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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22914

FusionGeneSummary for MX1_ERG

check button Fusion gene summary
Fusion gene informationFusion gene name: MX1_ERG
Fusion gene ID: 22914
HgeneTgene
Gene symbol

MX1

ERG

Gene ID

4599

2078

Gene nameMX dynamin like GTPase 1ERG, ETS transcription factor
SynonymsIFI-78K|IFI78|MX|MxAerg-3|p55
Cytomap

21q22.3

21q22.2

Type of geneprotein-codingprotein-coding
Descriptioninterferon-induced GTP-binding protein Mx1interferon-induced protein p78interferon-inducible protein p78interferon-regulated resistance GTP-binding protein MxAmyxoma resistance protein 1myxovirus (influenza virus) resistance 1, interferon-inducible ptranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 on
Modification date2018052320180523
UniProtAcc

P20591

P11308

Ensembl transtripts involved in fusion geneENST00000490220, ENST00000398600, 
ENST00000398598, ENST00000455164, 
ENST00000288383, 
ENST00000398907, 
ENST00000398905, ENST00000288319, 
ENST00000398897, ENST00000398911, 
ENST00000398910, ENST00000417133, 
ENST00000442448, ENST00000453032, 
ENST00000398919, ENST00000429727, 
ENST00000485493, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 15 X 8=1560
# samples 2226
** MAII scorelog2(2/8*10)=1.32192809488736log2(226/1560*10)=0.53477674355294
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MX1 [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMX1

GO:0045071

negative regulation of viral genome replication

14687945|15047845|16202617

HgeneMX1

GO:0051607

defense response to virus

21478870

TgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-C5-A7CJ-01AMX1chr21

42809079

+ERGchr21

39817544

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000490220ENST00000398907MX1chr21

42809079

+ERGchr21

39817544

-
intron-3CDSENST00000490220ENST00000398905MX1chr21

42809079

+ERGchr21

39817544

-
intron-3CDSENST00000490220ENST00000288319MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000398897MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000398911MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000398910MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000417133MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000442448MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000453032MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000398919MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000429727MX1chr21

42809079

+ERGchr21

39817544

-
intron-intronENST00000490220ENST00000485493MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000398600ENST00000398907MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000398600ENST00000398905MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000398600ENST00000288319MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000398897MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000398911MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000398910MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000417133MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000442448MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000453032MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000398919MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000429727MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398600ENST00000485493MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000398598ENST00000398907MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000398598ENST00000398905MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000398598ENST00000288319MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000398897MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000398911MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000398910MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000417133MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000442448MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000453032MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000398919MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000429727MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000398598ENST00000485493MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000455164ENST00000398907MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000455164ENST00000398905MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000455164ENST00000288319MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000398897MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000398911MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000398910MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000417133MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000442448MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000453032MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000398919MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000429727MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000455164ENST00000485493MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000288383ENST00000398907MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000288383ENST00000398905MX1chr21

42809079

+ERGchr21

39817544

-
Frame-shitENST00000288383ENST00000288319MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000398897MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000398911MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000398910MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000417133MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000442448MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000453032MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000398919MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000429727MX1chr21

42809079

+ERGchr21

39817544

-
5CDS-intronENST00000288383ENST00000485493MX1chr21

42809079

+ERGchr21

39817544

-

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FusionProtFeatures for MX1_ERG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MX1

P20591

ERG

P11308

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MX1_ERG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MX1_ERG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MX1FANCA, DAXX, SUMO1, PIAS1, SP100, BLM, ISG15, APP, MX1, SIAH1, CAB39L, HNRNPA1, RELA, EPM2AIP1, ZBTB16, UBE2I, KIF26B, ZNF251, CASP8AP2, ZNF623, PSD3, ZCCHC12, CBX4, KLHL35, C7orf25, CHD3, ADRM1, BRD7, TDG, PLRG1, TUBA1A, HMGXB4, SLC25A3, LRRC4B, GMEB1, BCS1LERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MX1_ERG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MX1_ERG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMX1C0015625Fanconi Anemia1CTD_human
HgeneMX1C0021400Influenza1CTD_human
HgeneMX1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMX1C0038356Stomach Neoplasms1CTD_human
HgeneMX1C0151744Myocardial Ischemia1CTD_human
TgeneERGC0033578Prostatic Neoplasms5CTD_human
TgeneERGC0023418leukemia1CTD_human
TgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human