![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22793 |
FusionGeneSummary for MTMR2_MMP8 |
![]() |
Fusion gene information | Fusion gene name: MTMR2_MMP8 | Fusion gene ID: 22793 | Hgene | Tgene | Gene symbol | MTMR2 | MMP8 | Gene ID | 8898 | 4317 |
Gene name | myotubularin related protein 2 | matrix metallopeptidase 8 | |
Synonyms | CMT4B|CMT4B1 | CLG1|HNC|MMP-8|PMNL-CL | |
Cytomap | 11q21 | 11q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | myotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatase | neutrophil collagenasePMN leukocyte collagenasePMNL collagenasecollagenase 2matrix metalloproteinase 8 (neutrophil collagenase)matrix metalloproteinase-8 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q13614 | P22894 | |
Ensembl transtripts involved in fusion gene | ENST00000393223, ENST00000346299, ENST00000409459, ENST00000352297, ENST00000484818, | ENST00000236826, | |
Fusion gene scores | * DoF score | 6 X 4 X 7=168 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MTMR2 [Title/Abstract] AND MMP8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MTMR2 | GO:0046856 | phosphatidylinositol dephosphorylation | 12668758 |
Hgene | MTMR2 | GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 16787938 |
Tgene | MMP8 | GO:0006508 | proteolysis | 2164002 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | COAD | TCGA-G4-6317-01A | MTMR2 | chr11 | 95647406 | - | MMP8 | chr11 | 102595734 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000393223 | ENST00000236826 | MTMR2 | chr11 | 95647406 | - | MMP8 | chr11 | 102595734 | - |
intron-intron | ENST00000346299 | ENST00000236826 | MTMR2 | chr11 | 95647406 | - | MMP8 | chr11 | 102595734 | - |
5UTR-intron | ENST00000409459 | ENST00000236826 | MTMR2 | chr11 | 95647406 | - | MMP8 | chr11 | 102595734 | - |
5UTR-intron | ENST00000352297 | ENST00000236826 | MTMR2 | chr11 | 95647406 | - | MMP8 | chr11 | 102595734 | - |
intron-intron | ENST00000484818 | ENST00000236826 | MTMR2 | chr11 | 95647406 | - | MMP8 | chr11 | 102595734 | - |
Top |
FusionProtFeatures for MTMR2_MMP8 |
![]() |
Hgene | Tgene |
MTMR2 | MMP8 |
Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate.{ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758,ECO:0000269|PubMed:21372139}. | Can degrade fibrillar type I, II, and III collagens. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MTMR2_MMP8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MTMR2_MMP8 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MTMR2 | SBF1, MTMR2, ELAVL1, RFC5, SNTA1, HSF1, SZRD1, CTPS2, EHD4, LRSAM1, PLIN3, XPNPEP1, UNK, MTMR11, CCDC22, MTMR1, MTMR10, MTMR12, NFKB1, SBF2, TUBA1B, MTMR9, EYA3, SEPSECS, NUDT16, GADD45GIP1, RPS19BP1, MRTO4, EBNA1BP2, RPL3L, ERBB4, ERBB3, ROR2 | MMP8 | BCAN |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MTMR2_MMP8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MTMR2_MMP8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MTMR2 | C1832399 | Charcot-Marie-Tooth disease, Type 4B1 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | MMP8 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | MMP8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MMP8 | C0024115 | Lung diseases | 1 | CTD_human |
Tgene | MMP8 | C0025202 | melanoma | 1 | CTD_human |
Tgene | MMP8 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | MMP8 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |