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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 22954

FusionGeneSummary for MYCBP2_CPB2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2_CPB2
Fusion gene ID: 22954
HgeneTgene
Gene symbol

MYCBP2

CPB2

Gene ID

23077

1361

Gene nameMYC binding protein 2, E3 ubiquitin protein ligasecarboxypeptidase B2
SynonymsMyc-bp2|PAM|PhrCPU|PCPB|TAFI
Cytomap

13q22.3

13q14.13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myccarboxypeptidase B2carboxypeptidase B-like proteincarboxypeptidase B2 (plasma)carboxypeptidase B2 (plasma, carboxypeptidase U)carboxypeptidase Rthrombin-activable fibrinolysis inhibitorthrombin-activatable fibrinolysis inhibitor
Modification date2018052320180523
UniProtAcc

O75592

Q96IY4

Ensembl transtripts involved in fusion geneENST00000544440, ENST00000407578, 
ENST00000357337, ENST00000360084, 
ENST00000482517, 		ENST00000181383, 
ENST00000439329, 
Fusion gene scores* DoF score9 X 9 X 7=5672 X 2 X 2=8
# samples 92
** MAII scorelog2(9/567*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: MYCBP2 [Title/Abstract] AND CPB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-UY-A78N-01AMYCBP2chr13

77862296

-CPB2chr13

46638876

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000544440ENST00000181383MYCBP2chr13

77862296

-CPB2chr13

46638876

-
In-frameENST00000544440ENST00000439329MYCBP2chr13

77862296

-CPB2chr13

46638876

-
In-frameENST00000407578ENST00000181383MYCBP2chr13

77862296

-CPB2chr13

46638876

-
In-frameENST00000407578ENST00000439329MYCBP2chr13

77862296

-CPB2chr13

46638876

-
Frame-shiftENST00000357337ENST00000181383MYCBP2chr13

77862296

-CPB2chr13

46638876

-
Frame-shiftENST00000357337ENST00000439329MYCBP2chr13

77862296

-CPB2chr13

46638876

-
5UTR-3CDSENST00000360084ENST00000181383MYCBP2chr13

77862296

-CPB2chr13

46638876

-
5UTR-3CDSENST00000360084ENST00000439329MYCBP2chr13

77862296

-CPB2chr13

46638876

-
intron-3CDSENST00000482517ENST00000181383MYCBP2chr13

77862296

-CPB2chr13

46638876

-
intron-3CDSENST00000482517ENST00000439329MYCBP2chr13

77862296

-CPB2chr13

46638876

-

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FusionProtFeatures for MYCBP2_CPB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYCBP2

O75592

CPB2

Q96IY4

Atypical E3 ubiquitin-protein ligase which specificallymediates ubiquitination of threonine and serine residues on targetproteins, instead of ubiquitinating lysine residues(PubMed:29643511). Shows esterification activity towards boththreonine and serine, with a preference for threonine, and actsvia two essential catalytic cysteine residues that relay ubiquitinto its substrate via thioester intermediates (PubMed:29643511).Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3(PubMed:18308511, PubMed:29643511). Plays a key role in neuraldevelopment, probably by mediating ubiquitination of threonineresidues on target proteins (Probable). Involved in differentprocesses such as regulation of neurite outgrowth, synapticgrowth, synaptogenesis and axon degeneration (By similarity).Required for the formation of major central nervous system axontracts (By similarity). Required for proper axon growth byregulating axon navigation and axon branching: acts by regulatingthe subcellular location and stability of MAP3K12/DLK (Bysimilarity). Required for proper localization of retinogeniculateprojections but not for eye-specific segregation (By similarity).Regulates axon guidance in the olfactory system (By similarity).Involved in Wallerian axon degeneration, an evolutionarilyconserved process that drives the loss of damaged axons: acts bypromoting destabilization of NMNAT2, probably via ubiquitinationof NMNAT2 (By similarity). Catalyzes ubiquitination of threonineand/or serine residues on NMNAT2, consequences of threonine and/orserine ubiquitination are however unknown (PubMed:29643511).Regulates the internalization of TRPV1 in peripheral sensoryneurons (By similarity). May mediate ubiquitination and subsequentproteasomal degradation of TSC2/tuberin (PubMed:18308511).Independently of the E3 ubiquitin-protein ligase activity, alsoacts as a guanosine exchange factor (GEF) for RAN in neurons ofdorsal root ganglia (PubMed:26304119). May function as afacilitator or regulator of transcriptional activation by MYC(PubMed:9689053). {ECO:0000250|UniProtKB:Q7TPH6,ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:26304119,ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}. Cleaves C-terminal arginine or lysine residues frombiologically active peptides such as kinins or anaphylatoxins inthe circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues fromfibrin that has already been partially degraded by plasmin.{ECO:0000269|PubMed:10574983}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-484103_1261604641Compositional biasLys-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-383103_1261604641Compositional biasLys-rich
TgeneCPB2chr13:77862296chr13:46638876ENST00000181383-611256_257234424RegionSubstrate binding
TgeneCPB2chr13:77862296chr13:46638876ENST00000181383-611311_312234424RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4842720_28441604641Compositional biasSer-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4843194_32151604641Compositional biasLys-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4843262_32931604641Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-484766_8141604641Compositional biasCys-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3832720_28441604641Compositional biasSer-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3833194_32151604641Compositional biasLys-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3833262_32931604641Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-383766_8141604641Compositional biasCys-rich
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4842466_25351604641DomainSH3b
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4843719_38971604641DomainDOC
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3832466_25351604641DomainSH3b
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3833719_38971604641DomainDOC
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4841235_13861604641RegionPHR domain 1
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4841726_18841604641RegionPHR domain 2
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4842022_25501604641RegionRAE1 binding
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4844539_46761604641RegionTandem cysteine domain
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3831235_13861604641RegionPHR domain 1
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3831726_18841604641RegionPHR domain 2
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3832022_25501604641RegionRAE1 binding
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3834539_46761604641RegionTandem cysteine domain
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4841010_10661604641RepeatRCC1 5
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4842341_24431604641RepeatFilamin
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-484600_6551604641RepeatRCC1 1
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-484699_7551604641RepeatRCC1 2
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-484907_9571604641RepeatRCC1 3
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-484958_10081604641RepeatRCC1 4
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3831010_10661604641RepeatRCC1 5
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3832341_24431604641RepeatFilamin
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-383600_6551604641RepeatRCC1 1
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-383699_7551604641RepeatRCC1 2
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-383907_9571604641RepeatRCC1 3
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-383958_10081604641RepeatRCC1 4
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4844428_44791604641Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000357337-4844582_46321604641Zinc fingerNote=B box-type
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3834428_44791604641Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77862296chr13:46638876ENST00000544440-3834582_46321604641Zinc fingerNote=B box-type
TgeneCPB2chr13:77862296chr13:46638876ENST00000181383-611181_184234424RegionSubstrate binding


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FusionGeneSequence for MYCBP2_CPB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MYCBP2_ENST00000544440_chr13_77862296_-_CPB2_ENST00000181383_chr13_46638876_-_350aa
MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSE
NLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKNRMWRKNRSFYANNHCIGTD
LNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAI

>In-frame_MYCBP2_ENST00000544440_chr13_77862296_-_CPB2_ENST00000439329_chr13_46638876_-_324aa
MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSE
NLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKNRMWRKNRSFYANNHCIGTD
LNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAI

>In-frame_MYCBP2_ENST00000407578_chr13_77862296_-_CPB2_ENST00000181383_chr13_46638876_-_388aa
MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQ
GGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGE
SDSDEEEESKEPPIKLPKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAY
ISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLL

>In-frame_MYCBP2_ENST00000407578_chr13_77862296_-_CPB2_ENST00000439329_chr13_46638876_-_362aa
MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQ
GGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGE
SDSDEEEESKEPPIKLPKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAY
ISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSVTSNPPVEKLLPLSL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MYCBP2_ENST00000544440_chr13_77862296_-_CPB2_ENST00000181383_chr13_46638876_-_1050nt
ATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTGCTG
TCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACACCCA
GCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAGACAAGAAGCAAGTCTGAA
AACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGTAATGTACGCCATTGCGTT
CTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGATAGTGATGAAGAAGAGGAA
TCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCGAACAATCATTGCATCGGAACAGAC
CTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACCTACTGTGGACTTTATCCTGAG
TCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATACATCAGCATGCATTCATACTCCCAG
CATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCCAGTGAAGCAGTTCGTGCTATT
GAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCTGGAGGTGGGGACGATTGGATCTAT
GATTTGGGCATCAAATATTCGTTTACAATTGAACTTCGAGATACGGGCACATACGGATTCTTGCTGCCGGAGCGTTACATCAAACCCACC

>In-frame_MYCBP2_ENST00000544440_chr13_77862296_-_CPB2_ENST00000439329_chr13_46638876_-_972nt
ATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTGCTG
TCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACACCCA
GCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAGACAAGAAGCAAGTCTGAA
AACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGTAATGTACGCCATTGCGTT
CTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGATAGTGATGAAGAAGAGGAA
TCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCGAACAATCATTGCATCGGAACAGAC
CTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACCTACTGTGGACTTTATCCTGAG
TCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATACATCAGCATGCATTCATACTCCCAG
CATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCCAGTGAAGCAGTTCGTGCTATT
GAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCTGGAGGTGGGGACGATTGGATCTAT

>In-frame_MYCBP2_ENST00000407578_chr13_77862296_-_CPB2_ENST00000181383_chr13_46638876_-_1164nt
ATGATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCC
TCCCCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCC
CGGGGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAG
GGGGGCGGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAA
GTGAAGACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATT
TACTGTAATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAA
TCAGATAGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCG
AACAATCATTGCATCGGAACAGACCTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAA
ACCTACTGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATAC
ATCAGCATGCATTCATACTCCCAGCATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTA
GCCAGTGAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCT
GGAGGTGGGGACGATTGGATCTATGATTTGGGCATCAAATATTCGTTTACAATTGAACTTCGAGATACGGGCACATACGGATTCTTGCTG

>In-frame_MYCBP2_ENST00000407578_chr13_77862296_-_CPB2_ENST00000439329_chr13_46638876_-_1086nt
ATGATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCC
TCCCCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCC
CGGGGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAG
GGGGGCGGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAA
GTGAAGACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATT
TACTGTAATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAA
TCAGATAGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCG
AACAATCATTGCATCGGAACAGACCTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAA
ACCTACTGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATAC
ATCAGCATGCATTCATACTCCCAGCATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTA
GCCAGTGAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCT
GGAGGTGGGGACGATTGGATCTATGATTTGGGCATCAAATATTCCGTTACATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MYCBP2_ENST00000544440_chr13_77862296_-_CPB2_ENST00000181383_chr13_46638876_-_1496nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAG
ACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGT
AATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGAT
AGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCGAACAAT
CATTGCATCGGAACAGACCTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACCTAC
TGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATACATCAGC
ATGCATTCATACTCCCAGCATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCCAGT
GAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCTGGAGGT
GGGGACGATTGGATCTATGATTTGGGCATCAAATATTCGTTTACAATTGAACTTCGAGATACGGGCACATACGGATTCTTGCTGCCGGAG
CGTTACATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTAAAATAGCTTGGCATGTCATTAGGAATGTTTAATGCCCCTGATTT
TATCATTCTGCTTCCGTATTTTAATTTACTGATTCCAGCAAGACCAAATCATTGTATCAAATTATTTTTAAGTTTTATCCGTAGTTTTGA
TAAAAGATTTTCCTATTCCTTGGTTCTGTCAGAGAACCTAATAAGTGCTACTTTGCCATTAAGGCAGACTAGGGTTCATGTCTTTTTACC
CTTTAAAAAAAATTGTAAAAGTCTAGTTACCTACTTTTTCTTTGATTTTCGACGTTTGACTAGCCATCTCAAGCAAGTTTCGACGTTTGA
CTAGCCATCTCAAGCAAGTTTAATCAATGATCATCTCACGCTGATCATTGGATCCTACTCAACAAAAGGAAGGGTGGTCAGAAGTACATT

>In-frame_MYCBP2_ENST00000544440_chr13_77862296_-_CPB2_ENST00000439329_chr13_46638876_-_1443nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAG
ACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGT
AATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGAT
AGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCGAACAAT
CATTGCATCGGAACAGACCTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACCTAC
TGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATACATCAGC
ATGCATTCATACTCCCAGCATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCCAGT
GAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCTGGAGGT
GGGGACGATTGGATCTATGATTTGGGCATCAAATATTCCGTTACATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTAAAATAG
CTTGGCATGTCATTAGGAATGTTTAATGCCCCTGATTTTATCATTCTGCTTCCGTATTTTAATTTACTGATTCCAGCAAGACCAAATCAT
TGTATCAAATTATTTTTAAGTTTTATCCGTAGTTTTGATAAAAGATTTTCCTATTCCTTGGTTCTGTCAGAGAACCTAATAAGTGCTACT
TTGCCATTAAGGCAGACTAGGGTTCATGTCTTTTTACCCTTTAAAAAAAATTGTAAAAGTCTAGTTACCTACTTTTTCTTTGATTTTCGA
CGTTTGACTAGCCATCTCAAGCAAGTTTCGACGTTTGACTAGCCATCTCAAGCAAGTTTAATCAATGATCATCTCACGCTGATCATTGGA
TCCTACTCAACAAAAGGAAGGGTGGTCAGAAGTACATTAAAGATTTCTGCTCCAAATTTTCAATAAATTTCTGCTTGTGCCTTTAGAAAT

>In-frame_MYCBP2_ENST00000407578_chr13_77862296_-_CPB2_ENST00000181383_chr13_46638876_-_1859nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTG
AAGACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTAC
TGTAATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCA
GATAGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCGAAC
AATCATTGCATCGGAACAGACCTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACC
TACTGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATACATC
AGCATGCATTCATACTCCCAGCATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCC
AGTGAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCTGGA
GGTGGGGACGATTGGATCTATGATTTGGGCATCAAATATTCGTTTACAATTGAACTTCGAGATACGGGCACATACGGATTCTTGCTGCCG
GAGCGTTACATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTAAAATAGCTTGGCATGTCATTAGGAATGTTTAATGCCCCTGA
TTTTATCATTCTGCTTCCGTATTTTAATTTACTGATTCCAGCAAGACCAAATCATTGTATCAAATTATTTTTAAGTTTTATCCGTAGTTT
TGATAAAAGATTTTCCTATTCCTTGGTTCTGTCAGAGAACCTAATAAGTGCTACTTTGCCATTAAGGCAGACTAGGGTTCATGTCTTTTT
ACCCTTTAAAAAAAATTGTAAAAGTCTAGTTACCTACTTTTTCTTTGATTTTCGACGTTTGACTAGCCATCTCAAGCAAGTTTCGACGTT
TGACTAGCCATCTCAAGCAAGTTTAATCAATGATCATCTCACGCTGATCATTGGATCCTACTCAACAAAAGGAAGGGTGGTCAGAAGTAC

>In-frame_MYCBP2_ENST00000407578_chr13_77862296_-_CPB2_ENST00000439329_chr13_46638876_-_1806nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTG
AAGACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTAC
TGTAATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCA
GATAGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGAATCGAATGTGGAGAAAGAACCGTTCTTTCTATGCGAAC
AATCATTGCATCGGAACAGACCTGAATAGGAACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACC
TACTGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATCAACCAGATTAAAGCATACATC
AGCATGCATTCATACTCCCAGCATATAGTGTTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCC
AGTGAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAAACCTTATACCTAGCTCCTGGA
GGTGGGGACGATTGGATCTATGATTTGGGCATCAAATATTCCGTTACATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTAAAA
TAGCTTGGCATGTCATTAGGAATGTTTAATGCCCCTGATTTTATCATTCTGCTTCCGTATTTTAATTTACTGATTCCAGCAAGACCAAAT
CATTGTATCAAATTATTTTTAAGTTTTATCCGTAGTTTTGATAAAAGATTTTCCTATTCCTTGGTTCTGTCAGAGAACCTAATAAGTGCT
ACTTTGCCATTAAGGCAGACTAGGGTTCATGTCTTTTTACCCTTTAAAAAAAATTGTAAAAGTCTAGTTACCTACTTTTTCTTTGATTTT
CGACGTTTGACTAGCCATCTCAAGCAAGTTTCGACGTTTGACTAGCCATCTCAAGCAAGTTTAATCAATGATCATCTCACGCTGATCATT
GGATCCTACTCAACAAAAGGAAGGGTGGTCAGAAGTACATTAAAGATTTCTGCTCCAAATTTTCAATAAATTTCTGCTTGTGCCTTTAGA


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FusionGenePPI for MYCBP2_CPB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYCBP2BAK1, SFN, MYC, USP11, RAE1, WDR48, NR1D1, UBC, UBE3A, YWHAB, YWHAG, CALM1, SIRT7, FBXO45, CUL4B, ATP13A2, YWHAQ, NOS2, CBX2, CBX4, ROBO2, HDAC11, LGR4, CCDC8, CCDC158, TDGF1, SESN3, DEF6, SKAP1, CLEC11A, CASQ2, LILRA3, ALDH1L2, WHSC1, PLK4, MED4, SRPK2, LGALS3BP, YWHAH, YWHAZ, SLAIN2, VPS26B, SKA1, HEY1, CRY1, CRY2, FBXW7, MEX3C, FAF1, ATOH1, CDC14A, STAT2, DOCK5, CETN1, TXNIP, CDH19, CCDC65, GUCY1B3, GDF10, PAPL, MYLIP, PGBD1, PDGFB, CTNNA3, PCDHA3, NEURL4CPB2A2M, F2, PLG, C5, FN1, TINAG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYCBP2_CPB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYCBP2_CPB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPB2C0002453Amenorrhea1CTD_human
TgeneCPB2C0028754Obesity1CTD_human