381998, ENST00000536385, | |
Fusion gene scores | * DoF score | 9 X 8 X 8=576 | 3 X 2 X 1=6 |
# samples | 17 | 3 | |
** MAII score | log2(17/576*10)=-1.76053406530461 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
Context | PubMed: MYO6 [Title/Abstract] AND MSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MYO6 | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 16507995 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-D8-A27H-01A | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000369981 | ENST00000350896 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369981 | ENST00000262101 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369981 | ENST00000445506 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369981 | ENST00000355282 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-intron | ENST00000369981 | ENST00000518343 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369981 | ENST00000381998 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369981 | ENST00000536385 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369985 | ENST00000350896 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369985 | ENST00000262101 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369985 | ENST00000445506 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369985 | ENST00000355282 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-intron | ENST00000369985 | ENST00000518343 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369985 | ENST00000381998 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369985 | ENST00000536385 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369977 | ENST00000350896 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369977 | ENST00000262101 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369977 | ENST00000445506 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369977 | ENST00000355282 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-intron | ENST00000369977 | ENST00000518343 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369977 | ENST00000381998 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
5UTR-5UTR | ENST00000369977 | ENST00000536385 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000369975 | ENST00000350896 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000369975 | ENST00000262101 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000369975 | ENST00000445506 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000369975 | ENST00000355282 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-intron | ENST00000369975 | ENST00000518343 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000369975 | ENST00000381998 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000369975 | ENST00000536385 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000462633 | ENST00000350896 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000462633 | ENST00000262101 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000462633 | ENST00000445506 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000462633 | ENST00000355282 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-intron | ENST00000462633 | ENST00000518343 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000462633 | ENST00000381998 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
intron-5UTR | ENST00000462633 | ENST00000536385 | MYO6 | chr6 | 76459140 | + | MSR1 | chr8 | 16035501 | - |
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FusionProtFeatures for MYO6_MSR1 |
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Hgene | Tgene |
MYO6 | MSR1 |
Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Myosin 6 is a reverse-direction motor protein that moves towardsthe minus-end of actin filaments. Has slow rate of actin-activatedADP release due to weak ATP binding. Functions in a variety ofintracellular processes such as vesicular membrane trafficking andcell migration. Required for the structural integrity of the Golgiapparatus via the p53-dependent pro-survival pathway. Appears tobe involved in a very early step of clathrin-mediated endocytosisin polarized epithelial cells. May act as a regulator of F-actindynamics. May play a role in transporting DAB2 from the plasmamembrane to specific cellular targets. Required for structuralintegrity of inner ear hair cells (By similarity). {ECO:0000250,ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109,ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370}. | Membrane glycoproteins implicated in the pathologicdeposition of cholesterol in arterial walls during atherogenesis.Two types of receptor subunits exist. These receptors mediate theendocytosis of a diverse group of macromolecules, includingmodified low density lipoproteins (LDL) (PubMed:2251254). IsoformIII does not internalize acetylated LDL (PubMed:9548586).{ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYO6_MSR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYO6_MSR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MYO6 | DAB2, GIPC1, CALM2, DAB1, CYLD, USP11, USP25, CDC42, APC, UBC, SP1, TAX1BP1, CALCOCO2, FBXO25, OPTN, LMTK2, AP2A1, CLTC, PAK1, CAPZA1, POLR2A, ESR1, RNF11, TOM1, TOM1L2, MYO6, PARK2, PAN2, FBXO6, TP53, ENO1, MOV10, NXF1, ALK, ABCE1, CDH1, NTRK1, DPP9, DNAJC2, G6PD, PAK2, RAD23A, RAD23B, NHLRC2, CAPZA2, CDK2, CLTB, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, ACTR2, SYNPO, GTSE1, ANLN, MYO5C, MYO19, MYO18A, CFTR, RNF126, UBXN1, SEC16A, AP2B1, AP2A2, AP2M1, CLINT1, PIK3C2A, EPS15, REPS2, COPB2, DDB1, EPRS, VPRBP, DCTN1, GTPBP4, ARHGEF12, YTHDC2, DCTN2, DOCK7, POTEI, FBXO34, PPP1R9A, CUEDC1, FBXO30, TMOD2, ACTBL2, GSN, REPS1, WBP2, COX15, DLST, HSD17B10, PDHA1, G3BP1 | MSR1 | HSPA1A, TRAF6, IQCB1, ATP6V0C, NKG7, MALL, LEPROTL1, SEC22A, IKBIP, COL4A2, COLGALT2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYO6_MSR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYO6_MSR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MYO6 | C2931767 | Deafness, autosomal dominant nonsyndromic sensorineural 22 | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | MYO6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | MYO6 | C1843028 | Deafness, Autosomal Recessive 37 | 1 | CTD_human;UNIPROT |
Tgene | MSR1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Tgene | MSR1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |