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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22765

FusionGeneSummary for MTHFS_ABCF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MTHFS_ABCF1
Fusion gene ID: 22765
HgeneTgene
Gene symbol

MTHFS

ABCF1

Gene ID

10588

23

Gene namemethenyltetrahydrofolate synthetaseATP binding cassette subfamily F member 1
SynonymsHsT19268ABC27|ABC50
Cytomap

15q25.1

6p21.33

Type of geneprotein-codingprotein-coding
Description5-formyltetrahydrofolate cyclo-ligase5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)methenyl-THF synthetaseATP-binding cassette sub-family F member 1ATP-binding cassette 50 (TNF-alpha stimulated)ATP-binding cassette, sub-family F (GCN20), member 1TNF-alpha-stimulated ABC proteinTNFalpha-inducible ATP-binding protein
Modification date2018052320180519
UniProtAcc

P49914

Q8NE71

Ensembl transtripts involved in fusion geneENST00000258874, ENST00000559722, 
ENST00000326195, ENST00000376545, 
ENST00000396515, ENST00000457111, 
ENST00000452530, ENST00000416932, 
ENST00000470464, ENST00000419893, 
ENST00000448939, ENST00000457970, 
ENST00000475528, ENST00000457078, 
ENST00000412443, ENST00000546690, 
ENST00000421608, ENST00000486105, 
ENST00000383588, ENST00000383587, 
ENST00000400609, ENST00000485585, 
ENST00000426219, ENST00000421042, 
ENST00000552867, ENST00000454094, 
ENST00000494413, ENST00000423247, 
ENST00000420257, ENST00000456791, 
ENST00000495194, 
Fusion gene scores* DoF score3 X 2 X 4=247 X 3 X 6=126
# samples 57
** MAII scorelog2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTHFS [Title/Abstract] AND ABCF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTHFS

GO:0046653

tetrahydrofolate metabolic process

7766710|19738041


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE763194MTHFSchr15

80157837

-ABCF1chr6

1890845

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000258874ENST00000326195MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000376545MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000396515MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000457111MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000452530MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000416932MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000470464MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000419893MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000448939MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000457970MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000475528MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000457078MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000412443MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000546690MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000421608MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000486105MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000383588MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000383587MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000400609MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000485585MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000426219MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000421042MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000552867MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000454094MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000258874ENST00000494413MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000258874ENST00000423247MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000258874ENST00000420257MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000258874ENST00000456791MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000258874ENST00000495194MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000326195MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000376545MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000396515MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000457111MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000452530MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000416932MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000470464MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000419893MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000448939MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000457970MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000475528MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000457078MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000412443MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000546690MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000421608MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000486105MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000383588MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000383587MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000400609MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000485585MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000426219MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000421042MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000552867MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000454094MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-intronENST00000559722ENST00000494413MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000559722ENST00000423247MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000559722ENST00000420257MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000559722ENST00000456791MTHFSchr15

80157837

-ABCF1chr6

1890845

+
intron-3UTRENST00000559722ENST00000495194MTHFSchr15

80157837

-ABCF1chr6

1890845

+

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FusionProtFeatures for MTHFS_ABCF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTHFS

P49914

ABCF1

Q8NE71

Contributes to tetrahydrofolate metabolism. Helpsregulate carbon flow through the folate-dependent one-carbonmetabolic network that supplies carbon for the biosynthesis ofpurines, thymidine and amino acids. Catalyzes the irreversibleconversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}. Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved inthe ribosome biogenesis. {ECO:0000269|PubMed:19570978}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTHFS_ABCF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTHFS_ABCF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MTHFS_ABCF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTHFS_ABCF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTHFSC0008924Cleft Lip1CTD_human
HgeneMTHFSC0008925Cleft Palate1CTD_human
TgeneABCF1C0020517Hypersensitivity1CTD_human
TgeneABCF1C0032285Pneumonia1CTD_human