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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 22961

FusionGeneSummary for MYCBP2_TAF6L

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2_TAF6L
Fusion gene ID: 22961
HgeneTgene
Gene symbol

MYCBP2

TAF6L

Gene ID

23077

10629

Gene nameMYC binding protein 2, E3 ubiquitin protein ligaseTATA-box binding protein associated factor 6 like
SynonymsMyc-bp2|PAM|PhrPAF65A
Cytomap

13q22.3

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with MycTAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6LPAF65-alphaPCAF-associated factor 65-alphaTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDap300/CBP-associated factor (PCAF
Modification date2018052320180523
UniProtAcc

O75592

Q9Y6J9

Ensembl transtripts involved in fusion geneENST00000544440, ENST00000407578, 
ENST00000357337, ENST00000360084, 
ENST00000482517, 		ENST00000294168, 
Fusion gene scores* DoF score9 X 9 X 7=5673 X 3 X 3=27
# samples 93
** MAII scorelog2(9/567*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYCBP2 [Title/Abstract] AND TAF6L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAF6L

GO:0043966

histone H3 acetylation

11564863


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9LZ-01AMYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000544440ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000407578ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000357337ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
5UTR-3CDSENST00000360084ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
intron-3CDSENST00000482517ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+

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FusionProtFeatures for MYCBP2_TAF6L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYCBP2

O75592

TAF6L

Q9Y6J9

Atypical E3 ubiquitin-protein ligase which specificallymediates ubiquitination of threonine and serine residues on targetproteins, instead of ubiquitinating lysine residues(PubMed:29643511). Shows esterification activity towards boththreonine and serine, with a preference for threonine, and actsvia two essential catalytic cysteine residues that relay ubiquitinto its substrate via thioester intermediates (PubMed:29643511).Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3(PubMed:18308511, PubMed:29643511). Plays a key role in neuraldevelopment, probably by mediating ubiquitination of threonineresidues on target proteins (Probable). Involved in differentprocesses such as regulation of neurite outgrowth, synapticgrowth, synaptogenesis and axon degeneration (By similarity).Required for the formation of major central nervous system axontracts (By similarity). Required for proper axon growth byregulating axon navigation and axon branching: acts by regulatingthe subcellular location and stability of MAP3K12/DLK (Bysimilarity). Required for proper localization of retinogeniculateprojections but not for eye-specific segregation (By similarity).Regulates axon guidance in the olfactory system (By similarity).Involved in Wallerian axon degeneration, an evolutionarilyconserved process that drives the loss of damaged axons: acts bypromoting destabilization of NMNAT2, probably via ubiquitinationof NMNAT2 (By similarity). Catalyzes ubiquitination of threonineand/or serine residues on NMNAT2, consequences of threonine and/orserine ubiquitination are however unknown (PubMed:29643511).Regulates the internalization of TRPV1 in peripheral sensoryneurons (By similarity). May mediate ubiquitination and subsequentproteasomal degradation of TSC2/tuberin (PubMed:18308511).Independently of the E3 ubiquitin-protein ligase activity, alsoacts as a guanosine exchange factor (GEF) for RAN in neurons ofdorsal root ganglia (PubMed:26304119). May function as afacilitator or regulator of transcriptional activation by MYC(PubMed:9689053). {ECO:0000250|UniProtKB:Q7TPH6,ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:26304119,ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}. Functions as a component of the PCAF complex. The PCAFcomplex is capable of efficiently acetylating histones in anucleosomal context. The PCAF complex could be considered as thehuman version of the yeast SAGA complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284103_126624641Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842720_2844624641Compositional biasSer-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843194_3215624641Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843262_3293624641Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284766_814624641Compositional biasCys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183103_126624641Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832720_2844624641Compositional biasSer-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833194_3215624641Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833262_3293624641Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183766_814624641Compositional biasCys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842466_2535624641DomainSH3b
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843719_3897624641DomainDOC
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832466_2535624641DomainSH3b
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833719_3897624641DomainDOC
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841235_1386624641RegionPHR domain 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841726_1884624641RegionPHR domain 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842022_2550624641RegionRAE1 binding
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844539_4676624641RegionTandem cysteine domain
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831235_1386624641RegionPHR domain 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831726_1884624641RegionPHR domain 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832022_2550624641RegionRAE1 binding
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834539_4676624641RegionTandem cysteine domain
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841010_1066624641RepeatRCC1 5
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842341_2443624641RepeatFilamin
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284600_655624641RepeatRCC1 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284699_755624641RepeatRCC1 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284907_957624641RepeatRCC1 3
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284958_1008624641RepeatRCC1 4
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831010_1066624641RepeatRCC1 5
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832341_2443624641RepeatFilamin
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183600_655624641RepeatRCC1 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183699_755624641RepeatRCC1 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183907_957624641RepeatRCC1 3
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183958_1008624641RepeatRCC1 4
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844428_4479624641Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844582_4632624641Zinc fingerNote=B box-type
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834428_4479624641Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834582_4632624641Zinc fingerNote=B box-type


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FusionGeneSequence for MYCBP2_TAF6L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MYCBP2_ENST00000544440_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_483aa
MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRXNLXAMTWSNCTGCCRWHGAYFVIRTC
AWGPMSAVWWAVSSTVSWSHWLPPSTPXMTTGLCGMGLPSCSATSSGLMGTLXVASISISCYPCRRSWQILCGRSAATMEPWWGCMLLAG
RQXNESCTHTCPPTGQTCRLCWMIIQYLMPRSKQMDTKSMEPFWWRXSDCXRXRPRQQSPTGVAQVAGGAGAWTTCHGTAFSFKSRPPGA
VQNPALGPASRCRQGARGRRTLLFRXPWPTSTGSSTPSSVTAWPHALAPASLHPRLRGRPGTRRSRRQPRTRCGRCRSXRQAPXSARTAT
RAPGAAAEAAPRRPLGPPPLRAGPCRACIGRAGHPGSRAPGPAPATFSRRAVSPRAAPRTFVSSXPGGRLGGAAAGAFSRLPSPRRTGLA

>In-frame_MYCBP2_ENST00000407578_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_521aa
MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQ
GGGSAGHPASRXNLXAMTWSNCTGCCRWHGAYFVIRTCAWGPMSAVWWAVSSTVSWSHWLPPSTPXMTTGLCGMGLPSCSATSSGLMGTL
XVASISISCYPCRRSWQILCGRSAATMEPWWGCMLLAGRQXNESCTHTCPPTGQTCRLCWMIIQYLMPRSKQMDTKSMEPFWWRXSDCXR
XRPRQQSPTGVAQVAGGAGAWTTCHGTAFSFKSRPPGAVQNPALGPASRCRQGARGRRTLLFRXPWPTSTGSSTPSSVTAWPHALAPASL
HPRLRGRPGTRRSRRQPRTRCGRCRSXRQAPXSARTATRAPGAAAEAAPRRPLGPPPLRAGPCRACIGRAGHPGSRAPGPAPATFSRRAV

>In-frame_MYCBP2_ENST00000357337_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_483aa
MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRXNLXAMTWSNCTGCCRWHGAYFVIRTC
AWGPMSAVWWAVSSTVSWSHWLPPSTPXMTTGLCGMGLPSCSATSSGLMGTLXVASISISCYPCRRSWQILCGRSAATMEPWWGCMLLAG
RQXNESCTHTCPPTGQTCRLCWMIIQYLMPRSKQMDTKSMEPFWWRXSDCXRXRPRQQSPTGVAQVAGGAGAWTTCHGTAFSFKSRPPGA
VQNPALGPASRCRQGARGRRTLLFRXPWPTSTGSSTPSSVTAWPHALAPASLHPRLRGRPGTRRSRRQPRTRCGRCRSXRQAPXSARTAT
RAPGAAAEAAPRRPLGPPPLRAGPCRACIGRAGHPGSRAPGPAPATFSRRAVSPRAAPRTFVSSXPGGRLGGAAAGAFSRLPSPRRTGLA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MYCBP2_ENST00000544440_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_1451nt
ATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTGCTG
TCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACACCCA
GCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTATTTCGTAATCCGCACCTGT
GCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCATCAACCCCCTGAATGACC
ACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTGGCCTCTATCAGCATATCC
TGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGCTGCATGCTCTTGGCTGGA
AGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATTATTCAGTATCTAATGCCC
AGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGGCCCAGGCAGCAGAGCCCA
ACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAGAGTCGTCCTCCGGGGGCG
GTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTTCGGTGACCCTGGCCGACA
TCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCACGGCTCCGCGGCCGCCCG
GGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAGTCAGCCCGCACGGCGACG
AGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCTTGCCGCGCGTGCATCGGG
CGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCCCGCGCGGCGCCCCGCACT
TTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCGCGCCGTACGGGCCTAGCC
CGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCTCGGACTACTCGCTGTACT

>In-frame_MYCBP2_ENST00000407578_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_1565nt
ATGATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCC
TCCCCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCC
CGGGGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAG
GGGGGCGGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGA
GCCTATTTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTG
CCTCCATCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTG
TAAGTGGCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGG
TGGGGCTGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGG
ATGATTATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGA
TGAAGGCCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCT
TTCAAGAGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTT
CTCTTTCGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTG
CACCCACGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCG
CCATAGTCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCA
GGCCCTTGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTT
TCGCCCCGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCT
TCCCCGCGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGG

>In-frame_MYCBP2_ENST00000357337_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_1451nt
ATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTGCTG
TCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACACCCA
GCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTATTTCGTAATCCGCACCTGT
GCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCATCAACCCCCTGAATGACC
ACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTGGCCTCTATCAGCATATCC
TGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGCTGCATGCTCTTGGCTGGA
AGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATTATTCAGTATCTAATGCCC
AGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGGCCCAGGCAGCAGAGCCCA
ACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAGAGTCGTCCTCCGGGGGCG
GTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTTCGGTGACCCTGGCCGACA
TCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCACGGCTCCGCGGCCGCCCG
GGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAGTCAGCCCGCACGGCGACG
AGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCTTGCCGCGCGTGCATCGGG
CGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCCCGCGCGGCGCCCCGCACT
TTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCGCGCCGTACGGGCCTAGCC
CGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCTCGGACTACTCGCTGTACT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MYCBP2_ENST00000544440_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_1515nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTAT
TTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCA
TCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTG
GCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGC
TGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATT
ATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGG
CCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAG
AGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTT
CGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCA
CGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAG
TCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCT
TGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCC
CGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCG
CGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCT

>In-frame_MYCBP2_ENST00000407578_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_1878nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCC
TATTTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCT
CCATCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAA
GTGGCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGG
GGCTGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATG
ATTATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGA
AGGCCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTC
AAGAGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTC
TTTCGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCAC
CCACGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCA
TAGTCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGC
CCTTGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCG
CCCCGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCC
CCGCGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGC

>In-frame_MYCBP2_ENST00000357337_chr13_77900609_-_TAF6L_ENST00000294168_chr11_62549585_+_1590nt
GGCGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGCCGGGGGCGCTG
TTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTG
CTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACAC
CCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTATTTCGTAATCCGCACC
TGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCATCAACCCCCTGAATG
ACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTGGCCTCTATCAGCATA
TCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGCTGCATGCTCTTGGCT
GGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATTATTCAGTATCTAATG
CCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGGCCCAGGCAGCAGAGC
CCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAGAGTCGTCCTCCGGGG
GCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTTCGGTGACCCTGGCCG
ACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCACGGCTCCGCGGCCGC
CCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAGTCAGCCCGCACGGCG
ACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCTTGCCGCGCGTGCATC
GGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCCCGCGCGGCGCCCCGC
ACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCGCGCCGTACGGGCCTA
GCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCTCGGACTACTCGCTGT


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FusionGenePPI for MYCBP2_TAF6L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYCBP2BAK1, SFN, MYC, USP11, RAE1, WDR48, NR1D1, UBC, UBE3A, YWHAB, YWHAG, CALM1, SIRT7, FBXO45, CUL4B, ATP13A2, YWHAQ, NOS2, CBX2, CBX4, ROBO2, HDAC11, LGR4, CCDC8, CCDC158, TDGF1, SESN3, DEF6, SKAP1, CLEC11A, CASQ2, LILRA3, ALDH1L2, WHSC1, PLK4, MED4, SRPK2, LGALS3BP, YWHAH, YWHAZ, SLAIN2, VPS26B, SKA1, HEY1, CRY1, CRY2, FBXW7, MEX3C, FAF1, ATOH1, CDC14A, STAT2, DOCK5, CETN1, TXNIP, CDH19, CCDC65, GUCY1B3, GDF10, PAPL, MYLIP, PGBD1, PDGFB, CTNNA3, PCDHA3, NEURL4TAF6LSTX11, SUPT3H, TAF9, USP22, TAF10, CREBBP, KAT2B, VCP, SOX2, MYOG, PASK, TAF9B, HIST3H3, CCDC8, SPINT2, HLA-DPA1, TADA1, TADA2B, TADA3, NTRK1, MED23, CCDC101, ATXN7, SUPT7L, TAF12, TAF5L, SUPT20H, KAT2A, TRRAP, STIP1, HSPA8, RFX3, HDAC1, XYLT2, ATXN7L3, ATXN7L3B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYCBP2_TAF6L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYCBP2_TAF6L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource