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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22743

FusionGeneSummary for MTF2_CTNND2

check button Fusion gene summary
Fusion gene informationFusion gene name: MTF2_CTNND2
Fusion gene ID: 22743
HgeneTgene
Gene symbol

MTF2

CTNND2

Gene ID

22823

1501

Gene namemetal response element binding transcription factor 2catenin delta 2
SynonymsM96|PCL2|TDRD19A|dJ976O13.2GT24|NPRAP
Cytomap

1p22.1

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionmetal-response element-binding transcription factor 2hPCl2metal regulatory transcription factor 2metal-response element DNA-binding protein M96polycomb-like 2polycomb-like protein 2putative DNA binding proteintudor domain containing 19Acatenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungin
Modification date2018052320180523
UniProtAcc

Q9Y483

Q9UQB3

Ensembl transtripts involved in fusion geneENST00000545708, ENST00000540243, 
ENST00000370298, ENST00000471953, 
ENST00000370303, 		ENST00000304623, 
ENST00000359640, ENST00000511377, 
ENST00000458100, ENST00000503622, 
ENST00000495388, 
Fusion gene scores* DoF score7 X 3 X 4=8412 X 8 X 8=768
# samples 812
** MAII scorelog2(8/84*10)=-0.070389327891398
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/768*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTF2 [Title/Abstract] AND CTNND2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-46-3765-01AMTF2chr1

93545088

+CTNND2chr5

11199773

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000545708ENST00000304623MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000545708ENST00000359640MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000545708ENST00000511377MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000545708ENST00000458100MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000545708ENST00000503622MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-5UTRENST00000545708ENST00000495388MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000540243ENST00000304623MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000540243ENST00000359640MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000540243ENST00000511377MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000540243ENST00000458100MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-3CDSENST00000540243ENST00000503622MTF2chr1

93545088

+CTNND2chr5

11199773

-
5UTR-5UTRENST00000540243ENST00000495388MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370298ENST00000304623MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370298ENST00000359640MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370298ENST00000511377MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370298ENST00000458100MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370298ENST00000503622MTF2chr1

93545088

+CTNND2chr5

11199773

-
5CDS-5UTRENST00000370298ENST00000495388MTF2chr1

93545088

+CTNND2chr5

11199773

-
3UTR-3CDSENST00000471953ENST00000304623MTF2chr1

93545088

+CTNND2chr5

11199773

-
3UTR-3CDSENST00000471953ENST00000359640MTF2chr1

93545088

+CTNND2chr5

11199773

-
3UTR-3CDSENST00000471953ENST00000511377MTF2chr1

93545088

+CTNND2chr5

11199773

-
3UTR-3CDSENST00000471953ENST00000458100MTF2chr1

93545088

+CTNND2chr5

11199773

-
3UTR-3CDSENST00000471953ENST00000503622MTF2chr1

93545088

+CTNND2chr5

11199773

-
3UTR-5UTRENST00000471953ENST00000495388MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370303ENST00000304623MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370303ENST00000359640MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370303ENST00000511377MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370303ENST00000458100MTF2chr1

93545088

+CTNND2chr5

11199773

-
Frame-shiftENST00000370303ENST00000503622MTF2chr1

93545088

+CTNND2chr5

11199773

-
5CDS-5UTRENST00000370303ENST00000495388MTF2chr1

93545088

+CTNND2chr5

11199773

-

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FusionProtFeatures for MTF2_CTNND2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTF2

Q9Y483

CTNND2

Q9UQB3

Polycomb group (PcG) that specifically binds histone H3trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2complex. Acts by binding to H3K36me3, a mark for transcriptionalactivation, and recruiting the PRC2 complex, leading to enhancePRC2 H3K27me3 methylation activity. Regulates the transcriptionalnetworks during embryonic stem cell self-renewal anddifferentiation. Promotes recruitment of the PRC2 complex to theinactive X chromosome in differentiating XX ES cells and PRC2recruitment to target genes in undifferentiated ES cells. Requiredto repress Hox genes by enhancing H3K27me3 methylation of the PRC2complex. In some conditions may act as an inhibitor of PRC2activity: able to activate the CDKN2A gene and promote cellularsenescence by suppressing the catalytic activity of the PRC2complex locally. Binds to the metal-regulating-element (MRE) ofMT1A gene promoter (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTF2_CTNND2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTF2_CTNND2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTF2EZH2, SUZ12, JARID2, CREB1, GSK3B, ELAVL1, SMAD3, PRKD2, TMED9, KDM1A, PRMT6, SUV39H1, SUV39H2, RBBP7, PIK3R3, JAK3, KIF2A, EED, TGDS, ADAM30CTNND2PDZD2, LRRC7, ATN1, ZBTB33, NUDT21, TTR, LNX1, CLK1, MCM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTF2_CTNND2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTF2_CTNND2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTNND2C0005586Bipolar Disorder1PSYGENET
TgeneCTNND2C0007621Neoplastic Cell Transformation1CTD_human
TgeneCTNND2C0017636Glioblastoma1CTD_human
TgeneCTNND2C0036341Schizophrenia1PSYGENET
TgeneCTNND2C0041696Unipolar Depression1PSYGENET
TgeneCTNND2C1269683Major Depressive Disorder1PSYGENET