FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22848

FusionGeneSummary for MTUS1_OASL

check button Fusion gene summary
Fusion gene informationFusion gene name: MTUS1_OASL
Fusion gene ID: 22848
HgeneTgene
Gene symbol

MTUS1

OASL

Gene ID

57509

8638

Gene namemicrotubule associated scaffold protein 12'-5'-oligoadenylate synthetase like
SynonymsATBP|ATIP|ATIP3|ICIS|MP44|MTSG1OASL1|OASLd|TRIP-14|TRIP14|p59 OASL|p59-OASL|p59OASL
Cytomap

8p22

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit2'-5'-oligoadenylate synthase-like protein2'-5'-OAS-RP2'-5'-OAS-related protein59 kDa 2'-5'-oligoadenylate synthase-like protein59 kDa 2'-5'-oligoadenylate synthetase-like proteinTR-interacting protein 14thyroid receptor-interacting protein 14
Modification date2018052320180523
UniProtAcc

Q9ULD2

Q15646

Ensembl transtripts involved in fusion geneENST00000544260, ENST00000381869, 
ENST00000381861, ENST00000262102, 
ENST00000519263, ENST00000400046, 
ENST00000297488, ENST00000518713, 
ENST00000381862, 
ENST00000257570, 
ENST00000339275, 
Fusion gene scores* DoF score3 X 3 X 4=364 X 4 X 3=48
# samples 67
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MTUS1 [Title/Abstract] AND OASL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOASL

GO:0009615

response to virus

18931074|20074559

TgeneOASL

GO:0045071

negative regulation of viral genome replication

18931074|20074559

TgeneOASL

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF063611MTUS1chr8

17612513

+OASLchr12

121476959

-
ChiTaRS3.1AF063612MTUS1chr8

17612513

+OASLchr12

121476959

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000544260ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000544260ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000381869ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000381869ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000381861ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000381861ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000262102ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000262102ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000519263ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000519263ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000400046ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000400046ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000297488ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000297488ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000518713ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000518713ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000381862ENST00000257570MTUS1chr8

17612513

+OASLchr12

121476959

-
intron-5UTRENST00000381862ENST00000339275MTUS1chr8

17612513

+OASLchr12

121476959

-

Top

FusionProtFeatures for MTUS1_OASL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTUS1

Q9ULD2

OASL

Q15646

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity againstencephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) viaan alternative antiviral pathway independent of RNase L.{ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559,ECO:0000269|PubMed:9826176}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MTUS1_OASL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MTUS1_OASL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MTUS1_OASL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MTUS1_OASL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTUS1C2239176Liver carcinoma1UNIPROT
TgeneOASLC0021400Influenza1CTD_human