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Fusion gene ID: 22848 |
FusionGeneSummary for MTUS1_OASL |
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Fusion gene information | Fusion gene name: MTUS1_OASL | Fusion gene ID: 22848 | Hgene | Tgene | Gene symbol | MTUS1 | OASL | Gene ID | 57509 | 8638 |
Gene name | microtubule associated scaffold protein 1 | 2'-5'-oligoadenylate synthetase like | |
Synonyms | ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1 | OASL1|OASLd|TRIP-14|TRIP14|p59 OASL|p59-OASL|p59OASL | |
Cytomap | 8p22 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit | 2'-5'-oligoadenylate synthase-like protein2'-5'-OAS-RP2'-5'-OAS-related protein59 kDa 2'-5'-oligoadenylate synthase-like protein59 kDa 2'-5'-oligoadenylate synthetase-like proteinTR-interacting protein 14thyroid receptor-interacting protein 14 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9ULD2 | Q15646 | |
Ensembl transtripts involved in fusion gene | ENST00000544260, ENST00000381869, ENST00000381861, ENST00000262102, ENST00000519263, ENST00000400046, ENST00000297488, ENST00000518713, ENST00000381862, | ENST00000257570, ENST00000339275, | |
Fusion gene scores | * DoF score | 3 X 3 X 4=36 | 4 X 4 X 3=48 |
# samples | 6 | 7 | |
** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/48*10)=0.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MTUS1 [Title/Abstract] AND OASL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | OASL | GO:0009615 | response to virus | 18931074|20074559 |
Tgene | OASL | GO:0045071 | negative regulation of viral genome replication | 18931074|20074559 |
Tgene | OASL | GO:0051607 | defense response to virus | 21478870 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF063611 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - | ||
ChiTaRS3.1 | AF063612 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000544260 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000544260 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000381869 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000381869 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000381861 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000381861 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000262102 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000262102 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000519263 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000519263 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000400046 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000400046 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000297488 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000297488 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000518713 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000518713 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000381862 | ENST00000257570 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
intron-5UTR | ENST00000381862 | ENST00000339275 | MTUS1 | chr8 | 17612513 | + | OASL | chr12 | 121476959 | - |
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FusionProtFeatures for MTUS1_OASL |
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Hgene | Tgene |
MTUS1 | OASL |
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity againstencephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) viaan alternative antiviral pathway independent of RNase L.{ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559,ECO:0000269|PubMed:9826176}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTUS1_OASL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTUS1_OASL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTUS1_OASL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTUS1_OASL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MTUS1 | C2239176 | Liver carcinoma | 1 | UNIPROT |
Tgene | OASL | C0021400 | Influenza | 1 | CTD_human |