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Fusion gene ID: 2273 |
FusionGeneSummary for APP_TSPEAR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APP_TSPEAR | Fusion gene ID: 2273 | Hgene | Tgene | Gene symbol | APP | TSPEAR | Gene ID | 351 | 54084 |
| Gene name | amyloid beta precursor protein | thrombospondin type laminin G domain and EAR repeats | |
| Synonyms | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 | C21orf29|DFNB98|TSP-EAR | |
| Cytomap | 21q21.3 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid-beta A4 proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteincereb | thrombospondin-type laminin G domain and EAR repeat-containing proteinthrombospondin-type laminin G domain and EAR repeats-containing protein | |
| Modification date | 20180527 | 20180409 | |
| UniProtAcc | P05067 | Q8WU66 | |
| Ensembl transtripts involved in fusion gene | ENST00000346798, ENST00000354192, ENST00000348990, ENST00000357903, ENST00000358918, ENST00000359726, ENST00000448388, ENST00000440126, ENST00000439274, ENST00000474136, | ENST00000323084, ENST00000397916, | |
| Fusion gene scores | * DoF score | 15 X 15 X 9=2025 | 3 X 3 X 3=27 |
| # samples | 19 | 3 | |
| ** MAII score | log2(19/2025*10)=-3.4138505843284 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: APP [Title/Abstract] AND TSPEAR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APP | GO:0001934 | positive regulation of protein phosphorylation | 11404397 |
| Hgene | APP | GO:0008285 | negative regulation of cell proliferation | 22944668 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-DC-4745-01A | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000346798 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000346798 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000354192 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000354192 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000348990 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000348990 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000357903 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000357903 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000358918 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000358918 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000359726 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000359726 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000448388 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000448388 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000440126 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000440126 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| In-frame | ENST00000439274 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| 5CDS-5UTR | ENST00000439274 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| intron-3CDS | ENST00000474136 | ENST00000323084 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
| intron-5UTR | ENST00000474136 | ENST00000397916 | APP | chr21 | 27326904 | - | TSPEAR | chr21 | 45987889 | - |
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FusionProtFeatures for APP_TSPEAR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APP | TSPEAR |
| May play a role in development or function of theauditory system. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 230_260 | 562 | 771 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 274_280 | 562 | 771 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 230_260 | 487 | 696 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 274_280 | 487 | 696 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 230_260 | 431 | 640 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 274_280 | 431 | 640 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 230_260 | 543 | 752 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 274_280 | 543 | 752 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 230_260 | 562 | 753 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 274_280 | 562 | 753 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 230_260 | 506 | 715 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 274_280 | 506 | 715 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 230_260 | 538 | 747 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 274_280 | 538 | 747 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 181_188 | 562 | 771 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 391_423 | 562 | 771 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 491_522 | 562 | 771 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 523_540 | 562 | 771 | Region | Note=Collagen-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 96_110 | 562 | 771 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 181_188 | 487 | 696 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 391_423 | 487 | 696 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 96_110 | 487 | 696 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 181_188 | 431 | 640 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 391_423 | 431 | 640 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 96_110 | 431 | 640 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 181_188 | 543 | 752 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 391_423 | 543 | 752 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 491_522 | 543 | 752 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 523_540 | 543 | 752 | Region | Note=Collagen-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 96_110 | 543 | 752 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 181_188 | 562 | 753 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 391_423 | 562 | 753 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 491_522 | 562 | 753 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 523_540 | 562 | 753 | Region | Note=Collagen-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 96_110 | 562 | 753 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 181_188 | 506 | 715 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 391_423 | 506 | 715 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 96_110 | 506 | 715 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 181_188 | 538 | 747 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 391_423 | 538 | 747 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 491_522 | 538 | 747 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 523_540 | 538 | 747 | Region | Note=Collagen-binding |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 96_110 | 538 | 747 | Region | Note=Heparin-binding |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 58_277 | 27 | 670 | Domain | Note=Laminin G-like |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 313_358 | 27 | 670 | Repeat | EAR 1 |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 360_408 | 27 | 670 | Repeat | EAR 2 |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 412_460 | 27 | 670 | Repeat | EAR 3 |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 464_506 | 27 | 670 | Repeat | EAR 4 |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 514_570 | 27 | 670 | Repeat | EAR 5 |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 574_622 | 27 | 670 | Repeat | EAR 6 |
| Tgene | >TSPEAR | chr21:27326904 | chr21:45987889 | ENST00000323084 | - | 0 | 12 | 625_668 | 27 | 670 | Repeat | EAR 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 724_734 | 562 | 771 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 759_762 | 562 | 771 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 724_734 | 487 | 696 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 759_762 | 487 | 696 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 724_734 | 431 | 640 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 759_762 | 431 | 640 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 724_734 | 543 | 752 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 759_762 | 543 | 752 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 724_734 | 562 | 753 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 759_762 | 562 | 753 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 724_734 | 506 | 715 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 759_762 | 506 | 715 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 724_734 | 538 | 747 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 759_762 | 538 | 747 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 491_522 | 487 | 696 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 523_540 | 487 | 696 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 491_522 | 431 | 640 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 523_540 | 431 | 640 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 491_522 | 506 | 715 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 523_540 | 506 | 715 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 18_699 | 562 | 771 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 724_770 | 562 | 771 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 18_699 | 487 | 696 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 724_770 | 487 | 696 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 18_699 | 431 | 640 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 724_770 | 431 | 640 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 18_699 | 543 | 752 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 724_770 | 543 | 752 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 18_699 | 562 | 753 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 724_770 | 562 | 753 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 18_699 | 506 | 715 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 724_770 | 506 | 715 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 18_699 | 538 | 747 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 724_770 | 538 | 747 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 700_723 | 562 | 771 | Transmembrane | Helical |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 700_723 | 487 | 696 | Transmembrane | Helical |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 700_723 | 431 | 640 | Transmembrane | Helical |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 700_723 | 543 | 752 | Transmembrane | Helical |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 700_723 | 562 | 753 | Transmembrane | Helical |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 700_723 | 506 | 715 | Transmembrane | Helical |
