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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22872

FusionGeneSummary for MUC1_LGALS4

check button Fusion gene summary
Fusion gene informationFusion gene name: MUC1_LGALS4
Fusion gene ID: 22872
HgeneTgene
Gene symbol

MUC1

LGALS4

Gene ID

4582

3960

Gene namemucin 1, cell surface associatedgalectin 4
SynonymsADMCKD|ADMCKD1|CA 15-3|CD227|EMA|H23AG|KL-6|MAM6|MCD|MCKD|MCKD1|MUC-1|MUC-1/SEC|MUC-1/X|MUC1/ZD|PEM|PEMT|PUMGAL4|L36LBP
Cytomap

1q22

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionmucin-1H23 antigenbreast carcinoma-associated antigen DF3cancer antigen 15-3carcinoma-associated mucinepisialinkrebs von den Lungen-6mucin 1, transmembranepeanut-reactive urinary mucinpolymorphic epithelial mucintumor associated epithelial mucingalectin-4L-36 lactose-binding proteinantigen NY-CO-27gal-4lactose-binding lectin 4lectin, galactoside-binding, soluble, 4
Modification date2018052720180519
UniProtAcc

P15941

P56470

Ensembl transtripts involved in fusion geneENST00000368395, ENST00000338684, 
ENST00000438413, ENST00000457295, 
ENST00000462215, ENST00000368392, 
ENST00000368393, ENST00000368390, 
ENST00000368396, ENST00000343256, 
ENST00000368398, ENST00000368389, 
ENST00000342482, ENST00000337604, 
ENST00000307751, ENST00000597803, 
Fusion gene scores* DoF score7 X 7 X 3=1475 X 4 X 4=80
# samples 85
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MUC1 [Title/Abstract] AND LGALS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMUC1

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

15710329

HgeneMUC1

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

15710329

HgeneMUC1

GO:0010944

negative regulation of transcription by competitive promoter binding

15710329

HgeneMUC1

GO:0033629

negative regulation of cell adhesion mediated by integrin

7698991

HgeneMUC1

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

15710329

HgeneMUC1

GO:0043618

regulation of transcription from RNA polymerase II promoter in response to stress

15710329

HgeneMUC1

GO:0090240

positive regulation of histone H4 acetylation

15710329

HgeneMUC1

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

15710329


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW391727MUC1chr1

155161943

-LGALS4chr19

39293186

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368395ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368395ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000338684ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000338684ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000438413ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000438413ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000457295ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000457295ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000462215ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000462215ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368392ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368392ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368393ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368393ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368390ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368390ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368396ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368396ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000343256ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000343256ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368398ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368398ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368389ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000368389ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000342482ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000342482ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000337604ENST00000307751MUC1chr1

155161943

-LGALS4chr19

39293186

-
intron-intronENST00000337604ENST00000597803MUC1chr1

155161943

-LGALS4chr19

39293186

-

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FusionProtFeatures for MUC1_LGALS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MUC1

P15941

LGALS4

P56470

Galectin that binds lactose and a related range ofsugars. May be involved in the assembly of adherens junctions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MUC1_LGALS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MUC1_LGALS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MUC1_LGALS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MUC1_LGALS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMUC1C0007621Neoplastic Cell Transformation1CTD_human
HgeneMUC1C0025500Mesothelioma1CTD_human
HgeneMUC1C0026764Multiple Myeloma1CTD_human
HgeneMUC1C0031149Peritoneal Neoplasms1CTD_human
HgeneMUC1C0038356Stomach Neoplasms1CTD_human
HgeneMUC1C0345967Malignant mesothelioma1CTD_human
HgeneMUC1C1868139Medullary cystic kidney disease 11CTD_human