FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22910

FusionGeneSummary for MVP_KIF22

check button Fusion gene summary
Fusion gene informationFusion gene name: MVP_KIF22
Fusion gene ID: 22910
HgeneTgene
Gene symbol

MVP

KIF22

Gene ID

9961

3835

Gene namemajor vault proteinkinesin family member 22
SynonymsLRP|VAULT1A-328A3.2|KID|KNSL4|OBP|OBP-1|OBP-2|SEMDJL2
Cytomap

16p11.2

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionmajor vault proteinlung resistance-related proteintesticular secretory protein Li 30kinesin-like protein KIF22kinesin-like DNA-binding protein pseudogenekinesin-like protein 4oriP binding proteinorigin of plasmid DNA replication-binding protein
Modification date2018052320180523
UniProtAcc

Q14764

Q14807

Ensembl transtripts involved in fusion geneENST00000357402, ENST00000452209, 
ENST00000395353, ENST00000566554, 
ENST00000561482, ENST00000160827, 
ENST00000400750, ENST00000400751, 
ENST00000569382, ENST00000563263, 
Fusion gene scores* DoF score4 X 3 X 4=483 X 2 X 2=12
# samples 65
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MVP [Title/Abstract] AND KIF22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMVP

GO:0023057

negative regulation of signaling

16441665

HgeneMVP

GO:0031953

negative regulation of protein autophosphorylation

16441665

HgeneMVP

GO:0038127

ERBB signaling pathway

15133037

HgeneMVP

GO:0061099

negative regulation of protein tyrosine kinase activity

16441665


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A7-A3J0-01AMVPchr16

29851780

+KIF22chr16

29814770

+
TCGARVBRCATCGA-BH-A18V-06AMVPchr16

29851780

+KIF22chr16

29814770

+
TCGALDBRCATCGA-BH-A18V-01AMVPchr16

29851780

+KIF22chr16

29814770

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000357402ENST00000561482MVPchr16

29851780

+KIF22chr16

29814770

+
In-frameENST00000357402ENST00000160827MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-5UTRENST00000357402ENST00000400750MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-5UTRENST00000357402ENST00000400751MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-5UTRENST00000357402ENST00000569382MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-intronENST00000357402ENST00000563263MVPchr16

29851780

+KIF22chr16

29814770

+
3UTR-3CDSENST00000452209ENST00000561482MVPchr16

29851780

+KIF22chr16

29814770

+
3UTR-3CDSENST00000452209ENST00000160827MVPchr16

29851780

+KIF22chr16

29814770

+
3UTR-5UTRENST00000452209ENST00000400750MVPchr16

29851780

+KIF22chr16

29814770

+
3UTR-5UTRENST00000452209ENST00000400751MVPchr16

29851780

+KIF22chr16

29814770

+
3UTR-5UTRENST00000452209ENST00000569382MVPchr16

29851780

+KIF22chr16

29814770

+
3UTR-intronENST00000452209ENST00000563263MVPchr16

29851780

+KIF22chr16

29814770

+
In-frameENST00000395353ENST00000561482MVPchr16

29851780

+KIF22chr16

29814770

+
In-frameENST00000395353ENST00000160827MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-5UTRENST00000395353ENST00000400750MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-5UTRENST00000395353ENST00000400751MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-5UTRENST00000395353ENST00000569382MVPchr16

29851780

+KIF22chr16

29814770

+
5CDS-intronENST00000395353ENST00000563263MVPchr16

29851780

+KIF22chr16

29814770

+
intron-3CDSENST00000566554ENST00000561482MVPchr16

29851780

+KIF22chr16

29814770

+
intron-3CDSENST00000566554ENST00000160827MVPchr16

29851780

+KIF22chr16

29814770

+
intron-5UTRENST00000566554ENST00000400750MVPchr16

29851780

+KIF22chr16

29814770

+
intron-5UTRENST00000566554ENST00000400751MVPchr16

29851780

+KIF22chr16

29814770

+
intron-5UTRENST00000566554ENST00000569382MVPchr16

29851780

+KIF22chr16

29814770

+
intron-intronENST00000566554ENST00000563263MVPchr16

29851780

+KIF22chr16

29814770

+

Top

FusionProtFeatures for MVP_KIF22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MVP

Q14764

KIF22

Q14807

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involvedin signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1signaling and subsequent activation of JAK. Down-regulates SRCactivity and signaling through MAP kinases.{ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217,ECO:0000269|PubMed:16441665}. Kinesin family member that is involved in spindleformation and the movements of chromosomes during mitosis andmeiosis. Binds to microtubules and to DNA (By similarity). Plays arole in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869,ECO:0000269|PubMed:25743205}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815112_164397894RepeatNote=MVP 3
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815165_217397894RepeatNote=MVP 4
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815218_272397894RepeatNote=MVP 5
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815273_323397894RepeatNote=MVP 6
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+8152_56397894RepeatNote=MVP 1
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815324_379397894RepeatNote=MVP 7
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+81557_111397894RepeatNote=MVP 2
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815112_164397894RepeatNote=MVP 3
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815165_217397894RepeatNote=MVP 4
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815218_272397894RepeatNote=MVP 5
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815273_323397894RepeatNote=MVP 6
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+8152_56397894RepeatNote=MVP 1
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815324_379397894RepeatNote=MVP 7
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+81557_111397894RepeatNote=MVP 2
TgeneKIF22chr16:29851780chr16:29814770ENST00000400751+814465_508415598Coiled coilOntology_term=ECO:0000255
TgeneKIF22chr16:29851780chr16:29814770ENST00000561482+814465_508415598Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815380_457397894RepeatNote=MVP 8
HgeneMVPchr16:29851780chr16:29814770ENST00000357402+815458_520397894RepeatNote=MVP 9
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815380_457397894RepeatNote=MVP 8
HgeneMVPchr16:29851780chr16:29814770ENST00000395353+815458_520397894RepeatNote=MVP 9
TgeneKIF22chr16:29851780chr16:29814770ENST00000160827+814465_508483666Coiled coilOntology_term=ECO:0000255
TgeneKIF22chr16:29851780chr16:29814770ENST00000160827+81443_368483666DomainKinesin motor
TgeneKIF22chr16:29851780chr16:29814770ENST00000400751+81443_368415598DomainKinesin motor
TgeneKIF22chr16:29851780chr16:29814770ENST00000561482+81443_368415598DomainKinesin motor
TgeneKIF22chr16:29851780chr16:29814770ENST00000160827+814127_134483666Nucleotide bindingATP
TgeneKIF22chr16:29851780chr16:29814770ENST00000400751+814127_134415598Nucleotide bindingATP
TgeneKIF22chr16:29851780chr16:29814770ENST00000561482+814127_134415598Nucleotide bindingATP


Top

FusionGeneSequence for MVP_KIF22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MVP_KIF22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MVPPARP4, ESR1, PTEN, SIRT7, SLC2A4, RFWD2, TEP1, DHX9, CHMP4B, NNT, EPHX2, HP, KPNA2, CYTB, PLSCR1, GIT2, MVP, CKAP4, POT1, BAG3, HSP90AB1, NCBP1, VAT1, PSAP, BZRAP1, DISC1, DLX2, ADAMTSL4, AES, BANP, C1orf94, CALCOCO2, CAMK2B, CCDC36, FAM154A, FAM46C, GOLGA2, KCTD9, KPNA3, MDFI, MEOX1, MEOX2, MID2, MKL1, NOTCH2NL, OBFC1, PIH1D2, PSTPIP1, RAB3IP, RBPMS, REL, RHOXF2, RIMBP3, RNF111, SERTAD1, SKIL, TCF4, TFCP2, TP53, TRAF2, TRIM27, TRIM42, TRIP13, TRIP6, VAC14, ZBTB32, ZMIZ2, DDX19B, KRAS, CLTC, LGALS3BP, PTPN1, STAT5B, TGM2, GTSE1, SKI, MCM2, NF2, SNW1, CDC5L, U2AF2, GOPC, RCOR3, HSPA8, UBC, CYLD, BRCA1KIF22SIAH1, GDF9, IMMT, PJA1, SVIL, CHFR, ATXN1, MOV10, NXF1, BRCA1, OBSL1, MAPK14, HIST1H2BG, HIST1H3A, C4A, CCNB1, FUS, SP110, RPL10, RBM45, KPNA3, KPNA4, LIMS1, PSEN2, STAT6, TAF12, MPDZ, COX5A, CEP350, BCL2L11, HMGXB4, MARCH6, CEPT1, CD2BP2, CKAP2, PHF21A, SFMBT1, EPB41L4B, BIRC6, ZNF668, C2orf44, CCNL2, C18orf21, UTP23, PSRC1, CIRH1A, KNSTRN, PGM2L1, TEAD2, FOXE1, FOXL1, FOXM1, FOXQ1, CDC14B, TBC1D15, CNPY2, USP47, ZYG11B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MVP_KIF22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MVP_KIF22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMVPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMVPC0029408Degenerative polyarthritis1CTD_human
TgeneKIF22C1863732Spondyloepimetaphyseal dysplasia with multiple dislocations2ORPHANET;UNIPROT