|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22730 |
FusionGeneSummary for MTDH_MAL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTDH_MAL2 | Fusion gene ID: 22730 | Hgene | Tgene | Gene symbol | MTDH | MAL2 | Gene ID | 92140 | 114569 |
| Gene name | metadherin | mal, T cell differentiation protein 2 (gene/pseudogene) | |
| Synonyms | 3D3|AEG-1|AEG1|LYRIC|LYRIC/3D3 | - | |
| Cytomap | 8q22.1 | 8q24.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion protein | protein MAL2MAL proteolipid protein 2MAL2 proteolipid proteinmal, T-cell differentiation protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86UE4 | Q969L2 | |
| Ensembl transtripts involved in fusion gene | ENST00000336273, ENST00000519934, | ENST00000276681, ENST00000521748, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MTDH [Title/Abstract] AND MAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTDH | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15927426 |
| Hgene | MTDH | GO:0010508 | positive regulation of autophagy | 21127263 |
| Hgene | MTDH | GO:0043066 | negative regulation of apoptotic process | 17704808 |
| Hgene | MTDH | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 16452207|18316612 |
| Hgene | MTDH | GO:0045766 | positive regulation of angiogenesis | 19940250 |
| Hgene | MTDH | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 16452207|18316612 |
| Hgene | MTDH | GO:0051897 | positive regulation of protein kinase B signaling | 17704808 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-JV-A5VE-01A | MTDH | chr8 | 98673401 | + | MAL2 | chr8 | 120233827 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336273 | ENST00000276681 | MTDH | chr8 | 98673401 | + | MAL2 | chr8 | 120233827 | + |
| 5CDS-3UTR | ENST00000336273 | ENST00000521748 | MTDH | chr8 | 98673401 | + | MAL2 | chr8 | 120233827 | + |
| In-frame | ENST00000519934 | ENST00000276681 | MTDH | chr8 | 98673401 | + | MAL2 | chr8 | 120233827 | + |
| 5CDS-3UTR | ENST00000519934 | ENST00000521748 | MTDH | chr8 | 98673401 | + | MAL2 | chr8 | 120233827 | + |
Top |
FusionProtFeatures for MTDH_MAL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTDH | MAL2 |
| Downregulates SLC1A2/EAAT2 promoter activity whenexpressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independentgrowth of immortalized melanocytes and astrocytes which is a keycomponent in tumor cell expansion. Promotes lung metastasis andalso has an effect on bone and brain metastasis, possibly byenhancing the seeding of tumor cells to the target organendothelium. Induces chemoresistance.{ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207,ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. | Member of the machinery of polarized transport. Requiredfor the indirect transcytotic route at the step of the egress ofthe transcytosing cargo from perinuclear endosomes in order for itto travel to the apical surface via a raft-dependent pathway.{ECO:0000269|PubMed:12370246}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 59_67 | 161 | 583 | Compositional bias | Note=Poly-Leu |
| Hgene | MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 1_71 | 161 | 583 | Region | Note=Activation of NF-kappa-B |
| Hgene | MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 1_48 | 161 | 583 | Topological domain | Lumenal |
| Hgene | MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 49_69 | 161 | 583 | Transmembrane | Helical |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 124_149 | 44 | 177 | Topological domain | Lumenal |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 171_176 | 44 | 177 | Topological domain | Cytoplasmic |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 56_66 | 44 | 177 | Topological domain | Lumenal |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 88_102 | 44 | 177 | Topological domain | Cytoplasmic |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 103_123 | 44 | 177 | Transmembrane | Helical |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 150_170 | 44 | 177 | Transmembrane | Helical |
| Tgene | >MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 67_87 | 44 | 177 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 441_451 | 161 | 583 | Compositional bias | Note=Poly-Lys |
| Hgene | >MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 573_577 | 161 | 583 | Compositional bias | Note=Poly-Lys |
| Hgene | >MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 381_443 | 161 | 583 | Region | Lung-homing for mammary tumors |
| Hgene | >MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 70_582 | 161 | 583 | Topological domain | Cytoplasmic |
| Tgene | MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 31_175 | 44 | 177 | Domain | MARVEL |
| Tgene | MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 1_34 | 44 | 177 | Topological domain | Cytoplasmic |
| Tgene | MAL2 | chr8:98673401 | chr8:120233827 | ENST00000276681 | + | 1 | 5 | 35_55 | 44 | 177 | Transmembrane | Helical |
Top |
FusionGeneSequence for MTDH_MAL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MTDH_ENST00000336273_chr8_98673401_+_MAL2_ENST00000276681_chr8_120233827_+_294aa MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKRE EAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKLFGGLVWILVASSNVPLPL LQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAAS >In-frame_MTDH_ENST00000519934_chr8_98673401_+_MAL2_ENST00000276681_chr8_120233827_+_271aa MLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEE QKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKLFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMF LSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MTDH_ENST00000336273_chr8_98673401_+_MAL2_ENST00000276681_chr8_120233827_+_882nt ATGGCTGCACGGAGCTGGCAGGACGAGCTGGCCCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGC TTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGG CTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAG GAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAG AAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAG CAGCCACCAGAGATTGACAAGAAAAATGAAAAGCTGTTCGGGGGTCTTGTCTGGATTTTGGTTGCCTCCTCCAATGTTCCTCTACCTCTA CTACAAGGATGGGTCATGTTTGTGTCCGTGACAGCGTTTTTCTTTTCGCTCCTCTTTCTGGGCATGTTCCTCTCTGGCATGGTGGCTCAA ATTGATGCTAACTGGAACTTCCTGGATTTTGCCTACCATTTTACAGTATTTGTCTTCTATTTTGGAGCCTTTTTATTGGAAGCAGCAGCC ACATCCCTGCATGATTTGCATTGCAATACAACCATAACCGGGCAGCCACTCCTGAGTGATAACCAGTATAACATAAACGTAGCAGCCTCA >In-frame_MTDH_ENST00000519934_chr8_98673401_+_MAL2_ENST00000276681_chr8_120233827_+_813nt ATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTG GTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGG AGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAA CAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACA CCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGCTGTTCGGGGGTCTTGTCTGGATTTTGGTTGCCTCC TCCAATGTTCCTCTACCTCTACTACAAGGATGGGTCATGTTTGTGTCCGTGACAGCGTTTTTCTTTTCGCTCCTCTTTCTGGGCATGTTC CTCTCTGGCATGGTGGCTCAAATTGATGCTAACTGGAACTTCCTGGATTTTGCCTACCATTTTACAGTATTTGTCTTCTATTTTGGAGCC TTTTTATTGGAAGCAGCAGCCACATCCCTGCATGATTTGCATTGCAATACAACCATAACCGGGCAGCCACTCCTGAGTGATAACCAGTAT AACATAAACGTAGCAGCCTCAATTTTTGCCTTTATGACGACAGCTTGTTATGGTTGCAGTTTGGGTCTGGCTTTACGAAGATGGCGACCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MTDH_ENST00000336273_chr8_98673401_+_MAL2_ENST00000276681_chr8_120233827_+_3391nt GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCG GACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAA GCTGTTCGGGGGTCTTGTCTGGATTTTGGTTGCCTCCTCCAATGTTCCTCTACCTCTACTACAAGGATGGGTCATGTTTGTGTCCGTGAC AGCGTTTTTCTTTTCGCTCCTCTTTCTGGGCATGTTCCTCTCTGGCATGGTGGCTCAAATTGATGCTAACTGGAACTTCCTGGATTTTGC CTACCATTTTACAGTATTTGTCTTCTATTTTGGAGCCTTTTTATTGGAAGCAGCAGCCACATCCCTGCATGATTTGCATTGCAATACAAC CATAACCGGGCAGCCACTCCTGAGTGATAACCAGTATAACATAAACGTAGCAGCCTCAATTTTTGCCTTTATGACGACAGCTTGTTATGG TTGCAGTTTGGGTCTGGCTTTACGAAGATGGCGACCGTAACACTCCTTAGAAACTGGCAGTCGTATGTTAGTTTCACTTGTCTACTTTAT ATGTCTGATCAATTTGGATACCATTTTGTCCAGATGCAAAAACATTCCAAAAGTAATGTGTTTAGTAGAGAGAGACTCTAAGCTCAAGTT CTGGTTTATTTCATGGATGGAATGTTAATTTTATTATGATATTAAAGAAATGGCCTTTTATTTTACATCTCTCCCCTTTTTCCCTTTCCC CCTTTATTTTCCTCCTTTTCTTTCTGAAAGTTTCCTTTTATGTCCATAAAATACAAATATATTGTTCATAAAAAATTAGTATCCCTTTTG TTTGGTTGCTGAGTCACCTGAACCTTAATTTTAATTGGTAATTACAGCCCCTAAAAAAAACACATTTCAAATAGGCTTCCCACTAAACTC TATATTTTAGTGTAAACCAGGAATTGGCACACTTTTTTTAGAATGGGCCAGATGGTAAATATTTATGCTTCACGGTCCATACAGTCTCTG TCACAACTATTCAGTTCTGCTAGTATAGCGTGAAAGCAGCTATACACAATACAGAAATGAATGAGTGTGGTTATGTTCTAATAAAACTTA TTTATAAAAACAAGGGGAGGCTGGGTTTAGCCTGTGGGCCATAGTTTGTCAACCACTGGTGTAAAACCTTAGTTATATATGATCTGCATT TTCTTGAACTGATCATTGAAAACTTATAAACCTAACAGAAAAGCCACATAATATTTAGTGTCATTATGCAATAATCACATTGCCTTTGTG TTAATAGTCAAATACTTACCTTTGGAGAATACTTACCTTTGGAGGAATGTATAAAATTTCTCAGGCAGAGTCCTGGATATAGGAAAAAGT AATTTATGAAGTAAACTTCAGTTGCTTAATCAAACTAATGATAGTCTAACAACTGAGCAAGATCCTCATCTGAGAGTGCTTAAAATGGGA TCCCCAGAGACCATTAACCAATACTGGAACTGGTATCTAGCTACTGATGTCTTACTTTGAGTTTATTTATGCTTCAGAATACAGTTGTTT GCCCTGTGCATGAATATACCCATATTTGTGTGTGGATATGTGAAGCTTTTCCAAATAGAGCTCTCAGAAGAATTAAGTTTTTACTTCTAA TTATTTTGCATTACTTTGAGTTAAATTTGAATAGAGTATTAAATATAAAGTTGTAGATTCTTATGTGTTTTTGTATTAGCCCAGACATCT GTAATGTTTTTGCACTGGTGACAGACAAAATCTGTTTTAAAATCATATCCAGCACAAAAACTATTTCTGGCTGAATAGCACAGAAAAGTA TTTTAACCTACCTGTAGAGATCCTCGTCATGGAAAGGTGCCAAACTGTTTTGAATGGAAGGACAAGTAAGAGTGAGGCCACAGTTCCCAC CACACGAGGGCTTTTGTATTGTTCTACTTTTTCAGCCCTTTACTTTCTGGCTGAAGCATCCCCTTGGAGTGCCATGTATAAGTTGGGCTA TTAGAGTTCATGGAACATAGAACAACCATGAATGAGTGGCATGATCCGTGCTTAATGATCAAGTGTTACTTATCTAATAATCCTCTAGAA AGAACCCTGTTAGATCTTGGTTTGTGATAAAAATATAAAGACAGAAGACATGAGGAAAAACAAAAGGTTTGAGGAAATCAGGCATATGAC TTTATACTTAACATCAGATCTTTTCTATAATATCCTACTACTTTGGTTTTCCTAGCTCCATACCACACACCTAAACCTGTATTATGAATT ACATATTACAAAGTCATAAATGTGCCATATGGATATACAGTACATTCTAGTTGGAATCGTTTACTCTGCTAGAATTTAGGTGTGAGATTT TTTGTTTCCCAGGTATAGCAGGCTTATGTTTGGTGGCATTAAATTGGTTTCTTTAAAATGCTTTGGTGGCACTTTTGTAAACAGATTGCT TCTAGATTGTTACAAACCAAGCCTAAGACACATCTGTGAATACTTAGATTTGTAGCTTAATCACATTCTAGACTTGTGAGTTGAATGACA AAGCAGTTGAACAAAAATTATGGCATTTAAGAATTTAACATGTCTTAGCTGTAAAAATGAGAAAGTGTTGGTTGGTTTTAAAATCTGGTA >In-frame_MTDH_ENST00000519934_chr8_98673401_+_MAL2_ENST00000276681_chr8_120233827_+_3024nt GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTT GAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGCTGTTC GGGGGTCTTGTCTGGATTTTGGTTGCCTCCTCCAATGTTCCTCTACCTCTACTACAAGGATGGGTCATGTTTGTGTCCGTGACAGCGTTT TTCTTTTCGCTCCTCTTTCTGGGCATGTTCCTCTCTGGCATGGTGGCTCAAATTGATGCTAACTGGAACTTCCTGGATTTTGCCTACCAT TTTACAGTATTTGTCTTCTATTTTGGAGCCTTTTTATTGGAAGCAGCAGCCACATCCCTGCATGATTTGCATTGCAATACAACCATAACC GGGCAGCCACTCCTGAGTGATAACCAGTATAACATAAACGTAGCAGCCTCAATTTTTGCCTTTATGACGACAGCTTGTTATGGTTGCAGT TTGGGTCTGGCTTTACGAAGATGGCGACCGTAACACTCCTTAGAAACTGGCAGTCGTATGTTAGTTTCACTTGTCTACTTTATATGTCTG ATCAATTTGGATACCATTTTGTCCAGATGCAAAAACATTCCAAAAGTAATGTGTTTAGTAGAGAGAGACTCTAAGCTCAAGTTCTGGTTT ATTTCATGGATGGAATGTTAATTTTATTATGATATTAAAGAAATGGCCTTTTATTTTACATCTCTCCCCTTTTTCCCTTTCCCCCTTTAT TTTCCTCCTTTTCTTTCTGAAAGTTTCCTTTTATGTCCATAAAATACAAATATATTGTTCATAAAAAATTAGTATCCCTTTTGTTTGGTT GCTGAGTCACCTGAACCTTAATTTTAATTGGTAATTACAGCCCCTAAAAAAAACACATTTCAAATAGGCTTCCCACTAAACTCTATATTT TAGTGTAAACCAGGAATTGGCACACTTTTTTTAGAATGGGCCAGATGGTAAATATTTATGCTTCACGGTCCATACAGTCTCTGTCACAAC TATTCAGTTCTGCTAGTATAGCGTGAAAGCAGCTATACACAATACAGAAATGAATGAGTGTGGTTATGTTCTAATAAAACTTATTTATAA AAACAAGGGGAGGCTGGGTTTAGCCTGTGGGCCATAGTTTGTCAACCACTGGTGTAAAACCTTAGTTATATATGATCTGCATTTTCTTGA ACTGATCATTGAAAACTTATAAACCTAACAGAAAAGCCACATAATATTTAGTGTCATTATGCAATAATCACATTGCCTTTGTGTTAATAG TCAAATACTTACCTTTGGAGAATACTTACCTTTGGAGGAATGTATAAAATTTCTCAGGCAGAGTCCTGGATATAGGAAAAAGTAATTTAT GAAGTAAACTTCAGTTGCTTAATCAAACTAATGATAGTCTAACAACTGAGCAAGATCCTCATCTGAGAGTGCTTAAAATGGGATCCCCAG AGACCATTAACCAATACTGGAACTGGTATCTAGCTACTGATGTCTTACTTTGAGTTTATTTATGCTTCAGAATACAGTTGTTTGCCCTGT GCATGAATATACCCATATTTGTGTGTGGATATGTGAAGCTTTTCCAAATAGAGCTCTCAGAAGAATTAAGTTTTTACTTCTAATTATTTT GCATTACTTTGAGTTAAATTTGAATAGAGTATTAAATATAAAGTTGTAGATTCTTATGTGTTTTTGTATTAGCCCAGACATCTGTAATGT TTTTGCACTGGTGACAGACAAAATCTGTTTTAAAATCATATCCAGCACAAAAACTATTTCTGGCTGAATAGCACAGAAAAGTATTTTAAC CTACCTGTAGAGATCCTCGTCATGGAAAGGTGCCAAACTGTTTTGAATGGAAGGACAAGTAAGAGTGAGGCCACAGTTCCCACCACACGA GGGCTTTTGTATTGTTCTACTTTTTCAGCCCTTTACTTTCTGGCTGAAGCATCCCCTTGGAGTGCCATGTATAAGTTGGGCTATTAGAGT TCATGGAACATAGAACAACCATGAATGAGTGGCATGATCCGTGCTTAATGATCAAGTGTTACTTATCTAATAATCCTCTAGAAAGAACCC TGTTAGATCTTGGTTTGTGATAAAAATATAAAGACAGAAGACATGAGGAAAAACAAAAGGTTTGAGGAAATCAGGCATATGACTTTATAC TTAACATCAGATCTTTTCTATAATATCCTACTACTTTGGTTTTCCTAGCTCCATACCACACACCTAAACCTGTATTATGAATTACATATT ACAAAGTCATAAATGTGCCATATGGATATACAGTACATTCTAGTTGGAATCGTTTACTCTGCTAGAATTTAGGTGTGAGATTTTTTGTTT CCCAGGTATAGCAGGCTTATGTTTGGTGGCATTAAATTGGTTTCTTTAAAATGCTTTGGTGGCACTTTTGTAAACAGATTGCTTCTAGAT TGTTACAAACCAAGCCTAAGACACATCTGTGAATACTTAGATTTGTAGCTTAATCACATTCTAGACTTGTGAGTTGAATGACAAAGCAGT TGAACAAAAATTATGGCATTTAAGAATTTAACATGTCTTAGCTGTAAAAATGAGAAAGTGTTGGTTGGTTTTAAAATCTGGTAACTCCAT |
Top |
FusionGenePPI for MTDH_MAL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTDH | OTUD6B, MME, CUL3, ZBTB16, PLEC, ESR1, RELA, CREBBP, CSNK2A1, LMNA, TARDBP, TOPORS, CCDC8, RNF2, SIRT2, NR2E1, ACTL6A, NTRK1, TMEM237, TMEM216, EXOSC4, BTRC, SNN, SND1, MTUS2, ZYG11B, JUN, EP300 | MAL2 | TPD52, TPD52L1, PPP1CA, ELAVL1, ATP4A, ABCG8, GAD2, PBX3, PTPN9, SH3GL1, TBRG4, ARFIP2, VARS2, FAM3A, TUBB, RAB37, CREB3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 72_169 | 161 | 583 | BCCIP |
| Hgene | MTDH | chr8:98673401 | chr8:120233827 | ENST00000336273 | + | 2 | 12 | 101_205 | 161 | 583 | RELA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MTDH_MAL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MTDH_MAL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MTDH | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | MTDH | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|