FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22875

FusionGeneSummary for MUC1_SIAE

check button Fusion gene summary
Fusion gene informationFusion gene name: MUC1_SIAE
Fusion gene ID: 22875
HgeneTgene
Gene symbol

MUC1

SIAE

Gene ID

4582

54414

Gene namemucin 1, cell surface associatedsialic acid acetylesterase
SynonymsADMCKD|ADMCKD1|CA 15-3|CD227|EMA|H23AG|KL-6|MAM6|MCD|MCKD|MCKD1|MUC-1|MUC-1/SEC|MUC-1/X|MUC1/ZD|PEM|PEMT|PUMAIS6|CSE-C|CSEC|LSE|YSG2
Cytomap

1q22

11q24.2

Type of geneprotein-codingprotein-coding
Descriptionmucin-1H23 antigenbreast carcinoma-associated antigen DF3cancer antigen 15-3carcinoma-associated mucinepisialinkrebs von den Lungen-6mucin 1, transmembranepeanut-reactive urinary mucinpolymorphic epithelial mucintumor associated epithelial mucinsialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II
Modification date2018052720180519
UniProtAcc

P15941

Q9HAT2

Ensembl transtripts involved in fusion geneENST00000368395, ENST00000338684, 
ENST00000438413, ENST00000457295, 
ENST00000462215, ENST00000368392, 
ENST00000368393, ENST00000368390, 
ENST00000368396, ENST00000343256, 
ENST00000368398, ENST00000368389, 
ENST00000342482, ENST00000337604, 
ENST00000263593, ENST00000545756, 
ENST00000525730, 
Fusion gene scores* DoF score7 X 7 X 3=14732 X 5 X 12=1920
# samples 836
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(36/1920*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MUC1 [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMUC1

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

15710329

HgeneMUC1

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

15710329

HgeneMUC1

GO:0010944

negative regulation of transcription by competitive promoter binding

15710329

HgeneMUC1

GO:0033629

negative regulation of cell adhesion mediated by integrin

7698991

HgeneMUC1

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

15710329

HgeneMUC1

GO:0043618

regulation of transcription from RNA polymerase II promoter in response to stress

15710329

HgeneMUC1

GO:0090240

positive regulation of histone H4 acetylation

15710329

HgeneMUC1

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

15710329

TgeneSIAE

GO:0005975

carbohydrate metabolic process

23308225


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-6776-01AMUC1chr1

155158302

-SIAEchr11

124543777

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000368395ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
5CDS-intronENST00000368395ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
5CDS-intronENST00000368395ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
In-frameENST00000338684ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
5CDS-intronENST00000338684ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
5CDS-intronENST00000338684ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000438413ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000438413ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000438413ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000457295ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000457295ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000457295ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000462215ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000462215ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000462215ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000368392ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368392ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368392ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000368393ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368393ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368393ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000368390ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368390ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368390ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000368396ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368396ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368396ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000343256ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000343256ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000343256ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000368398ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368398ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368398ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000368389ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368389ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000368389ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000342482ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000342482ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000342482ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-3CDSENST00000337604ENST00000263593MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000337604ENST00000545756MUC1chr1

155158302

-SIAEchr11

124543777

-
intron-intronENST00000337604ENST00000525730MUC1chr1

155158302

-SIAEchr11

124543777

-

Top

FusionProtFeatures for MUC1_SIAE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MUC1

P15941

SIAE

Q9HAT2

Catalyzes the removal of O-acetyl ester groups fromposition 9 of the parent sialic acid, N-acetylneuraminic acid.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MUC1_SIAE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MUC1_ENST00000338684_chr1_155158302_-_SIAE_ENST00000263593_chr11_124543777_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MUC1_ENST00000338684_chr1_155158302_-_SIAE_ENST00000263593_chr11_124543777_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_MUC1_ENST00000338684_chr1_155158302_-_SIAE_ENST00000263593_chr11_124543777_-_6633nt
ACCTCTCAAGCAGCCAGCGCCTGCCTGAATCTGTTCTGCCCCCTCCCCACCCATTTCACCACCACCATGACACCGGGCACCCAGTCTCCT
TTCTTCCTGCTGCTGCTCCTCACAGTGCTTACAGCTACCACAGCCCCTAAACCCGCAACAGTTGTTACGGGTTCTGGTCATGCAAGCTCT
ACCCCAGGTGGAGAAAAGGAGACTTCGGCTACCCAGAGAAGTTCAGTGCCCAGCTCTACTGAGAAGAATGCTTTCAGGCCAGGATCTGTG
GTGGTACAATTGACTCTGGCCTTCCGAGAAGGTACCATCAATGTCCACGACGTGGAGACACAGTTCAATCAGTATAAAACGGAAGCAGCC
TCTCGATATAACCTGACGATCTCAGACGTCAGCGTGAGTGATGTGCCATTTCCTTTCTCTGCCCAGTCTGGGGCTGGGGTGCCAGGCTGG
GGCATCGCGCTGCTGGTGCTGGTCTGTGTTCTGGTTGCGCTGGCCATTGTCTATCTCATTGCCTTGGCTGTCTGTCAGTGCCGCCGAAAG
AACTACGGGCAGCTGGACATCTTTCCAGCCCGGGATACCTACCATCCTATGAGCGAGTACCCCACCTACCACACCCATGGGCGCTATGTG
CCCCCTAGCAGTACCGATCGTAGCCCCTATGAGAAGGTTTCTGCAGGTAATGGTGGCAGCAGCCTCTCTTACACAAACCCAGCAGTGGCA
GCCACTTCTGCCAACTTGTAGGGGCACGTCGCCCGCTGAGCTGAGTGGCCAGCCAGTGCCATTCCACTCCACTCAGGTTCTTCAGGGCCA
GAGCCCCTGCACCCTGTTTGGGCTGGTGAGCTGGGAGTTCAGGTGGGCTGCTCACAGCCTCCTTCAGAGGCCCCACCAATTTCTCGGACA
CTTCTCAGTGTGTGGAAGCTCATGTGGGCCCCTGAGGGCTCATGCCTGGGAAGTGTTGTGGTGGGGGCTCCCAGGAGGACTGGCCCAGAG
AGCCCTGAGATAGCGGGGATCCTGAACTGGACTGAATAAAACGTGGTCTCCCACTGCGCCAAAAAAAAAAAAAAACTACGGCGGCCGAGA
AGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCC
CCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGC
CATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTG
CTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGA
CCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTT
TGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTG
TGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAG
AGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGT
CAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCA
TTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTA
AGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAA
ATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGG
AGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATC
AAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTT
TTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGA
CCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGA
AAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGT
CCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTC
CCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTA
AATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTT
TAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAAC
TTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATT
TACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTT
TAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTC
CGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTAT
GAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATT
GAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAA
ATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAG
GCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAG
TTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCAC
ATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTG
ATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTAT
GTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAA
AAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATA
TTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACT
TTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGG
TTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGG
AACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCA
TAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATG
GGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGA
AAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCA
CTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTA
AAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATAT
TATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTT
TGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGA
ATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGA
TATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGA
TGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTG
TTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGT
TCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAG
AGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC
ACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGT
ATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTC
TTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCAT
TTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGAT
TTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAA
CTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAA
AGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTT
CTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAG
GTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACAT
GGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTG


Top

FusionGenePPI for MUC1_SIAE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MUC1APC, CTNNB1, GSK3B, LYN, ERBB2, JUP, GALNT4, GALNT12, GRB2, SOS1, SRC, CTNND1, ERBB3, ERBB4, EGFR, PRKCD, ESR1, IKBKB, IKBKG, TNFRSF1A, TP53, TBP, JUN, ABL1, IPO5, NUP62, PPARG, ATP6V0A2, ATP6V0A1, HBD, BMI1, TMEM199, ATP11C, TMEM59L, TMEM63B, MYADM, TMEM67, CCDC115, TNFSF9, ACTBL2, VAMP2, ACTA2SIAEFBXO6, PTPRK, CPE, HLA-B, ENTPD6, NPTX1, CNTNAP3, MANEAL, OAF, TMEM30A, MR1, COCH, FAM162A, GPR98, GFPT2, MOXD1, LNPEP, PLXNB2, TCTN1, POC1A, NDST2, SGSH, TENM3, ERAP1, MANBA, ITGA8, TMEM2, LAMB2, FASTKD3, CHSY3, GDF11, DDX47, TMEM131, ARSK, ARSB, MBTPS1, COL18A1, MANEA, NAAA, RPP38, NRP2, PTGFRN, PLTP, KIAA1161, DCBLD2, SEPN1, GALNT7, TGFBR3, MAN2B2, TMEM132A, GALNS, NAGLU, CTSF, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MUC1_SIAE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MUC1_SIAE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMUC1C0007621Neoplastic Cell Transformation1CTD_human
HgeneMUC1C0025500Mesothelioma1CTD_human
HgeneMUC1C0026764Multiple Myeloma1CTD_human
HgeneMUC1C0031149Peritoneal Neoplasms1CTD_human
HgeneMUC1C0038356Stomach Neoplasms1CTD_human
HgeneMUC1C0345967Malignant mesothelioma1CTD_human
HgeneMUC1C1868139Medullary cystic kidney disease 11CTD_human
TgeneSIAEC3150797AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 61UNIPROT