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Fusion gene ID: 22917 |
FusionGeneSummary for MXD1_ANTXR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MXD1_ANTXR1 | Fusion gene ID: 22917 | Hgene | Tgene | Gene symbol | MXD1 | ANTXR1 | Gene ID | 4084 | 84168 |
| Gene name | MAX dimerization protein 1 | ANTXR cell adhesion molecule 1 | |
| Synonyms | BHLHC58|MAD|MAD1 | ATR|GAPO|TEM8 | |
| Cytomap | 2p13.3 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | max dimerization protein 1MAX-binding proteinantagonizer of myc transcriptional activitymax dimerizer 1 | anthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q05195 | Q9H6X2 | |
| Ensembl transtripts involved in fusion gene | ENST00000264444, ENST00000540449, ENST00000465446, | ENST00000303714, ENST00000409829, ENST00000409349, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 5 X 3=75 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MXD1 [Title/Abstract] AND ANTXR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MXD1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10723141|12837246 |
| Tgene | ANTXR1 | GO:0031532 | actin cytoskeleton reorganization | 16762926 |
| Tgene | ANTXR1 | GO:0034446 | substrate adhesion-dependent cell spreading | 16762926 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-24-2023-01A | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264444 | ENST00000303714 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| In-frame | ENST00000264444 | ENST00000409829 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| In-frame | ENST00000264444 | ENST00000409349 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| intron-3CDS | ENST00000540449 | ENST00000303714 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| intron-3CDS | ENST00000540449 | ENST00000409829 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| intron-3CDS | ENST00000540449 | ENST00000409349 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| intron-3CDS | ENST00000465446 | ENST00000303714 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| intron-3CDS | ENST00000465446 | ENST00000409829 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
| intron-3CDS | ENST00000465446 | ENST00000409349 | MXD1 | chr2 | 70148897 | + | ANTXR1 | chr2 | 69267176 | + |
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FusionProtFeatures for MXD1_ANTXR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MXD1 | ANTXR1 |
| Transcriptional repressor. MAD binds with MAX to form asequence-specific DNA-binding protein complex which recognizes thecore sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYCtranscriptional activity by competing for MAX. | Plays a role in cell attachment and migration. Interactswith extracellular matrix proteins and with the actincytoskeleton. Mediates adhesion of cells to type 1 collagen andgelatin, reorganization of the actin cytoskeleton and promotescell spreading. Plays a role in the angiogenic response ofcultured umbilical vein endothelial cells.{ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MXD1 | chr2:70148897 | chr2:69267176 | ENST00000264444 | + | 3 | 6 | 21_49 | 67 | 222 | Motif | Nuclear localization signal |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 360_368 | 50 | 565 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 506_564 | 50 | 565 | Compositional bias | Note=Pro-rich |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 360_368 | 50 | 369 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 506_564 | 50 | 369 | Compositional bias | Note=Pro-rich |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 360_368 | 50 | 334 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 506_564 | 50 | 334 | Compositional bias | Note=Pro-rich |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 343_564 | 50 | 565 | Topological domain | Cytoplasmic |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 343_564 | 50 | 369 | Topological domain | Cytoplasmic |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 343_564 | 50 | 334 | Topological domain | Cytoplasmic |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 322_342 | 50 | 565 | Transmembrane | Helical |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 322_342 | 50 | 369 | Transmembrane | Helical |
| Tgene | >ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 322_342 | 50 | 334 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MXD1 | chr2:70148897 | chr2:69267176 | ENST00000264444 | + | 3 | 6 | 56_108 | 67 | 222 | Domain | bHLH |
| Hgene | >MXD1 | chr2:70148897 | chr2:69267176 | ENST00000540449 | + | 1 | 5 | 56_108 | -48 | 212 | Domain | bHLH |
| Hgene | >MXD1 | chr2:70148897 | chr2:69267176 | ENST00000540449 | + | 1 | 5 | 21_49 | -48 | 212 | Motif | Nuclear localization signal |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 44_215 | 50 | 565 | Domain | VWFA |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 44_215 | 50 | 369 | Domain | VWFA |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 44_215 | 50 | 334 | Domain | VWFA |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 33_321 | 50 | 565 | Topological domain | Extracellular |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 33_321 | 50 | 369 | Topological domain | Extracellular |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 33_321 | 50 | 334 | Topological domain | Extracellular |
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FusionGeneSequence for MXD1_ANTXR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000303714_chr2_69267176_+_582aa MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRSGSVLHHWNEIYYFVEQLAHKF ISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSER EANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVD RVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFW PLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNL NNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPP >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000409829_chr2_69267176_+_351aa MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRSGSVLHHWNEIYYFVEQLAHKF ISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSER EANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVD >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000409349_chr2_69267176_+_386aa MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRSGSVLHHWNEIYYFVEQLAHKF ISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSER EANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVD RVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFW |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000303714_chr2_69267176_+_1746nt ATGGCGGCGGCGGTTCGGATGAACATCCAGATGCTGCTGGAGGCGGCCGACTATCTGGAGCGGCGGGAGAGAGAAGCTGAACATGGTTAT GCCTCCATGTTACCATACAATAACAAGGACAGAGATGCCTTAAAACGGAGGAACAAATCCAAAAAGAATAACAGCAGTAGCAGATCAACT CACAATGAAATGGAGAAGAATAGATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTC ATCAGCCCACAGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAGACAGAGAACAAATCCGT CAAGGCCTAGAAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTAT GAAAACAGACAAGGGTACAGGACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGG GAGGCTAATAGGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGAC AGTAAGGATCATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATT CTAGCAGCTGAACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGAC AGGGTCCTCTGCAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCG CCTATCTTAAAAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCTTTTATCTCCAGTTCTGTCATCATCACC ACCACACACTGTTCTGACGGTTCCATCCTGGCCATCGCCCTGCTGATCCTGTTCCTGCTCCTAGCCCTGGCTCTCCTCTGGTGGTTCTGG CCCCTCTGCTGCACTGTGATTATCAAGGAGGTCCCTCCACCCCCTGCCGAGGAGAGTGAGGAAGAAGATGATGATGGTCTGCCTAAGAAA AAGTGGCCAACGGTAGACGCCTCTTATTATGGTGGGAGAGGCGTTGGAGGCATTAAAAGAATGGAGGTTCGTTGGGGAGAAAAGGGCTCC ACAGAAGAAGGTGCTAAGTTGGAAAAGGCAAAGAATGCAAGAGTCAAGATGCCGGAGCAGGAATATGAATTCCCTGAGCCGCGAAATCTC AACAACAATATGCGTCGGCCTTCTTCCCCCCGGAAGTGGTACTCTCCAATCAAGGGAAAACTCGATGCCTTGTGGGTCCTACTGAGGAAA GGATATGATCGTGTGTCTGTGATGCGTCCACAGCCAGGAGACACGGGGCGCTGCATCAACTTCACCAGGGTCAAGAACAACCAGCCAGCC AAGTACCCACTCAACAACGCCTACCACACCTCCTCGCCGCCTCCTGCCCCCATCTACACTCCCCCACCTCCTGCGCCCCACTGCCCTCCC CCGCCCCCCAGCGCCCCTACCCCTCCCATCCCGTCCCCACCTTCCACCCTTCCCCCTCCTCCCCAGGCTCCACCTCCCAACAGGGCACCT >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000409829_chr2_69267176_+_1053nt ATGGCGGCGGCGGTTCGGATGAACATCCAGATGCTGCTGGAGGCGGCCGACTATCTGGAGCGGCGGGAGAGAGAAGCTGAACATGGTTAT GCCTCCATGTTACCATACAATAACAAGGACAGAGATGCCTTAAAACGGAGGAACAAATCCAAAAAGAATAACAGCAGTAGCAGATCAACT CACAATGAAATGGAGAAGAATAGATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTC ATCAGCCCACAGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAGACAGAGAACAAATCCGT CAAGGCCTAGAAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTAT GAAAACAGACAAGGGTACAGGACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGG GAGGCTAATAGGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGAC AGTAAGGATCATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATT CTAGCAGCTGAACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGAC AGGGTCCTCTGCAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCG CCTATCTTAAAAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCTTTTATCTCCAGTTCTGTCATCATCACC >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000409349_chr2_69267176_+_1158nt ATGGCGGCGGCGGTTCGGATGAACATCCAGATGCTGCTGGAGGCGGCCGACTATCTGGAGCGGCGGGAGAGAGAAGCTGAACATGGTTAT GCCTCCATGTTACCATACAATAACAAGGACAGAGATGCCTTAAAACGGAGGAACAAATCCAAAAAGAATAACAGCAGTAGCAGATCAACT CACAATGAAATGGAGAAGAATAGATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTC ATCAGCCCACAGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAGACAGAGAACAAATCCGT CAAGGCCTAGAAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTAT GAAAACAGACAAGGGTACAGGACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGG GAGGCTAATAGGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGAC AGTAAGGATCATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATT CTAGCAGCTGAACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGAC AGGGTCCTCTGCAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCG CCTATCTTAAAAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCTTTTATCTCCAGTTCTGTCATCATCACC ACCACACACTGTTCTGACGGTTCCATCCTGGCCATCGCCCTGCTGATCCTGTTCCTGCTCCTAGCCCTGGCTCTCCTCTGGTGGTTCTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000303714_chr2_69267176_+_5848nt GAGTCGGGGATAAACACTCCGCGGCGGTGGCGGCTGCTGCTCTGCTCCGGGTTCTGTCACTGTGTCGGCGGTGCCCAGCTCACTGGCCCC CTCCCTCTCTTGTCGAGCGTGGTTGCCAGAGAGGCTCCCTCAGCCCTGCTCCGCGGGGTCCACAGCGGGCTCCACAGCGGGCTCCATAGC GGGCTCCACAGCGGTCCGGCGGCGGCAGCGAGCCCGTGGGCAGTGGGGGTTGGTCCCGTGGCTCCGGCCCCCGGTGCAGAATGGCGGCGG CGGTTCGGATGAACATCCAGATGCTGCTGGAGGCGGCCGACTATCTGGAGCGGCGGGAGAGAGAAGCTGAACATGGTTATGCCTCCATGT TACCATACAATAACAAGGACAGAGATGCCTTAAAACGGAGGAACAAATCCAAAAAGAATAACAGCAGTAGCAGATCAACTCACAATGAAA TGGAGAAGAATAGATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTCATCAGCCCAC AGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAGACAGAGAACAAATCCGTCAAGGCCTAG AAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTATGAAAACAGAC AAGGGTACAGGACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGGGAGGCTAATA GGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGACAGTAAGGATC ATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATTCTAGCAGCTG AACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGACAGGGTCCTCT GCAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCGCCTATCTTAA AAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCTTTTATCTCCAGTTCTGTCATCATCACCACCACACACT GTTCTGACGGTTCCATCCTGGCCATCGCCCTGCTGATCCTGTTCCTGCTCCTAGCCCTGGCTCTCCTCTGGTGGTTCTGGCCCCTCTGCT GCACTGTGATTATCAAGGAGGTCCCTCCACCCCCTGCCGAGGAGAGTGAGGAAGAAGATGATGATGGTCTGCCTAAGAAAAAGTGGCCAA CGGTAGACGCCTCTTATTATGGTGGGAGAGGCGTTGGAGGCATTAAAAGAATGGAGGTTCGTTGGGGAGAAAAGGGCTCCACAGAAGAAG GTGCTAAGTTGGAAAAGGCAAAGAATGCAAGAGTCAAGATGCCGGAGCAGGAATATGAATTCCCTGAGCCGCGAAATCTCAACAACAATA TGCGTCGGCCTTCTTCCCCCCGGAAGTGGTACTCTCCAATCAAGGGAAAACTCGATGCCTTGTGGGTCCTACTGAGGAAAGGATATGATC GTGTGTCTGTGATGCGTCCACAGCCAGGAGACACGGGGCGCTGCATCAACTTCACCAGGGTCAAGAACAACCAGCCAGCCAAGTACCCAC TCAACAACGCCTACCACACCTCCTCGCCGCCTCCTGCCCCCATCTACACTCCCCCACCTCCTGCGCCCCACTGCCCTCCCCCGCCCCCCA GCGCCCCTACCCCTCCCATCCCGTCCCCACCTTCCACCCTTCCCCCTCCTCCCCAGGCTCCACCTCCCAACAGGGCACCTCCTCCCTCCC GCCCTCCTCCAAGGCCTTCTGTCTAGAGCCCAAAGTTCCTGCTCTGGGCTCTCTCAGAAACTTCAGGAGATGTTAGAACAAGTCTTTCCA GTTAGAGAAGAGGAGTGGTGATAAAGCCCACTGACCTTCACACATTCTAAAAATTGGTTGGCAATGCCAGTATACCAACAATCATGATCA GCTGAAAGAAACAGATATTTTAAATTGCCAGAAAACAAATGATGAGGCAACTACAGTCAGATTTATAGCCAGCCATCTATCACCTCTAGA AGGTTCCAGAGACAGTGAAACTGCAAGATGCTCTCAACAGGATTATGTCTCATGGAGACCAGTAAGAAAATCATTTATCTGAAGGTGAAA TGCAGAGTTGGATAAGAAATACATTGCTGGGTTTCTAAAATGCTGCCTTCCTGCCTCTACTCCACCTCCATCCCTGGACTTTGGACCCTT GGCCTAGGAGCCTAAGGACCTTCACCCCTGTGCACCACCCAAGAAAGAGGAAAACTTTGCCTACAACTTTGGAAATGCTGGGGTCCCTGG TGTGGTAAGAAACTCAACATCAGACGGGTATGCAGAAGGATGTTCTTCTGGGATTTGCAGGTACATAAAAAATGTATGGCATCTTTTCCT TGCAAATTCTTCCAGTTTCCAAGTGAGAAGGGGAGCAGGTGTTTACTGATGGAAAAGGTATGTTGCTATGTTGATGTGTAAGTGAAATCA GTTGTGTGCAATAGACAGGGGCGTATTCATGGGAGCATCAGCCAGTTTCTAAAACCCACAGGCCATCAGCAGCTAGAGGTGGCTGGCTTT GGCCAGACATGGACCCTAAATCAACAGACAATGGCATTGTCGAAGAGCAACCTGTTAATGAATCATGTTAAAAATCAAGGTTTGGCTTCA GTTTAAATCACTTGAGGTATGAAGTTTATCCTGTTTTCCAGAGATAAACATAAGTTGATCTTCCCAAAATACCATCATTAGGACCTATCA CACAATATCACTAGTTTTTTTTGTTTGTTTGTTTTTTGTTTTTTTTCTTGGTAAAGCCATGCACCACAGACTTCTGGGCAGAGCTGAGAG ACAATGGTCCTGACATAATAAGGATCTTTGATTAACCCCCATAAGGCATGTGTGTGTATACAAATATACTTCTCTTTGGCTTTTCGACAT AGAACCTCAGCTGTTAACCAAGGGGAAATACATCAGATCTGCAACACAGAAATGCTCTGCCTGAAATTTCCACCATGCCTAGGACTCACC CCATTTATCCAGGTCTTTCTGGATCTGTTTAATCAATAAGCCCTATAATCACTTGCTAAACACTGGGCTTCATCACCCAGGGATAAAAAC AGAGATCATTGTCTTGGACCTCCTGCATCAGCCTATTCAAAATTATCTCTCTCTCTAGCTTTCCACAAATCCTAAAATTCCTGTCCCAAG CCACCCAAATTCTCAGATCTTTTCTGGAACAAGGCAGAATATAAAATAAATATACATTTAGTGGCTTGGGCTATGGTCTCCAAAGATCCT TCAAAAATACATCAAGCCAGCTTCATTCACTCACTTTACTTAGAACAGAGATATAAGGGCCTGGGATGCATTTATTTTATCAATACCAAT TTTTGTGGCCATGGCAGACATTGCTAATCAATCACAGCACTATTTCCTATTAAGCCCACTGATTTCTTCACAATCCTTCTCAAATTACAA TTCCAAAGAGCCGCCACTCAACAGTCAGATGAACCCAACAGTCAGATGAGAGAAATGAACCCTACTTGCTATCTCTATCTTAGAAAGCAA AAACAAACAGGAGTTTCCAGGGAGAATGGGAAAGCCAGGGGGCATAAAAGGTACAGTCAGGGGAAAATAGATCTAGGCAGAGTGCCTTAG TCAGGGACCACGGGCGCTGAATCTGCAGTGCCAACACCAAACTGACACATCTCCAGGTGTACCTCCAACCCTAGCCTTCTCCCACAGCTG CCTACAACAGAGTCTCCCAGCCTTCTCAGAGAGCTAAAACCAGAAATTTCCAGACTCATGAAAGCAACCCCCCAGCCTCTCCCCAACCCT GCCGCATTGTCTAATTTTTAGAACACTAGGCTTCTTCTTTCATGTAGTTCCTCATAAGCAGGGGCCAGAATATCTCAGCCACCTGCAGTG ACATTGCTGGACCCCTGAAAACCATTCCATAGGAGAATGGGTTCCCCAGGCTCACAGTGTAGAGACATTGAGCCCATCACAACTGTTTTG ACTGCTGGCAGTCTAAAACAGTCCACCCACCCCATGGCACTGCCGCGTGATTCCCGCGGCCATTCAGAAGTTCAAGCCGAGATGCTGACG TTGCTGAGCAACGAGATGGTGAGCATCAGTGCAAATGCACCATTCAGCACATCAGTCATATGCCCAGTGCAGTTACAAGATGTTGTTTCG GCAAAGCATTTTGATGGAATAGGGAACTGCAAATGTATGATGATTTTGAAAAGGCTCAGCAGGATTTGTTCTTAAACCGACTCAGTGTGT CATCCCCGGTTATTTAGAATTACAGTTAAGAAGGAGAAACTTCTATAAGACTGTATGAACAAGGTGATATCTTCATAGTGGGCTATTACA GGCAGGAAAATGTTTTAACTGGTTTACAAAATCCATCAATACTTGTGTCATTCCCTGTAAAAGGCAGGAGACATGTGATTATGATCAGGA AACTGCACAAAATTATTGTTTTCAGCCCCCGTGTTATTGTCCTTTTGAACTGTTTTTTTTTTTATTAAAGCCAAATTTGTGTTGTATATA TTCGTATTCCATGTGTTAGATGGAAGCATTTCCTATCCAGTGTGAATAAAAAGAACAGTTGTAGTAAATTATTATAAAGCCGATGATATT TCATGGCAGGTTATTCTACCAAGCTGTGCTTGTTGGTTTTTCCCATGACTGTATTGCTTTTATAAATGTACAAATAGTTACTGAAATGAC GAGACCCTTGTTTGCACAGCATTAATAAGAACCTTGATAAGAACCATATTCTGTTGACAGCCAGCTCACAGTTTCTTGCCTGAAGCTTGG TGCACCCTCCAGTGAGACACAAGATCTCTCTTTTACCAAAGTTGAGAACAGAGCTGGTGGATTAATTAATAGTCTTCGATATCTGGCCAT GGGTAACCTCATTGTAACTATCATCAGAATGGGCAGAGATGATCTTGAAGTGTCACATACACTAAAGTCCAAACACTATGTCAGATGGGG GTAAAATCCATTAAAGAACAGGAAAAAATAATTATAAGATGATAAGCAAATGTTTCAGCCCAATGTCAACCCAGTTAAAAAAAAAATTAA TGCTGTGTAAAATGGTTGAATTAGTTTGCAAACTATATAAAGACATATGCAGTAAAAAGTCTGTTAATGCACATCCTGTGGGAATGGAGT GTTCTAACCAATTGCCTTTTCTTGTTATCTGAGCTCTCCTATATTATCATACTCAGATAACCAAATTAAAAGAATTAGAATATGATTTTT AATACACTTAACATTAAACTCTTCTAACTTTCTTCTTTCTGTGATAATTCAGAAGATAGTTATGGATCTTCAATGCCTCTGAGTCATTGT TATAAAAAATCAGTTATCACTATACCATGCTATAGGAGACTGGGCAAAACCTGTACAATGACAACCCTGGAAGTTGCTTTTTTTAAAAAA ATAATAAATTTCTTAAATCAACTCTTTTTTCTGGTTGTCTGTTTGTTATAAAGTGCAACGTATTCAAGTCCTCAATATCCTGATCATAAT >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000409829_chr2_69267176_+_2338nt GAGTCGGGGATAAACACTCCGCGGCGGTGGCGGCTGCTGCTCTGCTCCGGGTTCTGTCACTGTGTCGGCGGTGCCCAGCTCACTGGCCCC CTCCCTCTCTTGTCGAGCGTGGTTGCCAGAGAGGCTCCCTCAGCCCTGCTCCGCGGGGTCCACAGCGGGCTCCACAGCGGGCTCCATAGC GGGCTCCACAGCGGTCCGGCGGCGGCAGCGAGCCCGTGGGCAGTGGGGGTTGGTCCCGTGGCTCCGGCCCCCGGTGCAGAATGGCGGCGG CGGTTCGGATGAACATCCAGATGCTGCTGGAGGCGGCCGACTATCTGGAGCGGCGGGAGAGAGAAGCTGAACATGGTTATGCCTCCATGT TACCATACAATAACAAGGACAGAGATGCCTTAAAACGGAGGAACAAATCCAAAAAGAATAACAGCAGTAGCAGATCAACTCACAATGAAA TGGAGAAGAATAGATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTCATCAGCCCAC AGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAGACAGAGAACAAATCCGTCAAGGCCTAG AAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTATGAAAACAGAC AAGGGTACAGGACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGGGAGGCTAATA GGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGACAGTAAGGATC ATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATTCTAGCAGCTG AACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGACAGGGTCCTCT GCAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCGCCTATCTTAA AAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCTTTTATCTCCAGTTCTGTCATCATCACCACCACACACT GTAGCCTCCACAAAATTGCATCAGGCCCCACAACAGCTGCTTGCATGGAATAGCAGAGAATACCGCCTGCTCCCTCCGGACAGCACACTC CTGAAAACGGGGAGAGAGGAGCCAAACATGCTCGGTTTACACTTTCCTTATTTACTGAATGAGTGGAGGGCAGAGACAGGCCTGGAGTTA CGCACACTGAGTGCCCCAACATGGAAAGAAACATCAGGAGGGACAGGAAACGTTCCCTCCTTAACCAACAGTTTTCAAGACCTTACTGGA GGCACTTTATTGGCTACATAATCACTCCATGCGGTGGGCATCAGGCAGAATCCTGGTGCAGACCCAACTTTGAGGTGGAGGATTTCACAG TTTCTTTATTTTGAACTTCCCCCAGGCTCCCACTAATTCCTCTCCATTCTATCCTCCTCCCTTTCCCACAAAAGAAAACAGAAAGGAGCA GCAGTGTTTGATACCGTATCATCCAGAGGCCTGGTTCTCTCCCATTATAGGGCAAACAAGCCCTGGCAAGATATTTCACTCCCGCCCCAT GCCATGCATTAAAAATCCAAAATTGCCTATATTCCACCTGCCAAGCAAGAGATGCTTTCATTATTGAAGTTCCAAATGTATACCTTTGAG AACAGTGCCTTCTCGTCTTAAAAGAGAGGTCCTCATTTTGTGAGTTGGGAGCAGAGGGAATTAAAGAAAGCCATGATGCAGGGATTTGGC CATTCAAGCCGGGCAGCCTTCAGAGAATGTCATCCCTAATGACACATGCCCGAATGAAGGAGCGGGGCTGAGCTTGTCCTGCCTTCGTAT TGAATGTTGCCTGTCTGCCTCCTTAATAGCGGGCCTCTGTGTGAGCATTTGACAAGACTTAAAACTATTCATTGAAGAAAATGGATGATC CCCCAACAGGAAGATGCAACCCCATGGGCTGCCTGCTTGACCACAGAAGTGCTTCCAGCTCCAGTTGCTCATCTGAGAACTCCCCCCACC >In-frame_MXD1_ENST00000264444_chr2_70148897_+_ANTXR1_ENST00000409349_chr2_69267176_+_1592nt GAGTCGGGGATAAACACTCCGCGGCGGTGGCGGCTGCTGCTCTGCTCCGGGTTCTGTCACTGTGTCGGCGGTGCCCAGCTCACTGGCCCC CTCCCTCTCTTGTCGAGCGTGGTTGCCAGAGAGGCTCCCTCAGCCCTGCTCCGCGGGGTCCACAGCGGGCTCCACAGCGGGCTCCATAGC GGGCTCCACAGCGGTCCGGCGGCGGCAGCGAGCCCGTGGGCAGTGGGGGTTGGTCCCGTGGCTCCGGCCCCCGGTGCAGAATGGCGGCGG CGGTTCGGATGAACATCCAGATGCTGCTGGAGGCGGCCGACTATCTGGAGCGGCGGGAGAGAGAAGCTGAACATGGTTATGCCTCCATGT TACCATACAATAACAAGGACAGAGATGCCTTAAAACGGAGGAACAAATCCAAAAAGAATAACAGCAGTAGCAGATCAACTCACAATGAAA TGGAGAAGAATAGATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTCATCAGCCCAC AGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAGACAGAGAACAAATCCGTCAAGGCCTAG AAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTATGAAAACAGAC AAGGGTACAGGACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGGGAGGCTAATA GGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGACAGTAAGGATC ATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATTCTAGCAGCTG AACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGACAGGGTCCTCT GCAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCGCCTATCTTAA AAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCTTTTATCTCCAGTTCTGTCATCATCACCACCACACACT GTTCTGACGGTTCCATCCTGGCCATCGCCCTGCTGATCCTGTTCCTGCTCCTAGCCCTGGCTCTCCTCTGGTGGTTCTGGCCCCTCTGCT GCACTGTGATTATCAAGGAGGTCCCTCCACCCCCTGCCGAGGAGAGTGAGGAAAATAAAATAAAATAACAAGAAGAAGAAAGAAAGAAAT CCCACAGAAACAGATAACCTAACACAGCCCGTGCAACGTATTTTATACAATGCTCTGAAAATCATAGTCTCAATCTAGACAGTCTTTTCC |
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FusionGenePPI for MXD1_ANTXR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MXD1 | HDAC2, SIN3A, MAX, SMC3, SAP30, HDAC1, MLX, KDM5A, AKT1, RPS6KA1, RPS6KB1, BIRC2, APP, VDR, SAP130, BRMS1L, SAP30L, ARID4B, SUDS3, ARID4A, BRMS1, PTEN | ANTXR1 | ELAVL1, SPACA1, TUBB3, RSAD1, CA11, ZNF146, POTEF, TUBB8, HSPA5, KANK2, RICTOR, LRP11, PDIA5, TUBA4A, TUBA1A, PC, DNAJC12, OBSL1, RPL23, H6PD, KIRREL, GALNT7, WFS1, PCYOX1, CNTNAP3, FOXF2, TUBB4A, DMXL2, MAP2K7, ETV3, MANEA, ERF, TRMT44, PAM16, GDF11, SAMD1, WNT5A, SLAMF1, PRMT2, FLNA, GJB2, MYH9, SYN1, KLF8, MYO19, B4GALNT4, OCLN, IL13RA2, FCGRT, PMEL, TMEM30A, UBC, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000303714 | + | 0 | 18 | 154_160 | 50 | 565 | PA |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409349 | + | 0 | 15 | 154_160 | 50 | 369 | PA |
| Tgene | ANTXR1 | chr2:70148897 | chr2:69267176 | ENST00000409829 | + | 0 | 13 | 154_160 | 50 | 334 | PA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MXD1_ANTXR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MXD1_ANTXR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MXD1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
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