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Fusion gene ID: 22792 |
FusionGeneSummary for MTMR2_MAML2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTMR2_MAML2 | Fusion gene ID: 22792 | Hgene | Tgene | Gene symbol | MTMR2 | MAML2 | Gene ID | 8898 | 84441 |
| Gene name | myotubularin related protein 2 | mastermind like transcriptional coactivator 2 | |
| Synonyms | CMT4B|CMT4B1 | MAM-3|MAM2|MAM3|MLL-MAML2 | |
| Cytomap | 11q21 | 11q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatase | mastermind-like protein 2mam-2mastermind-like 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q13614 | Q8IZL2 | |
| Ensembl transtripts involved in fusion gene | ENST00000393223, ENST00000346299, ENST00000409459, ENST00000352297, ENST00000484818, | ENST00000524717, | |
| Fusion gene scores | * DoF score | 6 X 4 X 7=168 | 10 X 12 X 4=480 |
| # samples | 7 | 16 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/480*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MTMR2 [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTMR2 | GO:0046856 | phosphatidylinositol dephosphorylation | 12668758 |
| Hgene | MTMR2 | GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 16787938 |
| Tgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
| Tgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A244-01A | MTMR2 | chr11 | 95598765 | - | MAML2 | chr11 | 95724887 | - |
| TCGA | RV | LGG | TCGA-HT-7477-01B | MTMR2 | chr11 | 95621320 | - | MAML2 | chr11 | 95826681 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393223 | ENST00000524717 | MTMR2 | chr11 | 95598765 | - | MAML2 | chr11 | 95724887 | - |
| Frame-shift | ENST00000346299 | ENST00000524717 | MTMR2 | chr11 | 95598765 | - | MAML2 | chr11 | 95724887 | - |
| Frame-shift | ENST00000409459 | ENST00000524717 | MTMR2 | chr11 | 95598765 | - | MAML2 | chr11 | 95724887 | - |
| In-frame | ENST00000352297 | ENST00000524717 | MTMR2 | chr11 | 95598765 | - | MAML2 | chr11 | 95724887 | - |
| 5UTR-3CDS | ENST00000484818 | ENST00000524717 | MTMR2 | chr11 | 95598765 | - | MAML2 | chr11 | 95724887 | - |
| 5UTR-3CDS | ENST00000393223 | ENST00000524717 | MTMR2 | chr11 | 95621320 | - | MAML2 | chr11 | 95826681 | - |
| In-frame | ENST00000346299 | ENST00000524717 | MTMR2 | chr11 | 95621320 | - | MAML2 | chr11 | 95826681 | - |
| 5UTR-3CDS | ENST00000409459 | ENST00000524717 | MTMR2 | chr11 | 95621320 | - | MAML2 | chr11 | 95826681 | - |
| 5UTR-3CDS | ENST00000352297 | ENST00000524717 | MTMR2 | chr11 | 95621320 | - | MAML2 | chr11 | 95826681 | - |
| 5UTR-3CDS | ENST00000484818 | ENST00000524717 | MTMR2 | chr11 | 95621320 | - | MAML2 | chr11 | 95826681 | - |
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FusionProtFeatures for MTMR2_MAML2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTMR2 | MAML2 |
| Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate.{ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758,ECO:0000269|PubMed:21372139}. | Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. Potentiates activation by NOTCH3 and NOTCH4 more efficientlythan MAML1 or MAML3. {ECO:0000269|PubMed:12370315,ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 4_53 | 87 | 644 | Compositional bias | Note=Ser-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 593_627 | 87 | 644 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 593_627 | 15 | 572 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 593_627 | 15 | 572 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 593_627 | 15 | 572 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 4_53 | 15 | 572 | Compositional bias | Note=Ser-rich |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 4_53 | 15 | 572 | Compositional bias | Note=Ser-rich |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 4_53 | 15 | 572 | Compositional bias | Note=Ser-rich |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 205_580 | 87 | 644 | Domain | Myotubularin phosphatase |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 68_139 | 87 | 644 | Domain | Note=GRAM |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 205_580 | 15 | 572 | Domain | Myotubularin phosphatase |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 68_139 | 15 | 572 | Domain | Note=GRAM |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 205_580 | 15 | 572 | Domain | Myotubularin phosphatase |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 68_139 | 15 | 572 | Domain | Note=GRAM |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 205_580 | 15 | 572 | Domain | Myotubularin phosphatase |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 68_139 | 15 | 572 | Domain | Note=GRAM |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 330_333 | 87 | 644 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 355_356 | 87 | 644 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000346299 | - | 3 | 15 | 417_423 | 87 | 644 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 330_333 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 355_356 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000352297 | - | 4 | 16 | 417_423 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 330_333 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 355_356 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000393223 | - | 5 | 17 | 417_423 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 330_333 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 355_356 | 15 | 572 | Region | Substrate binding |
| Hgene | >MTMR2 | chr11:95598765 | chr11:95724887 | ENST00000409459 | - | 5 | 17 | 417_423 | 15 | 572 | Region | Substrate binding |
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FusionGeneSequence for MTMR2_MAML2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MTMR2_ENST00000393223_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_459aa MEEPPLLPGENIKDMGSTLCGRPEHRPQSKSXPLLKSKHWKWLHELPAITVESAIDGKEADSTEADHGAETATSSPAADAGXRGENCSTR SDKPTFVKATSRLXRPKKKCGQYATNCSVFWWLIHNKLKLXPGFGKPSFNTHHFNSQFQPPVYFSRDKNAIIIYSSSEYGDVWKSALXST XHIQCHFRNESIDPTEKPKAIVSKSKQPYDATATYLRAKXXXQCSHFWSWICWXFTTIETKFNPXYGKHATTENIKRNDHIQHNCTKLGL SRRNKQTARSPDVCRSPLPHRYTCSLYPKSVTATGSRXPAIFPEGSGSSXPVNTSSANETHEPNEPNTKWANHGSPQGSESQTQSAKHTD FAXFESVRNRVESVEDGHQPATIPDAQQFSFTQPKFQGFSRNXPQQXLSFXLPQPTKXXHGPCPKQXCXFHXFFIEDRAWXXXLDERHQS >In-frame_MTMR2_ENST00000352297_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_459aa MEEPPLLPGENIKDMGSTLCGRPEHRPQSKSXPLLKSKHWKWLHELPAITVESAIDGKEADSTEADHGAETATSSPAADAGXRGENCSTR SDKPTFVKATSRLXRPKKKCGQYATNCSVFWWLIHNKLKLXPGFGKPSFNTHHFNSQFQPPVYFSRDKNAIIIYSSSEYGDVWKSALXST XHIQCHFRNESIDPTEKPKAIVSKSKQPYDATATYLRAKXXXQCSHFWSWICWXFTTIETKFNPXYGKHATTENIKRNDHIQHNCTKLGL SRRNKQTARSPDVCRSPLPHRYTCSLYPKSVTATGSRXPAIFPEGSGSSXPVNTSSANETHEPNEPNTKWANHGSPQGSESQTQSAKHTD FAXFESVRNRVESVEDGHQPATIPDAQQFSFTQPKFQGFSRNXPQQXLSFXLPQPTKXXHGPCPKQXCXFHXFFIEDRAWXXXLDERHQS >In-frame_MTMR2_ENST00000346299_chr11_95621320_-_MAML2_ENST00000524717_chr11_95826681_-_1048aa MEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPDLRLQGSLKRKQVVNLSPANSKRPNGFVDNS FLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIF PNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGS PQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAG PSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPL FHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQ QQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGS GYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSN QALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNN NNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQF SQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MTMR2_ENST00000393223_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_1378nt ATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAG TCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCA GACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGA TCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTC TGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCT CCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACC TAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGAT GCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACC AAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTC TCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCA GTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACC CATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGAT TTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCC TTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACAT GGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCT >In-frame_MTMR2_ENST00000352297_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_1378nt ATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAG TCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCA GACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGA TCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTC TGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCT CCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACC TAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGAT GCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACC AAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTC TCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCA GTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACC CATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGAT TTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCC TTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACAT GGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCT >In-frame_MTMR2_ENST00000346299_chr11_95621320_-_MAML2_ENST00000524717_chr11_95826681_-_3144nt ATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTGCCTCCACT TCTCATTCAGAGAATTCAGTGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGAT TTGAGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCA TTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATG TCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAAC ATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTT CCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCT CCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAG AGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCT CCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAG AGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATA GCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGA CCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGG GTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTC ATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTG TTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAG CAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAA CAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAG CAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTG CTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAA CAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGT GGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAG CAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCA GATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAAC CAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCA TTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAA TTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAAT AACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCA CAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTG ACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTT TCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAA ACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTG AATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGA ACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MTMR2_ENST00000393223_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_4391nt AGATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTA CAGGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACT CCGCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAG CTGCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTT GAAGATCATCAGAAGTGAAGATAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCT TCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGAGGGAGTCTCGCTCTATCCCCTAGGCTGGA GTGCATTGGCGCCATCTCGGCTCATTTGCAACCTCTGTCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCGAGGAGCTGGGATTA CAGGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTC TGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATC ACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGAT GCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAA TGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTC AACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATAT GGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAA GCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGC TGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGAT CACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCC CACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCC TAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCT GAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAA CCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGC TTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCC TGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTC CAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAA ATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCAC TTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTT CCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAG CAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGAT AGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTA CAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAA AAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTC CTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTA TTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCC TACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGA TAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCC TTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGT GATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGT CATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTT TCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTAT TTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTG GAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGT AAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAA AGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTA CACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAA GCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTG TGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAA TGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAG CTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTAT >In-frame_MTMR2_ENST00000352297_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_4161nt GGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCCGCCCTCCGCTTCTCC CGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCT CCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTTGAAGATCATCAGAAGTG AAGATAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCTTCTGTTGTATCATCAGA TTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTT GCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAA ATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGA TCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATT TGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAA TAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACG GGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCA CTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCT TAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTA TGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCA AACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAG TAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCC AAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATC AGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTT CCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACA GTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGA ACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGT TGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTT GTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAA CTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGT TTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCC ATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATT AAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAAT CCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAA TCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTT TTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTG GTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGA AGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAG TTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGG TCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTC CCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACG TGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGC TCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTG AAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCC CTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTG GGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATAT GCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGG CTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTT TAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGA TTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTAT ATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATT TAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTCTATTTATTCAGCTATTCATTAAA >In-frame_MTMR2_ENST00000346299_chr11_95621320_-_MAML2_ENST00000524717_chr11_95826681_-_5835nt CTCCTTCCATAAGGGTCTGGTCCTTCATCCCTCCCGCTTCACCAGACCCCCTCACCCTGGGAGCCGCCACCTCCCTTTCCCCAAGACCAG ATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTACA GGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCC GCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCT GCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTGCCTCCACTTCTCATTCAGAGAATTCAG TGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGCTCCAGGGTTCCT TGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAA TTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGA GCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAA AGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACG ACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAAC TGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCT CCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCAT CAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGA CAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGC ATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTG GGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCC AGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGG ATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATC AAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGC AGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAG CTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGC AACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCAC TTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAAC ACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGC AATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGC AGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAA GAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAG TTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGA ATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACC CAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTG GAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAA TGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCT TCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTC CTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGG GTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCA TCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACT TAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAG AGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAA ACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTT AAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGA TCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAG CCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTC CAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCA GGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGG ATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAA ACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACT TGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGA TTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCC TCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTG GAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTT GTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTG ATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTT GAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATC ATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAG TTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATG TCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTT TTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTAT CAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGC TCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAA GAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCT GCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAA AAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAG TCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTT 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FusionGenePPI for MTMR2_MAML2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTMR2 | SBF1, MTMR2, ELAVL1, RFC5, SNTA1, HSF1, SZRD1, CTPS2, EHD4, LRSAM1, PLIN3, XPNPEP1, UNK, MTMR11, CCDC22, MTMR1, MTMR10, MTMR12, NFKB1, SBF2, TUBA1B, MTMR9, EYA3, SEPSECS, NUDT16, GADD45GIP1, RPS19BP1, MRTO4, EBNA1BP2, RPL3L, ERBB4, ERBB3, ROR2 | MAML2 | MAML1, NOTCH1, DIABLO, CREBBP, EP300, RBPJ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTMR2_MAML2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTMR2_MAML2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MTMR2 | C1832399 | Charcot-Marie-Tooth disease, Type 4B1 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | MAML2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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