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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22922

FusionGeneSummary for MXD4_PSMC4

check button Fusion gene summary
Fusion gene informationFusion gene name: MXD4_PSMC4
Fusion gene ID: 22922
HgeneTgene
Gene symbol

MXD4

PSMC4

Gene ID

10608

5704

Gene nameMAX dimerization protein 4proteasome 26S subunit, ATPase 4
SynonymsMAD4|MST149|MSTP149|bHLHc12MIP224|RPT3|S6|TBP-7|TBP7
Cytomap

4p16.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionmax dimerization protein 4Mad4 homologclass C basic helix-loop-helix protein 12max dimerizer 4max-associated protein 4max-interacting transcriptional repressor MAD426S proteasome regulatory subunit 6B26S protease regulatory subunit 6B26S proteasome AAA-ATPase subunit RPT3MB67-interacting proteinTat-binding protein 7protease 26S subunit 6proteasome (prosome, macropain) 26S subunit, ATPase, 4
Modification date2018051920180523
UniProtAcc

Q14582

P43686

Ensembl transtripts involved in fusion geneENST00000337190, ENST00000515378, 
ENST00000157812, ENST00000455878, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 5 X 1=15
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MXD4 [Title/Abstract] AND PSMC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP432759MXD4chr4

2259708

-PSMC4chr19

40485976

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000337190ENST00000157812MXD4chr4

2259708

-PSMC4chr19

40485976

+
Frame-shiftENST00000337190ENST00000455878MXD4chr4

2259708

-PSMC4chr19

40485976

+
5UTR-3CDSENST00000515378ENST00000157812MXD4chr4

2259708

-PSMC4chr19

40485976

+
5UTR-3CDSENST00000515378ENST00000455878MXD4chr4

2259708

-PSMC4chr19

40485976

+

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FusionProtFeatures for MXD4_PSMC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MXD4

Q14582

PSMC4

P43686

Transcriptional repressor. Binds with MAX to form asequence-specific DNA-binding protein complex which recognizes thecore sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptionalactivity by competing for MAX and suppresses MYC dependent celltransformation (By similarity). {ECO:0000250}. Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. PSMC4 belongs to theheterohexameric ring of AAA (ATPases associated with diversecellular activities) proteins that unfolds ubiquitinated targetproteins that are concurrently translocated into a proteolyticchamber and degraded into peptides. {ECO:0000269|PubMed:1317798,ECO:0000269|PubMed:8060531}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MXD4_PSMC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MXD4_PSMC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MXD4TCP10L, MLX, MAX, SMC3, SHBGPSMC4PSMC5, PSMD10, PSMD2, PAAF1, PSMD13, PSMD1, PSMC3, PSMC2, PSMD11, PAICS, BAG2, PSMD6, PSMC1, HTR1E, PSMD7, CMYA5, RIOK3, UCHL5, USP14, ATG4C, RNF2, SRRM2, UBC, MYC, HDAC5, RORB, PSMA3, PCK1, MAP3K5, RAD23A, SHFM1, FKBP8, PSMD8, PSMB5, TRIM5, PSMC6, SNCAIP, PFDN5, KIAA0368, PSMA2, CUL3, TRAP1, PRAME, NR1I3, PSMD12, PSMD3, PSMD4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB7, PSMD14, PSMA1, PSMB2, PSMB3, PSMB6, PSMA4, PSME1, PSME2, PSMB8, PSMA8, TUBA4A, ACTR1A, DCTN2, TUBA1B, TMOD3, ZCCHC8, RBBP4, YBX1, SMURF1, NOS2, CFTR, PARK2, NPM1, ADRM1, PPFIA1, RPS7, VCP, HUWE1, MOV10, NXF1, CCDC74B, CCDC92, PSMB9, FBXW11, AMBRA1, AHSA1, DNAJA2, ELP6, FTSJ3, GFPT1, IKBKAP, LONP1, MCFD2, MTCH1, PSMB4, CAD, PSMD5, PSMD9, RAD23B, RFC5, NTRK1, TMEM67, CENPJ, CRY1, CRY2, SNW1, CDC5L, HERC3, PTPN2, UBLCP1, GPAM, MYO1D, KXD1, KIAA0100, TTF2, SMC2, ZFAND2B, FLNC, RAB3GAP1, INTU, USP44, DLD, DLST, DNM1L, HSD17B10, CCND2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MXD4_PSMC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MXD4_PSMC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource