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Fusion gene ID: 22936 |
FusionGeneSummary for MYBBP1A_CAMTA2 |
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Fusion gene information | Fusion gene name: MYBBP1A_CAMTA2 | Fusion gene ID: 22936 | Hgene | Tgene | Gene symbol | MYBBP1A | CAMTA2 | Gene ID | 10514 | 23125 |
Gene name | MYB binding protein 1a | calmodulin binding transcription activator 2 | |
Synonyms | P160|PAP2|Pol5 | - | |
Cytomap | 17p13.2 | 17p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | myb-binding protein 1AMYB binding protein (P160) 1ap53-activated protein-2 | calmodulin-binding transcription activator 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BQG0 | O94983 | |
Ensembl transtripts involved in fusion gene | ENST00000381556, ENST00000254718, | ENST00000358183, ENST00000414043, ENST00000361571, ENST00000572543, ENST00000381311, ENST00000348066, ENST00000571831, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 4 X 3 X 4=48 |
# samples | 5 | 5 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MYBBP1A [Title/Abstract] AND CAMTA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MYBBP1A | GO:0042149 | cellular response to glucose starvation | 21471221 |
Tgene | CAMTA2 | GO:0006357 | regulation of transcription by RNA polymerase II | 16678093 |
Tgene | CAMTA2 | GO:0014898 | cardiac muscle hypertrophy in response to stress | 16678093 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-1842-01A | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000381556 | ENST00000358183 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000381556 | ENST00000414043 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000381556 | ENST00000361571 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000381556 | ENST00000572543 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000381556 | ENST00000381311 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000381556 | ENST00000348066 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
5CDS-5UTR | ENST00000381556 | ENST00000571831 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000254718 | ENST00000358183 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000254718 | ENST00000414043 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000254718 | ENST00000361571 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000254718 | ENST00000572543 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000254718 | ENST00000381311 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
Frame-shift | ENST00000254718 | ENST00000348066 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
5CDS-5UTR | ENST00000254718 | ENST00000571831 | MYBBP1A | chr17 | 4451819 | - | CAMTA2 | chr17 | 4886338 | - |
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FusionProtFeatures for MYBBP1A_CAMTA2 |
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Hgene | Tgene |
MYBBP1A | CAMTA2 |
May activate or repress transcription via interactionswith sequence specific DNA-binding proteins. Repression may bemediated at least in part by histone deacetylase activity (HDACactivity). Acts as a corepressor and in concert with CRY1,represses the transcription of the core circadian clock componentPER2. Preferentially binds to dimethylated histone H3 'Lys-9'(H3K9me2) on the PER2 promoter. {ECO:0000250|UniProtKB:Q7TPV4}. | Transcription activator. May act as tumor suppressor.{ECO:0000269|PubMed:11925432}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MYBBP1A_CAMTA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MYBBP1A_CAMTA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MYBBP1A | DDX56, LYAR, MYC, PCNA, AIRE, NR4A1, HOXB9, BAZ1B, VHL, TCEB1, TCEB2, TAF1D, NOP2, NCL, MINA, BOP1, ZBTB7B, SMN1, NOP56, MARK4, WDR5, UBTF, POLR1A, SIRT7, SMARCA5, HDGF, CUL3, CUL1, COPS5, CAND1, GRK5, APP, RPL7, RPL4, RPL6, RPS3, RPS13, RPL23A, RPS6, EEF1A1, RPL37A, RSL1D1, RPL18, RPS2, RPL5, RPS11, RPS14, RPS24, RPS23, RPS8, HNRNPC, RNPS1, FTSJ3, IK, RRS1, RRP7A, PTRF, NOP16, SND1, HNRNPA0, MCM5, NCSTN, HNRNPR, ESR1, EP300, TP53, SRPK3, TARDBP, RELA, LGR4, STAU1, CUL7, OBSL1, CCDC8, UBE2I, EED, RNF2, BMI1, RPL14, BSG, NIFK, NPM1, ZBTB38, PRR11, ILF2, WHSC1, PRPF8, NTRK1, SCARNA22, HNRNPU, MYH6, RPL10, CDC5L, PES1, C1orf131, ZNF746, CDC14B, KIAA0020, RBM34, H2AFY2, GPATCH4, MECP2, RPL30, RRP8, FGF3, FGF8, PDGFB, RPL18A, SRP68, CDX1, PLEKHO1, KNOP1, MAGEB10, TRIM44, CCDC59, MARC1, SOD1, TRIM25, BRCA1, LMNA, MTF1 | CAMTA2 | NKX2-5, HDAC5, CALM2, CALM3, FAM192A, PSME3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYBBP1A_CAMTA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYBBP1A_CAMTA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |