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Fusion gene ID: 22828 |
FusionGeneSummary for MTRR_SLC30A5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MTRR_SLC30A5 | Fusion gene ID: 22828 | Hgene | Tgene | Gene symbol | MTRR | SLC30A5 | Gene ID | 4552 | 64924 |
Gene name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | solute carrier family 30 member 5 | |
Synonyms | MSR|cblE | ZNT5|ZNTL1|ZTL1|ZnT-5 | |
Cytomap | 5p15.31 | 5q13.1-q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | methionine synthase reductase[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)methionine synthase reductase, mitochondrial | zinc transporter 5solute carrier family 30 (zinc transporter), member 5zinc transporter ZTL1znT-like transporter 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UBK8 | Q8TAD4 | |
Ensembl transtripts involved in fusion gene | ENST00000502509, ENST00000264668, ENST00000341013, ENST00000440940, | ENST00000396591, ENST00000380860, ENST00000502979, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 3 X 3=27 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MTRR [Title/Abstract] AND SLC30A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MTRR | GO:0009086 | methionine biosynthetic process | 11466310 |
Hgene | MTRR | GO:0043418 | homocysteine catabolic process | 11466310 |
Hgene | MTRR | GO:0046655 | folic acid metabolic process | 11466310 |
Hgene | MTRR | GO:1904042 | negative regulation of cystathionine beta-synthase activity | 24416422 |
Tgene | SLC30A5 | GO:0006824 | cobalt ion transport | 10330022|11937503 |
Tgene | SLC30A5 | GO:0006829 | zinc ion transport | 10330022|11937503 |
Tgene | SLC30A5 | GO:0006882 | cellular zinc ion homeostasis | 11937503 |
Tgene | SLC30A5 | GO:0010043 | response to zinc ion | 11937503 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-8260-01A | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000502509 | ENST00000396591 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
intron-intron | ENST00000502509 | ENST00000380860 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
intron-intron | ENST00000502509 | ENST00000502979 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
In-frame | ENST00000264668 | ENST00000396591 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
5CDS-intron | ENST00000264668 | ENST00000380860 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
5CDS-intron | ENST00000264668 | ENST00000502979 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
3UTR-3CDS | ENST00000341013 | ENST00000396591 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
3UTR-intron | ENST00000341013 | ENST00000380860 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
3UTR-intron | ENST00000341013 | ENST00000502979 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
In-frame | ENST00000440940 | ENST00000396591 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
5CDS-intron | ENST00000440940 | ENST00000380860 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
5CDS-intron | ENST00000440940 | ENST00000502979 | MTRR | chr5 | 7878435 | + | SLC30A5 | chr5 | 68413066 | + |
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FusionProtFeatures for MTRR_SLC30A5 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MTRR | SLC30A5 |
Involved in the reductive regeneration of cob(I)alamin(vitamin B12) cofactor required for the maintenance of methioninesynthase in a functional state. Necessary for utilization ofmethylgroups from the folate cycle, thereby affectingtransgenerational epigenetic inheritance. Folate pathway donatesmethyl groups necessary for cellular methylation and affectsdifferent pathways such as DNA methylation, possibly explainingthe transgenerational epigenetic inheritance effects.{ECO:0000269|PubMed:17892308}. | Functions as a zinc transporter. May be a transporter ofzinc into beta cells in order to form insulin crystals. Partlyregulates cellular zinc homeostasis. Required with ZNT7 for theactivation of zinc-requiring enzymes, alkaline phosphatases(ALPs). Transports zinc into the lumens of the Golgi apparatus andvesicular compartments where ALPs locate, thus, converting apoALPsto holoALPs. Required with ZNT6 and ZNT7 for the activation ofTNAP. {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503,ECO:0000269|PubMed:15276077, ECO:0000269|PubMed:15525635,ECO:0000269|PubMed:15994300}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTRR_SLC30A5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MTRR_ENST00000264668_chr5_7878435_+_SLC30A5_ENST00000396591_chr5_68413066_+_626aa MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP GLPPEYLQVHLQESLGQLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIA FFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMR GVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPH >In-frame_MTRR_ENST00000440940_chr5_7878435_+_SLC30A5_ENST00000396591_chr5_68413066_+_599aa MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLR YGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLV KSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQLFTFVELFYG VLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSV GGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFG WFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MTRR_ENST00000264668_chr5_7878435_+_SLC30A5_ENST00000396591_chr5_68413066_+_1878nt ATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTCACTGTTACATGCCTTGAAGTGATGAGGAGG TTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCA GATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACGGGCACCGGA GACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTA CTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCCCGGCATTTC TATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCAT TTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTGAAGTCAGAG CTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAAC AGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTGAATATTCCT GGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGCTTTTTACCTTTGTGGAATTATTCTATGGCGTGCTGACC AATAGTCTGGGCCTGATCTCGGATGGATTCCACATGCTTTTTGACTGCTCTGCTTTAGTCATGGGACTTTTTGCTGCCCTGATGAGTAGG TGGAAAGCCACTCGGATTTTCTCCTATGGGTACGGCCGAATAGAAATTCTGTCTGGATTTATTAATGGACTTTTTCTAATAGTAATAGCG TTTTTTGTGTTTATGGAGTCAGTGGCTAGATTGATTGATCCTCCAGAATTAGACACTCACATGTTAACACCAGTCTCAGTTGGAGGGCTG ATAGTAAACCTTATTGGTATCTGTGCCTTTAGCCATGCCCATAGCCATGCCCATGGAGCTTCTCAAGGAAGCTGTCACTCATCTGATCAC AGCCATTCACACCATATGCATGGACACAGTGACCATGGGCATGGTCACAGCCACGGATCTGCGGGTGGAGGCATGAATGCTAACATGAGG GGTGTATTTCTACATGTTTTGGCAGATACACTTGGCAGCATTGGTGTGATCGTATCCACAGTTCTTATAGAGCAGTTTGGATGGTTCATC GCTGACCCACTCTGTTCTCTTTTTATTGCTATATTAATATTTCTCAGTGTTGTTCCACTGATTAAAGATGCCTGCCAGGTTCTACTCCTG AGATTGCCACCAGAATATGAAAAAGAACTACATATTGCTTTAGAAAAGATACAGAAAATTGAAGGATTAATATCATACCGAGACCCTCAT TTTTGGCGTCATTCTGCTAGTATTGTGGCAGGAACAATTCATATACAGGTGACATCTGATGTGCTAGAACAAAGAATAGTACAGCAGGTT ACAGGAATACTTAAAGATGCTGGAGTAAACAATTTAACAATTCAAGTGGAAAAGGAGGCATACTTTCAACATATGTCTGGCCTAAGTACT >In-frame_MTRR_ENST00000440940_chr5_7878435_+_SLC30A5_ENST00000396591_chr5_68413066_+_1797nt ATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGA TTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACG GGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGG TATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCC CGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTC AGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTG AAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAAT GCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTG AATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGCTTTTTACCTTTGTGGAATTATTCTATGGC GTGCTGACCAATAGTCTGGGCCTGATCTCGGATGGATTCCACATGCTTTTTGACTGCTCTGCTTTAGTCATGGGACTTTTTGCTGCCCTG ATGAGTAGGTGGAAAGCCACTCGGATTTTCTCCTATGGGTACGGCCGAATAGAAATTCTGTCTGGATTTATTAATGGACTTTTTCTAATA GTAATAGCGTTTTTTGTGTTTATGGAGTCAGTGGCTAGATTGATTGATCCTCCAGAATTAGACACTCACATGTTAACACCAGTCTCAGTT GGAGGGCTGATAGTAAACCTTATTGGTATCTGTGCCTTTAGCCATGCCCATAGCCATGCCCATGGAGCTTCTCAAGGAAGCTGTCACTCA TCTGATCACAGCCATTCACACCATATGCATGGACACAGTGACCATGGGCATGGTCACAGCCACGGATCTGCGGGTGGAGGCATGAATGCT AACATGAGGGGTGTATTTCTACATGTTTTGGCAGATACACTTGGCAGCATTGGTGTGATCGTATCCACAGTTCTTATAGAGCAGTTTGGA TGGTTCATCGCTGACCCACTCTGTTCTCTTTTTATTGCTATATTAATATTTCTCAGTGTTGTTCCACTGATTAAAGATGCCTGCCAGGTT CTACTCCTGAGATTGCCACCAGAATATGAAAAAGAACTACATATTGCTTTAGAAAAGATACAGAAAATTGAAGGATTAATATCATACCGA GACCCTCATTTTTGGCGTCATTCTGCTAGTATTGTGGCAGGAACAATTCATATACAGGTGACATCTGATGTGCTAGAACAAAGAATAGTA CAGCAGGTTACAGGAATACTTAAAGATGCTGGAGTAAACAATTTAACAATTCAAGTGGAAAAGGAGGCATACTTTCAACATATGTCTGGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MTRR_ENST00000264668_chr5_7878435_+_SLC30A5_ENST00000396591_chr5_68413066_+_3360nt GGAGCTTTCTATTGGTCCTGGGTACCGAGCATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTC ACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGT GAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTT GTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTT GATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAA CGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATT GCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCA TCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGAT TCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCC CCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGCTTTTTACC TTTGTGGAATTATTCTATGGCGTGCTGACCAATAGTCTGGGCCTGATCTCGGATGGATTCCACATGCTTTTTGACTGCTCTGCTTTAGTC ATGGGACTTTTTGCTGCCCTGATGAGTAGGTGGAAAGCCACTCGGATTTTCTCCTATGGGTACGGCCGAATAGAAATTCTGTCTGGATTT ATTAATGGACTTTTTCTAATAGTAATAGCGTTTTTTGTGTTTATGGAGTCAGTGGCTAGATTGATTGATCCTCCAGAATTAGACACTCAC ATGTTAACACCAGTCTCAGTTGGAGGGCTGATAGTAAACCTTATTGGTATCTGTGCCTTTAGCCATGCCCATAGCCATGCCCATGGAGCT TCTCAAGGAAGCTGTCACTCATCTGATCACAGCCATTCACACCATATGCATGGACACAGTGACCATGGGCATGGTCACAGCCACGGATCT GCGGGTGGAGGCATGAATGCTAACATGAGGGGTGTATTTCTACATGTTTTGGCAGATACACTTGGCAGCATTGGTGTGATCGTATCCACA GTTCTTATAGAGCAGTTTGGATGGTTCATCGCTGACCCACTCTGTTCTCTTTTTATTGCTATATTAATATTTCTCAGTGTTGTTCCACTG ATTAAAGATGCCTGCCAGGTTCTACTCCTGAGATTGCCACCAGAATATGAAAAAGAACTACATATTGCTTTAGAAAAGATACAGAAAATT GAAGGATTAATATCATACCGAGACCCTCATTTTTGGCGTCATTCTGCTAGTATTGTGGCAGGAACAATTCATATACAGGTGACATCTGAT GTGCTAGAACAAAGAATAGTACAGCAGGTTACAGGAATACTTAAAGATGCTGGAGTAAACAATTTAACAATTCAAGTGGAAAAGGAGGCA TACTTTCAACATATGTCTGGCCTAAGTACTGGATTTCATGATGTTCTGGCTATGACAAAACAAATGGAATCCATGAAATACTGCAAAGAT GGTACTTACATCATGTGAGATAACTCAAGAATTACCCCTGGAGAATAAACAATGAAGATTAAATGACTCAGTATTTGTAATATTGCCAGA AGGATAAAAATTACACATTAACTGTACAGAAACAGAGTTCCCTACTACTGGATCAAGGAATCTTTCTTGAAGGAAATTTAAATACAGAAT GAAACATTAATGGTAAAAGTGGAGTAATTATTTAAATTATGTGTATAAAAGGAATCAAATTTTGAGTAAACATGATGTATTACATCATCT TCAAAAATAGATATGATGGATTCTAGTGAAGACCAAAATTACTTCTGTTTACTTTCTATCAGGAAGCATCTCCATTGTAAATATGTATTT ACATGTTTATTACAAAGACCCAAATGAAAAATTTTTAGTCCATTTTTTGCATAGCCTAAAGATAAAATAGGAATAAAAGTTCTATATTTA TGGATTTTCTGTATATAAAACTGGTTTCTAATTATAACTTAAGTCCATTAAGTAAAATCTGTATTGCCACTTTAAATGTAAACTAAATTA TTTGGGAGAAACTTCAACCACTGATATGAGATAAGCAATGAGAATAGGGAAGTGTATAACATCACAGTTTTTGATGTATTACAAAAATCA ACCACTCTATAAAATAAATTTTTTTTACTTTTGGTAATATTTGCAAATGAATAATTAATTTATTAGGGTAAAGAACTTATACTAAGTTGT GTCCATGTTATTCATTTACTTACCATGTTCCTTTAAAGTAGAATATTTCCTTTCTTGTTATATATTTGACATTCCAAGCTGCTTATCAAG CTGGTATCCAAGCAGTGGTAAGCTTTCATCCTTTCTTAGCTCCATAACGTTGTGAAACAGCCAGTTAAGAGAATCGTAAATAATTGTCAA CTCACAGTTGAATTCTCTGCCTATGTAGGTAACTTTTTTCTAATTTCTGGAACATATAGATATATAAGAAATATCAAAGAATAGGTAGTT ATTTCAAAGTTTAATAAGTAAAACTTGTTCATAAACATTTGAGCACCATGAAATCAAAATACCCTATAACTACTTTCTATAGTCATATCT AATTTATATTTTTTTCATTTCCAGTTGTAACTAGATATGTAGTAAAGTCTGAAAAGACTTTACCATAGACAATAACATGCAGTTTTATCA GCACCAAAGAATGTTGTCCAAAAGAAACTTTTTAATACCTGTCTTTCTATTTATAACATCTGAATATTTTCATTCTTATATTAAGAATTT TGATAAGTAGATTGAATTTAGTATGAGTACTATTTTCTTATATATACCACAATGGCAAACATGTATTATAAATCATATTTTTGTCTTACC AATTTTAATATATGAGGGGTTTTAGAAATTTGTTGTAAGTTATTTTTATATTCCTTGTCTTTTGCATATTTTTTGGCCAAAATCTTCAAT >In-frame_MTRR_ENST00000440940_chr5_7878435_+_SLC30A5_ENST00000396591_chr5_68413066_+_3301nt GGTTCGTGCCCGGCTGGCGCGGCGTGGTTTCACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGG ACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAA GTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGT TAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTA CTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGT AGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGAT AAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCT TCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGA CTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACA TCTGCAGGAGTCTCTTGGCCAGCTTTTTACCTTTGTGGAATTATTCTATGGCGTGCTGACCAATAGTCTGGGCCTGATCTCGGATGGATT CCACATGCTTTTTGACTGCTCTGCTTTAGTCATGGGACTTTTTGCTGCCCTGATGAGTAGGTGGAAAGCCACTCGGATTTTCTCCTATGG GTACGGCCGAATAGAAATTCTGTCTGGATTTATTAATGGACTTTTTCTAATAGTAATAGCGTTTTTTGTGTTTATGGAGTCAGTGGCTAG ATTGATTGATCCTCCAGAATTAGACACTCACATGTTAACACCAGTCTCAGTTGGAGGGCTGATAGTAAACCTTATTGGTATCTGTGCCTT TAGCCATGCCCATAGCCATGCCCATGGAGCTTCTCAAGGAAGCTGTCACTCATCTGATCACAGCCATTCACACCATATGCATGGACACAG TGACCATGGGCATGGTCACAGCCACGGATCTGCGGGTGGAGGCATGAATGCTAACATGAGGGGTGTATTTCTACATGTTTTGGCAGATAC ACTTGGCAGCATTGGTGTGATCGTATCCACAGTTCTTATAGAGCAGTTTGGATGGTTCATCGCTGACCCACTCTGTTCTCTTTTTATTGC TATATTAATATTTCTCAGTGTTGTTCCACTGATTAAAGATGCCTGCCAGGTTCTACTCCTGAGATTGCCACCAGAATATGAAAAAGAACT ACATATTGCTTTAGAAAAGATACAGAAAATTGAAGGATTAATATCATACCGAGACCCTCATTTTTGGCGTCATTCTGCTAGTATTGTGGC AGGAACAATTCATATACAGGTGACATCTGATGTGCTAGAACAAAGAATAGTACAGCAGGTTACAGGAATACTTAAAGATGCTGGAGTAAA CAATTTAACAATTCAAGTGGAAAAGGAGGCATACTTTCAACATATGTCTGGCCTAAGTACTGGATTTCATGATGTTCTGGCTATGACAAA ACAAATGGAATCCATGAAATACTGCAAAGATGGTACTTACATCATGTGAGATAACTCAAGAATTACCCCTGGAGAATAAACAATGAAGAT TAAATGACTCAGTATTTGTAATATTGCCAGAAGGATAAAAATTACACATTAACTGTACAGAAACAGAGTTCCCTACTACTGGATCAAGGA ATCTTTCTTGAAGGAAATTTAAATACAGAATGAAACATTAATGGTAAAAGTGGAGTAATTATTTAAATTATGTGTATAAAAGGAATCAAA TTTTGAGTAAACATGATGTATTACATCATCTTCAAAAATAGATATGATGGATTCTAGTGAAGACCAAAATTACTTCTGTTTACTTTCTAT CAGGAAGCATCTCCATTGTAAATATGTATTTACATGTTTATTACAAAGACCCAAATGAAAAATTTTTAGTCCATTTTTTGCATAGCCTAA AGATAAAATAGGAATAAAAGTTCTATATTTATGGATTTTCTGTATATAAAACTGGTTTCTAATTATAACTTAAGTCCATTAAGTAAAATC TGTATTGCCACTTTAAATGTAAACTAAATTATTTGGGAGAAACTTCAACCACTGATATGAGATAAGCAATGAGAATAGGGAAGTGTATAA CATCACAGTTTTTGATGTATTACAAAAATCAACCACTCTATAAAATAAATTTTTTTTACTTTTGGTAATATTTGCAAATGAATAATTAAT TTATTAGGGTAAAGAACTTATACTAAGTTGTGTCCATGTTATTCATTTACTTACCATGTTCCTTTAAAGTAGAATATTTCCTTTCTTGTT ATATATTTGACATTCCAAGCTGCTTATCAAGCTGGTATCCAAGCAGTGGTAAGCTTTCATCCTTTCTTAGCTCCATAACGTTGTGAAACA GCCAGTTAAGAGAATCGTAAATAATTGTCAACTCACAGTTGAATTCTCTGCCTATGTAGGTAACTTTTTTCTAATTTCTGGAACATATAG ATATATAAGAAATATCAAAGAATAGGTAGTTATTTCAAAGTTTAATAAGTAAAACTTGTTCATAAACATTTGAGCACCATGAAATCAAAA TACCCTATAACTACTTTCTATAGTCATATCTAATTTATATTTTTTTCATTTCCAGTTGTAACTAGATATGTAGTAAAGTCTGAAAAGACT TTACCATAGACAATAACATGCAGTTTTATCAGCACCAAAGAATGTTGTCCAAAAGAAACTTTTTAATACCTGTCTTTCTATTTATAACAT CTGAATATTTTCATTCTTATATTAAGAATTTTGATAAGTAGATTGAATTTAGTATGAGTACTATTTTCTTATATATACCACAATGGCAAA CATGTATTATAAATCATATTTTTGTCTTACCAATTTTAATATATGAGGGGTTTTAGAAATTTGTTGTAAGTTATTTTTATATTCCTTGTC 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FusionGenePPI for MTRR_SLC30A5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MTRR | ELAVL1, FH, HIST1H2AG, PAPSS1, GMCL1, SMS, UBA6, ATM, KIF2A, TSNAX | SLC30A5 | ELAVL1, SRSF1, ATP6V1B1, ATP6V0A1, TCIRG1, NT5E, HNRNPD, ABCC2, VAMP2, ATP6V1E1, DNM2, SLC30A6, RIC3, B3GNT3, LPAR1, CHRNA9, CLPSL1, TCTN3, TMEM17, TMEM216, SPPL2B, CSGALNACT2, FPR2, CYB5D2, TPRA1, CD79B, CD70, MAS1, IPPK, FUT3, DPEP1, CD83, IL1R2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTRR_SLC30A5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MTRR | Q9UBK8 | DB00200 | Hydroxocobalamin | Methionine synthase reductase | small molecule | approved |
Hgene | MTRR | Q9UBK8 | DB00115 | Cyanocobalamin | Methionine synthase reductase | small molecule | approved|nutraceutical |
Hgene | MTRR | Q9UBK8 | DB00134 | Methionine | Methionine synthase reductase | small molecule | approved|nutraceutical |
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RelatedDiseases for MTRR_SLC30A5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MTRR | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Hgene | MTRR | C0019880 | Homocystinuria | 2 | CTD_human;HPO |
Hgene | MTRR | C0598608 | Hyperhomocysteinemia | 2 | CTD_human |
Hgene | MTRR | C0001430 | Adenoma | 1 | CTD_human |
Hgene | MTRR | C0021364 | Male infertility | 1 | CTD_human |
Hgene | MTRR | C0027765 | nervous system disorder | 1 | CTD_human |
Hgene | MTRR | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | MTRR | C1856057 | Homocystinuria-Megaloblastic Anemia due to Defect in Cobalamin Metabolism, CblE Complementation Type | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | MTRR | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |