|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22757 |
FusionGeneSummary for MTHFD1L_RGS17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTHFD1L_RGS17 | Fusion gene ID: 22757 | Hgene | Tgene | Gene symbol | MTHFD1L | RGS17 | Gene ID | 25902 | 26575 |
| Gene name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | regulator of G protein signaling 17 | |
| Synonyms | FTHFSDC1|MTC1THFS|dJ292B18.2 | RGS-17|RGSZ2|hRGS17 | |
| Cytomap | 6q25.1 | 6q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | monofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1 | regulator of G-protein signaling 17 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6UB35 | Q9UGC6 | |
| Ensembl transtripts involved in fusion gene | ENST00000367321, ENST00000367307, ENST00000478643, | ENST00000367225, ENST00000206262, | |
| Fusion gene scores | * DoF score | 6 X 8 X 4=192 | 3 X 3 X 2=18 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/192*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MTHFD1L [Title/Abstract] AND RGS17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTHFD1L | GO:0006760 | folic acid-containing compound metabolic process | 12937168 |
| Hgene | MTHFD1L | GO:0015942 | formate metabolic process | 16171773 |
| Hgene | MTHFD1L | GO:0046653 | tetrahydrofolate metabolic process | 12937168 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0CY-01A | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367321 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| 5CDS-5UTR | ENST00000367321 | ENST00000206262 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| In-frame | ENST00000367307 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| 5CDS-5UTR | ENST00000367307 | ENST00000206262 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| intron-3CDS | ENST00000478643 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| intron-5UTR | ENST00000478643 | ENST00000206262 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
Top |
FusionProtFeatures for MTHFD1L_RGS17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTHFD1L | RGS17 |
| May provide the missing metabolic reaction required tolink the mitochondria and the cytoplasm in the mammalian model ofone-carbon folate metabolism in embryonic an transformed cellscomplementing thus the enzymatic activities of MTHFD2.{ECO:0000250, ECO:0000269|PubMed:16171773}. | Regulates G protein-coupled receptor signaling cascades,including signaling via muscarinic acetylcholine receptor CHRM2and dopamine receptor DRD2. Inhibits signal transduction byincreasing the GTPase activity of G protein alpha subunits,thereby driving them into their inactive GDP-bound form(PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits,accelerates their GTPase activity and regulates their signalingactivities. Negatively regulates mu-opioid receptor-mediatedactivation of the G-proteins (By similarity).{ECO:0000250|UniProtKB:Q9QZB0, ECO:0000269|PubMed:15096504}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 34_42 | 260 | 276 | Compositional bias | Note=Poly-Gly |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 34_42 | 260 | 932 | Compositional bias | Note=Poly-Gly |
| Tgene | >RGS17 | chr6:151209117 | chr6:153365178 | ENST00000206262 | - | 0 | 5 | 28_40 | -9 | 211 | Compositional bias | Note=Poly-Cys |
| Tgene | >RGS17 | chr6:151209117 | chr6:153365178 | ENST00000206262 | - | 0 | 5 | 84_200 | -9 | 211 | Domain | RGS |
| Tgene | >RGS17 | chr6:151209117 | chr6:153365178 | ENST00000367225 | - | -1 | 4 | 84_200 | 39 | 211 | Domain | RGS |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 423_430 | 260 | 276 | Nucleotide binding | ATP |
| Hgene | >MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 423_430 | 260 | 932 | Nucleotide binding | ATP |
| Hgene | >MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 31_348 | 260 | 276 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase |
| Hgene | >MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 349_978 | 260 | 276 | Region | Note=Formyltetrahydrofolate synthetase |
| Hgene | >MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 31_348 | 260 | 932 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase |
| Hgene | >MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 349_978 | 260 | 932 | Region | Note=Formyltetrahydrofolate synthetase |
| Tgene | RGS17 | chr6:151209117 | chr6:153365178 | ENST00000367225 | - | -1 | 4 | 28_40 | 39 | 211 | Compositional bias | Note=Poly-Cys |
Top |
FusionGeneSequence for MTHFD1L_RGS17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MTHFD1L_ENST00000367321_chr6_151209117_+_RGS17_ENST00000367225_chr6_153365178_-_260aa MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQ EKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD >In-frame_MTHFD1L_ENST00000367307_chr6_151209117_+_RGS17_ENST00000367225_chr6_153365178_-_260aa MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQ EKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MTHFD1L_ENST00000367321_chr6_151209117_+_RGS17_ENST00000367225_chr6_153365178_-_780nt ATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGC GCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGC TGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAA GAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAG GAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGAT ACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGAT GGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTT CTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTC >In-frame_MTHFD1L_ENST00000367307_chr6_151209117_+_RGS17_ENST00000367225_chr6_153365178_-_780nt ATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGC GCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGC TGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAA GAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAG GAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGAT ACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGAT GGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTT CTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MTHFD1L_ENST00000367321_chr6_151209117_+_RGS17_ENST00000367225_chr6_153365178_-_8827nt TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCCAACTGGGTCCTGAAGTAGCTGAAA TGCGAAAAAGGCAGCAGTCCCAAAATGAAGGAACACCTGCCGTGTCTCAAGCTCCTGGAAACCAGAGGCCCAACAACACCTGTTGCTTTT GTTGGTGCTGTTGTTGCAGCTGCTCCTGCCTCACTGTGAGGAATGAAGAAAGAGGGGAAAATGCGGGAAGACCCACACACACTACAAAAA TGGAGAGTATCCAGGTCCTAGAGGAATGCCAAAACCCCACTGCAGAGGAAGTCTTGTCCTGGTCTCAAAATTTTGACAAGATGATGAAGG CCCCAGCAGGAAGAAACCTTTTCAGAGAGTTCCTCCGAACAGAATACAGTGAAGAGAACCTACTTTTCTGGCTTGCTTGTGAAGACTTAA AGAAGGAGCAGAACAAAAAAGTAATTGAAGAAAAGGCTAGGATGATATATGAAGATTACATTTCTATACTATCACCAAAAGAGGTCAGTC TTGATTCTCGAGTTAGAGAGGTGATCAATAGAAATCTGTTGGATCCCAATCCTCACATGTATGAAGATGCCCAACTTCAGATATATACTT TAATGCACAGAGATTCTTTTCCAAGGTTTTTGAACTCTCAAATTTATAAGTCATTTGTTGAAAGTACTGCTGGCTCTTCTTCTGAATCTT AATGTTCATTTAAAAACAATCATTTTGGAGGGCTGAGATGGGAAATAAAAGTAGTTAAATAACATCAGAAACTGAGTTCCTGGAGAACTA CAGTTTAGCATTCCTCAGGCTACTGTGAAAACACAACCGTTATGGTCTTTGTCTCCATTTTTATCAAGGTTTTCCATGGTTAAGTTTGGA GAAAATACCACACAAAACAATGAATTGCCAAATTGTTTGTTTTATTCAAGACTCATTCTACTTGCAAGCAAAGTGTATTTGTAGTCCTAT GAACAGTCTCCTCGTGTATCTCCAGAGACTGCATGTGCAAAGTAAAATGCTTCATTTGCCACATAGTTGTTGTAATATTTAATCCAGTAG CATAACTTATATCTGTATTTAAGGACTTTTGTGCAATATGGTCTTAAGAAATAATTGCCAAAAAAATCGGCCATGGTTTGCATTTTTTAA CATAATCTAAGACAGAAAAAAAGCAATTTTTACTATGTAACAATGGTATTCAACATTCTATATACTGTGTTTAGTACACTAATTTTGAAG CCAATATTTCTGTACATGAAAAAGAGCTATTTATCTCTGTTTGTTGGAAAATCCTAATGGGGATTCCTCTGGTTGTTCACTGCCAAAACT GTGGCATTTTCATTACAGGAGAGTTTACTATGCTAAAAGCAAAAAACAAAAAAAAAAAAAAAGGGAAGAAGGAAAAAAGCACAAAACAAT TTGAAGATATCCTATCTCAATGACAAATCAAAAGAGTGATATTGCTTTTAACTGTAATAGAAGAAAATGAATTTATGTATATATCAGATG TCCAATACTGTAATTAATTTATTAAAGACTGGCTCTCCAGTTTTAAAATGGTTGTGTAAAGTTATGTACTTCAGCAAGAAAAAAATAATA ATAAGCTTGATAACTTAGTTTTGGAATATAAAGAAAAGGACTTAATAAAGGAATGCCTACATGTAGCACTGTAAAACATTTTGATGAATA GCATCTGTCCTGTGGCATATTTTCCTTGAAAGTGAAATCCAATGAAAAGCTAAGTTTTTACCAGGAAAAGTTTTATAAGGGTTATGAAGA AAATAATCCTCTACTTCAGACCTTAACTGTTTTCACATAATATCTTAAGGATGACATTTTAAAGATGTTTAAACCAAACTATTAGTTTTC ATCCATCATTAAAAGGCAGTACAGTGCTCAAATCTTCCAGCTGCCATATTATTTTTTATAAGTACACTAAATCTTTACGACAAAACACTT GCCTGACATTGTCATGTACTTCTGACCTTCAAGGAAACAATATTCTGTCATGCATAAAAGTGATAATTAAAATAATCAGTGTCATATTTA TATCAAAGTGTTACATTTGAATATTAATATCCCCTGAAGACTATTTTTTTAATATTAAACTGAATGAATATAATACTGAGTAACCTAAAA TGAAAGTTTTAAAAAGATTTATATCCACTGAGAACACTGGCCTTATATTAAGGATGATATTACAGTTACAGGTTTTCTTTGTCATTTTTT TAACTACCTCTCATTTTTTAATTTATTAAACATATTTTTTAAAAAAACAAGTTTGGGGGTTTCTTTTTAAATTTATTTTACTTGAAAGGT TGGCATCACAAGTTTCTTTTTCCATAAACTTAAAACATTTCAAAAATGGTTTTTTTAAGCAAGTATGATTTTCTAATTTATATAGAATTC AGGAGACATGAATAAAAGGGCTATTATCTATTCCCTATGCAAATATTTTAACTGTTGCAGTGTTTGACAAAATGGGATTTTTTAAAAATT GCAGAGTAGAAAACAAAATATTCTGTTTACACTGGCGTTGCTGACTATCCTACCATATTCAGCACTTTTAAATACGTTATTTATGAAAAT GCAGTTAAAATGCAAGATAGAAAATATTTATAATAATCATTTCTTTTAACAAATGCCTGTGTTTTCTGAAAGTGTTAGTGTGTTAAGACA TATTTTATTCATGTCATTTAAATACTATTTGAATAAGTTTTCAGTAATATGTTGAAAAAAAGATAGCTATGAAGATGTTTACAAAAAGTC ATATTTTTTCCTAAAGAGTAAAGAAAAACCTAAAAGAATCATCACTTCTATTGTGAAGTTCTATTGTTCCTAAATTATTTAATTTTTTTC TTGCTTAGAATTGAGTTTATTATGCTACTATGATATATACACATGTATGGTGTAGTATCATATTTGTTTCTGTGTGTGAGGCTCAACAAA TTGGTGCACATGACTAGAAAATATGTAATATACTGTGATACACTGCATGCATCCATCTTTTTAAATGTAGACTTTATATTCTCGTTGTTA CTATATATGATGGTGACCTGCTAGTCATAAGTTATCTTTATAAGATACTTTGGACTATTAGATGAATTGTCTGTTTGACAATATCTTTAA TATTTTACCAAATGTAAAAGATAAGGGCCGTTATAAAGAGTCCTAATCTCTAACCTGGGCATTTGTAGAACACAGATTTTAAAGTTGGTA TATCCTTTTGAAACCTGATGAGGAAGTTGAGTTAAAAAAGATTCGAGAGCAGATTTACACATCAGATGTTGATAACCATGCTATGTGAGC ATTTCTGTGCTAAACTCGTATTTTTGGGTGAGGGGAGGGTTTCTCATTTAAGAGTATGTCTGTATATTTGCAACTCTACTAATTTTCTAA GTATGATATAATTCCTTCTGTTTAAGTTACAGAGCTATTATAAATAAACAAAAGAGCCTTCAACTGGTGTCTATGCTACCATTCCAAGAG CACAATATTTGTTTTCTTAGAATTTGAGTTTTCCTAGTGAGTAAATTCCTCCCTGGGGAAAAATTAGCACTTTAAAATGGACACTTTGTG TTTTCAATTGCCAAGGTATCTTTGTATACTATTAGAATTTGCTGATGCACACAGAAAGAGATTAATGCACTTTCTATAGTGCCTAACTTT AGATGTATCTATAAAAGAAAGTAGAGGATACAGATTATGTATATATAAATAAATTGGAGAGCCAGATTTCTTCAGAGATTGATCTTGTAC ATTAATCACACCAGTAATGGATGGATGGCACTTCTTTACTCGGGCTGTTATGATGTTATCCAAAGGTAGTAGAGATGCTCTGACAGTGTT GGAGTGTGCACATGAACAACAAGAGCAAAACACAACTTTGATACTAAAGTTACGAAATGCAGAAGTCAAGACCATAATGTGATGTTTTTT TTTTTTGAAATCTTAAAATATGTACATAGAATGACCAGTTCTGATATGCCGTCTTAGTGCATGGATGTTTATTAGTATCCTTTAATGCTG CCTAGGTTCTGACTTACAGAATGAAATACGTGTTGTTTATCTACCTGATAGTTCAGTTTTGCCAAAGGACTATAGGGATAAGTGAATAAT ATTTATTTATTAGGAGCAAAAATACATTTTCATCCCATTAAGCTAATTTAAAATAATGCCTGATTTTTACTTTTGAGTTTATCCATTTTT CTATACCTTTAACTTATTTATACTTTAAAAAATCATATTGTAATTGTGACAAATTATATCTCAAAAAATACCAATTATTAGATGCTTTGG TGTTGAAATGTAAAAGAGAAGGAATTTAAAATACAATCAAAAAAGTCAAAAATAAAACGTATTTGAAAACCACCTAAAATTTCTTGGCCA GGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAAGCCAAAGAGGGCGGATCACTTGAGCTCAGGAGTTTGAGACCAGACTGGCC AACATGGTGAAACCCCGACTCTAGTAAAAATACAAAATTAGCCGGGCATGGTGGTGGGTGCCTTTAATCCCGGCTACTTGAGAGGCTGAG GCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTCGCAGTGAGCTGATATCATGCCACTGCACTCCAGCCTTGGCAACAGAGTGACTCCA TCTCAAAATAATAATAATAATTATAATAATAATATTTTTAAGTCTTAGACAGAAAATGCCTATAGATAGAAGCCTATCAAACATGTATTT TGAATACTTTGATCTTGACACATTGCCTAATTATTTTGAAAGATGGTAAAGATATTTCCAAAAAATATTTTCGCCTATCTGTTTACATTG ACAGTTTACAACCATAATTTTCTAAGTATATTTTTCAAACATGTATTTTTGTGTTTTCCATCTTCAAATTTCTGACCAATGGGTTTGTTC TCCTGCAAAAACAATATCCAATCTGCAAAAATTTTTAATTCTTCACTTGCTACAACTGCAAATATTTATCAATAAAACTGATAACCCAAA ACTTGCTTCAGATTTTCCCTGCAGTGCTTAAAATATCCTTGCAACACAAGATGGTGCACAATGACAAGTATTATTTCTGAATACCCAGAT TTGATTTATTTATAGGTATTTTTGAAATTATTACTCTTACAGGTGTAGTCCTCTCCAGCCCCAAGTAACATCTTTTCAGATGAATTCAAG AGGCTGTTCAAGACTTTGACTCTACTGAAAACACTACAAAAGGCAAAATGTTGCCCTAGGTGATAGAAGGTCCCAGTTTGGGAACTGATT TTCTTCCTATGACAAAAGCTATAAGATGAGTAAGGTTACTAATGGAAATGTATGTCCACAGATTCACTTAGGGAGCATAGTGTAAAAACA TCAGGAACTTAAAATTACAAATTTGATTTCAAGTTATATTTCTGTCTCATGTGACTTTGGGCAAATCATTTATCTTCTCTGAGTTCATTT CCTCATCTGCAAATGACAAATAAAATACGTAATTATCAGGATAACTATGAGCATTAAATAAAACAAACGTGGAAAGAATAAAGTGTGGCA TACATTATTATTTTATCAAAGTGCATCACGTCAATAATTGTTATTGTATACTTGTATTAAATGTCACTTTAATGCACTTTCCCCTATTTT TTTCCAAAACATACGTTAAACATCTGATTTAGCTACTCATCAAAACATACAATCATGTTTTAAGATGGAACACTATATCAGTGTTACTGC TTTTCTCAATAATGTGATCCCAAATCAGTACTTTCAGTTCACCATCACCTCAAATCTATAGAAATGTTTCTTTCAATGACATAGATAGAT AGATGATTGATAGATAGATGATAGATAGATGATAAATGGATATACAATTATAGGTTAAAATTAAAGTTTAAATAAGATCAATCATTTGAA AGTTTTATTTCCAAAGGAAATAAAACAACATTCCCAAGGACAGAAATAATATCAAATTACTTGCTAAATATATAAATGAGTTATAGGGCT AAGACTAAGTTATAAGAGATTGACAATTAGAAAACACTCTTTTTAATATTAAGGTGGTATGATTTTCTTTAACAATTTTACAATGAAAAT AAAAACTTAATAAAAGGTGGTAATGGGCCAGGCACGGTGGCTCACGCATACAATCCCAGCACTTTGGGAGACTAAGGCGTGAGGATCACT TGAGCCCAGGAGTTCCAGACATGTCTATGCAACAAAGTGAGACCCTGACTCTAAGAAAAAAATAAAATGTATAAAATTTAAAATAGTAAT GTGTCCATTAAACCTTTTATTTTAGAGTAGTTTTAGATTTACAGAAAAACTCCAAATAGAGAGGTCCCATATACATCTATGGGCATTAAT GAGCCAATATTGATCATTACATTCATACTTCATTCAGATTTCCTTAGTTTATAACCTAATGTCCTTTTTCTGTCCCAGGATCCCATTCAG GATACCACATTACATTTAGTTGTCATGTTTCCTTAGGCTTCCCTTGGCTGTGACAGTTTCTGCAACTTTCCTTGTTTTTGATGACAGTTT TGAGAAATAAACTGGTATTTTGTAGAATGTCCTTCTATGGGGATTCGTCTGATGTTTTTCTCGTGACTAGACACAGGTTTTTGGTTTTTG AAAGAACACAACGGTAAAGTGCCATGCTCATCACATGGTATCAAAGGTATATGCCATCACCGGGACTCGTCTTAGCTGTGACAGTTTCTC AAACTTTAGGCTACTCTTAGCTGTTGATGTTAACCTTGATCACTTAGCTGAGGTAGCATCTATTATATTTCTCCACTGTAAAGTAATGCG TTTTTAAAGAGATTATATTGAAGGTAAATTTTCTGGACATTTACACTGAGCTAAACAAATTCTAAACACTAATATTAGGTTCCACTAAGT GATTACTAATAAATGCTATAAAGAAAATACAGTGAAGTGGAAAAATAAAACTCCAGAAGTCTTAGCCTGAATATTCACCTAATAGAGGTG AAAGTGAATTTTTCCCTTGAACTGTCTGCGCAATTTACAATAATCCTCCACATACTTTGGATATTAAAGATCTTATCTTACTAATTGTCA TAAGAGGTAATTTAAATTTAAACTAACCATTTTGCTTATTGCATTTTTATATTGCCCTCCACTAATCAATGAACACTGAATATTGAAATA ATGTAAAAGACCTATTTCCCGCTAGCTTTAACCGATTTGTCATAAACACCTTTCTTGTATATGATTTTTAAATGTTTGCTAAATATTAAA AAGAATTCAATGTGTTTGGTTTTGTAAAATTACATATCGAATGTGTATAATTTTTTACTACCATGTTCATCACACTTAATCTATATCCAT ATATTGTACTCCACCAATATTTATCAGTGGACAATAAAGAAGTTTTGAATGCATGAATGCAACTTAAGAGGCACCACACTTGGTTATTTT GCAATGCCAGAATAACGGTGGGTATTCACAAATTGAATAGATAATCCAGATTATGTTTCCTCCAATTTAAGTTTTTCTGGGTTTTTTTTT CCCCCTTCCTAGAATCAATTTTATCATTTTACCTATGTACAATAATATACTTCTGGAAAATGCTAGAATTTTCACCATGTAACAGAATTT GAGCATGACAGTAATGTAAAAATATTCAGAAGTCTCGAACTATAGGTTTGAGTTTTCAAAGTAAATCAAAATACAGCTGTTTTCATTTTA CTAGATTGTGGAAACCTATGGATGTTATTGTAAAATGCATATGCATTACACTGACTTTCTTAAAATGTTTTGAATTAATAAAGAATTCAA >In-frame_MTHFD1L_ENST00000367307_chr6_151209117_+_RGS17_ENST00000367225_chr6_153365178_-_8821nt CCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAGGCCCCC GCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGCCGCCGC CGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCGCGCCAT GGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGCGC TAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGCTG CAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAAGA AAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGA GGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATAC CAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGG AGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCT TGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCA GAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCCAACTGGGTCCTGAAGTAGCTGAAATGCGAA AAAGGCAGCAGTCCCAAAATGAAGGAACACCTGCCGTGTCTCAAGCTCCTGGAAACCAGAGGCCCAACAACACCTGTTGCTTTTGTTGGT GCTGTTGTTGCAGCTGCTCCTGCCTCACTGTGAGGAATGAAGAAAGAGGGGAAAATGCGGGAAGACCCACACACACTACAAAAATGGAGA GTATCCAGGTCCTAGAGGAATGCCAAAACCCCACTGCAGAGGAAGTCTTGTCCTGGTCTCAAAATTTTGACAAGATGATGAAGGCCCCAG CAGGAAGAAACCTTTTCAGAGAGTTCCTCCGAACAGAATACAGTGAAGAGAACCTACTTTTCTGGCTTGCTTGTGAAGACTTAAAGAAGG AGCAGAACAAAAAAGTAATTGAAGAAAAGGCTAGGATGATATATGAAGATTACATTTCTATACTATCACCAAAAGAGGTCAGTCTTGATT CTCGAGTTAGAGAGGTGATCAATAGAAATCTGTTGGATCCCAATCCTCACATGTATGAAGATGCCCAACTTCAGATATATACTTTAATGC ACAGAGATTCTTTTCCAAGGTTTTTGAACTCTCAAATTTATAAGTCATTTGTTGAAAGTACTGCTGGCTCTTCTTCTGAATCTTAATGTT CATTTAAAAACAATCATTTTGGAGGGCTGAGATGGGAAATAAAAGTAGTTAAATAACATCAGAAACTGAGTTCCTGGAGAACTACAGTTT AGCATTCCTCAGGCTACTGTGAAAACACAACCGTTATGGTCTTTGTCTCCATTTTTATCAAGGTTTTCCATGGTTAAGTTTGGAGAAAAT ACCACACAAAACAATGAATTGCCAAATTGTTTGTTTTATTCAAGACTCATTCTACTTGCAAGCAAAGTGTATTTGTAGTCCTATGAACAG TCTCCTCGTGTATCTCCAGAGACTGCATGTGCAAAGTAAAATGCTTCATTTGCCACATAGTTGTTGTAATATTTAATCCAGTAGCATAAC TTATATCTGTATTTAAGGACTTTTGTGCAATATGGTCTTAAGAAATAATTGCCAAAAAAATCGGCCATGGTTTGCATTTTTTAACATAAT CTAAGACAGAAAAAAAGCAATTTTTACTATGTAACAATGGTATTCAACATTCTATATACTGTGTTTAGTACACTAATTTTGAAGCCAATA TTTCTGTACATGAAAAAGAGCTATTTATCTCTGTTTGTTGGAAAATCCTAATGGGGATTCCTCTGGTTGTTCACTGCCAAAACTGTGGCA TTTTCATTACAGGAGAGTTTACTATGCTAAAAGCAAAAAACAAAAAAAAAAAAAAAGGGAAGAAGGAAAAAAGCACAAAACAATTTGAAG ATATCCTATCTCAATGACAAATCAAAAGAGTGATATTGCTTTTAACTGTAATAGAAGAAAATGAATTTATGTATATATCAGATGTCCAAT ACTGTAATTAATTTATTAAAGACTGGCTCTCCAGTTTTAAAATGGTTGTGTAAAGTTATGTACTTCAGCAAGAAAAAAATAATAATAAGC TTGATAACTTAGTTTTGGAATATAAAGAAAAGGACTTAATAAAGGAATGCCTACATGTAGCACTGTAAAACATTTTGATGAATAGCATCT GTCCTGTGGCATATTTTCCTTGAAAGTGAAATCCAATGAAAAGCTAAGTTTTTACCAGGAAAAGTTTTATAAGGGTTATGAAGAAAATAA TCCTCTACTTCAGACCTTAACTGTTTTCACATAATATCTTAAGGATGACATTTTAAAGATGTTTAAACCAAACTATTAGTTTTCATCCAT CATTAAAAGGCAGTACAGTGCTCAAATCTTCCAGCTGCCATATTATTTTTTATAAGTACACTAAATCTTTACGACAAAACACTTGCCTGA CATTGTCATGTACTTCTGACCTTCAAGGAAACAATATTCTGTCATGCATAAAAGTGATAATTAAAATAATCAGTGTCATATTTATATCAA AGTGTTACATTTGAATATTAATATCCCCTGAAGACTATTTTTTTAATATTAAACTGAATGAATATAATACTGAGTAACCTAAAATGAAAG TTTTAAAAAGATTTATATCCACTGAGAACACTGGCCTTATATTAAGGATGATATTACAGTTACAGGTTTTCTTTGTCATTTTTTTAACTA CCTCTCATTTTTTAATTTATTAAACATATTTTTTAAAAAAACAAGTTTGGGGGTTTCTTTTTAAATTTATTTTACTTGAAAGGTTGGCAT CACAAGTTTCTTTTTCCATAAACTTAAAACATTTCAAAAATGGTTTTTTTAAGCAAGTATGATTTTCTAATTTATATAGAATTCAGGAGA CATGAATAAAAGGGCTATTATCTATTCCCTATGCAAATATTTTAACTGTTGCAGTGTTTGACAAAATGGGATTTTTTAAAAATTGCAGAG TAGAAAACAAAATATTCTGTTTACACTGGCGTTGCTGACTATCCTACCATATTCAGCACTTTTAAATACGTTATTTATGAAAATGCAGTT AAAATGCAAGATAGAAAATATTTATAATAATCATTTCTTTTAACAAATGCCTGTGTTTTCTGAAAGTGTTAGTGTGTTAAGACATATTTT ATTCATGTCATTTAAATACTATTTGAATAAGTTTTCAGTAATATGTTGAAAAAAAGATAGCTATGAAGATGTTTACAAAAAGTCATATTT TTTCCTAAAGAGTAAAGAAAAACCTAAAAGAATCATCACTTCTATTGTGAAGTTCTATTGTTCCTAAATTATTTAATTTTTTTCTTGCTT AGAATTGAGTTTATTATGCTACTATGATATATACACATGTATGGTGTAGTATCATATTTGTTTCTGTGTGTGAGGCTCAACAAATTGGTG CACATGACTAGAAAATATGTAATATACTGTGATACACTGCATGCATCCATCTTTTTAAATGTAGACTTTATATTCTCGTTGTTACTATAT ATGATGGTGACCTGCTAGTCATAAGTTATCTTTATAAGATACTTTGGACTATTAGATGAATTGTCTGTTTGACAATATCTTTAATATTTT ACCAAATGTAAAAGATAAGGGCCGTTATAAAGAGTCCTAATCTCTAACCTGGGCATTTGTAGAACACAGATTTTAAAGTTGGTATATCCT TTTGAAACCTGATGAGGAAGTTGAGTTAAAAAAGATTCGAGAGCAGATTTACACATCAGATGTTGATAACCATGCTATGTGAGCATTTCT GTGCTAAACTCGTATTTTTGGGTGAGGGGAGGGTTTCTCATTTAAGAGTATGTCTGTATATTTGCAACTCTACTAATTTTCTAAGTATGA TATAATTCCTTCTGTTTAAGTTACAGAGCTATTATAAATAAACAAAAGAGCCTTCAACTGGTGTCTATGCTACCATTCCAAGAGCACAAT ATTTGTTTTCTTAGAATTTGAGTTTTCCTAGTGAGTAAATTCCTCCCTGGGGAAAAATTAGCACTTTAAAATGGACACTTTGTGTTTTCA ATTGCCAAGGTATCTTTGTATACTATTAGAATTTGCTGATGCACACAGAAAGAGATTAATGCACTTTCTATAGTGCCTAACTTTAGATGT ATCTATAAAAGAAAGTAGAGGATACAGATTATGTATATATAAATAAATTGGAGAGCCAGATTTCTTCAGAGATTGATCTTGTACATTAAT CACACCAGTAATGGATGGATGGCACTTCTTTACTCGGGCTGTTATGATGTTATCCAAAGGTAGTAGAGATGCTCTGACAGTGTTGGAGTG TGCACATGAACAACAAGAGCAAAACACAACTTTGATACTAAAGTTACGAAATGCAGAAGTCAAGACCATAATGTGATGTTTTTTTTTTTT GAAATCTTAAAATATGTACATAGAATGACCAGTTCTGATATGCCGTCTTAGTGCATGGATGTTTATTAGTATCCTTTAATGCTGCCTAGG TTCTGACTTACAGAATGAAATACGTGTTGTTTATCTACCTGATAGTTCAGTTTTGCCAAAGGACTATAGGGATAAGTGAATAATATTTAT TTATTAGGAGCAAAAATACATTTTCATCCCATTAAGCTAATTTAAAATAATGCCTGATTTTTACTTTTGAGTTTATCCATTTTTCTATAC CTTTAACTTATTTATACTTTAAAAAATCATATTGTAATTGTGACAAATTATATCTCAAAAAATACCAATTATTAGATGCTTTGGTGTTGA AATGTAAAAGAGAAGGAATTTAAAATACAATCAAAAAAGTCAAAAATAAAACGTATTTGAAAACCACCTAAAATTTCTTGGCCAGGCACA GTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAAGCCAAAGAGGGCGGATCACTTGAGCTCAGGAGTTTGAGACCAGACTGGCCAACATG GTGAAACCCCGACTCTAGTAAAAATACAAAATTAGCCGGGCATGGTGGTGGGTGCCTTTAATCCCGGCTACTTGAGAGGCTGAGGCAGGA GAATCGCTTGAACCCAGGAGGCAGAGGTCGCAGTGAGCTGATATCATGCCACTGCACTCCAGCCTTGGCAACAGAGTGACTCCATCTCAA AATAATAATAATAATTATAATAATAATATTTTTAAGTCTTAGACAGAAAATGCCTATAGATAGAAGCCTATCAAACATGTATTTTGAATA CTTTGATCTTGACACATTGCCTAATTATTTTGAAAGATGGTAAAGATATTTCCAAAAAATATTTTCGCCTATCTGTTTACATTGACAGTT TACAACCATAATTTTCTAAGTATATTTTTCAAACATGTATTTTTGTGTTTTCCATCTTCAAATTTCTGACCAATGGGTTTGTTCTCCTGC AAAAACAATATCCAATCTGCAAAAATTTTTAATTCTTCACTTGCTACAACTGCAAATATTTATCAATAAAACTGATAACCCAAAACTTGC TTCAGATTTTCCCTGCAGTGCTTAAAATATCCTTGCAACACAAGATGGTGCACAATGACAAGTATTATTTCTGAATACCCAGATTTGATT TATTTATAGGTATTTTTGAAATTATTACTCTTACAGGTGTAGTCCTCTCCAGCCCCAAGTAACATCTTTTCAGATGAATTCAAGAGGCTG TTCAAGACTTTGACTCTACTGAAAACACTACAAAAGGCAAAATGTTGCCCTAGGTGATAGAAGGTCCCAGTTTGGGAACTGATTTTCTTC CTATGACAAAAGCTATAAGATGAGTAAGGTTACTAATGGAAATGTATGTCCACAGATTCACTTAGGGAGCATAGTGTAAAAACATCAGGA ACTTAAAATTACAAATTTGATTTCAAGTTATATTTCTGTCTCATGTGACTTTGGGCAAATCATTTATCTTCTCTGAGTTCATTTCCTCAT CTGCAAATGACAAATAAAATACGTAATTATCAGGATAACTATGAGCATTAAATAAAACAAACGTGGAAAGAATAAAGTGTGGCATACATT ATTATTTTATCAAAGTGCATCACGTCAATAATTGTTATTGTATACTTGTATTAAATGTCACTTTAATGCACTTTCCCCTATTTTTTTCCA AAACATACGTTAAACATCTGATTTAGCTACTCATCAAAACATACAATCATGTTTTAAGATGGAACACTATATCAGTGTTACTGCTTTTCT CAATAATGTGATCCCAAATCAGTACTTTCAGTTCACCATCACCTCAAATCTATAGAAATGTTTCTTTCAATGACATAGATAGATAGATGA TTGATAGATAGATGATAGATAGATGATAAATGGATATACAATTATAGGTTAAAATTAAAGTTTAAATAAGATCAATCATTTGAAAGTTTT ATTTCCAAAGGAAATAAAACAACATTCCCAAGGACAGAAATAATATCAAATTACTTGCTAAATATATAAATGAGTTATAGGGCTAAGACT AAGTTATAAGAGATTGACAATTAGAAAACACTCTTTTTAATATTAAGGTGGTATGATTTTCTTTAACAATTTTACAATGAAAATAAAAAC TTAATAAAAGGTGGTAATGGGCCAGGCACGGTGGCTCACGCATACAATCCCAGCACTTTGGGAGACTAAGGCGTGAGGATCACTTGAGCC CAGGAGTTCCAGACATGTCTATGCAACAAAGTGAGACCCTGACTCTAAGAAAAAAATAAAATGTATAAAATTTAAAATAGTAATGTGTCC ATTAAACCTTTTATTTTAGAGTAGTTTTAGATTTACAGAAAAACTCCAAATAGAGAGGTCCCATATACATCTATGGGCATTAATGAGCCA ATATTGATCATTACATTCATACTTCATTCAGATTTCCTTAGTTTATAACCTAATGTCCTTTTTCTGTCCCAGGATCCCATTCAGGATACC ACATTACATTTAGTTGTCATGTTTCCTTAGGCTTCCCTTGGCTGTGACAGTTTCTGCAACTTTCCTTGTTTTTGATGACAGTTTTGAGAA ATAAACTGGTATTTTGTAGAATGTCCTTCTATGGGGATTCGTCTGATGTTTTTCTCGTGACTAGACACAGGTTTTTGGTTTTTGAAAGAA CACAACGGTAAAGTGCCATGCTCATCACATGGTATCAAAGGTATATGCCATCACCGGGACTCGTCTTAGCTGTGACAGTTTCTCAAACTT TAGGCTACTCTTAGCTGTTGATGTTAACCTTGATCACTTAGCTGAGGTAGCATCTATTATATTTCTCCACTGTAAAGTAATGCGTTTTTA AAGAGATTATATTGAAGGTAAATTTTCTGGACATTTACACTGAGCTAAACAAATTCTAAACACTAATATTAGGTTCCACTAAGTGATTAC TAATAAATGCTATAAAGAAAATACAGTGAAGTGGAAAAATAAAACTCCAGAAGTCTTAGCCTGAATATTCACCTAATAGAGGTGAAAGTG AATTTTTCCCTTGAACTGTCTGCGCAATTTACAATAATCCTCCACATACTTTGGATATTAAAGATCTTATCTTACTAATTGTCATAAGAG GTAATTTAAATTTAAACTAACCATTTTGCTTATTGCATTTTTATATTGCCCTCCACTAATCAATGAACACTGAATATTGAAATAATGTAA AAGACCTATTTCCCGCTAGCTTTAACCGATTTGTCATAAACACCTTTCTTGTATATGATTTTTAAATGTTTGCTAAATATTAAAAAGAAT TCAATGTGTTTGGTTTTGTAAAATTACATATCGAATGTGTATAATTTTTTACTACCATGTTCATCACACTTAATCTATATCCATATATTG TACTCCACCAATATTTATCAGTGGACAATAAAGAAGTTTTGAATGCATGAATGCAACTTAAGAGGCACCACACTTGGTTATTTTGCAATG CCAGAATAACGGTGGGTATTCACAAATTGAATAGATAATCCAGATTATGTTTCCTCCAATTTAAGTTTTTCTGGGTTTTTTTTTCCCCCT TCCTAGAATCAATTTTATCATTTTACCTATGTACAATAATATACTTCTGGAAAATGCTAGAATTTTCACCATGTAACAGAATTTGAGCAT GACAGTAATGTAAAAATATTCAGAAGTCTCGAACTATAGGTTTGAGTTTTCAAAGTAAATCAAAATACAGCTGTTTTCATTTTACTAGAT TGTGGAAACCTATGGATGTTATTGTAAAATGCATATGCATTACACTGACTTTCTTAAAATGTTTTGAATTAATAAAGAATTCAACAATGT |
Top |
FusionGenePPI for MTHFD1L_RGS17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTHFD1L | CASP4, MAGED1, WRAP73, HGS, USP50, SIRT7, CUL3, COPS5, ADRB2, HECW2, ASB12, BPHL, CNN1, CNN3, ISOC1, TAGLN2, PAPOLA, PAPOLB, XPNPEP1, NTRK1, CEP152, NPM1, LRPPRC, NFATC1, MTMR7, CYLD | RGS17 | OSTM1, RBBP8, RABEP1, ADRB2, AQP1, GNAI1, GNAI3, HOXA1, SMCP, RPL10A, OTX1, PTGER3, NUFIP2, DHX37, TBC1D16, LCE4A, LCE2A, LCE3C |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MTHFD1L_RGS17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MTHFD1L_RGS17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RGS17 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
| Tgene | RGS17 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|