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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23105

FusionGeneSummary for MYO18A_MYO18A

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO18A_MYO18A
Fusion gene ID: 23105
HgeneTgene
Gene symbol

MYO18A

MYO18A

Gene ID

399687

399687

Gene namemyosin XVIIIAmyosin XVIIIA
SynonymsMAJN|MYSPDZ|SP-R210|SPR210MAJN|MYSPDZ|SP-R210|SPR210
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210unconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210
Modification date2018051920180519
UniProtAcc

Q92614

Q92614

Ensembl transtripts involved in fusion geneENST00000354329, ENST00000529578, 
ENST00000533112, ENST00000531253, 
ENST00000527372, 		ENST00000354329, 
ENST00000529578, ENST00000533112, 
ENST00000531253, ENST00000527372, 
Fusion gene scores* DoF score18 X 14 X 9=226815 X 13 X 10=1950
# samples 2120
** MAII scorelog2(21/2268*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1950*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO18A [Title/Abstract] AND MYO18A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE171182MYO18Achr17

27400729

+MYO18Achr17

27400679

-
ChiTaRS3.1AW503292MYO18Achr17

27401386

+MYO18Achr17

27400943

-
ChiTaRS3.1CN268132MYO18Achr17

27400802

+MYO18Achr17

27400745

-
ChiTaRS3.1BF895994MYO18Achr17

27442455

+MYO18Achr17

27447765

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000354329ENST00000354329MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-5UTRENST00000354329ENST00000529578MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000354329ENST00000533112MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000354329ENST00000531253MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000354329ENST00000527372MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000529578ENST00000354329MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-5UTRENST00000529578ENST00000529578MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000529578ENST00000533112MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000529578ENST00000531253MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000529578ENST00000527372MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000533112ENST00000354329MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-5UTRENST00000533112ENST00000529578MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000533112ENST00000533112MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000533112ENST00000531253MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000533112ENST00000527372MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000531253ENST00000354329MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-5UTRENST00000531253ENST00000529578MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000531253ENST00000533112MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000531253ENST00000531253MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000531253ENST00000527372MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000527372ENST00000354329MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-5UTRENST00000527372ENST00000529578MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000527372ENST00000533112MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000527372ENST00000531253MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000527372ENST00000527372MYO18Achr17

27400729

+MYO18Achr17

27400679

-
intron-3UTRENST00000354329ENST00000354329MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-5UTRENST00000354329ENST00000529578MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000354329ENST00000533112MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000354329ENST00000531253MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000354329ENST00000527372MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000529578ENST00000354329MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-5UTRENST00000529578ENST00000529578MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000529578ENST00000533112MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000529578ENST00000531253MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000529578ENST00000527372MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000533112ENST00000354329MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-5UTRENST00000533112ENST00000529578MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000533112ENST00000533112MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000533112ENST00000531253MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000533112ENST00000527372MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000531253ENST00000354329MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-5UTRENST00000531253ENST00000529578MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000531253ENST00000533112MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000531253ENST00000531253MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000531253ENST00000527372MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000527372ENST00000354329MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-5UTRENST00000527372ENST00000529578MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000527372ENST00000533112MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000527372ENST00000531253MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000527372ENST00000527372MYO18Achr17

27401386

+MYO18Achr17

27400943

-
intron-3UTRENST00000354329ENST00000354329MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-5UTRENST00000354329ENST00000529578MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000354329ENST00000533112MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000354329ENST00000531253MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000354329ENST00000527372MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000529578ENST00000354329MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-5UTRENST00000529578ENST00000529578MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000529578ENST00000533112MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000529578ENST00000531253MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000529578ENST00000527372MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000533112ENST00000354329MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-5UTRENST00000533112ENST00000529578MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000533112ENST00000533112MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000533112ENST00000531253MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000533112ENST00000527372MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000531253ENST00000354329MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-5UTRENST00000531253ENST00000529578MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000531253ENST00000533112MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000531253ENST00000531253MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000531253ENST00000527372MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000527372ENST00000354329MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-5UTRENST00000527372ENST00000529578MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000527372ENST00000533112MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000527372ENST00000531253MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3UTRENST00000527372ENST00000527372MYO18Achr17

27400802

+MYO18Achr17

27400745

-
intron-3CDSENST00000354329ENST00000354329MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000354329ENST00000529578MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000354329ENST00000533112MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000354329ENST00000531253MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000354329ENST00000527372MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-3CDSENST00000529578ENST00000354329MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000529578ENST00000529578MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000529578ENST00000533112MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000529578ENST00000531253MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000529578ENST00000527372MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-3CDSENST00000533112ENST00000354329MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000533112ENST00000529578MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000533112ENST00000533112MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000533112ENST00000531253MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000533112ENST00000527372MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-3CDSENST00000531253ENST00000354329MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000531253ENST00000529578MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000531253ENST00000533112MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000531253ENST00000531253MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000531253ENST00000527372MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-3CDSENST00000527372ENST00000354329MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000527372ENST00000529578MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000527372ENST00000533112MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000527372ENST00000531253MYO18Achr17

27442455

+MYO18Achr17

27447765

-
intron-intronENST00000527372ENST00000527372MYO18Achr17

27442455

+MYO18Achr17

27447765

-

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FusionProtFeatures for MYO18A_MYO18A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO18A

Q92614

MYO18A

Q92614

May link Golgi membranes to the cytoskeleton andparticipate in the tensile force required for vesicle budding fromthe Golgi. Thereby, may play a role in Golgi membrane traffickingand could indirectly give its flattened shape to the Golgiapparatus (PubMed:19837035, PubMed:23345592). Alternatively, inconcert with LURAP1 and CDC42BPA/CDC42BPB, has been involved inmodulating lamellar actomyosin retrograde flow that is crucial tocell protrusion and migration (PubMed:18854160). May be involvedin the maintenance of the stromal cell architectures required forcell to cell contact (By similarity). Regulates trafficking,expression, and activation of innate immune receptors onmacrophages. Plays a role to suppress inflammatory responsivenessof macrophages via a mechanism that modulates CD14 trafficking(PubMed:25965346). Acts as a receptor of surfactant-associatedprotein A (SFTPA1/SP-A) and plays an important role ininternalization and clearance of SFTPA1-opsonized S.aureus byalveolar macrophages (PubMed:16087679, PubMed:21123169). Stronglyenhances natural killer cell cytotoxicity (PubMed:27467939).{ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679,ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592,ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. May link Golgi membranes to the cytoskeleton andparticipate in the tensile force required for vesicle budding fromthe Golgi. Thereby, may play a role in Golgi membrane traffickingand could indirectly give its flattened shape to the Golgiapparatus (PubMed:19837035, PubMed:23345592). Alternatively, inconcert with LURAP1 and CDC42BPA/CDC42BPB, has been involved inmodulating lamellar actomyosin retrograde flow that is crucial tocell protrusion and migration (PubMed:18854160). May be involvedin the maintenance of the stromal cell architectures required forcell to cell contact (By similarity). Regulates trafficking,expression, and activation of innate immune receptors onmacrophages. Plays a role to suppress inflammatory responsivenessof macrophages via a mechanism that modulates CD14 trafficking(PubMed:25965346). Acts as a receptor of surfactant-associatedprotein A (SFTPA1/SP-A) and plays an important role ininternalization and clearance of SFTPA1-opsonized S.aureus byalveolar macrophages (PubMed:16087679, PubMed:21123169). Stronglyenhances natural killer cell cytotoxicity (PubMed:27467939).{ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679,ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592,ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO18A_MYO18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO18A_MYO18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO18A_MYO18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO18A_MYO18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource