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Fusion gene ID: 22860 |
FusionGeneSummary for MUC16_MUC16 |
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Fusion gene information | Fusion gene name: MUC16_MUC16 | Fusion gene ID: 22860 | Hgene | Tgene | Gene symbol | MUC16 | MUC16 | Gene ID | 94025 | 94025 |
Gene name | mucin 16, cell surface associated | mucin 16, cell surface associated | |
Synonyms | CA125 | CA125 | |
Cytomap | 19p13.2 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | mucin-16CA125 ovarian cancer antigenovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125 | mucin-16CA125 ovarian cancer antigenovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | |||
Ensembl transtripts involved in fusion gene | ENST00000397910, ENST00000380951, ENST00000596956, | ENST00000397910, ENST00000380951, ENST00000596956, | |
Fusion gene scores | * DoF score | 10 X 10 X 2=200 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/200*10)=-0.862496476250065 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MUC16 [Title/Abstract] AND MUC16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA640762 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000397910 | ENST00000397910 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-3CDS | ENST00000397910 | ENST00000380951 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-intron | ENST00000397910 | ENST00000596956 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-3CDS | ENST00000380951 | ENST00000397910 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-3CDS | ENST00000380951 | ENST00000380951 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-intron | ENST00000380951 | ENST00000596956 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-3CDS | ENST00000596956 | ENST00000397910 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-3CDS | ENST00000596956 | ENST00000380951 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
intron-intron | ENST00000596956 | ENST00000596956 | MUC16 | chr19 | 9000482 | - | MUC16 | chr19 | 8999456 | + |
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FusionProtFeatures for MUC16_MUC16 |
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Hgene | Tgene |
MUC16 | MUC16 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MUC16_MUC16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MUC16_MUC16 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MUC16_MUC16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MUC16_MUC16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MUC16 | C0033687 | Proteinuria | 1 | CTD_human |
Hgene | MUC16 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | MUC16 | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | MUC16 | C0919267 | ovarian neoplasm | 1 | CTD_human |