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Fusion gene ID: 23159 |
FusionGeneSummary for MYO3B_UBE2H |
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Fusion gene information | Fusion gene name: MYO3B_UBE2H | Fusion gene ID: 23159 | Hgene | Tgene | Gene symbol | MYO3B | UBE2H | Gene ID | 140469 | 7328 |
Gene name | myosin IIIB | ubiquitin conjugating enzyme E2 H | |
Synonyms | - | E2-20K|GID3|UBC8|UBCH|UBCH2 | |
Cytomap | 2q31.1 | 7q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | myosin-IIIb | ubiquitin-conjugating enzyme E2 H(E3-independent) E2 ubiquitin-conjugating enzyme HE2 ubiquitin-conjugating enzyme HGID complex subunit 3, UBC8 homologubiquitin carrier protein Hubiquitin conjugating enzyme E2Hubiquitin-conjugating enzyme E2-20Kubi | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8WXR4 | P62256 | |
Ensembl transtripts involved in fusion gene | ENST00000408978, ENST00000409044, ENST00000334231, ENST00000602629, | ENST00000355621, ENST00000473814, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 8 X 4=224 |
# samples | 3 | 10 | |
** MAII score | log2(3/8*10)=1.90689059560852 | log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MYO3B [Title/Abstract] AND UBE2H [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBE2H | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
Tgene | UBE2H | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI972676 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000408978 | ENST00000355621 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-intron | ENST00000408978 | ENST00000473814 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-3UTR | ENST00000409044 | ENST00000355621 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-intron | ENST00000409044 | ENST00000473814 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-3UTR | ENST00000334231 | ENST00000355621 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-intron | ENST00000334231 | ENST00000473814 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-3UTR | ENST00000602629 | ENST00000355621 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
intron-intron | ENST00000602629 | ENST00000473814 | MYO3B | chr2 | 171115489 | + | UBE2H | chr7 | 129473838 | + |
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FusionProtFeatures for MYO3B_UBE2H |
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Hgene | Tgene |
MYO3B | UBE2H |
Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, toubiquitinate histone H2A. {ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:8132613}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYO3B_UBE2H |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYO3B_UBE2H |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYO3B_UBE2H |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYO3B_UBE2H |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | UBE2H | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | UBE2H | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |