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Fusion gene ID: 22913 |
FusionGeneSummary for MVP_ZNF267 |
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Fusion gene information | Fusion gene name: MVP_ZNF267 | Fusion gene ID: 22913 | Hgene | Tgene | Gene symbol | MVP | ZNF267 | Gene ID | 9961 | 10308 |
Gene name | major vault protein | zinc finger protein 267 | |
Synonyms | LRP|VAULT1 | HZF2 | |
Cytomap | 16p11.2 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | major vault proteinlung resistance-related proteintesticular secretory protein Li 30 | zinc finger protein 267zinc finger (C2H2)zinc finger protein 2zinc finger protein HZF2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q14764 | Q14586 | |
Ensembl transtripts involved in fusion gene | ENST00000357402, ENST00000452209, ENST00000395353, ENST00000566554, | ENST00000300870, ENST00000394846, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MVP [Title/Abstract] AND ZNF267 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MVP | GO:0023057 | negative regulation of signaling | 16441665 |
Hgene | MVP | GO:0031953 | negative regulation of protein autophosphorylation | 16441665 |
Hgene | MVP | GO:0038127 | ERBB signaling pathway | 15133037 |
Hgene | MVP | GO:0061099 | negative regulation of protein tyrosine kinase activity | 16441665 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CR-6474-01A | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000357402 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
5CDS-3UTR | ENST00000357402 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
intron-3CDS | ENST00000452209 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
intron-3UTR | ENST00000452209 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
Frame-shift | ENST00000395353 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
5CDS-3UTR | ENST00000395353 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
intron-3CDS | ENST00000566554 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
intron-3UTR | ENST00000566554 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
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FusionProtFeatures for MVP_ZNF267 |
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Hgene | Tgene |
MVP | ZNF267 |
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involvedin signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1signaling and subsequent activation of JAK. Down-regulates SRCactivity and signaling through MAP kinases.{ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217,ECO:0000269|PubMed:16441665}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MVP_ZNF267 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MVP_ZNF267 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MVP | PARP4, ESR1, PTEN, SIRT7, SLC2A4, RFWD2, TEP1, DHX9, CHMP4B, NNT, EPHX2, HP, KPNA2, CYTB, PLSCR1, GIT2, MVP, CKAP4, POT1, BAG3, HSP90AB1, NCBP1, VAT1, PSAP, BZRAP1, DISC1, DLX2, ADAMTSL4, AES, BANP, C1orf94, CALCOCO2, CAMK2B, CCDC36, FAM154A, FAM46C, GOLGA2, KCTD9, KPNA3, MDFI, MEOX1, MEOX2, MID2, MKL1, NOTCH2NL, OBFC1, PIH1D2, PSTPIP1, RAB3IP, RBPMS, REL, RHOXF2, RIMBP3, RNF111, SERTAD1, SKIL, TCF4, TFCP2, TP53, TRAF2, TRIM27, TRIM42, TRIP13, TRIP6, VAC14, ZBTB32, ZMIZ2, DDX19B, KRAS, CLTC, LGALS3BP, PTPN1, STAT5B, TGM2, GTSE1, SKI, MCM2, NF2, SNW1, CDC5L, U2AF2, GOPC, RCOR3, HSPA8, UBC, CYLD, BRCA1 | ZNF267 | ADORA2B, ATP6V0A1, EPHA7, CDK11A, TRIM28, CACNG5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MVP_ZNF267 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MVP_ZNF267 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MVP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MVP | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | ZNF267 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | ZNF267 | C0311375 | Arsenic Poisoning | 1 | CTD_human |