| Hgene | >APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 700_723 | 538 | 747 | Transmembrane | Helical |
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FusionGeneSequence for APP_TSPEAR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_APP_ENST00000346798_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1205aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER MNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRV PNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADV PFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQP PCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQ NIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVI YKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANS HSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTV >In-frame_APP_ENST00000354192_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1074aa MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATS GIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLRED TAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDAT PRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVE EHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKW SHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTF NGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSA >In-frame_APP_ENST00000348990_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1130aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQC DLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFS LTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLK YPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKAT SAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAV ANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWE VFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRW >In-frame_APP_ENST00000357903_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1186aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ DEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEES DLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRR RAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGL YLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKI FLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATS GAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSV IYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAYLIYS >In-frame_APP_ENST00000358918_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1205aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER MNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRV PNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADV PFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQP PCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQ NIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVI YKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANS HSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTV >In-frame_APP_ENST00000359726_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1149aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQL SVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPA LVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLS IPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIE VFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIAT HSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRL LGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLV >In-frame_APP_ENST00000448388_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1095aa MFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADT DYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLE TPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR LALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQD EVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESD LLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRR AKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLY LCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIF LAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSG AYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVI YELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAYLIYSS >In-frame_APP_ENST00000440126_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1181aa MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQ NWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATT TTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGD ENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALE NYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDL RPLDILAEVVPSDGATSGIRIVQVHGARGLQLSVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLL GLRLSPAQLHFLFLREDTAGAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGL FMGLVRQLVLLPGSDATPRLCPSRNAPLAVLSIPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVG NEWVSVLAAKERLDYVEEHQNLSTNSETLGIEVFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVA NFEPDEKGQEFSVIYKWSHRKLKFTPYQSIATHSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDW EFFSVGPYSFLVVANTFNGTSTKVHSHLYIRLLGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELN VTAQAFVKFQDILTCSALDWEFFSVGEDYFLVVANSFDGRTFSVNSIIYRWQGYEGFVAVHSLPTVGCRDWEAFSTTAGAYLIYSSAKEP >In-frame_APP_ENST00000439274_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_1149aa MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDLRPLDILAEVVPSDGATSGIRIVQVHGARGLQL SVAAPRTMSFPASRIFSQCDLFPEEFSIVVTLRVPNLPPKRNEYLLTVVAEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTRVSFRSPA LVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGSRRRAKGLFMGLVRQLVLLPGSDATPRLCPSRNAPLAVLS IPRVLQALTGKPEDNEVLKYPYETNIRVTLGPQPPCTEVEDAQFWFDASRKGLYLCVGNEWVSVLAAKERLDYVEEHQNLSTNSETLGIE VFRIPQVGLFVATANRKATSAVYKWTEEKFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFEPDEKGQEFSVIYKWSHRKLKFTPYQSIAT HSARDWEAFEVDGEHFLAVANHREGDNHNIDSVIYKWNPATRLFEANQTIATSGAYDWEFFSVGPYSFLVVANTFNGTSTKVHSHLYIRL LGSFQLFQSFPTFGAADWEVFQIGERIFLAVANSHSYDVEMQVQNDSYVINSVIYELNVTAQAFVKFQDILTCSALDWEFFSVGEDYFLV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_APP_ENST00000346798_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3615nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAG CATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGC ATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACATCCTG GCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCC CCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAGAGTT CCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCT GCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGC CGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGATGTG CCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGG CAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTC CTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCAGCCA CCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTG TTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCGCATC CCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAG AACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGATGAG AAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACACACAGCGCCCGA GACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATCGACAGTGTCATC TACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGG CCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTC CAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGT CACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGCCTTT GTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCC TTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTC GGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCCAGGGTCCTGCGG >In-frame_APP_ENST00000354192_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3222nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTA GAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGC TGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACT CATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATT GACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCG GATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAG GTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACA GAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACC CCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAG CACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTT ATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTG GAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTC AATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAG AAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTG CCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGC GGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATT TTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTG CTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGAC ACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCA GGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCT CGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACC CCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAAC GAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGG TTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAG GAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAAT CGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGG CATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGG AGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCAC TTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAG GCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTC AACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCT GCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAAT GATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCT CTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATT ATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACG >In-frame_APP_ENST00000348990_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3390nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTT GACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGA ATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTC CAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTC AATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAG AAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAG ATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCC GAGGAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATA GTTCAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGT GACCTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTG GCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCC TGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCC CTCACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTC GGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGT CCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAA TATCCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGC CGGAAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAAC TTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACA TCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATC GGGAAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAG CTGAAGTTTACCCCATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTG GCCAACCACCGGGAAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACC ATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCC ACCAAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAG GTCTTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTC ATCAACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAG TTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGG CAGGGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTAC >In-frame_APP_ENST00000357903_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3558nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTC GAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTC ATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTG GAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGC CGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGC GCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAG GTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAG GATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCAC GGTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCT GAAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGC GACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGA GTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGAC TGCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGG AGAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAAC GCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAA ACCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTG TATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAAC TCAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTAC AAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATC TTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACC CCATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGG GAAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCC GGCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCAC TCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATC GGGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTC ATCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTG GGAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAG GGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCC >In-frame_APP_ENST00000358918_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3615nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAG CATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGC ATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACATCCTG GCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCC CCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAGAGTT CCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCT GCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGC CGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGATGTG CCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGG CAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTC CTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCAGCCA CCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTG TTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCGCATC CCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAG AACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGATGAG AAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACACACAGCGCCCGA GACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATCGACAGTGTCATC TACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGG CCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTC CAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGT CACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGCCTTT GTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCC TTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTC GGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCCAGGGTCCTGCGG >In-frame_APP_ENST00000359726_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3447nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTACTCAAGACTACCCAGGAACCT CTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCC CTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTC TCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTA ACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTG CGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCC CTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATA ATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATG GGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCC ATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTG GGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAG TGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAG GTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTC GTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTT GAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACA CACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATC GACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTC TTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTC CTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCT GTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACC GCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTG GTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGC CTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCC >In-frame_APP_ENST00000448388_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3285nt ATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACC AAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAG AACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGAT GCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAA GAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTG TGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACA GACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGAC GAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACC ACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAG ACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATG AGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAA TCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGC CTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCA GAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTT ATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGAT GAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGT GCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAA GAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGAC CTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTG TCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGC GGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGA GCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCC CCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACC AACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTAT CTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCA GAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAG TGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTC CTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCA TATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAA GGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGC GCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCG CACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGG GAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATC TACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGA GAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGC TTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGC >In-frame_APP_ENST00000440126_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3543nt ATGGACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCC ATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACC AAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAG AACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGAT GCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAA GAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTG TGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACA GACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGAC GAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACC ACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCC CGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAG TACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGAT GAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAA GAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAG GAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAG AACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGAC AGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTC CGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTG CGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTC CAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATC GTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTC GGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGC CCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTG GACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTG TTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTG CTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTG ACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGC AACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGC ATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAG AAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCT AATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATT GCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCAC AACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGG GAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATC CGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTC CTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAAC GTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTC CTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTG CACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCC >In-frame_APP_ENST00000439274_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_3447nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTA GAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGC TGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACT CATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATT GACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCG GATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAG GTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACA GAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAG ACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGC AACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCT CTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCC CTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTC TCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTA ACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTG CGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCC CTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATA ATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATG GGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCC ATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTG GGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAG TGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAG GTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTC GTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTT GAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACA CACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATC GACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTC TTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTC CTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCT GTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACC GCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTG GTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGC CTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_APP_ENST00000346798_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5540nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCG CGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCA GGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCA GGATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCA CGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCC TGAAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAG CGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCG AGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGA CTGCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAG GAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAA CGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGA AACCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCT GTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAA CTCAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTA CAAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGAT CTTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTAC CCCATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCG GGAAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTC CGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCA CTCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGAT CGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGT CATCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGT GGGAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGA GGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTC CAGCGCCAAGGAGCCCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGG CGGGACCCCAGCACCTCCCCCAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAG GTGGGGCCATCTGCGGCCCTGGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTG CAGGCAGAGGCCCAGAGCCCCTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTT ACCTCAAACAACAGGACCTCGGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTG TGGTGCCGTCCCGCCATTGCCGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGC TCCTCTCTAGGCAGCGGGTGGGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGC CTCAGTTTACCCGTAAATGCACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCC ACAGGGACCTCAACTTCTGGGCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGC GTGCCTCCGTCTGCCTGTGTGCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGC TGGGAGAGCTGCTTGTCTGTCCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCAT GTAGGTGCCAGAGAAACCACCCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGG TCTTCCAGGAACGGTGCTCCTGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCA GAACTGTGGACAAAACTTCCTATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATG GAAGCCTCCCCTTGTCTGGCAAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCAC TCCAGCCATCGCTGTGGCCAGTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTT TCCCAAGCGTCCTGGGCAGGAGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTC AGCACCTGTGAAAGGAAGATTAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTG CCTTTCCCTTTGCCCTAAGCAGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAA GTGCCAATTTACTGAGCACGAGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGA CCACACCCTCCTCCCTCTGCCCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTC >In-frame_APP_ENST00000354192_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5240nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC TCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCT AAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGA GCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACAT CCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGC CGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAG AGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTC ACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGA TGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGA TGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGT GAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACG GGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCA GCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTC CGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCG CATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATA TCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGA TGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACACACAGCGC CCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATCGACAGTGT CATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGT GGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTC CTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAA CAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGC CTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAA CTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCAC CGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCCAGGGTCCT GCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGGCGGGACCCCAGCACCTCCCCCAACTGACCC TGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAGGTGGGGCCATCTGCGGCCCTGGTTCGGGCA GGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTGCAGGCAGAGGCCCAGAGCCCCTGCCAGTGC TCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTTACCTCAAACAACAGGACCTCGGTTCATGTC CCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTGTGGTGCCGTCCCGCCATTGCCGCCACCTAT TTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGCTCCTCTCTAGGCAGCGGGTGGGCACAGCCC CTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGCCTCAGTTTACCCGTAAATGCACTAGCGCGA GGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCCACAGGGACCTCAACTTCTGGGCCCGGGATT TTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGCGTGCCTCCGTCTGCCTGTGTGCTGGCTGTC CTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGCTGGGAGAGCTGCTTGTCTGTCCGTCACAGG CAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCATGTAGGTGCCAGAGAAACCACCCCCACTCCA TGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGGTCTTCCAGGAACGGTGCTCCTGCTTCTGCA ACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCAGAACTGTGGACAAAACTTCCTATTTCCTAC ACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATGGAAGCCTCCCCTTGTCTGGCAAATAATAAA CTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCACTCCAGCCATCGCTGTGGCCAGTGGAGAGCC ACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTTTCCCAAGCGTCCTGGGCAGGAGGGTTGGGC CCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTCAGCACCTGTGAAAGGAAGATTAAAAACTCG ACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTGCCTTTCCCTTTGCCCTAAGCAGACAGCTGC AGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAAGTGCCAATTTACTGAGCACGAGATAAACAG GTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGACCACACCCTCCTCCCTCTGCCCCCTCCAGC CGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTCTCCTGGGTGCATCCTTAGCCTTGGCAAAAT >In-frame_APP_ENST00000348990_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5428nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCCCC CTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGCTC TCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCGTA ACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTG CGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCC CTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACATA ATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATG GGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCC ATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGCTG GGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAG TGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAG GTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTC GTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTT GAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCACA CACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATC GACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTC TTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGACTC CTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCT GTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGACC GCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTG GTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGC CTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCC AGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGGCGGGACCCCAGCACCTCCCCCA ACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAGGTGGGGCCATCTGCGGCCCTGG TTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTGCAGGCAGAGGCCCAGAGCCCCT GCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTTACCTCAAACAACAGGACCTCGG TTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTGTGGTGCCGTCCCGCCATTGCCG CCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGCTCCTCTCTAGGCAGCGGGTGGG CACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGCCTCAGTTTACCCGTAAATGCAC TAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCCACAGGGACCTCAACTTCTGGGC CCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGCGTGCCTCCGTCTGCCTGTGTGC TGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGCTGGGAGAGCTGCTTGTCTGTCC GTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCATGTAGGTGCCAGAGAAACCACCC CCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGGTCTTCCAGGAACGGTGCTCCTG CTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCAGAACTGTGGACAAAACTTCCTA TTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATGGAAGCCTCCCCTTGTCTGGCAA ATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCACTCCAGCCATCGCTGTGGCCAGT GGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTTTCCCAAGCGTCCTGGGCAGGAG GGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTCAGCACCTGTGAAAGGAAGATTA AAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTGCCTTTCCCTTTGCCCTAAGCAG ACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAAGTGCCAATTTACTGAGCACGAG ATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGACCACACCCTCCTCCCTCTGCCC CCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTCTCCTGGGTGCATCCTTAGCCTT >In-frame_APP_ENST00000357903_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5616nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACC TGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGAC TCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCA TCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGC TCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCA GCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGG TGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCC TGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGG TGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAG TGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTG GCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGG GCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAG AGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGG CTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCA TTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACC ACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACT GGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACA TCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCT TCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGA ACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATT TCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGG TGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGC CCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGGCGGGACCCCAGCAC CTCCCCCAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAGGTGGGGCCATCTGC GGCCCTGGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTGCAGGCAGAGGCCCA GAGCCCCTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTTACCTCAAACAACAG GACCTCGGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTGTGGTGCCGTCCCGC CATTGCCGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGCTCCTCTCTAGGCAG CGGGTGGGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGCCTCAGTTTACCCGT AAATGCACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCCACAGGGACCTCAAC TTCTGGGCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGCGTGCCTCCGTCTGC CTGTGTGCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGCTGGGAGAGCTGCTT GTCTGTCCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCATGTAGGTGCCAGAGA AACCACCCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGGTCTTCCAGGAACGG TGCTCCTGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCAGAACTGTGGACAAA ACTTCCTATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATGGAAGCCTCCCCTTG TCTGGCAAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCACTCCAGCCATCGCTG TGGCCAGTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTTTCCCAAGCGTCCTG GGCAGGAGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTCAGCACCTGTGAAAG GAAGATTAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTGCCTTTCCCTTTGCC CTAAGCAGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAAGTGCCAATTTACTG AGCACGAGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGACCACACCCTCCTCC CTCTGCCCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTCTCCTGGGTGCATCC >In-frame_APP_ENST00000358918_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5706nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAAC AAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGAT GTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCC AGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACC TGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGAC TCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCA TCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGC TCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCA GCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGG TGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCC TGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGG TGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAG TGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTG GCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGG GCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAG AGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGG CTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCA TTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACC ACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACT GGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACA TCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCT TCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGA ACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATT TCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGG TGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGC CCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGGCGGGACCCCAGCAC CTCCCCCAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAGGTGGGGCCATCTGC GGCCCTGGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTGCAGGCAGAGGCCCA GAGCCCCTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTTACCTCAAACAACAG GACCTCGGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTGTGGTGCCGTCCCGC CATTGCCGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGCTCCTCTCTAGGCAG CGGGTGGGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGCCTCAGTTTACCCGT AAATGCACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCCACAGGGACCTCAAC TTCTGGGCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGCGTGCCTCCGTCTGC CTGTGTGCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGCTGGGAGAGCTGCTT GTCTGTCCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCATGTAGGTGCCAGAGA AACCACCCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGGTCTTCCAGGAACGG TGCTCCTGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCAGAACTGTGGACAAA ACTTCCTATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATGGAAGCCTCCCCTTG TCTGGCAAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCACTCCAGCCATCGCTG TGGCCAGTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTTTCCCAAGCGTCCTG GGCAGGAGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTCAGCACCTGTGAAAG GAAGATTAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTGCCTTTCCCTTTGCC CTAAGCAGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAAGTGCCAATTTACTG AGCACGAGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGACCACACCCTCCTCC CTCTGCCCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTCTCCTGGGTGCATCC >In-frame_APP_ENST00000359726_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5538nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCG CAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGG TTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG ATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACG GTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTG AAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCG ACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAG TGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACT GCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGA GAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACG CCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAA CCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGT ATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACT CAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACA AGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCT TCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCC CATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGG AAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCG GCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACT CGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCG GGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCA TCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGG GAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGG GCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCA GCGCCAAGGAGCCCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGGCG GGACCCCAGCACCTCCCCCAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAGGT GGGGCCATCTGCGGCCCTGGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTGCA GGCAGAGGCCCAGAGCCCCTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTTAC CTCAAACAACAGGACCTCGGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTGTG GTGCCGTCCCGCCATTGCCGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGCTC CTCTCTAGGCAGCGGGTGGGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGCCT CAGTTTACCCGTAAATGCACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCCAC AGGGACCTCAACTTCTGGGCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGCGT GCCTCCGTCTGCCTGTGTGCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGCTG GGAGAGCTGCTTGTCTGTCCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCATGT AGGTGCCAGAGAAACCACCCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGGTC TTCCAGGAACGGTGCTCCTGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCAGA ACTGTGGACAAAACTTCCTATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATGGA AGCCTCCCCTTGTCTGGCAAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCACTC CAGCCATCGCTGTGGCCAGTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTTTC CCAAGCGTCCTGGGCAGGAGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTCAG CACCTGTGAAAGGAAGATTAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTGCC TTTCCCTTTGCCCTAAGCAGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAAGT GCCAATTTACTGAGCACGAGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGACC ACACCCTCCTCCCTCTGCCCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTCTC >In-frame_APP_ENST00000448388_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5368nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAG TATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATC CGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAG GAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTT CAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGAC CTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCA GAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGG CAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTC ACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGC AGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCC AGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATAT CCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGG AAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTG TCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCC GCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGG AAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTG AAGTTTACCCCATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCC AACCACCGGGAAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATC GCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACC AAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTC TTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATC AACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTT TTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAG GGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTC ATCTACTCCAGCGCCAAGGAGCCCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCC AGGTGGGGCGGGACCCCAGCACCTCCCCCAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCA GGGTGCAGGTGGGGCCATCTGCGGCCCTGGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTC TGGTCTTGCAGGCAGAGGCCCAGAGCCCCTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTAT ACATTTTTACCTCAAACAACAGGACCTCGGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTG AGCAGGTGTGGTGCCGTCCCGCCATTGCCGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGC ACCGGTGCTCCTCTCTAGGCAGCGGGTGGGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCC CTCCCAGCCTCAGTTTACCCGTAAATGCACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGG CCCCACCCACAGGGACCTCAACTTCTGGGCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACT CAGGCTGCGTGCCTCCGTCTGCCTGTGTGCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTC TCTGCAGCTGGGAGAGCTGCTTGTCTGTCCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCT TAACCCATGTAGGTGCCAGAGAAACCACCCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACC TGCCACGGTCTTCCAGGAACGGTGCTCCTGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCC GCCAATCAGAACTGTGGACAAAACTTCCTATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTA ATGAAATGGAAGCCTCCCCTTGTCTGGCAAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCA GGTCTCACTCCAGCCATCGCTGTGGCCAGTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAG CAAGGCTTTCCCAAGCGTCCTGGGCAGGAGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTC ATTGGGTCAGCACCTGTGAAAGGAAGATTAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCA GGAAGCTGCCTTTCCCTTTGCCCTAAGCAGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCT CATGGAAAGTGCCAATTTACTGAGCACGAGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAG TCATGTGACCACACCCTCCTCCCTCTGCCCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACA >In-frame_APP_ENST00000440126_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5700nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGACCTGCGCC CCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGATAGTTCAGGTTCACGGTGCACGGGGACTCCAGC TCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTGTGACCTCTTCCCTGAAGAATTTTCCATCGTCG TAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAGGAGAGCGACCTGCTGCTGCTCGGCC TGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCCTTCCGCAGCCCGG CCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGACA TAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCA TGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCCAGCAGGAACGCCCCGCTGGCGGTGCTGT CCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAACCAACATTCGAGTGACGC TGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGCAACG AGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTG AGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCACATCCGCCGTCTACAAGTGGACCGAAGAGAAGT TCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGATCTTCCTGGCAGTGGCTAATT TTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAGCATTGCCA CACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACA TCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGT TCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAGGTGCACTCGCACCTCTACATCCGAC TCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGAGGATCTTCCTCG CTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGA CCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGG TGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCTACGAGGGCTTCGTGGCGGTGCACA GCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCAAGGAGCCCCTCT CCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGTGGCCAGGTGGGGCGGGACCCCAGCACCTCCCC CAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCAGGCAGGGTGCAGGTGGGGCCATCTGCGGCCCT GGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGACGGTCTGGTCTTGCAGGCAGAGGCCCAGAGCCC CTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTTCTATACATTTTTACCTCAAACAACAGGACCTC GGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCGCCTGAGCAGGTGTGGTGCCGTCCCGCCATTGC CGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAAAAGCACCGGTGCTCCTCTCTAGGCAGCGGGTG GGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGCTTCCCTCCCAGCCTCAGTTTACCCGTAAATGC ACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCCACGGCCCCACCCACAGGGACCTCAACTTCTGG GCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGGGACTCAGGCTGCGTGCCTCCGTCTGCCTGTGT GCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCTTGTCTCTGCAGCTGGGAGAGCTGCTTGTCTGT CCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCCCTCTTAACCCATGTAGGTGCCAGAGAAACCAC CCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCACACCTGCCACGGTCTTCCAGGAACGGTGCTCC TGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTTTTCCGCCAATCAGAACTGTGGACAAAACTTCC TATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTTCGTAATGAAATGGAAGCCTCCCCTTGTCTGGC AAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGGCTCAGGTCTCACTCCAGCCATCGCTGTGGCCA GTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAGCCAGCAAGGCTTTCCCAAGCGTCCTGGGCAGG AGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGGCCTCATTGGGTCAGCACCTGTGAAAGGAAGAT TAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCCTGCAGGAAGCTGCCTTTCCCTTTGCCCTAAGC AGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTTATCTCATGGAAAGTGCCAATTTACTGAGCACG AGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAATCAGTCATGTGACCACACCCTCCTCCCTCTGC CCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGGCACAGACCTGTCTCCTGGGTGCATCCTTAGCC >In-frame_APP_ENST00000439274_chr21_27326904_-_TSPEAR_ENST00000323084_chr21_45987889_-_5372nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAA GAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCA GATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGC CGAGGAGATTCAGGATGAAGTTGACCTGCGCCCCCTGGACATCCTGGCGGAAGTGGTCCCTTCTGATGGCGCCACAAGCGGGATCAGGAT AGTTCAGGTTCACGGTGCACGGGGACTCCAGCTCTCAGTAGCCGCCCCCCGCACCATGAGCTTCCCAGCATCCAGGATTTTCTCCCAGTG TGACCTCTTCCCTGAAGAATTTTCCATCGTCGTAACTTTGAGAGTTCCCAATCTTCCACCCAAGAGGAACGAGTACCTGCTGACGGTGGT GGCAGAGGAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCACTTCCTGTTCCTTCGCGAGGACACGGCCGGCGC CTGGCAGACCCGAGTGTCCTTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCTGTGTCCGCAGGCGTCTTCTC CCTCACCACGGACTGCGGCCTCCCGGTGGACATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGATTCTTCGT CGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTGAGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTG TCCCAGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCTCTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAA ATATCCCTATGAAACCAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGACGCCCAGTTCTGGTTTGATGCCAG CCGGAAGGGCCTGTATCTGTGTGTTGGCAACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGAGGAGCATCAGAA CTTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTTCCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCAC ATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACATCCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCAT CGGGAAAAAGATCTTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTCTGTCATTTACAAATGGAGCCACAGAAA GCTGAAGTTTACCCCATATCAGAGCATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGGAGCACTTCCTGGCGGT GGCCAACCACCGGGAAGGCGACAACCACAACATCGACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAACCAGAC CATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGGCCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTC CACCAAGGTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGTCCTTCCCGACGTTCGGTGCTGCAGACTGGGA GGTCTTCCAGATCGGGGAGAGGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAGTCCAGAATGATTCCTATGT CATCAACTCCGTCATCTACGAGCTGAACGTGACCGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGACTGGGA GTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCCTTCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTG GCAGGGCTACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACTGGGAGGCCTTCAGCACCACGGCTGGTGCCTA CCTCATCTACTCCAGCGCCAAGGAGCCCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGAGGCCGCGGCTGCCCGGCAGCAACTGGGGT GGCCAGGTGGGGCGGGACCCCAGCACCTCCCCCAACTGACCCTGGACGTCCAGGTGGGCCCAGCCTAGGGCATCCCGGGCCTGGGCATCA GGCAGGGTGCAGGTGGGGCCATCTGCGGCCCTGGTTCGGGCAGGGACATCCATCCACCTCTGAGTCCTTCTGAGCCACAGCCCCAGTGAC GGTCTGGTCTTGCAGGCAGAGGCCCAGAGCCCCTGCCAGTGCTCGCCCATCTGAGTGTCAAGCGGGGATTTCGCTGTCAAGGAACCGTTT CTATACATTTTTACCTCAAACAACAGGACCTCGGTTCATGTCCCTGCGGCTGGCCTCTCGCCAGCCACTCCTGCAGTGTGCGTCCGGCCG CCTGAGCAGGTGTGGTGCCGTCCCGCCATTGCCGCCACCTATTTATTGTGTTTTATCTGAACGGAAGTGTATTTATACTGCTCTTTACAA AAGCACCGGTGCTCCTCTCTAGGCAGCGGGTGGGCACAGCCCCTCACCACGGACACGGACAGAGGACCACCTCCCCATACAGAGAGAGGC TTCCCTCCCAGCCTCAGTTTACCCGTAAATGCACTAGCGCGAGGTCAGAAATCACAAGCCTGGGCATGGCCTGGGTCGCACCCCCTCCCC ACGGCCCCACCCACAGGGACCTCAACTTCTGGGCCCGGGATTTTTTCCCTATTCAGCAGCATTTTAATCACATGTCCTCCAGCTGACTGG GACTCAGGCTGCGTGCCTCCGTCTGCCTGTGTGCTGGCTGTCCTAGCTCCCTGGTAACAGCATCCTCTGCTGGCTCTCCTGTGGTCATCT TGTCTCTGCAGCTGGGAGAGCTGCTTGTCTGTCCGTCACAGGCAGTGAGGATGAGAGGGGGTGATGGGCGCAAGGCCCCAGGGGTCCTCC CTCTTAACCCATGTAGGTGCCAGAGAAACCACCCCCACTCCATGAGAAGAGGCTCAGACAGCAGGCTCCGGGGCCACGCAGCCCAGACCA CACCTGCCACGGTCTTCCAGGAACGGTGCTCCTGCTTCTGCAACACAAATCGGAACAGGAGCGATCCTCAGAGAGTTTACAATGTGCTTT TTCCGCCAATCAGAACTGTGGACAAAACTTCCTATTTCCTACACCGCAGCTGTCTGTTCACCTTCAGCTCAGAGAGCACTCCTGACCTTT CGTAATGAAATGGAAGCCTCCCCTTGTCTGGCAAATAATAAACTCAGTGTCTACTTTTGCCGGCTTTGGGACCTTCGTGTTTTTCCGGGG CTCAGGTCTCACTCCAGCCATCGCTGTGGCCAGTGGAGAGCCACTCCCCTCTGGGGGCAGTCGCCGAGAGCCTCCTTCCCCTCCGTCCAG CCAGCAAGGCTTTCCCAAGCGTCCTGGGCAGGAGGGTTGGGCCCTGCTTTCCACCAAGTCACTCAGAAGGTCCCAATCACACATGATTGG CCTCATTGGGTCAGCACCTGTGAAAGGAAGATTAAAAACTCGACACCCCAATTCACTCAACCAAGAAGAAAAAAGCTGAAAGCTGAGTCC TGCAGGAAGCTGCCTTTCCCTTTGCCCTAAGCAGACAGCTGCAGATGAGAGGGTCAGCATCTCCACTAGTGGCTGCTCTGTGTGCCCCTT ATCTCATGGAAAGTGCCAATTTACTGAGCACGAGATAAACAGGTAACTGACTGTTCCCACCTGCTCCTTTTCTCCTGCAGCATGGAGCAA TCAGTCATGTGACCACACCCTCCTCCCTCTGCCCCCTCCAGCCGGCTTTTCCCCTTGACTGAAGCCTTCAACATCATCTTGGGAGAGAGG |
