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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22802

FusionGeneSummary for MTMR3_MB

check button Fusion gene summary
Fusion gene informationFusion gene name: MTMR3_MB
Fusion gene ID: 22802
HgeneTgene
Gene symbol

MTMR3

MB

Gene ID

8897

4151

Gene namemyotubularin related protein 3myoglobin
SynonymsFYVE-DSP1|ZFYVE10PVALB|myoglobgin
Cytomap

22q12.2

22q12.3

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 3FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphataseFYVE domain-containing dual specificity protein phosphatase 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phomyoglobin
Modification date2018051920180519
UniProtAcc

Q13615

P02144

Ensembl transtripts involved in fusion geneENST00000401950, ENST00000333027, 
ENST00000323630, ENST00000351488, 
ENST00000406629, ENST00000415511, 
ENST00000401702, ENST00000397326, 
ENST00000397328, ENST00000359787, 
ENST00000406324, ENST00000472240, 
Fusion gene scores* DoF score12 X 5 X 9=5406 X 3 X 6=108
# samples 156
** MAII scorelog2(15/540*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTMR3 [Title/Abstract] AND MB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR3

GO:0006470

protein dephosphorylation

10733931

HgeneMTMR3

GO:0046856

phosphatidylinositol dephosphorylation

10900271|11676921

HgeneMTMR3

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

HgeneMTMR3

GO:1904562

phosphatidylinositol 5-phosphate metabolic process

11676921


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A197-06AMTMR3chr22

30279348

+MBchr22

36033255

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000401950ENST00000401702MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000401950ENST00000397326MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000401950ENST00000397328MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000401950ENST00000359787MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000401950ENST00000406324MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000401950ENST00000472240MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000333027ENST00000401702MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000333027ENST00000397326MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000333027ENST00000397328MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000333027ENST00000359787MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000333027ENST00000406324MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000333027ENST00000472240MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000323630ENST00000401702MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000323630ENST00000397326MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000323630ENST00000397328MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000323630ENST00000359787MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000323630ENST00000406324MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000323630ENST00000472240MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000351488ENST00000401702MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000351488ENST00000397326MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000351488ENST00000397328MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000351488ENST00000359787MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000351488ENST00000406324MTMR3chr22

30279348

+MBchr22

36033255

-
5UTR-intronENST00000351488ENST00000472240MTMR3chr22

30279348

+MBchr22

36033255

-
intron-intronENST00000406629ENST00000401702MTMR3chr22

30279348

+MBchr22

36033255

-
intron-intronENST00000406629ENST00000397326MTMR3chr22

30279348

+MBchr22

36033255

-
intron-intronENST00000406629ENST00000397328MTMR3chr22

30279348

+MBchr22

36033255

-
intron-intronENST00000406629ENST00000359787MTMR3chr22

30279348

+MBchr22

36033255

-
intron-intronENST00000406629ENST00000406324MTMR3chr22

30279348

+MBchr22

36033255

-
intron-intronENST00000406629ENST00000472240MTMR3chr22

30279348

+MBchr22

36033255

-
3UTR-intronENST00000415511ENST00000401702MTMR3chr22

30279348

+MBchr22

36033255

-
3UTR-intronENST00000415511ENST00000397326MTMR3chr22

30279348

+MBchr22

36033255

-
3UTR-intronENST00000415511ENST00000397328MTMR3chr22

30279348

+MBchr22

36033255

-
3UTR-intronENST00000415511ENST00000359787MTMR3chr22

30279348

+MBchr22

36033255

-
3UTR-intronENST00000415511ENST00000406324MTMR3chr22

30279348

+MBchr22

36033255

-
3UTR-intronENST00000415511ENST00000472240MTMR3chr22

30279348

+MBchr22

36033255

-

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FusionProtFeatures for MTMR3_MB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR3

Q13615

MB

P02144

Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate. May alsodephosphorylate proteins phosphorylated on Ser, Thr, and Tyrresidues (PubMed:10733931). {ECO:0000269|PubMed:10733931,ECO:0000269|PubMed:11676921}. Serves as a reserve supply of oxygen and facilitates themovement of oxygen within muscles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTMR3_MB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTMR3_MB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTMR3CUL3, HIVEP1, ANKRD28, PNO1, WRAP73, AURKA, HERC2, ATM, THOC2, MTOR, MTMR4, MLST8, RPTOR, PLK1, EYA3, MTMR3, ORC4, HEATR1, MAPK1IP1L, IPO5, SSBP1, NUP205, MED18, ALOX5, HDAC11, TULP3, DNAJC10, FGFR2, TRIM25MBPSMD4, APP, HSPB2, ANK1, CORT


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTMR3_MB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMBP02144DB09112Nitrous acidMyoglobinsmall moleculeapproved|investigational

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RelatedDiseases for MTMR3_MB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource