![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 23062 |
FusionGeneSummary for MYLK3_HSPA12B |
![]() |
Fusion gene information | Fusion gene name: MYLK3_HSPA12B | Fusion gene ID: 23062 | Hgene | Tgene | Gene symbol | MYLK3 | HSPA12B | Gene ID | 91807 | 116835 |
Gene name | myosin light chain kinase 3 | heat shock protein family A (Hsp70) member 12B | |
Synonyms | MLCK|MLCK2|caMLCK | C20orf60 | |
Cytomap | 16q11.2 | 20p13 | |
Type of gene | protein-coding | protein-coding | |
Description | myosin light chain kinase 3MLC kinasecardiac-MLCKcardiac-MyBP-C associated Ca/CaM kinaseputative myosin light chain kinase 3 | heat shock 70 kDa protein 12B | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q32MK0 | Q96MM6 | |
Ensembl transtripts involved in fusion gene | ENST00000536476, ENST00000394809, ENST00000562104, | ENST00000254963, ENST00000542646, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MYLK3 [Title/Abstract] AND HSPA12B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | R47378 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000536476 | ENST00000254963 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
intron-intron | ENST00000536476 | ENST00000542646 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
intron-intron | ENST00000394809 | ENST00000254963 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
intron-intron | ENST00000394809 | ENST00000542646 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
intron-intron | ENST00000562104 | ENST00000254963 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
intron-intron | ENST00000562104 | ENST00000542646 | MYLK3 | chr16 | 46740994 | + | HSPA12B | chr20 | 3722477 | - |
Top |
FusionProtFeatures for MYLK3_HSPA12B |
![]() |
Hgene | Tgene |
MYLK3 | HSPA12B |
Kinase that phosphorylates MYL2 in vitro. Promotessarcomere formation in cardiomyocytes and increases cardiomyocytecontractility (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MYLK3_HSPA12B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MYLK3_HSPA12B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MYLK3_HSPA12B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MYLK3_HSPA12B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |