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Fusion gene ID: 22956 |
FusionGeneSummary for MYCBP2_PCBP2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MYCBP2_PCBP2 | Fusion gene ID: 22956 | Hgene | Tgene | Gene symbol | MYCBP2 | PCBP2 | Gene ID | 23077 | 5094 |
Gene name | MYC binding protein 2, E3 ubiquitin protein ligase | poly(rC) binding protein 2 | |
Synonyms | Myc-bp2|PAM|Phr | HNRNPE2|HNRPE2|hnRNP-E2 | |
Cytomap | 13q22.3 | 12q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc | poly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O75592 | Q15366 | |
Ensembl transtripts involved in fusion gene | ENST00000544440, ENST00000407578, ENST00000357337, ENST00000360084, ENST00000482517, | ENST00000359282, ENST00000603815, ENST00000437231, ENST00000447282, ENST00000549863, ENST00000359462, ENST00000546463, ENST00000552296, ENST00000552819, ENST00000455667, ENST00000439930, ENST00000548933, ENST00000541275, | |
Fusion gene scores | * DoF score | 9 X 9 X 7=567 | 14 X 14 X 7=1372 |
# samples | 9 | 15 | |
** MAII score | log2(9/567*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1372*10)=-3.19324607567693 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MYCBP2 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PCBP2 | GO:0039694 | viral RNA genome replication | 12414943 |
Tgene | PCBP2 | GO:0075522 | IRES-dependent viral translational initiation | 12414943 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T05177 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000544440 | ENST00000359282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000603815 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000437231 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000447282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000549863 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000359462 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000546463 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000552296 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000552819 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000455667 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000439930 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000548933 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000544440 | ENST00000541275 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000359282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000603815 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000437231 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000447282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000549863 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000359462 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000546463 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000552296 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000552819 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000455667 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000439930 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000548933 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000407578 | ENST00000541275 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000359282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000603815 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000437231 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000447282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000549863 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000359462 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000546463 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000552296 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000552819 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000455667 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000439930 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000548933 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000357337 | ENST00000541275 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000359282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000603815 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000437231 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000447282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000549863 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000359462 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000546463 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000552296 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000552819 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000455667 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000439930 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000548933 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000360084 | ENST00000541275 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000359282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000603815 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000437231 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000447282 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000549863 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000359462 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000546463 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000552296 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000552819 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000455667 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000439930 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000548933 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
intron-intron | ENST00000482517 | ENST00000541275 | MYCBP2 | chr13 | 77779507 | - | PCBP2 | chr12 | 53856264 | + |
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FusionProtFeatures for MYCBP2_PCBP2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MYCBP2 | PCBP2 |
Atypical E3 ubiquitin-protein ligase which specificallymediates ubiquitination of threonine and serine residues on targetproteins, instead of ubiquitinating lysine residues(PubMed:29643511). Shows esterification activity towards boththreonine and serine, with a preference for threonine, and actsvia two essential catalytic cysteine residues that relay ubiquitinto its substrate via thioester intermediates (PubMed:29643511).Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3(PubMed:18308511, PubMed:29643511). Plays a key role in neuraldevelopment, probably by mediating ubiquitination of threonineresidues on target proteins (Probable). Involved in differentprocesses such as regulation of neurite outgrowth, synapticgrowth, synaptogenesis and axon degeneration (By similarity).Required for the formation of major central nervous system axontracts (By similarity). Required for proper axon growth byregulating axon navigation and axon branching: acts by regulatingthe subcellular location and stability of MAP3K12/DLK (Bysimilarity). Required for proper localization of retinogeniculateprojections but not for eye-specific segregation (By similarity).Regulates axon guidance in the olfactory system (By similarity).Involved in Wallerian axon degeneration, an evolutionarilyconserved process that drives the loss of damaged axons: acts bypromoting destabilization of NMNAT2, probably via ubiquitinationof NMNAT2 (By similarity). Catalyzes ubiquitination of threonineand/or serine residues on NMNAT2, consequences of threonine and/orserine ubiquitination are however unknown (PubMed:29643511).Regulates the internalization of TRPV1 in peripheral sensoryneurons (By similarity). May mediate ubiquitination and subsequentproteasomal degradation of TSC2/tuberin (PubMed:18308511).Independently of the E3 ubiquitin-protein ligase activity, alsoacts as a guanosine exchange factor (GEF) for RAN in neurons ofdorsal root ganglia (PubMed:26304119). May function as afacilitator or regulator of transcriptional activation by MYC(PubMed:9689053). {ECO:0000250|UniProtKB:Q7TPH6,ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:26304119,ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYCBP2_PCBP2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYCBP2_PCBP2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYCBP2_PCBP2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYCBP2_PCBP2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |