FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 2302

FusionGeneSummary for ARAP2_PACS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARAP2_PACS1
Fusion gene ID: 2302
HgeneTgene
Gene symbol

ARAP2

PACS1

Gene ID

116984

55690

Gene nameArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2phosphofurin acidic cluster sorting protein 1
SynonymsCENTD1|PARXMRD17|SHMS
Cytomap

4p14

11q13.1-q13.2

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Arf and Rho GAP adapter protein 2centaurin-delta-1phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1
Modification date2018052220180523
UniProtAcc

Q8WZ64

Q6VY07

Ensembl transtripts involved in fusion geneENST00000513032, ENST00000303965, 
ENST00000320580, ENST00000529757, 
ENST00000524815, 
Fusion gene scores* DoF score3 X 3 X 3=2716 X 11 X 9=1584
# samples 319
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(19/1584*10)=-3.05950101174866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARAP2 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG987597ARAP2chr4

36066586

+PACS1chr11

65983613

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000513032ENST00000320580ARAP2chr4

36066586

+PACS1chr11

65983613

+
intron-intronENST00000513032ENST00000529757ARAP2chr4

36066586

+PACS1chr11

65983613

+
intron-intronENST00000513032ENST00000524815ARAP2chr4

36066586

+PACS1chr11

65983613

+
intron-3CDSENST00000303965ENST00000320580ARAP2chr4

36066586

+PACS1chr11

65983613

+
intron-intronENST00000303965ENST00000529757ARAP2chr4

36066586

+PACS1chr11

65983613

+
intron-intronENST00000303965ENST00000524815ARAP2chr4

36066586

+PACS1chr11

65983613

+

Top

FusionProtFeatures for ARAP2_PACS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARAP2

Q8WZ64

PACS1

Q6VY07

Phosphatidylinositol 3,4,5-trisphosphate-dependentGTPase-activating protein that modulates actin cytoskeletonremodeling by regulating ARF and RHO family members. Is activatedby phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3)binding. Can be activated by phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4,5)P2) binding, albeit with lower efficiency (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ARAP2_PACS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ARAP2_PACS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARAP2_PACS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARAP2_PACS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePACS1C0028754Obesity1CTD_human
TgenePACS1C0236969Substance-Related Disorders1CTD_human
TgenePACS1C3554343MENTAL RETARDATION, AUTOSOMAL DOMINANT 171ORPHANET;UNIPROT