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Fusion gene ID: 2311 |
FusionGeneSummary for AREL1_SRPK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AREL1_SRPK2 | Fusion gene ID: 2311 | Hgene | Tgene | Gene symbol | AREL1 | SRPK2 | Gene ID | 9870 | 6733 |
| Gene name | apoptosis resistant E3 ubiquitin protein ligase 1 | SRSF protein kinase 2 | |
| Synonyms | FIEL1|KIAA0317 | SFRSK2 | |
| Cytomap | 14q24.3 | 7q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apoptosis-resistant E3 ubiquitin protein ligase 1apoptosis-resistant HECT-type E3 ubiquitin transferase 1fibrosis-inducing E3 ligase 1 | SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15033 | P78362 | |
| Ensembl transtripts involved in fusion gene | ENST00000557401, ENST00000356357, | ENST00000393651, ENST00000357311, ENST00000489828, ENST00000493638, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 7 X 7 X 2=98 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AREL1 [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AREL1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 23479728 |
| Hgene | AREL1 | GO:0043066 | negative regulation of apoptotic process | 23479728 |
| Tgene | SRPK2 | GO:0000245 | spliceosomal complex assembly | 9472028 |
| Tgene | SRPK2 | GO:0006468 | protein phosphorylation | 9472028 |
| Tgene | SRPK2 | GO:0008284 | positive regulation of cell proliferation | 18559500 |
| Tgene | SRPK2 | GO:0008380 | RNA splicing | 9472028 |
| Tgene | SRPK2 | GO:0035556 | intracellular signal transduction | 9472028 |
| Tgene | SRPK2 | GO:0045070 | positive regulation of viral genome replication | 20498328 |
| Tgene | SRPK2 | GO:0045071 | negative regulation of viral genome replication | 12417631 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE258233 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000557401 | ENST00000393651 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000557401 | ENST00000357311 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000557401 | ENST00000489828 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000557401 | ENST00000493638 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000356357 | ENST00000393651 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000356357 | ENST00000357311 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000356357 | ENST00000489828 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
| intron-intron | ENST00000356357 | ENST00000493638 | AREL1 | chr14 | 75130255 | - | SRPK2 | chr7 | 104885858 | - |
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FusionProtFeatures for AREL1_SRPK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AREL1 | SRPK2 |
| E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.Inhibits apoptosis by ubiquitinating and targeting for degradationa number of proapoptotic proteins including DIABLO/SMAC, HTRA2 andSEPT4/ARTS which are released from the mitochondrion into thecytosol following apoptotic stimulation.{ECO:0000269|PubMed:23479728}. | Serine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residueslocated in regions rich in arginine/serine dipeptides, known as RSdomains and is involved in the phosphorylation of SR splicingfactors and the regulation of splicing. Promotes neuronalapoptosis by up-regulating cyclin-D1 (CCND1) expression. This isdone by the phosphorylation of SRSF2, leading to the suppressionof p53/TP53 phosphorylation thereby relieving the repressiveeffect of p53/TP53 on cyclin-D1 (CCND1) expression. PhosphorylatesACIN1, and redistributes it from the nuclear speckles to thenucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complexformation via the phosphorylation of DDX23/PRP28. Can mediatehepatitis B virus (HBV) core protein phosphorylation. Plays anegative role in the regulation of HBV replication through amechanism not involving the phosphorylation of the core proteinbut by reducing the packaging efficiency of the pregenomic RNA(pgRNA) without affecting the formation of the viral coreparticles. {ECO:0000269|PubMed:12134018,ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142,ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427,ECO:0000269|PubMed:9472028}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AREL1_SRPK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AREL1_SRPK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AREL1_SRPK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AREL1_SRPK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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