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Fusion gene ID: 22888 |
FusionGeneSummary for MUC5B_SMR3B |
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Fusion gene information | Fusion gene name: MUC5B_SMR3B | Fusion gene ID: 22888 | Hgene | Tgene | Gene symbol | MUC5B | SMR3B | Gene ID | 727897 | 10879 |
Gene name | mucin 5B, oligomeric mucus/gel-forming | submaxillary gland androgen regulated protein 3B | |
Synonyms | MG1|MUC-5B|MUC5|MUC9 | P-B|PBII|PRL3|PROL3|SMR1B | |
Cytomap | 11p15.5 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mucin-5Bcervical mucin MUC5Bhigh molecular weight salivary mucin MG1mucin 5, subtype B, tracheobronchialsublingual gland mucin | submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9HC84 | P02814 | |
Ensembl transtripts involved in fusion gene | ENST00000529681, ENST00000447027, ENST00000531082, | ENST00000504825, ENST00000304915, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 8 X 2=144 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/144*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MUC5B [Title/Abstract] AND SMR3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0G0-01A | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000529681 | ENST00000504825 | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
5CDS-3UTR | ENST00000529681 | ENST00000304915 | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
5CDS-intron | ENST00000447027 | ENST00000504825 | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
5CDS-3UTR | ENST00000447027 | ENST00000304915 | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
intron-intron | ENST00000531082 | ENST00000504825 | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
intron-3UTR | ENST00000531082 | ENST00000304915 | MUC5B | chr11 | 1282698 | + | SMR3B | chr4 | 71255709 | + |
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FusionProtFeatures for MUC5B_SMR3B |
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Hgene | Tgene |
MUC5B | SMR3B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MUC5B_SMR3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MUC5B_SMR3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MUC5B | AMY1A, STATH, HTN1, UBC, KIR2DS2, C7orf25, ICE2, FRMD1, PCK2, HBM, ARHGAP12, TIMM50, DDX31 | SMR3B | RAD21, UBQLN1, UBTD2, RASSF10, BCHE, TNFRSF19, SNRPF |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MUC5B_SMR3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MUC5B_SMR3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MUC5B | C1800706 | Idiopathic Pulmonary Fibrosis | 1 | CTD_human;ORPHANET |