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Fusion gene ID: 22831 |
FusionGeneSummary for MTR_IFI16 |
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Fusion gene information | Fusion gene name: MTR_IFI16 | Fusion gene ID: 22831 | Hgene | Tgene | Gene symbol | MTR | IFI16 | Gene ID | 4548 | 3428 |
Gene name | 5-methyltetrahydrofolate-homocysteine methyltransferase | interferon gamma inducible protein 16 | |
Synonyms | HMAG|MS|cblG | IFNGIP1|PYHIN2 | |
Cytomap | 1q43 | 1q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | methionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase | gamma-interferon-inducible protein 16interferon-gamma induced protein IFI 16interferon-inducible myeloid differentiation transcriptional activator | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q99707 | Q16666 | |
Ensembl transtripts involved in fusion gene | ENST00000366577, ENST00000418145, ENST00000535889, ENST00000470570, | ENST00000340979, ENST00000368131, ENST00000368132, ENST00000295809, ENST00000430894, ENST00000359709, ENST00000448393, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 4 X 3 X 3=36 |
# samples | 6 | 4 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MTR [Title/Abstract] AND IFI16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IFI16 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12894224|24413532 |
Tgene | IFI16 | GO:0002218 | activation of innate immune response | 21575908 |
Tgene | IFI16 | GO:0030224 | monocyte differentiation | 9766636 |
Tgene | IFI16 | GO:0032731 | positive regulation of interleukin-1 beta production | 21575908 |
Tgene | IFI16 | GO:0042149 | cellular response to glucose starvation | 21573174 |
Tgene | IFI16 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 14654789 |
Tgene | IFI16 | GO:0043392 | negative regulation of DNA binding | 22291595 |
Tgene | IFI16 | GO:0045071 | negative regulation of viral genome replication | 22291595 |
Tgene | IFI16 | GO:0045824 | negative regulation of innate immune response | 22046441 |
Tgene | IFI16 | GO:0045892 | negative regulation of transcription, DNA-templated | 9642285 |
Tgene | IFI16 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11146555 |
Tgene | IFI16 | GO:0051607 | defense response to virus | 21478870 |
Tgene | IFI16 | GO:0071479 | cellular response to ionizing radiation | 14654789 |
Tgene | IFI16 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 22046441 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A07O-01A | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000366577 | ENST00000340979 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000366577 | ENST00000368131 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000366577 | ENST00000368132 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000366577 | ENST00000295809 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000366577 | ENST00000430894 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000366577 | ENST00000359709 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000366577 | ENST00000448393 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000340979 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000368131 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000368132 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000295809 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000430894 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000359709 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000418145 | ENST00000448393 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000340979 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000368131 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000368132 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000295809 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000430894 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000359709 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
5CDS-intron | ENST00000535889 | ENST00000448393 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000340979 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000368131 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000368132 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000295809 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000430894 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000359709 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
intron-intron | ENST00000470570 | ENST00000448393 | MTR | chr1 | 237001899 | + | IFI16 | chr1 | 159019222 | + |
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FusionProtFeatures for MTR_IFI16 |
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Hgene | Tgene |
MTR | IFI16 |
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin andmethionine. Subsequently, remethylates the cofactor usingmethyltetrahydrofolate (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTR_IFI16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTR_IFI16 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MTR | TSC22D1, UBC, ELAVL1, LSM4, DHX16, NAPG, ILF2, CDK18, CDKN2A, DPP9, ARPC1A, ARPC2, CALU, THG1L, TPD52L2, MOV10, NXF1, AKAP13, NTRK1, BTRC, B9D1, B9D2, CEP19, NEK8, XRCC3, FAM196A, DOCK5, LINC01587, IQCF1, LPCAT1, SPATA5L1 | IFI16 | TP53, SP1, BRCA1, APP, NOTCH1, IGSF8, ICAM1, MDM2, AR, TMEM173, SCARNA22, ACADVL, ACIN1, ADAR, ADD1, AHCTF1, ASCC3, BAZ1B, BAZ2A, BOP1, BYSL, CBX1, CBX3, CEBPZ, CEP170, DDX18, DDX24, DDX27, DDX47, DHX30, DKC1, EDC4, EXOSC10, EXOSC4, FLII, FXR1, PAEP, GLYR1, GNL3, GTPBP4, H1F0, HEATR1, HELZ2, HLA-A, HLA-C, HP1BP3, HUWE1, INF2, KIF23, KRI1, LARP7, LAS1L, LGALS7, LRRFIP1, LRRFIP2, LZTR1, MAPK3, MKI67, NIFK, MRTO4, NAT10, NHP2, NMNAT1, NOC2L, NOL10, NOL11, NOL6, NUMA1, NUP153, NVL, NXF1, OSBPL8, PAF1, PBRM1, PDCD11, PDCD6IP, PELP1, PHIP, POLDIP3, POLR2A, POLR2B, POM121C, POP1, PRKAR1A, PRKRA, PRRC2A, PWP1, RBM19, RBM28, RBM34, RRP12, RRP1B, SDCBP, SKIV2L2, SMARCA1, SMARCA5, SMARCC2, SNRNP27, SNX6, SON, SP100, SPATS2L, SQSTM1, SRP72, STAU1, SUN1, SVIL, TBL3, TEX10, TJP1, TNKS1BP1, TOP2A, TRIM26, USP7, UTP6, WDR36, WHSC1, ZNF512, AAAS, AATF, APOBEC3C, ATAD2, BRIX1, BTF3, CCDC86, CDC42, CIRH1A, CKAP5, CSNK2A2, CSNK2B, CUL4A, DBP, DCAF13, DDX28, DDX51, DDX52, DDX56, DDX60L, DNAJC10, DNTTIP2, DOCK7, DYNLL1, EIF2AK2, EIF3K, EXOSC6, FGF2, FHL2, FTSJ3, FXR2, GLE1, GRWD1, GSDMA, IFIT2, IMP4, IPO7, KIAA0020, LEMD2, MCM3AP, MPHOSPH10, NDC1, NGDN, NKRF, NLE1, NOC4L, NOP16, NSA2, NUP133, NUP188, NUP205, NUP214, NUP37, NUP62, NUP85, NUP88, NUP93, NUP98, PDAP1, PLRG1, PML, PPHLN1, PPP2CB, PRPF40A, PSPC1, PTPLAD1, PWP2, RAB14, RAE1, RCL1, RGPD8, RNF213, RPF2, RPP30, RRP9, RSL24D1, SAP18, SEH1L, SMCHD1, SSRP1, SUMO1, SUN2, SYNE1, TKT, TMEM43, URB1, UTP15, UTP18, WDR12, WDR3, WDR43, WDR46, WDR75, WTAP, TFG, C17orf85, C8orf33, TLDC1, SPATS2, ZCCHC3, RGPD3, LSM12, TMEM209, AGO2, APOBEC3B, BMS1, BRD1, CARM1, CBX5, CCDC137, CDK1, CENPB, CENPV, CNOT1, COIL, CRNKL1, CTCF, CTNND1, DDX10, DDX54, DHX16, DHX29, DHX33, DHX36, DHX57, DHX8, EBNA1BP2, EIF6, EMG1, ESF1, EXOSC2, EXOSC3, EXOSC7, EXOSC8, FAM208A, FBXW11, FCF1, FMR1, GNL2, H2AFY, H2AFY2, INCENP, KAT7, KHDRBS3, KRR1, LARP1, LARP4B, LYAR, MAK16, MBD2, MPHOSPH8, NCBP1, NEMF, NHP2L1, NOC3L, NOL9, NUP107, NUP160, NUP35, NUP43, NUP50, NUP54, NUPL1, PAK1IP1, PCID2, PES1, PHF14, PIP4K2A, PNN, POP4, PPAN, PRPF38A, RACGAP1, RBM14, RBM15, RBM25, RBM8A, REXO4, RFC2, RFC3, RPF1, RPL36A, RRP1, RRP8, RRS1, SART1, SART3, SEC13, SENP3, SMU1, SRP68, SRPK1, SRRM1, SSFA2, STK3, SUPT16H, SUPT5H, TCEB1, TOP2B, TOR1AIP1, TRIM56, TRIP12, TSR1, UACA, UBTF, UPF1, URB2, USP36, UTP11L, UTP14A, UTP20, UTP3, WDR18, WDR61, WDR74, XAB2, XRN1, YTHDC1, YTHDC2, ZC3H14, ZC3HAV1, ZNF574, ZNF579, ZNF638, HNRNPU, RPL10, PYCARD, CASP1, U2AF2, NFATC1, NFATC2, AURKA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTR_IFI16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MTR | Q99707 | DB00200 | Hydroxocobalamin | Methionine synthase | small molecule | approved |
Hgene | MTR | Q99707 | DB11590 | Thimerosal | Methionine synthase | small molecule | approved |
Hgene | MTR | Q99707 | DB00115 | Cyanocobalamin | Methionine synthase | small molecule | approved|nutraceutical |
Hgene | MTR | Q99707 | DB00134 | Methionine | Methionine synthase | small molecule | approved|nutraceutical |
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RelatedDiseases for MTR_IFI16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MTR | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | MTR | C0011581 | Depressive disorder | 2 | PSYGENET |
Hgene | MTR | C0041755 | Adverse reaction to drug | 2 | CTD_human |
Hgene | MTR | C1855128 | Methylcobalamin Deficiency, CblG Type | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | MTR | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Hgene | MTR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | MTR | C0008924 | Cleft Lip | 1 | CTD_human |
Hgene | MTR | C0008925 | Cleft Palate | 1 | CTD_human |
Hgene | MTR | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Hgene | MTR | C0018939 | Hematological Disease | 1 | CTD_human |
Hgene | MTR | C0021364 | Male infertility | 1 | CTD_human |
Hgene | MTR | C0024299 | Lymphoma | 1 | CTD_human |
Hgene | MTR | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
Hgene | MTR | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | MTR | C0162429 | Malnutrition | 1 | CTD_human |
Hgene | MTR | C0270612 | Leukoencephalopathies | 1 | CTD_human |
Hgene | MTR | C0588008 | Severe depression | 1 | PSYGENET |
Hgene | MTR | C1458155 | Mammary Neoplasms | 1 | CTD_human |