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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22832

FusionGeneSummary for MTR_MTR

check button Fusion gene summary
Fusion gene informationFusion gene name: MTR_MTR
Fusion gene ID: 22832
HgeneTgene
Gene symbol

MTR

MTR

Gene ID

4548

4548

Gene name5-methyltetrahydrofolate-homocysteine methyltransferase5-methyltetrahydrofolate-homocysteine methyltransferase
SynonymsHMAG|MS|cblGHMAG|MS|cblG
Cytomap

1q43

1q43

Type of geneprotein-codingprotein-coding
Descriptionmethionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthasemethionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase
Modification date2018052320180523
UniProtAcc

Q99707

Q99707

Ensembl transtripts involved in fusion geneENST00000366577, ENST00000418145, 
ENST00000535889, ENST00000470570, 
ENST00000366577, ENST00000418145, 
ENST00000535889, ENST00000470570, 
Fusion gene scores* DoF score5 X 5 X 2=501 X 1 X 1=1
# samples 61
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: MTR [Title/Abstract] AND MTR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV363529MTRchr1

237052621

-MTRchr1

237057750

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000366577ENST00000366577MTRchr1

237052621

-MTRchr1

237057750

+
5CDS-intronENST00000366577ENST00000418145MTRchr1

237052621

-MTRchr1

237057750

+
5CDS-intronENST00000366577ENST00000535889MTRchr1

237052621

-MTRchr1

237057750

+
5CDS-3UTRENST00000366577ENST00000470570MTRchr1

237052621

-MTRchr1

237057750

+
intron-3CDSENST00000418145ENST00000366577MTRchr1

237052621

-MTRchr1

237057750

+
intron-intronENST00000418145ENST00000418145MTRchr1

237052621

-MTRchr1

237057750

+
intron-intronENST00000418145ENST00000535889MTRchr1

237052621

-MTRchr1

237057750

+
intron-3UTRENST00000418145ENST00000470570MTRchr1

237052621

-MTRchr1

237057750

+
Frame-shiftENST00000535889ENST00000366577MTRchr1

237052621

-MTRchr1

237057750

+
5CDS-intronENST00000535889ENST00000418145MTRchr1

237052621

-MTRchr1

237057750

+
5CDS-intronENST00000535889ENST00000535889MTRchr1

237052621

-MTRchr1

237057750

+
5CDS-3UTRENST00000535889ENST00000470570MTRchr1

237052621

-MTRchr1

237057750

+
intron-3CDSENST00000470570ENST00000366577MTRchr1

237052621

-MTRchr1

237057750

+
intron-intronENST00000470570ENST00000418145MTRchr1

237052621

-MTRchr1

237057750

+
intron-intronENST00000470570ENST00000535889MTRchr1

237052621

-MTRchr1

237057750

+
intron-3UTRENST00000470570ENST00000470570MTRchr1

237052621

-MTRchr1

237057750

+

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FusionProtFeatures for MTR_MTR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTR

Q99707

MTR

Q99707

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin andmethionine. Subsequently, remethylates the cofactor usingmethyltetrahydrofolate (By similarity). {ECO:0000250}. Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin andmethionine. Subsequently, remethylates the cofactor usingmethyltetrahydrofolate (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTR_MTR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTR_MTR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTR_MTR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMTRQ99707DB00200HydroxocobalaminMethionine synthasesmall moleculeapproved
HgeneMTRQ99707DB11590ThimerosalMethionine synthasesmall moleculeapproved
HgeneMTRQ99707DB00115CyanocobalaminMethionine synthasesmall moleculeapproved|nutraceutical
HgeneMTRQ99707DB00134MethionineMethionine synthasesmall moleculeapproved|nutraceutical
TgeneMTRQ99707DB00200HydroxocobalaminMethionine synthasesmall moleculeapproved
TgeneMTRQ99707DB11590ThimerosalMethionine synthasesmall moleculeapproved
TgeneMTRQ99707DB00115CyanocobalaminMethionine synthasesmall moleculeapproved|nutraceutical
TgeneMTRQ99707DB00134MethionineMethionine synthasesmall moleculeapproved|nutraceutical

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RelatedDiseases for MTR_MTR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTRC0011570Mental Depression2PSYGENET
HgeneMTRC0011581Depressive disorder2PSYGENET
HgeneMTRC0041755Adverse reaction to drug2CTD_human
HgeneMTRC1855128Methylcobalamin Deficiency, CblG Type2CTD_human;ORPHANET;UNIPROT
HgeneMTRC0001969Alcoholic Intoxication1PSYGENET
HgeneMTRC0005586Bipolar Disorder1PSYGENET
HgeneMTRC0008924Cleft Lip1CTD_human
HgeneMTRC0008925Cleft Palate1CTD_human
HgeneMTRC0017178Gastrointestinal Diseases1CTD_human
HgeneMTRC0018939Hematological Disease1CTD_human
HgeneMTRC0021364Male infertility1CTD_human
HgeneMTRC0024299Lymphoma1CTD_human
HgeneMTRC0024301Lymphoma, Follicular1CTD_human
HgeneMTRC0036341Schizophrenia1PSYGENET
HgeneMTRC0162429Malnutrition1CTD_human
HgeneMTRC0270612Leukoencephalopathies1CTD_human
HgeneMTRC0588008Severe depression1PSYGENET
HgeneMTRC1458155Mammary Neoplasms1CTD_human
TgeneMTRC0011570Mental Depression2PSYGENET
TgeneMTRC0011581Depressive disorder2PSYGENET
TgeneMTRC0041755Adverse reaction to drug2CTD_human
TgeneMTRC1855128Methylcobalamin Deficiency, CblG Type2CTD_human;ORPHANET;UNIPROT
TgeneMTRC0001969Alcoholic Intoxication1PSYGENET
TgeneMTRC0005586Bipolar Disorder1PSYGENET
TgeneMTRC0008924Cleft Lip1CTD_human
TgeneMTRC0008925Cleft Palate1CTD_human
TgeneMTRC0017178Gastrointestinal Diseases1CTD_human
TgeneMTRC0018939Hematological Disease1CTD_human
TgeneMTRC0021364Male infertility1CTD_human
TgeneMTRC0024299Lymphoma1CTD_human
TgeneMTRC0024301Lymphoma, Follicular1CTD_human
TgeneMTRC0036341Schizophrenia1PSYGENET
TgeneMTRC0162429Malnutrition1CTD_human
TgeneMTRC0270612Leukoencephalopathies1CTD_human
TgeneMTRC0588008Severe depression1PSYGENET
TgeneMTRC1458155Mammary Neoplasms1CTD_human