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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22877

FusionGeneSummary for MUC2_CLCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: MUC2_CLCN3
Fusion gene ID: 22877
HgeneTgene
Gene symbol

MUC2

CLCN3

Gene ID

4583

1182

Gene namemucin 2, oligomeric mucus/gel-formingchloride voltage-gated channel 3
SynonymsMLP|MUC-2|SMUCCLC3|ClC-3
Cytomap

11p15.5

4q33

Type of geneprotein-codingprotein-coding
Descriptionmucin-2mucin 2, intestinal/trachealH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date2018051920180523
UniProtAcc

Q02817

P51790

Ensembl transtripts involved in fusion geneENST00000441003, ENST00000359061, 
ENST00000361558, ENST00000333592, 
ENST00000513761, ENST00000347613, 
ENST00000360642, ENST00000504131, 
ENST00000506924, 
Fusion gene scores* DoF score3 X 3 X 2=1836 X 4 X 19=2736
# samples 339
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(39/2736*10)=-2.81052220113629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MUC2 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-US-A776-01AMUC2chr11

1104419

+CLCN3chr4

170623929

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000441003ENST00000513761MUC2chr11

1104419

+CLCN3chr4

170623929

+
5CDS-intronENST00000441003ENST00000347613MUC2chr11

1104419

+CLCN3chr4

170623929

+
5CDS-intronENST00000441003ENST00000360642MUC2chr11

1104419

+CLCN3chr4

170623929

+
5CDS-intronENST00000441003ENST00000504131MUC2chr11

1104419

+CLCN3chr4

170623929

+
5CDS-intronENST00000441003ENST00000506924MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000359061ENST00000513761MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000359061ENST00000347613MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000359061ENST00000360642MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000359061ENST00000504131MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000359061ENST00000506924MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000361558ENST00000513761MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000361558ENST00000347613MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000361558ENST00000360642MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000361558ENST00000504131MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000361558ENST00000506924MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000333592ENST00000513761MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000333592ENST00000347613MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000333592ENST00000360642MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000333592ENST00000504131MUC2chr11

1104419

+CLCN3chr4

170623929

+
intron-intronENST00000333592ENST00000506924MUC2chr11

1104419

+CLCN3chr4

170623929

+

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FusionProtFeatures for MUC2_CLCN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MUC2

Q02817

CLCN3

P51790

Coats the epithelia of the intestines, airways, andother mucus membrane-containing organs. Thought to provide aprotective, lubricating barrier against particles and infectiousagents at mucosal surfaces. Major constituent of both the innerand outer mucus layers of the colon and may play a role inexcluding bacteria from the inner mucus layer.{ECO:0000269|PubMed:19432394}. Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MUC2_CLCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MUC2_CLCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MUC2GALNT14, MLH1CLCN3CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MUC2_CLCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMUC2Q02817DB01411PranlukastMucin-2small moleculeapproved|investigational

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RelatedDiseases for MUC2_CLCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMUC2C0001418Adenocarcinoma1CTD_human
HgeneMUC2C0001430Adenoma1CTD_human
HgeneMUC2C0021841Intestinal Neoplasms1CTD_human
HgeneMUC2C0034885Rectal Neoplasms1CTD_human
TgeneCLCN3C0017638Glioma1CTD_human
TgeneCLCN3C0038356Stomach Neoplasms1CTD_human
TgeneCLCN3C2931822Nasopharyngeal carcinoma1CTD_human