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Fusion gene ID: 23063 |
FusionGeneSummary for MYLK_CCDC14 |
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Fusion gene information | Fusion gene name: MYLK_CCDC14 | Fusion gene ID: 23063 | Hgene | Tgene | Gene symbol | MYLK | CCDC14 | Gene ID | 4638 | 64770 |
Gene name | myosin light chain kinase | coiled-coil domain containing 14 | |
Synonyms | AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MSTP083|MYLK1|smMLCK | - | |
Cytomap | 3q21.1 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | myosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin | coiled-coil domain-containing protein 14 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q15746 | Q49A88 | |
Ensembl transtripts involved in fusion gene | ENST00000360772, ENST00000359169, ENST00000360304, ENST00000418370, ENST00000578202, ENST00000354792, ENST00000346322, ENST00000583087, ENST00000475616, ENST00000510775, | ENST00000310351, ENST00000488653, ENST00000485727, ENST00000489746, ENST00000433542, ENST00000483247, | |
Fusion gene scores | * DoF score | 10 X 8 X 5=400 | 4 X 3 X 3=36 |
# samples | 11 | 4 | |
** MAII score | log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MYLK [Title/Abstract] AND CCDC14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MYLK | GO:0030335 | positive regulation of cell migration | 19826488 |
Hgene | MYLK | GO:0051928 | positive regulation of calcium ion transport | 16284075 |
Hgene | MYLK | GO:0071476 | cellular hypotonic response | 11976941 |
Hgene | MYLK | GO:0090303 | positive regulation of wound healing | 15825080 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A04U-01A | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000360772 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360772 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360772 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360772 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360772 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360772 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000359169 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000359169 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000359169 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000359169 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000359169 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000359169 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360304 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360304 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360304 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360304 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360304 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000360304 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000418370 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000418370 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000418370 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000418370 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000418370 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000418370 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000578202 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000578202 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000578202 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000578202 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000578202 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000578202 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000354792 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000354792 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000354792 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000354792 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000354792 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000354792 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000346322 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000346322 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000346322 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000346322 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000346322 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000346322 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000583087 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000583087 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000583087 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000583087 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000583087 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000583087 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000475616 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000475616 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000475616 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000475616 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000475616 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
5CDS-intron | ENST00000475616 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000510775 | ENST00000310351 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000510775 | ENST00000488653 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000510775 | ENST00000485727 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000510775 | ENST00000489746 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000510775 | ENST00000433542 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
intron-intron | ENST00000510775 | ENST00000483247 | MYLK | chr3 | 123512524 | - | CCDC14 | chr3 | 123616460 | - |
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FusionProtFeatures for MYLK_CCDC14 |
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Hgene | Tgene |
MYLK | CCDC14 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYLK_CCDC14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYLK_CCDC14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MYLK | PRKG2, CALM1, CTTN, PAK1, MLC1, SRC, ALK, MYC, TP53, GOPC, HSPB1, MYH9, PPP1CB, ANLN, MYO19 | CCDC14 | MAGEA11, UCHL1, MAPK14, CALM1, CEP63, ELAVL1, UBQLN4, APP, PLAC9, KDM1A, RNF31, PEX5, CCDC183, MAGEA1, PIK3R3, STIP1, CEP55, CDK1, ZWINT, SDCCAG3, COMMD8, CEP85, SKA3, THOC7, OFD1, FGFR1OP, HAUS2, SPAG5, HAUS8, CEP72, MAGED1, CNTROB, CCDC138, MPHOSPH9, CCNB2, TRIM37, PIBF1, MED4, PCM1, KIAA0753, CEP128, CEP135, CEP89, CNTRL, NINL, POC5, ATP5I, KIFC3, CCP110, KIF14, CEP131, TTLL5, MCM10, MIB1, KIAA1328, CSPP1, CEP290, HYI, CCDC77, CEP295, TBC1D31, SSX2IP, FOPNL, SCLT1, WDR90, CCDC18, CCDC61, TPTE2, JPH4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYLK_CCDC14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYLK_CCDC14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MYLK | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Hgene | MYLK | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Hgene | MYLK | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Hgene | MYLK | C0017601 | Glaucoma | 1 | CTD_human |
Hgene | MYLK | C0017638 | Glioma | 1 | CTD_human |
Hgene | MYLK | C0020443 | Hypercholesterolemia | 1 | CTD_human |
Hgene | MYLK | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | MYLK | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | MYLK | C0042373 | Vascular Diseases | 1 | CTD_human |
Hgene | MYLK | C0242488 | Acute Lung Injury | 1 | CTD_human |
Hgene | MYLK | C1527311 | Brain Edema | 1 | CTD_human |
Hgene | MYLK | C3151077 | AORTIC ANEURYSM, FAMILIAL THORACIC 7 | 1 | UNIPROT |