FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22831

FusionGeneSummary for MTR_IFI16

check button Fusion gene summary
Fusion gene informationFusion gene name: MTR_IFI16
Fusion gene ID: 22831
HgeneTgene
Gene symbol

MTR

IFI16

Gene ID

4548

3428

Gene name5-methyltetrahydrofolate-homocysteine methyltransferaseinterferon gamma inducible protein 16
SynonymsHMAG|MS|cblGIFNGIP1|PYHIN2
Cytomap

1q43

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionmethionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthasegamma-interferon-inducible protein 16interferon-gamma induced protein IFI 16interferon-inducible myeloid differentiation transcriptional activator
Modification date2018052320180519
UniProtAcc

Q99707

Q16666

Ensembl transtripts involved in fusion geneENST00000366577, ENST00000418145, 
ENST00000535889, ENST00000470570, 
ENST00000340979, ENST00000368131, 
ENST00000368132, ENST00000295809, 
ENST00000430894, ENST00000359709, 
ENST00000448393, 
Fusion gene scores* DoF score5 X 5 X 2=504 X 3 X 3=36
# samples 64
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MTR [Title/Abstract] AND IFI16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFI16

GO:0000122

negative regulation of transcription by RNA polymerase II

12894224|24413532

TgeneIFI16

GO:0002218

activation of innate immune response

21575908

TgeneIFI16

GO:0030224

monocyte differentiation

9766636

TgeneIFI16

GO:0032731

positive regulation of interleukin-1 beta production

21575908

TgeneIFI16

GO:0042149

cellular response to glucose starvation

21573174

TgeneIFI16

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

14654789

TgeneIFI16

GO:0043392

negative regulation of DNA binding

22291595

TgeneIFI16

GO:0045071

negative regulation of viral genome replication

22291595

TgeneIFI16

GO:0045824

negative regulation of innate immune response

22046441

TgeneIFI16

GO:0045892

negative regulation of transcription, DNA-templated

9642285

TgeneIFI16

GO:0045944

positive regulation of transcription by RNA polymerase II

11146555

TgeneIFI16

GO:0051607

defense response to virus

21478870

TgeneIFI16

GO:0071479

cellular response to ionizing radiation

14654789

TgeneIFI16

GO:2000117

negative regulation of cysteine-type endopeptidase activity

22046441


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A07O-01AMTRchr1

237001899

+IFI16chr1

159019222

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000366577ENST00000340979MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000366577ENST00000368131MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000366577ENST00000368132MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000366577ENST00000295809MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000366577ENST00000430894MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000366577ENST00000359709MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000366577ENST00000448393MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000340979MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000368131MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000368132MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000295809MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000430894MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000359709MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000418145ENST00000448393MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000340979MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000368131MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000368132MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000295809MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000430894MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000359709MTRchr1

237001899

+IFI16chr1

159019222

+
5CDS-intronENST00000535889ENST00000448393MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000340979MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000368131MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000368132MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000295809MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000430894MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000359709MTRchr1

237001899

+IFI16chr1

159019222

+
intron-intronENST00000470570ENST00000448393MTRchr1

237001899

+IFI16chr1

159019222

+

Top

FusionProtFeatures for MTR_IFI16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTR

Q99707

IFI16

Q16666

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin andmethionine. Subsequently, remethylates the cofactor usingmethyltetrahydrofolate (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MTR_IFI16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MTR_IFI16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTRTSC22D1, UBC, ELAVL1, LSM4, DHX16, NAPG, ILF2, CDK18, CDKN2A, DPP9, ARPC1A, ARPC2, CALU, THG1L, TPD52L2, MOV10, NXF1, AKAP13, NTRK1, BTRC, B9D1, B9D2, CEP19, NEK8, XRCC3, FAM196A, DOCK5, LINC01587, IQCF1, LPCAT1, SPATA5L1IFI16TP53, SP1, BRCA1, APP, NOTCH1, IGSF8, ICAM1, MDM2, AR, TMEM173, SCARNA22, ACADVL, ACIN1, ADAR, ADD1, AHCTF1, ASCC3, BAZ1B, BAZ2A, BOP1, BYSL, CBX1, CBX3, CEBPZ, CEP170, DDX18, DDX24, DDX27, DDX47, DHX30, DKC1, EDC4, EXOSC10, EXOSC4, FLII, FXR1, PAEP, GLYR1, GNL3, GTPBP4, H1F0, HEATR1, HELZ2, HLA-A, HLA-C, HP1BP3, HUWE1, INF2, KIF23, KRI1, LARP7, LAS1L, LGALS7, LRRFIP1, LRRFIP2, LZTR1, MAPK3, MKI67, NIFK, MRTO4, NAT10, NHP2, NMNAT1, NOC2L, NOL10, NOL11, NOL6, NUMA1, NUP153, NVL, NXF1, OSBPL8, PAF1, PBRM1, PDCD11, PDCD6IP, PELP1, PHIP, POLDIP3, POLR2A, POLR2B, POM121C, POP1, PRKAR1A, PRKRA, PRRC2A, PWP1, RBM19, RBM28, RBM34, RRP12, RRP1B, SDCBP, SKIV2L2, SMARCA1, SMARCA5, SMARCC2, SNRNP27, SNX6, SON, SP100, SPATS2L, SQSTM1, SRP72, STAU1, SUN1, SVIL, TBL3, TEX10, TJP1, TNKS1BP1, TOP2A, TRIM26, USP7, UTP6, WDR36, WHSC1, ZNF512, AAAS, AATF, APOBEC3C, ATAD2, BRIX1, BTF3, CCDC86, CDC42, CIRH1A, CKAP5, CSNK2A2, CSNK2B, CUL4A, DBP, DCAF13, DDX28, DDX51, DDX52, DDX56, DDX60L, DNAJC10, DNTTIP2, DOCK7, DYNLL1, EIF2AK2, EIF3K, EXOSC6, FGF2, FHL2, FTSJ3, FXR2, GLE1, GRWD1, GSDMA, IFIT2, IMP4, IPO7, KIAA0020, LEMD2, MCM3AP, MPHOSPH10, NDC1, NGDN, NKRF, NLE1, NOC4L, NOP16, NSA2, NUP133, NUP188, NUP205, NUP214, NUP37, NUP62, NUP85, NUP88, NUP93, NUP98, PDAP1, PLRG1, PML, PPHLN1, PPP2CB, PRPF40A, PSPC1, PTPLAD1, PWP2, RAB14, RAE1, RCL1, RGPD8, RNF213, RPF2, RPP30, RRP9, RSL24D1, SAP18, SEH1L, SMCHD1, SSRP1, SUMO1, SUN2, SYNE1, TKT, TMEM43, URB1, UTP15, UTP18, WDR12, WDR3, WDR43, WDR46, WDR75, WTAP, TFG, C17orf85, C8orf33, TLDC1, SPATS2, ZCCHC3, RGPD3, LSM12, TMEM209, AGO2, APOBEC3B, BMS1, BRD1, CARM1, CBX5, CCDC137, CDK1, CENPB, CENPV, CNOT1, COIL, CRNKL1, CTCF, CTNND1, DDX10, DDX54, DHX16, DHX29, DHX33, DHX36, DHX57, DHX8, EBNA1BP2, EIF6, EMG1, ESF1, EXOSC2, EXOSC3, EXOSC7, EXOSC8, FAM208A, FBXW11, FCF1, FMR1, GNL2, H2AFY, H2AFY2, INCENP, KAT7, KHDRBS3, KRR1, LARP1, LARP4B, LYAR, MAK16, MBD2, MPHOSPH8, NCBP1, NEMF, NHP2L1, NOC3L, NOL9, NUP107, NUP160, NUP35, NUP43, NUP50, NUP54, NUPL1, PAK1IP1, PCID2, PES1, PHF14, PIP4K2A, PNN, POP4, PPAN, PRPF38A, RACGAP1, RBM14, RBM15, RBM25, RBM8A, REXO4, RFC2, RFC3, RPF1, RPL36A, RRP1, RRP8, RRS1, SART1, SART3, SEC13, SENP3, SMU1, SRP68, SRPK1, SRRM1, SSFA2, STK3, SUPT16H, SUPT5H, TCEB1, TOP2B, TOR1AIP1, TRIM56, TRIP12, TSR1, UACA, UBTF, UPF1, URB2, USP36, UTP11L, UTP14A, UTP20, UTP3, WDR18, WDR61, WDR74, XAB2, XRN1, YTHDC1, YTHDC2, ZC3H14, ZC3HAV1, ZNF574, ZNF579, ZNF638, HNRNPU, RPL10, PYCARD, CASP1, U2AF2, NFATC1, NFATC2, AURKA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MTR_IFI16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMTRQ99707DB00200HydroxocobalaminMethionine synthasesmall moleculeapproved
HgeneMTRQ99707DB11590ThimerosalMethionine synthasesmall moleculeapproved
HgeneMTRQ99707DB00115CyanocobalaminMethionine synthasesmall moleculeapproved|nutraceutical
HgeneMTRQ99707DB00134MethionineMethionine synthasesmall moleculeapproved|nutraceutical

Top

RelatedDiseases for MTR_IFI16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTRC0011570Mental Depression2PSYGENET
HgeneMTRC0011581Depressive disorder2PSYGENET
HgeneMTRC0041755Adverse reaction to drug2CTD_human
HgeneMTRC1855128Methylcobalamin Deficiency, CblG Type2CTD_human;ORPHANET;UNIPROT
HgeneMTRC0001969Alcoholic Intoxication1PSYGENET
HgeneMTRC0005586Bipolar Disorder1PSYGENET
HgeneMTRC0008924Cleft Lip1CTD_human
HgeneMTRC0008925Cleft Palate1CTD_human
HgeneMTRC0017178Gastrointestinal Diseases1CTD_human
HgeneMTRC0018939Hematological Disease1CTD_human
HgeneMTRC0021364Male infertility1CTD_human
HgeneMTRC0024299Lymphoma1CTD_human
HgeneMTRC0024301Lymphoma, Follicular1CTD_human
HgeneMTRC0036341Schizophrenia1PSYGENET
HgeneMTRC0162429Malnutrition1CTD_human
HgeneMTRC0270612Leukoencephalopathies1CTD_human
HgeneMTRC0588008Severe depression1PSYGENET
HgeneMTRC1458155Mammary Neoplasms1CTD_human