FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22942

FusionGeneSummary for MYBL2_TOX2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYBL2_TOX2
Fusion gene ID: 22942
HgeneTgene
Gene symbol

MYBL2

TOX2

Gene ID

4605

84969

Gene nameMYB proto-oncogene like 2TOX high mobility group box family member 2
SynonymsB-MYB|BMYBC20orf100|GCX-1|GCX1|dJ1108D11.2|dJ495O3.1
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionmyb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2TOX high mobility group box family member 2granulosa cell HMG box 1
Modification date2018052320180522
UniProtAcc

P10244

Q96NM4

Ensembl transtripts involved in fusion geneENST00000396863, ENST00000217026, 
ENST00000341197, ENST00000423191, 
ENST00000372999, ENST00000358131, 
ENST00000435864, 
Fusion gene scores* DoF score3 X 4 X 3=3610 X 6 X 8=480
# samples 610
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYBL2 [Title/Abstract] AND TOX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYBL2

GO:0045944

positive regulation of transcription by RNA polymerase II

10770937

TgeneTOX2

GO:0045944

positive regulation of transcription by RNA polymerase II

25352127


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GV-A40G-01AMYBL2chr20

42315712

+TOX2chr20

42635187

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000396863ENST00000341197MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000396863ENST00000423191MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000396863ENST00000372999MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000396863ENST00000358131MYBL2chr20

42315712

+TOX2chr20

42635187

+
5CDS-intronENST00000396863ENST00000435864MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000217026ENST00000341197MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000217026ENST00000423191MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000217026ENST00000372999MYBL2chr20

42315712

+TOX2chr20

42635187

+
Frame-shitENST00000217026ENST00000358131MYBL2chr20

42315712

+TOX2chr20

42635187

+
5CDS-intronENST00000217026ENST00000435864MYBL2chr20

42315712

+TOX2chr20

42635187

+

Top

FusionProtFeatures for MYBL2_TOX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYBL2

P10244

TOX2

Q96NM4

Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MYBL2_TOX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MYBL2_TOX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYBL2ZNF622, CDKN1C, RBL1, E2F1, E2F3, EP300, CREBBP, PARP1, CDK2, CCNA1, MYBL2, CDK9, CCNT1, SKP2, LZTR1, TRIM15, ZBTB9, NLK, HIPK2, LIN54, LIN9, LIN37, LIN52, MAPK6, MAP1LC3B, RBBP4, FLNA, SPTA1, CLTC, SPTBN1, CLTA, CCNE1, CXCR4, UBE2D4, TTF2, EWSR1, CTDSPL2, NUF2, PPP2R3C, ZSCAN26, TEAD2, CCNF, FOXM1, PLA2G4A, EPAS1TOX2APP, TOX, TOX4, AKT3, GINS4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MYBL2_TOX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MYBL2_TOX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource