![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22976 |
FusionGeneSummary for MYH11_RAB2A |
![]() |
Fusion gene information | Fusion gene name: MYH11_RAB2A | Fusion gene ID: 22976 | Hgene | Tgene | Gene symbol | MYH11 | RAB2A | Gene ID | 4629 | 5862 |
Gene name | myosin heavy chain 11 | RAB2A, member RAS oncogene family | |
Synonyms | AAT4|FAA4|SMHC|SMMHC | LHX|RAB2 | |
Cytomap | 16p13.11 | 8q12.1-q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | myosin-11myosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle | ras-related protein Rab-2ARAB2, member RAS oncogene familysmall GTP binding protein RAB2A | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P35749 | P61019 | |
Ensembl transtripts involved in fusion gene | ENST00000396324, ENST00000452625, ENST00000576790, ENST00000300036, ENST00000573908, | ENST00000262646, ENST00000531289, ENST00000529579, ENST00000530071, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 7 X 6 X 4=168 |
# samples | 7 | 8 | |
** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MYH11 [Title/Abstract] AND RAB2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW377018 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000396324 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000396324 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000396324 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000396324 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000452625 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000452625 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000452625 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000452625 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000576790 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000576790 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000576790 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000576790 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000300036 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000300036 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000300036 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000300036 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000573908 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000573908 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000573908 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
intron-intron | ENST00000573908 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
Top |
FusionProtFeatures for MYH11_RAB2A |
![]() |
Hgene | Tgene |
MYH11 | RAB2A |
Muscle contraction. | Required for protein transport from the endoplasmicreticulum to the Golgi complex. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MYH11_RAB2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MYH11_RAB2A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MYH11_RAB2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MYH11_RAB2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MYH11 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
Hgene | MYH11 | C0023479 | Acute myelomonocytic leukemia | 1 | CTD_human;ORPHANET |
Hgene | MYH11 | C1851504 | Aortic aneurysm, familial thoracic 4 | 1 | CTD_human;UNIPROT |
Tgene | RAB2A | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |