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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 22792

FusionGeneSummary for MTMR2_MAML2

check button Fusion gene summary
Fusion gene informationFusion gene name: MTMR2_MAML2
Fusion gene ID: 22792
HgeneTgene
Gene symbol

MTMR2

MAML2

Gene ID

8898

84441

Gene namemyotubularin related protein 2mastermind like transcriptional coactivator 2
SynonymsCMT4B|CMT4B1MAM-3|MAM2|MAM3|MLL-MAML2
Cytomap

11q21

11q21

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatasemastermind-like protein 2mam-2mastermind-like 2
Modification date2018051920180523
UniProtAcc

Q13614

Q8IZL2

Ensembl transtripts involved in fusion geneENST00000393223, ENST00000346299, 
ENST00000409459, ENST00000352297, 
ENST00000484818, 
ENST00000524717, 
Fusion gene scores* DoF score6 X 4 X 7=16810 X 12 X 4=480
# samples 716
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/480*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTMR2 [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR2

GO:0046856

phosphatidylinositol dephosphorylation

12668758

HgeneMTMR2

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

TgeneMAML2

GO:0007219

Notch signaling pathway

12370315

TgeneMAML2

GO:0045944

positive regulation of transcription by RNA polymerase II

12370315


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A244-01AMTMR2chr11

95598765

-MAML2chr11

95724887

-
TCGARVLGGTCGA-HT-7477-01BMTMR2chr11

95621320

-MAML2chr11

95826681

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393223ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
Frame-shitENST00000346299ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
Frame-shitENST00000409459ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
In-frameENST00000352297ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
5UTR-3CDSENST00000484818ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
5UTR-3CDSENST00000393223ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
In-frameENST00000346299ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
5UTR-3CDSENST00000409459ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
5UTR-3CDSENST00000352297ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
5UTR-3CDSENST00000484818ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-

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FusionProtFeatures for MTMR2_MAML2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR2

Q13614

MAML2

Q8IZL2

Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate.{ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758,ECO:0000269|PubMed:21372139}. Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. Potentiates activation by NOTCH3 and NOTCH4 more efficientlythan MAML1 or MAML3. {ECO:0000269|PubMed:12370315,ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-3154_5387644Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315593_62787644Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416593_62715572Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517593_62715572Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517593_62715572Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-4164_5315572Compositional biasNote=Ser-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-5174_5315572Compositional biasNote=Ser-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-5174_5315572Compositional biasNote=Ser-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315205_58087644DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-31568_13987644DomainNote=GRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416205_58015572DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-41668_13915572DomainNote=GRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517205_58015572DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-51768_13915572DomainNote=GRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517205_58015572DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-51768_13915572DomainNote=GRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315330_33387644RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315355_35687644RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315417_42387644RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416330_33315572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416355_35615572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416417_42315572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517330_33315572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517355_35615572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517417_42315572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517330_33315572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517355_35615572RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517417_42315572RegionSubstrate binding


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FusionGeneSequence for MTMR2_MAML2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MTMR2_ENST00000393223_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_459aa
MEEPPLLPGENIKDMGSTLCGRPEHRPQSKSXPLLKSKHWKWLHELPAITVESAIDGKEADSTEADHGAETATSSPAADAGXRGENCSTR
SDKPTFVKATSRLXRPKKKCGQYATNCSVFWWLIHNKLKLXPGFGKPSFNTHHFNSQFQPPVYFSRDKNAIIIYSSSEYGDVWKSALXST
XHIQCHFRNESIDPTEKPKAIVSKSKQPYDATATYLRAKXXXQCSHFWSWICWXFTTIETKFNPXYGKHATTENIKRNDHIQHNCTKLGL
SRRNKQTARSPDVCRSPLPHRYTCSLYPKSVTATGSRXPAIFPEGSGSSXPVNTSSANETHEPNEPNTKWANHGSPQGSESQTQSAKHTD
FAXFESVRNRVESVEDGHQPATIPDAQQFSFTQPKFQGFSRNXPQQXLSFXLPQPTKXXHGPCPKQXCXFHXFFIEDRAWXXXLDERHQS

>In-frame_MTMR2_ENST00000352297_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_459aa
MEEPPLLPGENIKDMGSTLCGRPEHRPQSKSXPLLKSKHWKWLHELPAITVESAIDGKEADSTEADHGAETATSSPAADAGXRGENCSTR
SDKPTFVKATSRLXRPKKKCGQYATNCSVFWWLIHNKLKLXPGFGKPSFNTHHFNSQFQPPVYFSRDKNAIIIYSSSEYGDVWKSALXST
XHIQCHFRNESIDPTEKPKAIVSKSKQPYDATATYLRAKXXXQCSHFWSWICWXFTTIETKFNPXYGKHATTENIKRNDHIQHNCTKLGL
SRRNKQTARSPDVCRSPLPHRYTCSLYPKSVTATGSRXPAIFPEGSGSSXPVNTSSANETHEPNEPNTKWANHGSPQGSESQTQSAKHTD
FAXFESVRNRVESVEDGHQPATIPDAQQFSFTQPKFQGFSRNXPQQXLSFXLPQPTKXXHGPCPKQXCXFHXFFIEDRAWXXXLDERHQS

>In-frame_MTMR2_ENST00000346299_chr11_95621320_-_MAML2_ENST00000524717_chr11_95826681_-_1048aa
MEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPDLRLQGSLKRKQVVNLSPANSKRPNGFVDNS
FLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIF
PNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGS
PQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAG
PSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPL
FHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQ
QQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGS
GYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSN
QALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNN
NNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQF
SQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MTMR2_ENST00000393223_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_1378nt
ATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAG
TCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCA
GACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGA
TCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTC
TGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCT
CCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACC
TAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGAT
GCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACC
AAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTC
TCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCA
GTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACC
CATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGAT
TTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCC
TTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACAT
GGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCT

>In-frame_MTMR2_ENST00000352297_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_1378nt
ATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAG
TCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCA
GACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGA
TCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTC
TGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCT
CCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACC
TAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGAT
GCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACC
AAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTC
TCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCA
GTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACC
CATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGAT
TTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCC
TTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACAT
GGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCT

>In-frame_MTMR2_ENST00000346299_chr11_95621320_-_MAML2_ENST00000524717_chr11_95826681_-_3144nt
ATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTGCCTCCACT
TCTCATTCAGAGAATTCAGTGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGAT
TTGAGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCA
TTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATG
TCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAAC
ATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTT
CCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCT
CCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAG
AGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCT
CCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAG
AGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATA
GCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGA
CCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGG
GTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTC
ATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTG
TTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAG
CAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAA
CAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAG
CAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTG
CTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAA
CAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGT
GGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAG
CAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCA
GATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAAC
CAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCA
TTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAA
TTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAAT
AACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCA
CAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTG
ACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTT
TCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAA
ACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTG
AATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGA
ACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MTMR2_ENST00000393223_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_4391nt
AGATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTA
CAGGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACT
CCGCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAG
CTGCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTT
GAAGATCATCAGAAGTGAAGATAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCT
TCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGAGGGAGTCTCGCTCTATCCCCTAGGCTGGA
GTGCATTGGCGCCATCTCGGCTCATTTGCAACCTCTGTCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCGAGGAGCTGGGATTA
CAGGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTC
TGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATC
ACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGAT
GCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAA
TGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTC
AACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATAT
GGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAA
GCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGC
TGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGAT
CACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCC
CACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCC
TAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCT
GAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAA
CCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGC
TTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCC
TGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTC
CAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAA
ATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCAC
TTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTT
CCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAG
CAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGAT
AGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTA
CAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAA
AAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTC
CTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTA
TTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCC
TACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGA
TAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCC
TTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGT
GATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGT
CATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTT
TCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTAT
TTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTG
GAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGT
AAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAA
AGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTA
CACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAA
GCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTG
TGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAA
TGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAG
CTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTAT

>In-frame_MTMR2_ENST00000352297_chr11_95598765_-_MAML2_ENST00000524717_chr11_95724887_-_4161nt
GGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCCGCCCTCCGCTTCTCC
CGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCT
CCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTTGAAGATCATCAGAAGTG
AAGATAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCTTCTGTTGTATCATCAGA
TTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTT
GCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAA
ATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGA
TCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATT
TGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAA
TAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACG
GGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCA
CTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCT
TAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTA
TGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCA
AACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAG
TAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCC
AAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATC
AGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTT
CCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACA
GTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGA
ACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGT
TGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTT
GTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAA
CTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGT
TTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCC
ATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATT
AAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAAT
CCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAA
TCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTT
TTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTG
GTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGA
AGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAG
TTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGG
TCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTC
CCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACG
TGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGC
TCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTG
AAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCC
CTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTG
GGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATAT
GCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGG
CTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTT
TAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGA
TTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTAT
ATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATT
TAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTCTATTTATTCAGCTATTCATTAAA

>In-frame_MTMR2_ENST00000346299_chr11_95621320_-_MAML2_ENST00000524717_chr11_95826681_-_5835nt
CTCCTTCCATAAGGGTCTGGTCCTTCATCCCTCCCGCTTCACCAGACCCCCTCACCCTGGGAGCCGCCACCTCCCTTTCCCCAAGACCAG
ATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTACA
GGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCC
GCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCT
GCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTGCCTCCACTTCTCATTCAGAGAATTCAG
TGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGCTCCAGGGTTCCT
TGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAA
TTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGA
GCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAA
AGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACG
ACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAAC
TGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCT
CCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCAT
CAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGA
CAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGC
ATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTG
GGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCC
AGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGG
ATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATC
AAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGC
AGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAG
CTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGC
AACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCAC
TTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAAC
ACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGC
AATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGC
AGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAA
GAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAG
TTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGA
ATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACC
CAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTG
GAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAA
TGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCT
TCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTC
CTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGG
GTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCA
TCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACT
TAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAG
AGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAA
ACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTT
AAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGA
TCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAG
CCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTC
CAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCA
GGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGG
ATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAA
ACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACT
TGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGA
TTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCC
TCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTG
GAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTT
GTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTG
ATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTT
GAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATC
ATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAG
TTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATG
TCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTT
TTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTAT
CAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGC
TCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAA
GAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCT
GCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAA
AAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAG
TCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTT


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FusionGenePPI for MTMR2_MAML2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTMR2SBF1, MTMR2, ELAVL1, RFC5, SNTA1, HSF1, SZRD1, CTPS2, EHD4, LRSAM1, PLIN3, XPNPEP1, UNK, MTMR11, CCDC22, MTMR1, MTMR10, MTMR12, NFKB1, SBF2, TUBA1B, MTMR9, EYA3, SEPSECS, NUDT16, GADD45GIP1, RPS19BP1, MRTO4, EBNA1BP2, RPL3L, ERBB4, ERBB3, ROR2MAML2MAML1, NOTCH1, DIABLO, CREBBP, EP300, RBPJ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTMR2_MAML2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTMR2_MAML2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTMR2C1832399Charcot-Marie-Tooth disease, Type 4B11CTD_human;ORPHANET;UNIPROT
TgeneMAML2C3495559Juvenile arthritis1CTD_human