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Fusion gene ID: 23028 |
FusionGeneSummary for MYH9_SORCS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYH9_SORCS1 | Fusion gene ID: 23028 | Hgene | Tgene | Gene symbol | MYH9 | SORCS1 | Gene ID | 4627 | 114815 |
| Gene name | myosin heavy chain 9 | sortilin related VPS10 domain containing receptor 1 | |
| Synonyms | BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA | hSorCS | |
| Cytomap | 22q12.3 | 10q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A | VPS10 domain-containing receptor SorCS1VPS10 domain receptor protein SORCS 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P35579 | Q8WY21 | |
| Ensembl transtripts involved in fusion gene | ENST00000216181, ENST00000475726, ENST00000401701, | ENST00000263054, ENST00000369698, ENST00000344440, ENST00000478809, | |
| Fusion gene scores | * DoF score | 36 X 33 X 15=17820 | 3 X 2 X 3=18 |
| # samples | 50 | 3 | |
| ** MAII score | log2(50/17820*10)=-5.1554254317472 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MYH9 [Title/Abstract] AND SORCS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYH9 | GO:0001525 | angiogenesis | 16403913 |
| Hgene | MYH9 | GO:0006509 | membrane protein ectodomain proteolysis | 16186248 |
| Hgene | MYH9 | GO:0030048 | actin filament-based movement | 12237319|15845534 |
| Hgene | MYH9 | GO:0031032 | actomyosin structure organization | 24072716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-EI-7004-01A | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000216181 | ENST00000263054 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| 5CDS-intron | ENST00000216181 | ENST00000369698 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| 5CDS-intron | ENST00000216181 | ENST00000344440 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| 5CDS-intron | ENST00000216181 | ENST00000478809 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-3CDS | ENST00000475726 | ENST00000263054 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-intron | ENST00000475726 | ENST00000369698 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-intron | ENST00000475726 | ENST00000344440 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-intron | ENST00000475726 | ENST00000478809 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-3CDS | ENST00000401701 | ENST00000263054 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-intron | ENST00000401701 | ENST00000369698 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-intron | ENST00000401701 | ENST00000344440 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
| intron-intron | ENST00000401701 | ENST00000478809 | MYH9 | chr22 | 36701079 | - | SORCS1 | chr10 | 108489872 | - |
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FusionProtFeatures for MYH9_SORCS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYH9 | SORCS1 |
| Cellular myosin that appears to play a role incytokinesis, cell shape, and specialized functions such assecretion and capping. During cell spreading, plays an importantrole in cytoskeleton reorganization, focal contacts formation (inthe margins but not the central part of spreading cells), andlamellipodial retraction; this function is mechanicallyantagonized by MYH10. {ECO:0000269|PubMed:20052411}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYH9 | chr22:36701079 | chr10:108489872 | ENST00000216181 | - | 18 | 41 | 27_77 | 743 | 1961 | Domain | Myosin N-terminal SH3-like |
| Hgene | MYH9 | chr22:36701079 | chr10:108489872 | ENST00000216181 | - | 18 | 41 | 174_181 | 743 | 1961 | Nucleotide binding | ATP |
| Hgene | MYH9 | chr22:36701079 | chr10:108489872 | ENST00000216181 | - | 18 | 41 | 654_676 | 743 | 1961 | Region | Note=Actin-binding |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 803_894 | 319 | 1169 | Domain | PKD |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 803_894 | 319 | 1199 | Domain | PKD |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 492_503 | 319 | 1169 | Repeat | Note=BNR 3 |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 569_580 | 319 | 1169 | Repeat | Note=BNR 4 |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 611_622 | 319 | 1169 | Repeat | Note=BNR 5 |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 492_503 | 319 | 1199 | Repeat | Note=BNR 3 |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 569_580 | 319 | 1199 | Repeat | Note=BNR 4 |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 611_622 | 319 | 1199 | Repeat | Note=BNR 5 |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 1121_1168 | 319 | 1169 | Topological domain | Cytoplasmic |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 1121_1168 | 319 | 1199 | Topological domain | Cytoplasmic |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 1100_1120 | 319 | 1169 | Transmembrane | Helical |
| Tgene | >SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 1100_1120 | 319 | 1199 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MYH9 | chr22:36701079 | chr10:108489872 | ENST00000216181 | - | 18 | 41 | 837_1926 | 743 | 1961 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MYH9 | chr22:36701079 | chr10:108489872 | ENST00000216181 | - | 18 | 41 | 779_808 | 743 | 1961 | Domain | IQ |
| Hgene | >MYH9 | chr22:36701079 | chr10:108489872 | ENST00000216181 | - | 18 | 41 | 81_776 | 743 | 1961 | Domain | Myosin motor |
| Tgene | SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 208_219 | 319 | 1169 | Repeat | Note=BNR 1 |
| Tgene | SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 256_267 | 319 | 1169 | Repeat | Note=BNR 2 |
| Tgene | SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 208_219 | 319 | 1199 | Repeat | Note=BNR 1 |
| Tgene | SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 256_267 | 319 | 1199 | Repeat | Note=BNR 2 |
| Tgene | SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000263054 | - | 4 | 26 | 34_1099 | 319 | 1169 | Topological domain | Lumenal |
| Tgene | SORCS1 | chr22:36701079 | chr10:108489872 | ENST00000344440 | - | 4 | 27 | 34_1099 | 319 | 1199 | Topological domain | Lumenal |
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FusionGeneSequence for MYH9_SORCS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MYH9_ENST00000216181_chr22_36701079_-_SORCS1_ENST00000263054_chr10_108489872_-_1592aa MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELT CLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGK TENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKE ERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNT DQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGI LDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDK SFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSET ALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQR YEILTPNSIPKGFMDGKQACVLMVCDGVKXRTRPCASXGQNCGWSFTLSNLPNAELYRGQQESAFSRLHXPRLFDCSGSLCVCSADIRRA ATLLRVLPKECICPNEASEICFAQGHACYQHRXESGVRSGPRMEPEXHVQPLHLRHTWCLLHPGLGECPEQQRPXGQHHDRPLXGSRDKG NVLGXQEDXQPSEDFHHIXQRQRLAFAAGAGHGSKGGPRALLAALLLTTPSPEGLXESLHIRDHCQQRHSSKHHSGIRXYRFXIVRHXHQ HVCLFRCREHLETDLXRRAQCFVPGSRWSPGCYETHISPNSTSLVEFXXREILEQIQFHIYSTFCGWGSGXAWRRDSHHDSVWTLQPPLX MAAGQSRLQVHFXXTVCRRGLQTLAAAQPGGSMYHGSKKDIXEAKIRAEVYARKICRSYGIXTLCLHXGXFXLRLWLXATQQWPVPAGIL VQSILSVKGLQLGTELPQXYWVQEGGFQXLHXWRKGTVHCQTAEVPRESPAGAADSHGXWKADSGTRTQRHSHGAIRRGXCSADTHPSGL WRWYRGVLRQSQLHGRWDQTRLSERGHFPCDRAGGQQSGFXQRRPVLTCNLSLGARAPVSSLCHHKEQRGQCDGSAVAQPSGHPHLRVVV RKQHGAFDHLGGKHILQIYFRRNEYHHSAGLSWECHPTRHKDHRSIXGIPVSSLVLFSKPGXLQPGHPXVEEGHRSSHQKIPGGSHRGSR PAHPGGGAPWLTHHCXTLCPTLSGSSWRKQKVNXXPGADIRIADPHAQPKLSTLRAEARSPSPCPCCSLNSGPPGGPHSNPQWICHADAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MYH9_ENST00000216181_chr22_36701079_-_SORCS1_ENST00000263054_chr10_108489872_-_4777nt ATGGCACAGCAAGCTGCCGATAAGTATCTCTATGTGGATAAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAG CTGGTATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCAGCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAG AATGGGAAGAAGGTGAAGGTGAACAAGGATGACATCCAGAAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACG TGCCTCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAGCGTTACTACTCAGGGCTCATCTACACCTATTCAGGCCTGTTCTGTGTGGTC ATCAATCCTTACAAGAACCTGCCCATCTACTCTGAAGAGATTGTGGAAATGTACAAGGGCAAGAAGAGGCACGAGATGCCCCCTCACATC TATGCCATCACAGACACCGCCTACAGGAGTATGATGCAAGACCGAGAAGATCAATCCATCTTGTGCACTGGTGAATCTGGAGCTGGCAAG ACGGAGAACACCAAGAAGGTCATCCAGTATCTGGCGTACGTGGCGTCCTCGCACAAGAGCAAGAAGGACCAGGGCGAGCTGGAGCGGCAG CTGCTGCAGGCCAACCCCATCCTGGAGGCCTTCGGGAACGCCAAGACCGTGAAGAATGACAACTCCTCCCGCTTCGGCAAATTCATTCGC ATCAACTTTGATGTCAATGGCTACATTGTTGGAGCCAACATTGAGACTTATCTTTTGGAGAAATCTCGTGCTATCCGCCAAGCCAAGGAA GAACGGACCTTCCACATCTTCTATTATCTCCTGTCTGGGGCTGGAGAGCACCTGAAGACCGATCTCCTGTTGGAGCCGTACAACAAATAC CGCTTCCTGTCCAATGGACACGTCACCATCCCCGGGCAGCAGGACAAGGACATGTTCCAGGAGACCATGGAGGCCATGAGGATTATGGGC ATCCCAGAAGAGGAGCAAATGGGCCTGCTGCGGGTCATCTCAGGGGTTCTTCAGCTCGGCAACATCGTCTTCAAGAAGGAGCGGAACACT GACCAGGCGTCCATGCCCGACAACACAGCTGCCCAAAAGGTGTCCCATCTCTTGGGTATCAATGTGACCGATTTCACCAGAGGAATCCTC ACCCCGCGCATCAAGGTGGGACGGGATTACGTCCAGAAGGCGCAGACTAAAGAGCAGGCTGACTTTGCCATCGAGGCCTTGGCCAAGGCG ACCTATGAGCGGATGTTCCGCTGGCTGGTGCTGCGCATCAACAAGGCTCTGGACAAGACCAAGAGGCAGGGCGCCTCCTTCATCGGGATC CTGGACATTGCCGGCTTCGAGATCTTTGATCTGAACTCGTTTGAGCAGCTGTGCATCAATTACACCAATGAGAAGCTGCAGCAGCTCTTC AACCACACCATGTTCATCCTGGAGCAGGAGGAGTACCAGCGCGAGGGCATCGAGTGGAACTTCATCGACTTTGGCCTCGACCTGCAGCCC TGCATCGACCTCATTGAGAAGCCAGCAGGCCCCCCGGGCATTCTGGCCCTGCTGGACGAGGAGTGCTGGTTCCCCAAAGCCACCGACAAG AGCTTCGTGGAGAAGGTGATGCAGGAGCAGGGCACCCACCCCAAGTTCCAGAAGCCCAAGCAGCTGAAGGACAAAGCTGATTTCTGCATT ATCCACTATGCCGGCAAGGTGGATTACAAAGCTGACGAGTGGCTGATGAAGAACATGGATCCCCTGAATGACAACATCGCCACACTGCTC CACCAGTCCTCTGACAAGTTTGTCTCGGAGCTGTGGAAGGATGTGGACCGCATCATCGGCCTGGACCAGGTGGCCGGCATGTCGGAGACC GCACTGCCCGGGGCCTTCAAGACGCGGAAGGGCATGTTCCGCACTGTGGGGCAGCTTTACAAGGAGCAGCTGGCCAAGCTGATGGCTACG CTGAGGAACACGAACCCCAACTTTGTCCGCTGCATCATCCCCAACCACGAGAAGAAGGCCGGCAAGCTGGACCCGCATCTCGTGCTGGAC CAGCTGCGCTGCAACGGTGTTCTCGAGGGCATCCGTATCTGCCGCCAGGGCTTCCCCAACAGGGTGGTCTTCCAGGAGTTTCGGCAGAGA TATGAGATCCTGACTCCAAACTCCATTCCCAAGGGTTTCATGGACGGGAAGCAGGCGTGCGTGCTCATGGTCTGTGATGGGGTCAAATAA AGAACCAGACCTTGTGCATCTTGAGGCCAGAACTGTGGATGGTCATTCACATTATCTAACTTGCCGAATGCAGAACTGTACAGAGGCCAA CAGGAATCAGCCTTTTCCAGGCTACATTGACCCAGACTCTTTGATTGTTCAGGATCATTATGTGTTTGTTCAGCTGACATCAGGAGGGCG GCCACATTACTACGTGTCCTACCGAAGGAATGCATTTGCCCAAATGAAGCTTCCGAAATATGCTTTGCCCAAGGACATGCATGTTATCAG CACCGATGAGAATCAGGTGTTCGCAGCGGTCCAAGAATGGAACCAGAATGACACGTACAACCTCTACATCTCAGACACACGTGGTGTCTA CTTCACCCTGGCCTTGGAGAATGTCCAGAGCAGCAGAGGCCCTGAGGGCAACATCATGATCGACCTCTATGAGGTAGCAGGGATAAAGGG AATGTTCTTGGCTAACAAGAAGATTGACAACCAAGTGAAGACTTTCATCACATATAACAAAGGCAGAGACTGGCGTTTGCTGCAGGCGCC GGACACGGATCTAAGGGGGGACCCCGTGCACTGCTTGCTGCCCTATTGCTCACTACACCTTCACCTGAAGGTCTCTGAGAATCCCTACAC ATCAGGGATCATTGCCAGCAAAGACACAGCTCCAAGCATCATAGTGGCATCAGGTAATATAGGTTCTGAATTGTCAGACACTGACATCAG CATGTTTGTCTCTTCAGATGCAGGGAACACCTGGAGACAGATCTTTGAAGAAGAGCACAGTGTTTTGTACCTGGATCAAGGTGGAGTCCT GGTTGCTATGAAACACACATCTCTCCCAATTCGACATCTTTGGTTGAGTTTTGATGAAGGGAGATCTTGGAGCAAATACAGTTTCACATC TATTCCACTTTTTGTGGATGGGGTTCTGGGTGAGCCTGGAGAAGAGACTCTCATCATGACAGTGTTTGGACACTTCAGCCACCGCTCTGA ATGGCAGCTGGTCAAAGTAGATTACAAGTCCATTTTTGATAGACGGTGTGCCGAAGAGGACTACAGACCTTGGCAGCTGCACAGCCAGGG GGAAGCATGTATCATGGGAGCAAAAAGGATATATAAGAAGCGAAAATCAGAGCGGAAGTGTATGCAAGGAAAATATGCAGGAGCTATGGA ATCTGAACCCTGTGTCTGCACTGAGGCTGATTTTGATTGCGACTATGGTTATGAGCGACACAGCAATGGCCAGTGCCTGCCGGCATTTTG GTTCAATCCATCCTCTCTGTCAAAGGATTGCAGCTTGGGACAGAGTTACCTCAATAGTACTGGGTACAGGAAGGTGGTTTCCAATAATTG CACTGATGGCGTAAGGGAACAGTACACTGCCAAACCGCAGAAGTGCCCAGGGAAAGCCCCGCGGGGGCTGCGGATAGTCACGGCTGATGG AAAGCTGACAGCGGAACAAGGACACAACGTCACTCTCATGGTGCAATTAGAAGAGGGTGATGTTCAGCGGACACTCATCCAAGTGGACTT TGGCGATGGTATCGCGGTGTCTTACGTCAATCTCAGCTCCATGGAAGATGGGATCAAACACGTCTATCAGAACGTGGGCATTTTCCGTGT GACCGTGCAGGTGGACAACAGTCTGGGTTCTGACAGCGCCGTCCTGTACTTACATGTAACTTGTCCCTTGGAGCACGTGCACCTGTCTCT TCCCTTTGTCACCACAAAGAACAAAGAGGTCAATGCGACGGCAGTGCTGTGGCCCAGCCAAGTGGGCACCCTCACTTACGTGTGGTGGTA CGGAAACAACACGGAGCCTTTGATCACCTTGGAGGGAAGCATATCCTTCAGATTTACTTCAGAAGGAATGAATACCATCACAGTGCAGGT CTCAGCTGGGAATGCCATCCTACAAGACACAAAGACCATCGCAGTATATGAGGAATTCCGGTCTCTTCGCTTGTCCTTTTCTCCAAACCT GGATGACTACAACCCGGACATCCCTGAGTGGAGGAGGGACATCGGTCGAGTCATCAAAAAATCCCTGGTGGAAGCCACAGGGGTTCCAGG CCAGCACATCCTGGTGGCGGTGCTCCCTGGCTTACCCACCACTGCTGAACTCTTTGTCCTACCCTATCAGGATCCAGCTGGAGAAAACAA AAGGTCAACTGATGACCTGGAGCAGATATCAGAATTGCTGATCCACACGCTCAACCAAAACTCAGTACACTTCGAGCTGAAGCCAGGAGT CCGAGTCCTTGTCCATGCTGCTCACTTAACAGCGGCCCCCCTGGTGGACCTCACTCCAACCCACAGTGGATCTGCCATGCTGATGCTGCT CTCAGTGGTGTTTGTGGGGCTGGCAGTGTTCGTCATCTACAAGTTTAAAAGGAGAGTAGCTTTACCCTCCCCTCCCTCCCCTTCTACTCA ACCTGGTGACTCATCTCTCCGATTGCAAAGAGCAAGACACGCCACTCCGCCTTCAACGCCAAAGCGGGGATCTGCTGGGGCACAGTATGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MYH9_ENST00000216181_chr22_36701079_-_SORCS1_ENST00000263054_chr10_108489872_-_8765nt GAGGGCGGGGCGGGAAGGCGGCGAGGAGCCGAGCTGGGTGCGGTGAGGCGCGCAGATCACCGCGGTTCCTGGGCAGGGCACGGAAGGCTA AGCAAGGCTGACCTGCTGCAGCTCCCGCCTCGTGCGCTCGCCCCACCCGGCCGCCGCCCGAGCGCTCGAGAAAGTCCTCTCGGGAGAAGC AGCGCCTGTTCCCGGGGCAGATCCAGGTTCAGGTCCTGGCTATAAGTCACCATGGCACAGCAAGCTGCCGATAAGTATCTCTATGTGGAT AAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGGTATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCA GCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATGGGAAGAAGGTGAAGGTGAACAAGGATGACATCCAG AAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCCTCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAG CGTTACTACTCAGGGCTCATCTACACCTATTCAGGCCTGTTCTGTGTGGTCATCAATCCTTACAAGAACCTGCCCATCTACTCTGAAGAG ATTGTGGAAATGTACAAGGGCAAGAAGAGGCACGAGATGCCCCCTCACATCTATGCCATCACAGACACCGCCTACAGGAGTATGATGCAA GACCGAGAAGATCAATCCATCTTGTGCACTGGTGAATCTGGAGCTGGCAAGACGGAGAACACCAAGAAGGTCATCCAGTATCTGGCGTAC GTGGCGTCCTCGCACAAGAGCAAGAAGGACCAGGGCGAGCTGGAGCGGCAGCTGCTGCAGGCCAACCCCATCCTGGAGGCCTTCGGGAAC GCCAAGACCGTGAAGAATGACAACTCCTCCCGCTTCGGCAAATTCATTCGCATCAACTTTGATGTCAATGGCTACATTGTTGGAGCCAAC ATTGAGACTTATCTTTTGGAGAAATCTCGTGCTATCCGCCAAGCCAAGGAAGAACGGACCTTCCACATCTTCTATTATCTCCTGTCTGGG GCTGGAGAGCACCTGAAGACCGATCTCCTGTTGGAGCCGTACAACAAATACCGCTTCCTGTCCAATGGACACGTCACCATCCCCGGGCAG CAGGACAAGGACATGTTCCAGGAGACCATGGAGGCCATGAGGATTATGGGCATCCCAGAAGAGGAGCAAATGGGCCTGCTGCGGGTCATC TCAGGGGTTCTTCAGCTCGGCAACATCGTCTTCAAGAAGGAGCGGAACACTGACCAGGCGTCCATGCCCGACAACACAGCTGCCCAAAAG GTGTCCCATCTCTTGGGTATCAATGTGACCGATTTCACCAGAGGAATCCTCACCCCGCGCATCAAGGTGGGACGGGATTACGTCCAGAAG GCGCAGACTAAAGAGCAGGCTGACTTTGCCATCGAGGCCTTGGCCAAGGCGACCTATGAGCGGATGTTCCGCTGGCTGGTGCTGCGCATC AACAAGGCTCTGGACAAGACCAAGAGGCAGGGCGCCTCCTTCATCGGGATCCTGGACATTGCCGGCTTCGAGATCTTTGATCTGAACTCG TTTGAGCAGCTGTGCATCAATTACACCAATGAGAAGCTGCAGCAGCTCTTCAACCACACCATGTTCATCCTGGAGCAGGAGGAGTACCAG CGCGAGGGCATCGAGTGGAACTTCATCGACTTTGGCCTCGACCTGCAGCCCTGCATCGACCTCATTGAGAAGCCAGCAGGCCCCCCGGGC ATTCTGGCCCTGCTGGACGAGGAGTGCTGGTTCCCCAAAGCCACCGACAAGAGCTTCGTGGAGAAGGTGATGCAGGAGCAGGGCACCCAC CCCAAGTTCCAGAAGCCCAAGCAGCTGAAGGACAAAGCTGATTTCTGCATTATCCACTATGCCGGCAAGGTGGATTACAAAGCTGACGAG TGGCTGATGAAGAACATGGATCCCCTGAATGACAACATCGCCACACTGCTCCACCAGTCCTCTGACAAGTTTGTCTCGGAGCTGTGGAAG GATGTGGACCGCATCATCGGCCTGGACCAGGTGGCCGGCATGTCGGAGACCGCACTGCCCGGGGCCTTCAAGACGCGGAAGGGCATGTTC CGCACTGTGGGGCAGCTTTACAAGGAGCAGCTGGCCAAGCTGATGGCTACGCTGAGGAACACGAACCCCAACTTTGTCCGCTGCATCATC CCCAACCACGAGAAGAAGGCCGGCAAGCTGGACCCGCATCTCGTGCTGGACCAGCTGCGCTGCAACGGTGTTCTCGAGGGCATCCGTATC TGCCGCCAGGGCTTCCCCAACAGGGTGGTCTTCCAGGAGTTTCGGCAGAGATATGAGATCCTGACTCCAAACTCCATTCCCAAGGGTTTC ATGGACGGGAAGCAGGCGTGCGTGCTCATGGTCTGTGATGGGGTCAAATAAAGAACCAGACCTTGTGCATCTTGAGGCCAGAACTGTGGA TGGTCATTCACATTATCTAACTTGCCGAATGCAGAACTGTACAGAGGCCAACAGGAATCAGCCTTTTCCAGGCTACATTGACCCAGACTC TTTGATTGTTCAGGATCATTATGTGTTTGTTCAGCTGACATCAGGAGGGCGGCCACATTACTACGTGTCCTACCGAAGGAATGCATTTGC CCAAATGAAGCTTCCGAAATATGCTTTGCCCAAGGACATGCATGTTATCAGCACCGATGAGAATCAGGTGTTCGCAGCGGTCCAAGAATG GAACCAGAATGACACGTACAACCTCTACATCTCAGACACACGTGGTGTCTACTTCACCCTGGCCTTGGAGAATGTCCAGAGCAGCAGAGG CCCTGAGGGCAACATCATGATCGACCTCTATGAGGTAGCAGGGATAAAGGGAATGTTCTTGGCTAACAAGAAGATTGACAACCAAGTGAA GACTTTCATCACATATAACAAAGGCAGAGACTGGCGTTTGCTGCAGGCGCCGGACACGGATCTAAGGGGGGACCCCGTGCACTGCTTGCT GCCCTATTGCTCACTACACCTTCACCTGAAGGTCTCTGAGAATCCCTACACATCAGGGATCATTGCCAGCAAAGACACAGCTCCAAGCAT CATAGTGGCATCAGGTAATATAGGTTCTGAATTGTCAGACACTGACATCAGCATGTTTGTCTCTTCAGATGCAGGGAACACCTGGAGACA GATCTTTGAAGAAGAGCACAGTGTTTTGTACCTGGATCAAGGTGGAGTCCTGGTTGCTATGAAACACACATCTCTCCCAATTCGACATCT TTGGTTGAGTTTTGATGAAGGGAGATCTTGGAGCAAATACAGTTTCACATCTATTCCACTTTTTGTGGATGGGGTTCTGGGTGAGCCTGG AGAAGAGACTCTCATCATGACAGTGTTTGGACACTTCAGCCACCGCTCTGAATGGCAGCTGGTCAAAGTAGATTACAAGTCCATTTTTGA TAGACGGTGTGCCGAAGAGGACTACAGACCTTGGCAGCTGCACAGCCAGGGGGAAGCATGTATCATGGGAGCAAAAAGGATATATAAGAA GCGAAAATCAGAGCGGAAGTGTATGCAAGGAAAATATGCAGGAGCTATGGAATCTGAACCCTGTGTCTGCACTGAGGCTGATTTTGATTG CGACTATGGTTATGAGCGACACAGCAATGGCCAGTGCCTGCCGGCATTTTGGTTCAATCCATCCTCTCTGTCAAAGGATTGCAGCTTGGG ACAGAGTTACCTCAATAGTACTGGGTACAGGAAGGTGGTTTCCAATAATTGCACTGATGGCGTAAGGGAACAGTACACTGCCAAACCGCA GAAGTGCCCAGGGAAAGCCCCGCGGGGGCTGCGGATAGTCACGGCTGATGGAAAGCTGACAGCGGAACAAGGACACAACGTCACTCTCAT GGTGCAATTAGAAGAGGGTGATGTTCAGCGGACACTCATCCAAGTGGACTTTGGCGATGGTATCGCGGTGTCTTACGTCAATCTCAGCTC CATGGAAGATGGGATCAAACACGTCTATCAGAACGTGGGCATTTTCCGTGTGACCGTGCAGGTGGACAACAGTCTGGGTTCTGACAGCGC CGTCCTGTACTTACATGTAACTTGTCCCTTGGAGCACGTGCACCTGTCTCTTCCCTTTGTCACCACAAAGAACAAAGAGGTCAATGCGAC GGCAGTGCTGTGGCCCAGCCAAGTGGGCACCCTCACTTACGTGTGGTGGTACGGAAACAACACGGAGCCTTTGATCACCTTGGAGGGAAG CATATCCTTCAGATTTACTTCAGAAGGAATGAATACCATCACAGTGCAGGTCTCAGCTGGGAATGCCATCCTACAAGACACAAAGACCAT CGCAGTATATGAGGAATTCCGGTCTCTTCGCTTGTCCTTTTCTCCAAACCTGGATGACTACAACCCGGACATCCCTGAGTGGAGGAGGGA CATCGGTCGAGTCATCAAAAAATCCCTGGTGGAAGCCACAGGGGTTCCAGGCCAGCACATCCTGGTGGCGGTGCTCCCTGGCTTACCCAC CACTGCTGAACTCTTTGTCCTACCCTATCAGGATCCAGCTGGAGAAAACAAAAGGTCAACTGATGACCTGGAGCAGATATCAGAATTGCT GATCCACACGCTCAACCAAAACTCAGTACACTTCGAGCTGAAGCCAGGAGTCCGAGTCCTTGTCCATGCTGCTCACTTAACAGCGGCCCC CCTGGTGGACCTCACTCCAACCCACAGTGGATCTGCCATGCTGATGCTGCTCTCAGTGGTGTTTGTGGGGCTGGCAGTGTTCGTCATCTA CAAGTTTAAAAGGAGAGTAGCTTTACCCTCCCCTCCCTCCCCTTCTACTCAACCTGGTGACTCATCTCTCCGATTGCAAAGAGCAAGACA CGCCACTCCGCCTTCAACGCCAAAGCGGGGATCTGCTGGGGCACAGTATGCAATTTAAGGAAAACCCCCAAAGGCTACAGGCGACCTGCT GATCAGGAAAGAATTTCGCTCTTGTCAAGTACATCATCCTTCATGACCACTAACTTTGTGTTTTTTTTCTTTCCTTTGTTGTTCTGTTTC CTATTTTGCCAGGAAGTATTTCCATAGTTGCTGAGAATCAAAGCACAAAAGAAATCCCTACCTATGTAAATGTTTGAATGGAGGACGCCA GTAAAAAAACAAAAACAAAAACAAAACAAAACATAAAATATAAACAATCAAAATCCAAACAAACAAACAAACACTCACTGCATCGGGACT TTTTAATTCTTCAGACACAGACAACAAGGGTTTTTAGCTTTAAGCCTGTGCATGTGGACAATACTCTGAGAACATGTCTGGAGGGGCAGT GTACAGGTGCTCTATTTTAATGGAAAACACTCCCCTCTCCCTCTTTCTTCTTCTCTCTCTTTTTTCTGATCGGTCGTGTTTGTAGAAAAT TCATAACATATATAGGCCAAGGAAATCTGCATGTATTTTTGGAAATATTCTTGGCTCTAGATTTATCAGCTATTTTAGCATTAAAGGCTG ATGGGTGGATTAGCTACCCCAGCTCCTTTCATAAGACACAAAGACGTGCACAGGAGTTTGAAACCCTGAGCTGTTTCTCTGTTCCACTTT CCATACTGTCATTTCCCTTCTAAGTTAGCTTTGGTAGCTCTGTTGGTCAGCAGTGGCCACAAGGCTGCTTTCTGCACTCTCTGTGGCCAC AGGAACAAAGATGCGAGTTGAAGATCCCTTTGTGCCGGTAGAATAAGGAAGGAAGGGAGGCAGGGAGGCAAAGCATGTCAGAAACGGACC TTGGTTTCCTGTTCACCTCTTTCCACCATGATTGCCTCCCCTTGCAGCTTTCCCTACTCCTGCCCCAACTGCAGTAGGAAATGGAATCCC ATTAGTTACCCATTGTCCTGTCTTCACATTTGTTTGTCATCCATGTGTGACCATGATCTGTTGATATCTTTGAATCTCTTCCCTCCAAAC CCCAAGTAAGTTGTCCTTCAACTGTTCTCAGTTTTTCTTCCCAAACATATTGCTAGATTCTGGACATTAACCCTGACGTTTCCTAAATAC TGGCCTGGCCTGTGCCGCCCCTGCCCCCACTACTCACAAGTTTCTGAGCCCTTTGTCAGTTTTGTACATTCCCAAGCATGCCAGCTTCTG TGCCCATGGACCTTGCTGCATCCTGCACAGCAGGGTTCAGTTTCATGTATCTTTGTCTTTTCCTCTAGAACCTGCCTTTTTCAAATATCC CTGCCTTTTCCCACCTGGAAACATATACTGTATGCGAAAGAGTTGATATATGCAAAGTAATTCAAACCTGGCCATGTACTTTGGAAAAGA AAGCATAGAGATGAATTGTGGTGTTCTCACACCTTAACGAAAATCTCGTGCGATCTGATTCCAGAAGATTCTTGTGAGAAATGTTTTGAA TGTGTGACAATTTCGCAGGGCAATTTCCTCCTGTGACGGTTGCTGTTACCTGGTATTTCCACTCTCACAGTAGAATAGAAATGTTTGTGA AATAAAACTGATTTTAACTGGAAGGAGAAACAGGTTAATGGACTTTGTGTTTAAGAGTGTCAAACAGTCTGAGAGAATAAATGGGGGTCT TGTCTTACATTAGGGTGAGAGTTTGATTATTTAGGATGATCCCAGTGATTTCATGTGTGCTCTCTGACCTCTGAGTATCATAGTATCATT AAAGTAAAGATTTAAGTCTGTATAAAGGAGGAGAGTTACTGATTGGCAAAAAAGATTGGCACAAAGCATGAAGAAACCCCATTTTTCCCA GGGTAATCATGAAAGAAGGCTCAGAGAAAGAGGGAAACAAAAGCCTGTTCAGCAGAGGCCCCTTTAGTATTATGGACTGGGCAAAGCCCA CTATAAACTATAGGAGAAAGAAGTTCTGATAAACCTCTTAGTATGCTCAGCCTCCTTCTTTGCTATGTCCCTAAGCCAACAGGGTATAAC ACAGGCCCTGGTGATAATGAGGGTGTCCTAAAGATCCTGATGTCCATGACTTCATGTAGTTCAGGCACAGAAAGAATAGCAAAGCTGCTG TCAGAAGTTTGTCAGGCAGAGATGTTTATGGTTGAGGATACCCCATATGAATCTGGGAAATGGGCTAGGCCTGAGGCAGTCACCTATTTG TAGAACTCAATTGATCCCCAACCTGCCAGGCTTCCTATCTCATAGGAAACATCCTCATTGATCCTCTTCAGTTGGAGTCTCCCAAATTTA ATGTGGAAGACAAAGTGTTGGAAAATCAAAAGAGGCTCACTCAAACCAGCACAGGGAGTCCTCAGAGTTGCAGTTCAATTCATTTTAATT AGAAAAGTATGAAAGAGGTATAACACTCTTATTCTAGCACAGTGCCTTGCCTAGAGTAGTAGTATGAAAACTATTTGTTGAAGAAATAAA TGAATGGAAAGACATAGGGAAGAATGGGCTGTAAATCCTAATTAAAAATAGAGGTCGACATGAGATACCTGGCATTTTGGGAAGTGACCA AAGATGGCCAGCTAGAGATTCAGCATCTCCAGGATCCTCATGTGCCTCTCCTCAAAGCTCCCTCCCATCTGTAGGAGATTAGTGAGGCAA GGTGCTGCTCAGAGAGGAGGACCTCATTGTTCTTAGGACCTTGGCCAGTTGTTCTCAAAGTGTGGTACCTGGATCAGCAGTATCACTATC ACTTGGGCTAGTTAGAGATCCAGATTCTGGATCCATACCCCATACCTACTGAATTAGAAACTCTAGGGGATGAATAGTGGTGTTCTCTGT TGCTAAGTGACAGTGGGCCCAGCCACCTATTTTAACAAGCCCTCCCAGTGATTGTGATACATACTAAAGTTTGAGAACCATTGTACTAGG CCATTCCAGCTGAATCTCAAACAGAAGGCAGTAATGAGAGCCTACAAATGGGAGGGACCTAAGTGCCTACCTACTCGCTAATCGCAGGTG CAAACACACAAGGAGTTTGGTGGGCTTAAGGTCAGAGGAGTGTGTAGGGAGGGATGTATGTGGAAGGTAAGATTCAGGGCAAGCTAAAAA TCCGATACTGCAACGTTTTCCAAAATCCCAGAAGGCAAACTGTGCATGTTCTACCCTGAACCACCCAAGCAACACTTTCTACCTTGCCTT ATTTTTAATTGGATTCACTGTCCAAAATGCAGAGGTTTGCTTTGCTTTTTTTTCAGAAGTTCCAAACAGCAACTTTGAGAGCAGTGGGGT GCTTGGCAGCTGTTCTGTGTTTTCCAGGAATCCAACTGAGCATTGAAATCTCTCATTTGCCGACTTATTTTTATAGGAAGCCAATTAAAA AAAAAAAAAGTTTTCTTATAGTATTGGAACTACTTCTAATTTTAAAATGACTTTTTTGATGTATTTTTTGTTAAATACTATGTAGTGTAA TGTATAATTGCTCTTGTTTATTGCTTTTACAATCATATTTATTAAACAGATAATGTCTCTAAAGTCTTTGCCTCAGGTATTTTTTTTTTT AATCCTAAACCCTTGGTGTTCATTCTAAATATAGAAGTGTTGCATGTATAGGATTTCATAAAGGCTAATTGCATAAGAAAGAGTAAACAC CACAGGCTTGAGGTTTTTGGCTGTTTTTTACTAACAAGGCAGAATGTATGTACTACCTGAATTCTACCTGCATTTCAATTAACTATACAA 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FusionGenePPI for MYH9_SORCS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MYH9 | EPB41, MARK4, ASCC2, MYL9, PRKCE, USP1, USP45, GRB2, RAC1, YWHAZ, EMD, TERF1, TERF2, CBL, PPP2R4, AGO3, YWHAQ, MME, HDAC5, NCOA3, CREBBP, UBE3A, ARRB1, ARRB2, SIRT7, TRAF4, SP1, ISG15, FBXO25, CDK2, CUL1, TRIM72, GRK5, UBASH3B, PIK3R2, SHC1, MYL6, SPTAN1, HSP90AB1, ACTA2, MYH10, HNRNPU, FLNA, ACTR1A, RAB11A, EIF4B, SEL1L, ATP5A1, SEPT7, RALA, HSPA5, TUBA4A, EIF3A, EIF3C, TPM4, MRPS18B, PSME3, HSPA1A, ESR1, TSGA10, EIF4A3, MAGOH, TRAF3IP1, MEN1, HSP90AA1, VCAM1, FN1, IQCB1, ITGA4, PAN2, ACE, ACTB, CSNK2A1, PIK3C3, PPP2CA, CASP4, TARDBP, AKAP10, CDC73, MYH14, OTUD6B, MYL12A, RPA1, RPA2, RPA3, LGR4, IVNS1ABP, TP53, HUWE1, ALK, UBE2I, EED, AMFR, OS9, SYVN1, ATG9A, USP7, HNRNPA1, ATP5L, MYO1E, SRSF5, SSB, NTRK1, ACTA1, ACTG1, ACTN4, ACTN1, AP2A1, AP2B1, ANXA2, APOB, DST, CALD1, CALM1, CALML3, CAPZA1, CAPZA2, CAPZB, CD44, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, DAPK3, DBN1, DSG2, CTTN, STOM, EPS15, FLII, FLNB, FYN, GNAI1, GNAI2, GNAS, GNB2, GSN, HIP1, ITPR2, ITPR3, JUP, LGALS1, ABLIM1, LMO7, LSS, LYN, MYO1B, MSN, PDLIM7, ANLN, MYO19, MYO18A, MYLK, MYO1C, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, NAP1L1, PAWR, PIK3C2A, PLEC, PLS1, PPIA, PPP1CA, PPP1CB, PPP1CC, PSMB10, TWF1, PEX5, RPL22, SIPA1, SORD, SPTBN1, SPTBN2, SSFA2, ST5, SVIL, TCEA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, CORO2A, YES1, LUZP1, PICALM, PIP5K1A, SORBS2, IQGAP1, HIP1R, GPRC5A, LRRFIP2, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, ARPC2, BCAP31, FLOT1, BASP1, IMMT, RBPMS, DSTN, TRIOBP, CEP250, AKAP2, TWF2, SYNPO, CEP162, LIMCH1, PALLD, SIPA1L3, MPRIP, COBL, KIF13B, SPECC1L, ATP13A2, MACF1, CORO1C, STX12, GCA, PLEKHG3, RAI14, ZBTB20, AHDC1, PACSIN3, TMOD3, PNMA3, FCF1, CEP83, LIMA1, GTSE1, KDM3B, UACA, CDCA8, BMP2K, UNC45A, MYO5C, GNG12, MUC13, CORO1B, MICAL3, ARHGAP21, SHROOM3, AFAP1, INF2, NARFL, METTL17, AHNAK, EFHD2, CYBRD1, WDR76, DSN1, RNF170, TRIM56, ARPC5L, ANTXR1, LZTS2, PPP1R9B, CEP89, STON2, DOCK7, DIXDC1, SSH2, NEXN, ELMSAN1, SPECC1, CCDC102A, FCHO2, MISP, JMY, CD109, ACTRT1, MYL6B, CCDC50, OARD1, GAS2L3, TTLL6, TPRN, ACTBL2, MCM2, MCM5, SNW1, CDC5L, BOP1, PES1, EGFR, CDH1, C9orf156, MYL3, H2AFY, CYLD, TRIM25, BRCA1, HDAC6 | SORCS1 | SORT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYH9_SORCS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MYH9 | P35579 | DB11638 | Artenimol | Myosin-9 | small molecule | approved|investigational |
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RelatedDiseases for MYH9_SORCS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MYH9 | C0403445 | Fechtner syndrome (disorder) | 9 | UNIPROT |
| Hgene | MYH9 | C0398641 | Epstein syndrome (disorder) | 7 | UNIPROT |
| Hgene | MYH9 | C0340978 | May-Hegglin anomaly | 6 | UNIPROT |
| Hgene | MYH9 | C0022661 | Kidney Failure, Chronic | 2 | CTD_human |
| Hgene | MYH9 | C1854520 | SEBASTIAN SYNDROME | 2 | CTD_human;ORPHANET;UNIPROT |
| Hgene | MYH9 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
| Hgene | MYH9 | C0020544 | Renal hypertension | 1 | CTD_human |
| Hgene | MYH9 | C0027706 | Hereditary nephritis | 1 | CTD_human |
| Hgene | MYH9 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | MYH9 | C1863659 | DEAFNESS, AUTOSOMAL DOMINANT 17 | 1 | UNIPROT |
| Hgene | MYH9 | C2673482 | Increased susceptibility to schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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