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Fusion gene ID: 22922 |
FusionGeneSummary for MXD4_PSMC4 |
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Fusion gene information | Fusion gene name: MXD4_PSMC4 | Fusion gene ID: 22922 | Hgene | Tgene | Gene symbol | MXD4 | PSMC4 | Gene ID | 10608 | 5704 |
Gene name | MAX dimerization protein 4 | proteasome 26S subunit, ATPase 4 | |
Synonyms | MAD4|MST149|MSTP149|bHLHc12 | MIP224|RPT3|S6|TBP-7|TBP7 | |
Cytomap | 4p16.3 | 19q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | max dimerization protein 4Mad4 homologclass C basic helix-loop-helix protein 12max dimerizer 4max-associated protein 4max-interacting transcriptional repressor MAD4 | 26S proteasome regulatory subunit 6B26S protease regulatory subunit 6B26S proteasome AAA-ATPase subunit RPT3MB67-interacting proteinTat-binding protein 7protease 26S subunit 6proteasome (prosome, macropain) 26S subunit, ATPase, 4 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14582 | P43686 | |
Ensembl transtripts involved in fusion gene | ENST00000337190, ENST00000515378, | ENST00000157812, ENST00000455878, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 5 X 1=15 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MXD4 [Title/Abstract] AND PSMC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP432759 | MXD4 | chr4 | 2259708 | - | PSMC4 | chr19 | 40485976 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000337190 | ENST00000157812 | MXD4 | chr4 | 2259708 | - | PSMC4 | chr19 | 40485976 | + |
Frame-shift | ENST00000337190 | ENST00000455878 | MXD4 | chr4 | 2259708 | - | PSMC4 | chr19 | 40485976 | + |
5UTR-3CDS | ENST00000515378 | ENST00000157812 | MXD4 | chr4 | 2259708 | - | PSMC4 | chr19 | 40485976 | + |
5UTR-3CDS | ENST00000515378 | ENST00000455878 | MXD4 | chr4 | 2259708 | - | PSMC4 | chr19 | 40485976 | + |
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FusionProtFeatures for MXD4_PSMC4 |
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Hgene | Tgene |
MXD4 | PSMC4 |
Transcriptional repressor. Binds with MAX to form asequence-specific DNA-binding protein complex which recognizes thecore sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptionalactivity by competing for MAX and suppresses MYC dependent celltransformation (By similarity). {ECO:0000250}. | Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. PSMC4 belongs to theheterohexameric ring of AAA (ATPases associated with diversecellular activities) proteins that unfolds ubiquitinated targetproteins that are concurrently translocated into a proteolyticchamber and degraded into peptides. {ECO:0000269|PubMed:1317798,ECO:0000269|PubMed:8060531}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MXD4_PSMC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MXD4_PSMC4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MXD4 | TCP10L, MLX, MAX, SMC3, SHBG | PSMC4 | PSMC5, PSMD10, PSMD2, PAAF1, PSMD13, PSMD1, PSMC3, PSMC2, PSMD11, PAICS, BAG2, PSMD6, PSMC1, HTR1E, PSMD7, CMYA5, RIOK3, UCHL5, USP14, ATG4C, RNF2, SRRM2, UBC, MYC, HDAC5, RORB, PSMA3, PCK1, MAP3K5, RAD23A, SHFM1, FKBP8, PSMD8, PSMB5, TRIM5, PSMC6, SNCAIP, PFDN5, KIAA0368, PSMA2, CUL3, TRAP1, PRAME, NR1I3, PSMD12, PSMD3, PSMD4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB7, PSMD14, PSMA1, PSMB2, PSMB3, PSMB6, PSMA4, PSME1, PSME2, PSMB8, PSMA8, TUBA4A, ACTR1A, DCTN2, TUBA1B, TMOD3, ZCCHC8, RBBP4, YBX1, SMURF1, NOS2, CFTR, PARK2, NPM1, ADRM1, PPFIA1, RPS7, VCP, HUWE1, MOV10, NXF1, CCDC74B, CCDC92, PSMB9, FBXW11, AMBRA1, AHSA1, DNAJA2, ELP6, FTSJ3, GFPT1, IKBKAP, LONP1, MCFD2, MTCH1, PSMB4, CAD, PSMD5, PSMD9, RAD23B, RFC5, NTRK1, TMEM67, CENPJ, CRY1, CRY2, SNW1, CDC5L, HERC3, PTPN2, UBLCP1, GPAM, MYO1D, KXD1, KIAA0100, TTF2, SMC2, ZFAND2B, FLNC, RAB3GAP1, INTU, USP44, DLD, DLST, DNM1L, HSD17B10, CCND2, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MXD4_PSMC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MXD4_PSMC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |