	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 22956

FusionGeneSummary for MYCBP2_PCBP2

Fusion gene summary

Fusion gene information	Fusion gene name: MYCBP2_PCBP2
	Fusion gene ID: 22956
		Hgene	Tgene
	Gene symbol	MYCBP2	PCBP2
	Gene ID	23077	5094
	Gene name	MYC binding protein 2, E3 ubiquitin protein ligase	poly(rC) binding protein 2
	Synonyms	Myc-bp2\|PAM\|Phr	HNRNPE2\|HNRPE2\|hnRNP-E2
	Cytomap	13q22.3	12q13.13
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc	poly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2
	Modification date	20180523	20180522
	UniProtAcc	O75592	Q15366
	Ensembl transtripts involved in fusion gene	ENST00000544440, ENST00000407578, ENST00000357337, ENST00000360084, ENST00000482517,	ENST00000359282, ENST00000603815, ENST00000437231, ENST00000447282, ENST00000549863, ENST00000359462, ENST00000546463, ENST00000552296, ENST00000552819, ENST00000455667, ENST00000439930, ENST00000548933, ENST00000541275,
Fusion gene scores	* DoF score	9 X 9 X 7=567	14 X 14 X 7=1372
	# samples	9	15
	** MAII score	log2(9/567*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1372*10)=-3.19324607567693 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MYCBP2 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PCBP2	GO:0039694	viral RNA genome replication	12414943
Tgene	PCBP2	GO:0075522	IRES-dependent viral translational initiation	12414943

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			T05177	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000544440	ENST00000359282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000603815	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000437231	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000447282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000549863	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000359462	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000546463	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000552296	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000552819	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000455667	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000439930	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000548933	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000544440	ENST00000541275	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000359282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000603815	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000437231	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000447282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000549863	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000359462	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000546463	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000552296	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000552819	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000455667	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000439930	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000548933	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000407578	ENST00000541275	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000359282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000603815	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000437231	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000447282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000549863	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000359462	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000546463	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000552296	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000552819	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000455667	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000439930	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000548933	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000357337	ENST00000541275	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000359282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000603815	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000437231	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000447282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000549863	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000359462	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000546463	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000552296	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000552819	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000455667	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000439930	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000548933	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000360084	ENST00000541275	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000359282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000603815	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000437231	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000447282	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000549863	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000359462	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000546463	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000552296	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000552819	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000455667	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000439930	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000548933	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+
intron-intron	ENST00000482517	ENST00000541275	MYCBP2	chr13	77779507	-	PCBP2	chr12	53856264	+

Top

FusionProtFeatures for MYCBP2_PCBP2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYCBP2 O75592	PCBP2 Q15366
Atypical E3 ubiquitin-protein ligase which specificallymediates ubiquitination of threonine and serine residues on targetproteins, instead of ubiquitinating lysine residues(PubMed:29643511). Shows esterification activity towards boththreonine and serine, with a preference for threonine, and actsvia two essential catalytic cysteine residues that relay ubiquitinto its substrate via thioester intermediates (PubMed:29643511).Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3(PubMed:18308511, PubMed:29643511). Plays a key role in neuraldevelopment, probably by mediating ubiquitination of threonineresidues on target proteins (Probable). Involved in differentprocesses such as regulation of neurite outgrowth, synapticgrowth, synaptogenesis and axon degeneration (By similarity).Required for the formation of major central nervous system axontracts (By similarity). Required for proper axon growth byregulating axon navigation and axon branching: acts by regulatingthe subcellular location and stability of MAP3K12/DLK (Bysimilarity). Required for proper localization of retinogeniculateprojections but not for eye-specific segregation (By similarity).Regulates axon guidance in the olfactory system (By similarity).Involved in Wallerian axon degeneration, an evolutionarilyconserved process that drives the loss of damaged axons: acts bypromoting destabilization of NMNAT2, probably via ubiquitinationof NMNAT2 (By similarity). Catalyzes ubiquitination of threonineand/or serine residues on NMNAT2, consequences of threonine and/orserine ubiquitination are however unknown (PubMed:29643511).Regulates the internalization of TRPV1 in peripheral sensoryneurons (By similarity). May mediate ubiquitination and subsequentproteasomal degradation of TSC2/tuberin (PubMed:18308511).Independently of the E3 ubiquitin-protein ligase activity, alsoacts as a guanosine exchange factor (GEF) for RAN in neurons ofdorsal root ganglia (PubMed:26304119). May function as afacilitator or regulator of transcriptional activation by MYC(PubMed:9689053). {ECO:0000250\|UniProtKB:Q7TPH6,ECO:0000269\|PubMed:18308511, ECO:0000269\|PubMed:26304119,ECO:0000269\|PubMed:29643511, ECO:0000269\|PubMed:9689053}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for MYCBP2_PCBP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MYCBP2_PCBP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for MYCBP2_PCBP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for MYCBP2_PCBP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 22956

FusionGeneSummary for MYCBP2_PCBP2

FusionProtFeatures for MYCBP2_PCBP2

FusionGeneSequence for MYCBP2_PCBP2

FusionGenePPI for MYCBP2_PCBP2

RelatedDrugs for MYCBP2_PCBP2

RelatedDiseases for MYCBP2_PCBP2