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Fusion gene ID: 22832 |
FusionGeneSummary for MTR_MTR |
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Fusion gene information | Fusion gene name: MTR_MTR | Fusion gene ID: 22832 | Hgene | Tgene | Gene symbol | MTR | MTR | Gene ID | 4548 | 4548 |
Gene name | 5-methyltetrahydrofolate-homocysteine methyltransferase | 5-methyltetrahydrofolate-homocysteine methyltransferase | |
Synonyms | HMAG|MS|cblG | HMAG|MS|cblG | |
Cytomap | 1q43 | 1q43 | |
Type of gene | protein-coding | protein-coding | |
Description | methionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase | methionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99707 | Q99707 | |
Ensembl transtripts involved in fusion gene | ENST00000366577, ENST00000418145, ENST00000535889, ENST00000470570, | ENST00000366577, ENST00000418145, ENST00000535889, ENST00000470570, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MTR [Title/Abstract] AND MTR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV363529 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000366577 | ENST00000366577 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
5CDS-intron | ENST00000366577 | ENST00000418145 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
5CDS-intron | ENST00000366577 | ENST00000535889 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
5CDS-3UTR | ENST00000366577 | ENST00000470570 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-3CDS | ENST00000418145 | ENST00000366577 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-intron | ENST00000418145 | ENST00000418145 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-intron | ENST00000418145 | ENST00000535889 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-3UTR | ENST00000418145 | ENST00000470570 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
Frame-shift | ENST00000535889 | ENST00000366577 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
5CDS-intron | ENST00000535889 | ENST00000418145 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
5CDS-intron | ENST00000535889 | ENST00000535889 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
5CDS-3UTR | ENST00000535889 | ENST00000470570 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-3CDS | ENST00000470570 | ENST00000366577 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-intron | ENST00000470570 | ENST00000418145 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-intron | ENST00000470570 | ENST00000535889 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
intron-3UTR | ENST00000470570 | ENST00000470570 | MTR | chr1 | 237052621 | - | MTR | chr1 | 237057750 | + |
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FusionProtFeatures for MTR_MTR |
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Hgene | Tgene |
MTR | MTR |
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin andmethionine. Subsequently, remethylates the cofactor usingmethyltetrahydrofolate (By similarity). {ECO:0000250}. | Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin andmethionine. Subsequently, remethylates the cofactor usingmethyltetrahydrofolate (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTR_MTR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTR_MTR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTR_MTR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MTR | Q99707 | DB00200 | Hydroxocobalamin | Methionine synthase | small molecule | approved |
Hgene | MTR | Q99707 | DB11590 | Thimerosal | Methionine synthase | small molecule | approved |
Hgene | MTR | Q99707 | DB00115 | Cyanocobalamin | Methionine synthase | small molecule | approved|nutraceutical |
Hgene | MTR | Q99707 | DB00134 | Methionine | Methionine synthase | small molecule | approved|nutraceutical |
Tgene | MTR | Q99707 | DB00200 | Hydroxocobalamin | Methionine synthase | small molecule | approved |
Tgene | MTR | Q99707 | DB11590 | Thimerosal | Methionine synthase | small molecule | approved |
Tgene | MTR | Q99707 | DB00115 | Cyanocobalamin | Methionine synthase | small molecule | approved|nutraceutical |
Tgene | MTR | Q99707 | DB00134 | Methionine | Methionine synthase | small molecule | approved|nutraceutical |
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RelatedDiseases for MTR_MTR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MTR | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | MTR | C0011581 | Depressive disorder | 2 | PSYGENET |
Hgene | MTR | C0041755 | Adverse reaction to drug | 2 | CTD_human |
Hgene | MTR | C1855128 | Methylcobalamin Deficiency, CblG Type | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | MTR | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Hgene | MTR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | MTR | C0008924 | Cleft Lip | 1 | CTD_human |
Hgene | MTR | C0008925 | Cleft Palate | 1 | CTD_human |
Hgene | MTR | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Hgene | MTR | C0018939 | Hematological Disease | 1 | CTD_human |
Hgene | MTR | C0021364 | Male infertility | 1 | CTD_human |
Hgene | MTR | C0024299 | Lymphoma | 1 | CTD_human |
Hgene | MTR | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
Hgene | MTR | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | MTR | C0162429 | Malnutrition | 1 | CTD_human |
Hgene | MTR | C0270612 | Leukoencephalopathies | 1 | CTD_human |
Hgene | MTR | C0588008 | Severe depression | 1 | PSYGENET |
Hgene | MTR | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | MTR | C0011570 | Mental Depression | 2 | PSYGENET |
Tgene | MTR | C0011581 | Depressive disorder | 2 | PSYGENET |
Tgene | MTR | C0041755 | Adverse reaction to drug | 2 | CTD_human |
Tgene | MTR | C1855128 | Methylcobalamin Deficiency, CblG Type | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | MTR | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Tgene | MTR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | MTR | C0008924 | Cleft Lip | 1 | CTD_human |
Tgene | MTR | C0008925 | Cleft Palate | 1 | CTD_human |
Tgene | MTR | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Tgene | MTR | C0018939 | Hematological Disease | 1 | CTD_human |
Tgene | MTR | C0021364 | Male infertility | 1 | CTD_human |
Tgene | MTR | C0024299 | Lymphoma | 1 | CTD_human |
Tgene | MTR | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
Tgene | MTR | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MTR | C0162429 | Malnutrition | 1 | CTD_human |
Tgene | MTR | C0270612 | Leukoencephalopathies | 1 | CTD_human |
Tgene | MTR | C0588008 | Severe depression | 1 | PSYGENET |
Tgene | MTR | C1458155 | Mammary Neoplasms | 1 | CTD_human |