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FusionGenePPI for APP_TSPEAR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| APP | APPBP2, CLSTN1, APBB2, APBA2, FBLN1, APBA1, APBA3, DAB2, CALR, COL25A1, HSD17B10, CAV1, KLC1, NCSTN, BGN, APBB1, SNCA, SNCB, DAB1, ACHE, SHC1, NAE1, GSN, BLMH, APBB3, HGS, BCAP31, SET, PARK2, STUB1, HSPD1, HSPA4, HSP90AA1, SYVN1, NOTCH1, FBXL2, YWHAG, KAT5, GSK3B, UBQLN1, NAPG, UBB, MAPK8IP1, MAPRE1, GGA1, CLU, LRP2, CRYAB, HSPA8, UBE2M, TPPP, NOS3, DMTN, TCEANC, WIBG, MRPL19, C17orf85, PRR16, HOMER2, VIM, NSRP1, RPL30, RTF1, E2F8, SMTNL2, SLAIN2, GABARAPL2, PLK1, IGBP1, MAP2, KCNAB1, EIF4E2, TPRXL, MPG, DDX19B, ENY2, WDR5, AKNAD1, ZNF706, ADAP2, KIF3B, PDAP1, RAD51AP1, TCP10L, TPT1, GIMAP4, C1orf131, STAC, FAM114A2, UBXN10, RASL11B, CDK16, TSLP, RPAP3, YY1, BOD1, TOX2, TMA16, NTMT1, ATP6V1G1, AURKA, ELK1, PNMAL1, CTNNA1, MCM10, TCEAL2, FGF12, PRR15, MZT2A, TRPT1, DCX, HMCES, MRPL1, SLIT1-AS1, RGS3, PSRC1, C7orf50, TOP1, KIFC3, RPS19, C11orf63, ERMN, IRS1, SERBP1, TRUB1, TBC1D10C, C1orf87, POGZ, TMA7, C19orf57, COASY, G3BP1, FEN1, RPL12, ARID3A, LMCD1, CWF19L2, ZFYVE27, NOLC1, ZMYM5, ARGLU1, DDX54, GCC1, C9orf41, LIMCH1, CENPB, PTBP1, PPID, NKIRAS1, WHSC1, TOM1L2, CSAG1, ASPSCR1, CLIP4, PPP1R32, POLD3, MOB3A, RGS10, SCEL, SH3GLB1, PLIN3, RPS10, BRWD1, FANCM, CAT, UBXN6, TAF1B, PP2D1, NOP16, SNRNP70, DDX47, EIF1AX, SOCS3, TRIM41, LSM6, DIRAS1, RGS14, ARL4C, ZAP70, ARFGAP1, RSRC2, STXBP1, DDX55, HINT2, C9orf43, PHF7, C12orf65, TCEA1, SOX5, SEPT9, PATL1, RITA1, KLC4, ACO2, FLOT2, CIRH1A, IER3, ODF2, EIF1, HK1, SECISBP2, CDK17, ANKZF1, PTTG2, APRT, ATAT1, PYCR2, FAM126B, C1orf35, TPH1, VPS33B, STK25, MLLT6, NUAK1, C1orf110, HMGB2, PTPN7, DDX18, IFRD2, HERPUD1, CASZ1, LRRC59, FMNL1, QKI, TTLL7, CCNB1IP1, BLOC1S1, TAF9B, OAS2, LATS1, NMT2, APEX2, EPB41L2, CWC15, SSB, TACO1, AICDA, NAT6, RPS20, SENP2, TCF19, KIF2C, ECI2, TARBP2, C6orf201, MAPK13, PRDX5, RP9, FDX1L, RNPC3, LIG3, MOB3C, NPM1, MRPL34, TCP10, KLC2, SPATA2, PRRC2B, LCP2, SURF2, ZW10, TSSC4, MYL5, BUD31, TRIM52, CCDC149, FAM53A, CELF2, CEP57, TRMT2A, GAK, STOML2, PPFIBP2, AVPI1, GAPDH, TAB2, SERPIND1, ING2, DEF6, EIF5, NOB1, KCTD18, BCL7C, CTF1, ZC3HAV1L, FAM64A, C9orf78, ALDOB, ZC2HC1A, TIGD1, HP1BP3, THAP3, EIF3G, ARFIP2, KIAA0930, CXorf56, SCYL1, ASXL1, SASH3, ANXA9, POP7, GRB10, SH3RF2, CRIP2, TASP1, IKBIP, LRRC8D, PSMC1, ARL4D, GOLGA4, FAM32A, RASL10B, RASL12, TOB1, MXI1, EIF2S2, KRAS, EME1, DNM2, C1orf115, COPS7B, ZGRF1, APLF, MRPS24, CDKL3, EPB41L5, GADD45GIP1, TRIM63, RPL31, LACRT, RASA1, UNG, SPZ1, OR2W1, RPUSD2, BBX, NUAK2, ACSL4, RPF2, DLGAP1-AS2, C11orf52, USE1, CDKN1A, HIST1H2BM, EPB41L4A, ZADH2, GYG2, PAK4, ARHGAP24, DCLK1, PCBD2, C19orf40, PDZD4, DHX58, MAPKAPK3, DFFB, DYRK2, RPS9, NFKBIB, LNX1, CD74, ECH1, RPS12, GPANK1, CPLX2, BCAR3, GALK1, PADI4, PAK6, RPS16, BIN1, COIL, TLE3, PDE6H, GPT2, ANKRD50, AIMP1, PPP1R14A, MPP3, GORAB, C2orf49, MKNK1, ETV3, PAPSS2, SMAD3, MTG1, TSPYL1, CLEC3B, ACTR1B, SPANXN3, MCM7, BLOC1S2, GTF2E2, GTPBP1, FANCI, MESDC2, GBA2, MRPL49, PRRC1, MLX, BTF3, DDX43, CSNK1G2, ADRM1, RPL36, HSPBP1, DDX42, PLEKHG2, BIK, AMOT, TCP11, AFAP1L2, ADD2, CUL3, GOSR2, MED8, SH3GL2, SMAP1, DDRGK1, PAK2, RPL41, MRPL10, ZNF622, NR1D1, DDX17, DNAJC8, SP2, ZFYVE1, ZNF365, ABLIM1, AURKB, RASGRP3, IQCH, ASXL2, FNDC3A, KCNAB3, C19orf43, C1orf174, RGS5, OSBPL11, LYRM7, MSL3, TRAF3IP1, LOC541472, BLOC1S5, PNKD, SEPT5, CRADD, EEPD1, CLK3, BAIAP2, LARP4, SART1, MRPS18A, SOCS5, RGL1, AGPAT3, ZHX2, STK40, ARHGEF40, MRPL28, KIF3A, TAF6, DYNLRB2, LAP3, ABCF1, CCNB3, ARMC1, FUBP3, ISL1, GLRX5, PTP4A1, BYSL, PCIF1, RPL23, UTP23, UCHL5, TRAPPC2L, ORC6, RNF32, ROPN1L, RAP1B, ITGB3BP, SHOC2, ZNF684, LIMA1, PRKCI, NFYA, TTPA, SMIM11, NBPF3, LARP1B, POGK, RBM42, DEDD, IMP4, MAGEH1, BCKDK, HADH, TPD52L3, PLEKHO2, TGFBR2, ADH5, CDK3, ZNF22, TBCC, SERP1, MED24, SF3B6, HS3ST1, CCDC106, AIFM3, FIP1L1, ATF2, DPY19L2P1, NEDD9, PHYH, LUC7L2, CSNK1D, RAB40B, MRPL35, CCSER2, TFPT, CCDC59, MRPL11, ZNF2, IFIH1, TRIM40, SETBP1, DMD, ZNF410, ATP5H, ERG, RSRP1, HBG1, GJB1, ATG16L1, UBE2E2, HIST2H2AA3, POLE3, DENND6B, PPP1R8, FAM133B, TK1, GYS1, SIVA1, LMNTD1, BMX, HNRNPA1, UBE2S, COL14A1, COX6A2, HOMER3, HBS1L, ZNF574, MND1, GABPA, SDC1, KLF12, ALDH4A1, LARP6, DDHD2, ULK4, MOB1A, BMPR1B, ATF6, PHF20L1, TIPIN, ENTHD2, GNL2, CHGB, TBPL1, PRSS23, EIF2B5, ECHDC2, ARPC1B, WASH2P, DUS3L, SLC4A1AP, SPX, ZSCAN1, CCDC60, ACBD6, KCNN3, NUSAP1, PDE4D, NECAP1, PIP4K2C, DCDC2, NOL7, ADAT2, TWF1, BCAT2, SIRT7, OLFML2A, TBC1D7, RNF41, MAP1LC3A, ANKS6, SMAD1, CAPNS2, PHGDH, ECHDC1, HDAC4, VPS37C, PPAN, PSMA1, PCK1, ENKD1, ARNT2, CACNB1, PSMD11, MAPK7, ZMAT4, CSNK1E, HSPB7, GPKOW, ELK3, DCTN6, POLR2K, XAF1, CDC20, OCEL1, MX1, MORF4L1, GFAP, MYBBP1A, IL15, CTNND1, VCY1B, PTPN12, CCDC115, SRRT, RNMTL1, RUSC1, TSPY2, ACAD10, FGF16, CCDC15, SYCP2L, ACLY, ENO3, ATP5C1, FKBP1A, OTX2, SAMHD1, PNKP, HEYL, RPS6KB1, CCNL1, HDDC3, PLA2G4D, RPS11, MTURN, CHKA, FCHO1, PACRG, TTK, DNAJB1, C3orf36, STK17B, AAMDC, DPY19L2P4, STAU1, RRP15, BRD3, SIRT5, DDX1, CAAP1, RBM8A, CSNK2A1, LARP7, HIST1H2BA, NME3, ZNF740, SYK, TCP11L1, EMG1, PPHLN1, PLEKHJ1, KRTCAP2, AK4, BEND5, CMAS, ZMYM3, PRR14, CARF, PLSCR1, RPL34, KIAA1191, ITGB1BP1, TSSK2, FGFR2, LOC254896, MMGT1, SYT6, LINC00982, ATP5A1, SPG20, FSD1L, DRAP1, ZRSR2, HRASLS5, SRSF3, SKA3, GAS2, KCNK5, NELFA, USP2, YWHAB, HMBS, C14orf93, RCAN1, LETM2, BLOC1S6, LMX1B, TSSK6, CMTM2, CAMKK2, DIDO1, NAA25, SGK2, SRSF8, HIC2, SPATA4, ZFC3H1, PHYHD1, SYNCRIP, ABR, NECAB3, CDCA7, PSMA5, SND1, ASS1, THAP4, CAMK1D, PHACTR4, FBXO38, ARAP1, LOC401068, SIK2, SETD3, ZNF343, MARCH10, HBZ, CDK5R1, RGS1, SRR, LAD1, MURC, ADARB1, MYOZ1, KANSL2, SUPT4H1, ZSCAN5A, CHRAC1, PAIP2, PAGR1, UPF3A, EXOC3, HMGCS2, SNX1, LOC554207, TBC1D9B, PDPK1, ZCCHC17, FKBPL, TOM1, CLDN16, ABHD11, URI1, SP140L, RLBP1, TARP, WARS, EXOSC3, DKFZP434K028, MAT2B, SAE1, DYRK1A, ELF2, PRKCD, MB, TBCD, FAM90A1, HELLS, NUMB, DNAJC4, STIP1, CENPI, CSNK1G1, TICRR, CINP, ZNF35, TPI1, GNAZ, STK33, E2F6, TMOD2, NOL12, ICK, TTC23, PAK1, DECR1, HAGH, RPL37A, SULF1, GPAM, DDX10, YWHAZ, CCZ1B, DPCR1, ANKS4B, MAK, DZIP1L, ABCB7, UBAC1, NIM1K, TFPI, SLC7A1, AGFG1, VAC14, NNMT, PPP3CC, NR1H3, ZSCAN16, NEIL1, CFDP1, RAB39A, DECR2, CPEB1, PRSS33, FILIP1, PRPSAP2, ACO1, OARD1, WASL, PPIL2, KIFC1, CCDC88C, SLFNL1, SSTR2, FAM184A, C18orf21, SF3B2, CFAP58, H1F0, PHF8, DUSP12, UBL4A, GIMAP5, POMZP3, BEGAIN, AKT1, SOX7, BEND2, SPSB2, GPN2, FIBP, TNIP2, SPATS2, KLHL32, ZCCHC8, C2orf57, ING3, WWC3, METTL2B, RPL37, IFI16, LETMD1, NUDT16L1, SSBP3, EFS, TSKS, ATPAF2, TRAIP, MAPRE2, MAPK11, EIF2B2, C22orf46, ANKRD36BP1, ETNPPL, DUSP4, SAR1A, LIN7A, PSMD4, VPS41, BCL2L13, MRPL24, FAM212B, ARL6IP6, TMEM53, SLCO2B1, DLGAP5, CENPQ, RPS26, MEF2D, USP39, KLF8, DYNC1LI2, ERH, INIP, MLLT3, CHEK1, CCL26, PCDHGA12, RCOR3, ACSL3, ODF2L, COPZ1, METAP2, MARS2, PLBD1, PCK2, YTHDF2, C4orf46, RBX1, SUSD3, METTL16, LIMD1, MRPL27, POLH, POMC, C19orf33, BCL2L11, BHLHB9, ACY1, PPP2R5C, NEK11, PLEKHF2, IL26, IGSF10, HOXC6, CDC7, PPP1R17, STK26, TARDBP, OLFM1, SRPK2, SIGIRR, KLF6, PWP1, LENG1, RASGRP2, VWA5A, FAAH2, RIOK2, CAPRIN1, RSU1, ZMAT3, GNAT2, TP53TG1, MCC, FAM50A, RASA3, ARHGAP9, BHMT2, RIT2, CHTOP, CCNG1, IFT81, MRPS6, TXNDC5, OR7A5, PRKRIP1, LOC142937, DGCR6, SLX4, LRRC42, FBF1, NDUFB1, PARD6B, FRMD8, CDC25A, RAB14, TAF9, C3orf33, TRIM44, GIMAP8, AHDC1, ECI1, NPL, MRPL53, C11orf71, IK, QARS, FAM19A4, C11orf53, DTWD1, NDUFB6, CDK2AP2, GSTA3, AGO4, ZFAND5, FTSJ1, SMURF1, SNRNP35, MTMR14, ZXDC, SCD, PTK2, CDC42EP4, NXT2, FRG1B, MBD1, DSN1, RUFY3, PUSL1, VAMP3, ORC3, KLF4, C11orf45, FBXL7, ZCCHC12, IL18RAP, NDP, MROH8, AGAP1, CDKN2B, SERPINB2, TEX2, PROSER2, CLP1, FHL2, MOBP, NOVA1, TET3, PKM, ZC3HAV1, PRPF4, RPS6KA6, OR4D6, LOC403312, TCL1B, TOMM5, IRF2, CCT7, ZNF720, MEOX1, HBD, IGSF6, NMNAT1, TBC1D3P2, CDK5, LURAP1L, AIMP2, ZNF839, HIST1H4I, RBM4B, ARHGAP17, DNAJB6, TRAP1, PSME1, MRPL3, ATG12, GPR78, VPS29, S100A16, CHURC1, EIF6, LIPT1, LGALS2, HIGD2A, HOXB7, C15orf43, ASB6, MVB12A, LIMS2, DNALI1, CCDC33, EOGT, HIST2H2AB, EPB41L1, LMAN1, FAM212A, EAF1, OSM, IGHM, MEIS2, MICU1, SENP1, LAMC1, GPATCH1, RPL3L, PCYT1B, ATP6V1E1, ZNF23, CHCHD6, SLC35B1, SRSF1, ESRRG, PRICKLE2, CXCL16, RTKN, TRAM1, DPCD, RAI2, POLI, DENND1C, PTBP3, CLUAP1, HINT3, FAM47B, OXSR1, ARMC9, HMBOX1, PHLDA1, C8orf33, EP400NL, TAF7L, HMG20B, VHL, NARF, MCFD2, CTSB, SCAMP3, STRIP2, MCM5, QPCTL, USP6, TP53TG5, AGR2, SLC41A3, CELF4, OLFM3, CD36, ICT1, C3orf20, PIBF1, COPB1, GSPT2, CENPT, TAGLN2, RAB43, CCNE2, MRPS2, TGIF1, USP12, CD58, USP6NL, TCN2, GABRA4, PDSS2, APOA1, COPS5, IARS2, AHSA1, OPA1, SGK3, LPL, MED19, TNNT2, RPS14, UBE2G1, PSME2, CDIPT, KIAA1143, RNF183, CD300LF, TMEM126B, DGCR8, ALKBH7, AAK1, FOXI1, FMNL2, GALE, PARVG, FERMT3, WARS2, ZWINT, C21orf33, LFNG, TRDMT1, COL4A6, SOD2, CCDC144NL, DERL1, SRPK1, AK1, KCNMB2, TCEANC2, NECAP2, KLF7, DCTPP1, RAB11B, ARMC7, IDO1, POLL, SDCCAG3, MRPL20, MSMB, CCDC40, LY86, VAPA, WDR45B, CRACR2B, RAB10, COMMD2, RNF115, SYF2, ACTL7B, IL7, SULT1A3, GSTA1, ANKRD39, CIART, DDX20, MCM2, GPR61, H2AFV, WDR88, PTGDR, CGB, TIMM17B, CMTM3, DGUOK, TPRA1, ERVFRD-1, LINC00341, PSAT1, ORC4, NDEL1, ORMDL1, BAALC-AS2, PPP5C, TRAPPC3, MTFMT, S100A8, VTA1, USF1, PPP1R3C, GAL3ST1, SMARCB1, BNIP1, TBX22, PLRG1, NME8, MDM4, IPO4, EXOSC1, RALGPS1, DIMT1, GTDC1, COX4I2, RETSAT, RXFP3, MPV17L, NDUFA2, POLR2F, SEPT1, SKAP2, RUVBL2, AFG3L1P, ALDH8A1, ARHGDIB, RAB1B, C21orf59, KIAA0825, NRIP1, MRAP2, HAPLN1, CAMKK1, TGM2, CELF1, TNFSF14, DSCR9, RAB8B, ANXA8, CDK18, PIP5K1A, SRSF9, RIMS4, THAP7, C15orf39, GAGE1, POMGNT2, DEFA6, IREB2, PCDHGC3, CERK, WASH3P, PARP3, SH3BP5, HSPA9, UGCG, CLASRP, CCDC28B, MITF, RAB7B, SNX21, GNLY, PCDHA7, MAP2K3, SERAC1, DNAJB14, WDR45, SHMT2, KRT36, TRMT1L, TPMT, DIEXF, GEMIN8, RAB5C, GTF2E1, NAPA, CDK4, STOML1, FAM131C, ANKRA2, GUCD1, AGER, SUB1, C19orf18, DNAJC12, RPA4, GRAMD4, ALDH2, PGM3, ETFB, COLEC12, PPP6R2, ACKR2, PCDHGC5, MAPK10, RAB38, KIAA1841, PPAP2B, ETHE1, NMNAT2, PIKFYVE, GUCY1B3, OPA3, PLA2G4C, CD300LB, ZDHHC23, PFKL, NXF2, SPINT2, PUS7L, TRIM69, ZNF483, CUL4B, RNF34, EIF4E, SNAI2, ASCL3, C7orf31, HMGB4, NECAB1, REG1A, PIK3R5, ADAD2, CAPSL, MYOT, BIN3-IT1, ASGR1, C1D, APOBEC3G, GSTO1, RPS27A, ARF6, SEC24C, PPP2R4, CRHR2, SPAG6, RAB26, HCFC1R1, RBM39, CCL13, NAT2, NDUFS4, RPS18, ZC3HC1, FMNL3, KIF4A, VIPR2, KLK7, ZKSCAN1, NUDT9, CBFA2T2, PPIA, SYNJ2BP, IFNW1, TRAF6, MIER1, C3orf62, UBE3A, WDR89, MXD1, EBF4, SPIC, KCNE1L, SRSF6, ZCCHC6, L3MBTL4, YAE1D1, ANXA2, PLK2, ANKS1B, ZSCAN18, GGA2, DCUN1D2, SH2D1B, CDPF1, GSDMB, SLC1A1, FERMT2, VPS37A, TSNAXIP1, P2RX6, MRRF, GAPDHS, INTS12, C1orf64, EIF3M, OBFC1, ASPH, KAT7, ETV5, HYPK, EPHA2, LGALS3, SPC24, SLC48A1, VASH2, KPNA2, CLDN3, TMEM97, ARRDC1, ACAA2, ANKRD13D, CDK7, LANCL2, YPEL3, DYNLT1, C12orf5, RWDD2B, PDE1A, C6orf118, ADH4, ALB, GNB5, EIF2A, PSMD5, CFAP53, PGM1, SERF1A, AEBP2, TBC1D20, ARCN1, USP5, RSPH3, CDKL2, CCDC107, RD3, UGGT2, TSPAN5, TMX3, FUCA1, AP2A2, ARPP19, C19orf12, MPI, GRHL2, CCIN, RSPH10B2, SUN5, EEF1B2, C16orf70, PYROXD1, TNFAIP8L1, CLDN20, PIK3R2, POLDIP2, TCEA2, NLRP2, LRRC1, NOL11, RAB35, FGFBP2, CHEK2, NARFL, ISOC2, UBE3C, BRMS1, TANK, BET1L, SRRM2, PLCD4, C17orf70, CSTF2, IFI6, R3HDML, FKBP5, NGLY1, OXSM, MKKS, FOXJ2, MCTP2, MAD2L1, RBPJ, ARL5A, FAM151A, CAMKV, AFG3L2, TEX37, MEST, PARVA, GLOD4, PTMS, MCEE, MED11, BDH1, FAM127B, FAM127A, INPP5B, LLPH, DNAH14, SDF4, GNRH2, CSRP1, NAV1, DEPTOR, CTBP2, NDUFA4, EMC8, ASMTL, HBG2, BCL11A, TSPAN13, CYB561D2, PEX2, MMP12, OSTF1, CHMP3, MTERF4, RRAGB, UBL3, DHRS7B, PDS5B, CDCA3, RBPJL, HAVCR2, TUBB, TAF11, UBXN7, C11orf54, CISD2, HIST1H2BB, STK11, STX11, LINGO2, HIRIP3, CXXC4, MARCH3, NOC2L, SMYD3, AKT2, RAB28, UXT, ACSBG1, RGS18, NNAT, DUSP21, ST3GAL6, SKAP1, C1orf112, FITM1, NAGA, FAM122A, CLIC3, ZDHHC7, MAP2K4, IRGC, STAT5B, FAM160B2, KIAA0513, TMEM175, ATL3, MOB1B, SSH3, DAPK2, ERC1, COA5, IL1B, PELI3, PRPF38A, GORASP2, FAM214B, BRF1, PDZK1, RING1, GTF3C6, RASSF8, RPA2, TEK, LOC90768, PFKFB1, POLR3C, HCK, ARL8B, SYT17, FN3KRP, MAGEA4, FAM213A, ROR1, KLK9, HSPA2, JAGN1, H2AFY, IGF1R, WAC, ETS1, BDNF, STARD10, TMCC2, CIAO1, CNPY2, TRIM16, MAB21L2, LAIR1, EFHD2, SPATA7, DNAAF2, KISS1, PRKAB1, GLB1L, TLL1, ART4, GNA12, CCDC14, METTL8, NUP50, KPNA4, FAM3B, RPS6KA5, RFWD3, SNURF, CAMK1, SMG5, FYCO1, TIMMDC1, SIX2, OTUB2, CHID1, GGCT, CCND3, ARID3B, EXOSC7, MRPL52, UBE2DNL, ODAM, NME6, PHLDA3, VPS35, NDUFA5, SNAP25, DCXR, INTS3, CALCOCO1, TBCK, PAEP, RNASE11, MYL10, TNFRSF14, PABPC3, CNOT7, ALOX5, TMEM35, TTLL6, GNA15, RABL3, METTL25, LYPLA2, LOC554223, ORMDL3, INS, TMOD4, GALNT12, CFHR2, TCP11L2, ZNF75A, PPP2R5E, SNRNP40, FCGR3A, NTM, AP4S1, SH3BGRL3, PRKCG, NOS1AP, ZNF581, KPTN, SLC17A5, MAST2, ALDH7A1, VAT1L, MTERF3, ANXA5, CASP4, PARP15, EPS8L2, WNT4, GADD45G, BTK, PCBP1, CASC4, HAUS6, ZFP36, RNF11, PTK6, CARS, TAP2, C1orf111, ZEB2, FLCN, MINA, MSTN, GPR12, TBC1D21, NUDT16P1, DPP3, TCEAL8, PIGG, UGT1A10, RNF138, CXCL14, DTD2, PTGIS, GTPBP8, PTPRO, NDUFAF7, MED9, CIRBP, AGFG2, SPINK6, RNF185, ARHGEF5, TMEM255A, SCO2, MS4A2, IFNA16, RPS21, TIPRL, PQBP1, RIOK1, CACNG2, EIF3F, MSI1, C6orf106, RBCK1, CYP20A1, ANKRD45, NMRK1, RAD51C, CACNG3, NXPE3, APITD1, HCP5, CYB5B, OSBPL5, ACAD11, MBNL1, RASSF3, SLC2A2, ABHD10, ANP32B, DHRSX, ACYP1, C14orf159, MAG, TNFSF13B, MOGAT3, OSTCP1, KRTAP10-7, RCBTB1, DIO3, TRIB3, PNPO, BCL2A1, RAB27A, RAPGEFL1, ZFYVE16, KLK2, PLS3, DRAM1, SF3A3, CAMKMT, ACTL7A, HPGD, ARFGAP3, RAB2B, PDK3, CCBL1, P2RY2, CATIP, TRIM47, DCAF7, C9orf72, SEPT12, SGCG, GIMAP6, MTCP1, OCIAD2, APEX1, POU2F1, CHAC2, NDUFB3, AIDA, CNDP1, ACTL6B, TRIM39, DIXDC1, EBP, LIMK1, RNF151, SLC38A2, ITGA6, C9orf142, OLFM4, NLN, AREG, DUSP3, PDCD7, VTN, NTRK3, C6orf203, ICAM3, FAM200A, FOXS1, ACBD4, AKAP1, SPEG, PSMB4, SLC22A6, IPO9, ATG13, CCT8, HAUS8, TRIB2, ODF4, ADI1, LSMEM2, MRPL48, HRASLS, IFNA5, MAPK8, DMKN, CDKN2D, PRDX2, C10orf88, RAB3D, C5orf28, FSIP1, MYL1, VSIG4, ATXN3, CEACAM6, IL1RL1, ATRAID, MED30, ETV4, TRIML1, PPARG, IFNA8, KCNIP4, TMEM261, NAAA, CEP250, ATG7, C11orf73, NMRK2, NUP62CL, PASD1, ZNF322, RPS25, ARMCX3, POLA2, ATF4, CHAF1B, PDZD9, KCNJ10, BSND, KIR2DL3, SERTM1, FAM134B, LSMEM1, C4orf22, PIGO, CLEC2B, C5orf15, TMEM183A, SCAND2P, LPAR3, LINC00663, CST2, PLCD1, COX4I1, CTNNB1, JTB, C1orf105, GOSR1, VDAC2, BOLA1, C2orf47, IARS, EVI2A, USP48, PDIA3, EPHB4, ATCAY, TBK1, PBRM1, COQ6, PDYN, TRAPPC4, FBXW9, SPRR4, TMUB1, DNAJC19, TMEM180, RMND5A, PLA1A, HERC2P9, PPP1CC, DHX16, PIM1, PKNOX1, NDUFS2, STOML3, GNPTAB, FAM3A, PDDC1, ANGPTL7, NAALADL2, DLK2, PSMA7, A2M, PSEN1, IFIT3, AP1M2, PRAM1, CDC37, EXOC6, MAST1, PAXIP1, PI4K2A, PSEN2, RAB3A, ECSIT, CFL1, APP, TM2D1, MAP3K11, MAPK8IP2, KIF1B, TPD52L2, TIRAP, FOS, PCBD1, JUN, MDM2, RANBP9, LRP1, BACE1, SNX17, SNX27, CUL7, MAPT, QRICH1, RNF2, EGFR, UBE2I, GSAP, SORL1, TMEM30A, USP25, FBXW11, SRP19, FAM27E3, RBM11, VCY, KIAA0020, LTV1, OR6B3, TUBG1, PINX1, ABT1, AGO1, TYMSOS, ZNF747, FGF13, UTP14A, MYC, RBM34, ZC3H3, HIST2H2AC, ADAM22, ERCC1, PES1, ATXN7L3, APOBEC3H, DDX49, RPL11, ZNF486, TBC1D26, ZNF385B, AKAP13, DNAJB7, PARD6A, RSL1D1, C1orf116, C16orf78, PURG, ALKBH8, FCF1, PNRC2, EHF, GLRB, CPED1, GPATCH2L, RAG1, ROBO3, FES, NCR1, THAP1, GRAMD1C, ST6GALNAC6, ZSCAN21, DNAJC30, ZNF449, PPP1R10, HDGF, ATP5O, S1PR1, GPR15, EEF1D, ZKSCAN8, TRAPPC9, TRIM46, HMGA1, THBS4, RFX5, HOXC4, ARHGAP15, TMCC1, ZNF641, LMF2, KATNA1, SGIP1, TMEM216, XRCC3, CASP3, CASP6, MAP3K5, NEFL, TGFB1, TGFB2, UCHL1, PTGS2, SRC, NF1, KDR, PTPN2, CES2, FRMD6, UTP11L, ZNF107, INHBE, ZNF431, SULF2, ZNF92, ZNF724P, ACADL, NME2, GSG2, CES3, GDF11, DNAJB9, TMEM30B, MAP7, OBSL1, F11, IL20RB, TIMP3, KEAP1, MAP7D1, ZNF445, AARS2, CBX6, COL18A1, CKAP2, C3orf17, CLEC12A, HS2ST1, PTCD2, QTRT1, TRIM25, TES | TSPEAR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000346798 | - | 13 | 18 | 732_751 | 562 | 771 | G(o)-alpha |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000348990 | - | 11 | 16 | 732_751 | 487 | 696 | G(o)-alpha |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000354192 | - | 10 | 15 | 732_751 | 431 | 640 | G(o)-alpha |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000357903 | - | 12 | 17 | 732_751 | 543 | 752 | G(o)-alpha |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000358918 | - | 13 | 17 | 732_751 | 562 | 753 | G(o)-alpha |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000359726 | - | 12 | 17 | 732_751 | 506 | 715 | G(o)-alpha |
| Hgene | APP | chr21:27326904 | chr21:45987889 | ENST00000440126 | - | 12 | 17 | 732_751 | 538 | 747 | G(o)-alpha |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for APP_TSPEAR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | APP | P05067 | DB06782 | Dimercaprol | Amyloid-beta A4 protein | small molecule | approved |
| Hgene | APP | P05067 | DB09148 | Florbetaben (18F) | Amyloid-beta A4 protein | small molecule | approved |
| Hgene | APP | P05067 | DB00746 | Deferoxamine | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB01370 | Aluminium | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB01593 | Zinc | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB09149 | Florbetapir (18F) | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB09151 | Flutemetamol (18F) | Amyloid-beta A4 protein | small molecule | approved|investigational |
Top |
RelatedDiseases for APP_TSPEAR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APP | C0002395 | Alzheimer's Disease | 55 | CTD_human;HPO;ORPHANET;UNIPROT |
| Hgene | APP | C0025261 | Memory Disorders | 12 | CTD_human |
| Hgene | APP | C0027746 | Nerve Degeneration | 11 | CTD_human |
| Hgene | APP | C0023186 | Learning Disorders | 6 | CTD_human |
| Hgene | APP | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | APP | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | APP | C2751536 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED | 5 | ORPHANET;UNIPROT |
| Hgene | APP | C0009241 | Cognition Disorders | 4 | CTD_human |
| Hgene | APP | C0522224 | Paralysed | 4 | CTD_human |
| Hgene | APP | C0524851 | Neurodegenerative Disorders | 2 | CTD_human |
| Hgene | APP | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
| Hgene | APP | C2931672 | Cerebral hemorrhage with amyloidosis, hereditary, Dutch type | 2 | CTD_human;ORPHANET |
| Hgene | APP | C0002622 | Amnesia | 1 | CTD_human |
| Hgene | APP | C0002726 | Amyloidosis | 1 | CTD_human |
| Hgene | APP | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Hgene | APP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | APP | C0006111 | Brain Diseases | 1 | CTD_human |
| Hgene | APP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Hgene | APP | C0016667 | Fragile X Syndrome | 1 | CTD_human |
| Hgene | APP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | APP | C0027540 | Necrosis | 1 | CTD_human |
| Hgene | APP | C0037928 | Spinal Cord Diseases | 1 | CTD_human |
| Hgene | APP | C0038002 | Splenomegaly | 1 | CTD_human |
| Hgene | APP | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | APP | C0085220 | Cerebral Amyloid Angiopathy | 1 | CTD_human;HPO |
| Hgene | APP | C0231341 | Premature aging syndrome | 1 | CTD_human |
| Hgene | APP | C0338656 | Impaired cognition | 1 | CTD_human |
| Hgene | APP | C0497327 | Dementia | 1 | CTD_human;HPO |
| Hgene | APP | C2936349 | Plaque, Amyloid | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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