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Fusion gene ID: 22942 |
FusionGeneSummary for MYBL2_TOX2 |
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Fusion gene information | Fusion gene name: MYBL2_TOX2 | Fusion gene ID: 22942 | Hgene | Tgene | Gene symbol | MYBL2 | TOX2 | Gene ID | 4605 | 84969 |
Gene name | MYB proto-oncogene like 2 | TOX high mobility group box family member 2 | |
Synonyms | B-MYB|BMYB | C20orf100|GCX-1|GCX1|dJ1108D11.2|dJ495O3.1 | |
Cytomap | 20q13.12 | 20q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | myb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2 | TOX high mobility group box family member 2granulosa cell HMG box 1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P10244 | Q96NM4 | |
Ensembl transtripts involved in fusion gene | ENST00000396863, ENST00000217026, | ENST00000341197, ENST00000423191, ENST00000372999, ENST00000358131, ENST00000435864, | |
Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 10 X 6 X 8=480 |
# samples | 6 | 10 | |
** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MYBL2 [Title/Abstract] AND TOX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MYBL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10770937 |
Tgene | TOX2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25352127 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-GV-A40G-01A | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000396863 | ENST00000341197 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000396863 | ENST00000423191 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000396863 | ENST00000372999 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000396863 | ENST00000358131 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
5CDS-intron | ENST00000396863 | ENST00000435864 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000217026 | ENST00000341197 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000217026 | ENST00000423191 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000217026 | ENST00000372999 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
Frame-shift | ENST00000217026 | ENST00000358131 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
5CDS-intron | ENST00000217026 | ENST00000435864 | MYBL2 | chr20 | 42315712 | + | TOX2 | chr20 | 42635187 | + |
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FusionProtFeatures for MYBL2_TOX2 |
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Hgene | Tgene |
MYBL2 | TOX2 |
Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYBL2_TOX2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYBL2_TOX2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MYBL2 | ZNF622, CDKN1C, RBL1, E2F1, E2F3, EP300, CREBBP, PARP1, CDK2, CCNA1, MYBL2, CDK9, CCNT1, SKP2, LZTR1, TRIM15, ZBTB9, NLK, HIPK2, LIN54, LIN9, LIN37, LIN52, MAPK6, MAP1LC3B, RBBP4, FLNA, SPTA1, CLTC, SPTBN1, CLTA, CCNE1, CXCR4, UBE2D4, TTF2, EWSR1, CTDSPL2, NUF2, PPP2R3C, ZSCAN26, TEAD2, CCNF, FOXM1, PLA2G4A, EPAS1 | TOX2 | APP, TOX, TOX4, AKT3, GINS4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYBL2_TOX2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYBL2_TOX2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |