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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22956

FusionGeneSummary for MYCBP2_PCBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2_PCBP2
Fusion gene ID: 22956
HgeneTgene
Gene symbol

MYCBP2

PCBP2

Gene ID

23077

5094

Gene nameMYC binding protein 2, E3 ubiquitin protein ligasepoly(rC) binding protein 2
SynonymsMyc-bp2|PAM|PhrHNRNPE2|HNRPE2|hnRNP-E2
Cytomap

13q22.3

12q13.13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Mycpoly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2
Modification date2018052320180522
UniProtAcc

O75592

Q15366

Ensembl transtripts involved in fusion geneENST00000544440, ENST00000407578, 
ENST00000357337, ENST00000360084, 
ENST00000482517, 
ENST00000359282, 
ENST00000603815, ENST00000437231, 
ENST00000447282, ENST00000549863, 
ENST00000359462, ENST00000546463, 
ENST00000552296, ENST00000552819, 
ENST00000455667, ENST00000439930, 
ENST00000548933, ENST00000541275, 
Fusion gene scores* DoF score9 X 9 X 7=56714 X 14 X 7=1372
# samples 915
** MAII scorelog2(9/567*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1372*10)=-3.19324607567693
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYCBP2 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePCBP2

GO:0039694

viral RNA genome replication

12414943

TgenePCBP2

GO:0075522

IRES-dependent viral translational initiation

12414943


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T05177MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000544440ENST00000359282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000603815MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000437231MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000447282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000549863MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000359462MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000546463MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000552296MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000552819MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000455667MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000439930MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000548933MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000544440ENST00000541275MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000359282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000603815MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000437231MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000447282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000549863MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000359462MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000546463MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000552296MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000552819MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000455667MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000439930MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000548933MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000407578ENST00000541275MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000359282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000603815MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000437231MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000447282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000549863MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000359462MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000546463MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000552296MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000552819MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000455667MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000439930MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000548933MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000357337ENST00000541275MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000359282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000603815MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000437231MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000447282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000549863MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000359462MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000546463MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000552296MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000552819MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000455667MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000439930MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000548933MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000360084ENST00000541275MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000359282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000603815MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000437231MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000447282MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000549863MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000359462MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000546463MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000552296MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000552819MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000455667MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000439930MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000548933MYCBP2chr13

77779507

-PCBP2chr12

53856264

+
intron-intronENST00000482517ENST00000541275MYCBP2chr13

77779507

-PCBP2chr12

53856264

+

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FusionProtFeatures for MYCBP2_PCBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYCBP2

O75592

PCBP2

Q15366

Atypical E3 ubiquitin-protein ligase which specificallymediates ubiquitination of threonine and serine residues on targetproteins, instead of ubiquitinating lysine residues(PubMed:29643511). Shows esterification activity towards boththreonine and serine, with a preference for threonine, and actsvia two essential catalytic cysteine residues that relay ubiquitinto its substrate via thioester intermediates (PubMed:29643511).Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3(PubMed:18308511, PubMed:29643511). Plays a key role in neuraldevelopment, probably by mediating ubiquitination of threonineresidues on target proteins (Probable). Involved in differentprocesses such as regulation of neurite outgrowth, synapticgrowth, synaptogenesis and axon degeneration (By similarity).Required for the formation of major central nervous system axontracts (By similarity). Required for proper axon growth byregulating axon navigation and axon branching: acts by regulatingthe subcellular location and stability of MAP3K12/DLK (Bysimilarity). Required for proper localization of retinogeniculateprojections but not for eye-specific segregation (By similarity).Regulates axon guidance in the olfactory system (By similarity).Involved in Wallerian axon degeneration, an evolutionarilyconserved process that drives the loss of damaged axons: acts bypromoting destabilization of NMNAT2, probably via ubiquitinationof NMNAT2 (By similarity). Catalyzes ubiquitination of threonineand/or serine residues on NMNAT2, consequences of threonine and/orserine ubiquitination are however unknown (PubMed:29643511).Regulates the internalization of TRPV1 in peripheral sensoryneurons (By similarity). May mediate ubiquitination and subsequentproteasomal degradation of TSC2/tuberin (PubMed:18308511).Independently of the E3 ubiquitin-protein ligase activity, alsoacts as a guanosine exchange factor (GEF) for RAN in neurons ofdorsal root ganglia (PubMed:26304119). May function as afacilitator or regulator of transcriptional activation by MYC(PubMed:9689053). {ECO:0000250|UniProtKB:Q7TPH6,ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:26304119,ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYCBP2_PCBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYCBP2_PCBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYCBP2_PCBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYCBP2_PCBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource