![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 2302 |
FusionGeneSummary for ARAP2_PACS1 |
![]() |
Fusion gene information | Fusion gene name: ARAP2_PACS1 | Fusion gene ID: 2302 | Hgene | Tgene | Gene symbol | ARAP2 | PACS1 | Gene ID | 116984 | 55690 |
Gene name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | phosphofurin acidic cluster sorting protein 1 | |
Synonyms | CENTD1|PARX | MRD17|SHMS | |
Cytomap | 4p14 | 11q13.1-q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Arf and Rho GAP adapter protein 2centaurin-delta-1 | phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8WZ64 | Q6VY07 | |
Ensembl transtripts involved in fusion gene | ENST00000513032, ENST00000303965, | ENST00000320580, ENST00000529757, ENST00000524815, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 16 X 11 X 9=1584 |
# samples | 3 | 19 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/1584*10)=-3.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARAP2 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG987597 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000513032 | ENST00000320580 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
intron-intron | ENST00000513032 | ENST00000529757 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
intron-intron | ENST00000513032 | ENST00000524815 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
intron-3CDS | ENST00000303965 | ENST00000320580 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
intron-intron | ENST00000303965 | ENST00000529757 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
intron-intron | ENST00000303965 | ENST00000524815 | ARAP2 | chr4 | 36066586 | + | PACS1 | chr11 | 65983613 | + |
Top |
FusionProtFeatures for ARAP2_PACS1 |
![]() |
Hgene | Tgene |
ARAP2 | PACS1 |
Phosphatidylinositol 3,4,5-trisphosphate-dependentGTPase-activating protein that modulates actin cytoskeletonremodeling by regulating ARF and RHO family members. Is activatedby phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3)binding. Can be activated by phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4,5)P2) binding, albeit with lower efficiency (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ARAP2_PACS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ARAP2_PACS1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ARAP2_PACS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ARAP2_PACS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PACS1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | PACS1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | PACS1 | C3554343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 17 | 1 | ORPHANET;UNIPROT |