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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 22728

FusionGeneSummary for MTDH_CALB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MTDH_CALB1
Fusion gene ID: 22728
HgeneTgene
Gene symbol

MTDH

CALB1

Gene ID

92140

793

Gene namemetadherincalbindin 1
Synonyms3D3|AEG-1|AEG1|LYRIC|LYRIC/3D3CALB|D-28K
Cytomap

8q22.1

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion proteincalbindinRTVL-H proteincalbindin 1, (28kD)calbindin 1, 28kDacalbindin 27calbindin D28vitamin D-dependent calcium-binding protein, avian-type
Modification date2018052320180523
UniProtAcc

Q86UE4

P05937

Ensembl transtripts involved in fusion geneENST00000336273, ENST00000519934, 
ENST00000265431, ENST00000518457, 
Fusion gene scores* DoF score7 X 6 X 5=2102 X 2 X 2=8
# samples 92
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MTDH [Title/Abstract] AND CALB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTDH

GO:0000122

negative regulation of transcription by RNA polymerase II

15927426

HgeneMTDH

GO:0010508

positive regulation of autophagy

21127263

HgeneMTDH

GO:0043066

negative regulation of apoptotic process

17704808

HgeneMTDH

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

16452207|18316612

HgeneMTDH

GO:0045766

positive regulation of angiogenesis

19940250

HgeneMTDH

GO:0051092

positive regulation of NF-kappaB transcription factor activity

16452207|18316612

HgeneMTDH

GO:0051897

positive regulation of protein kinase B signaling

17704808


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A07C-01AMTDHchr8

98735263

+CALB1chr8

91094330

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336273ENST00000265431MTDHchr8

98735263

+CALB1chr8

91094330

-
5CDS-intronENST00000336273ENST00000518457MTDHchr8

98735263

+CALB1chr8

91094330

-
In-frameENST00000519934ENST00000265431MTDHchr8

98735263

+CALB1chr8

91094330

-
5CDS-intronENST00000519934ENST00000518457MTDHchr8

98735263

+CALB1chr8

91094330

-

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FusionProtFeatures for MTDH_CALB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTDH

Q86UE4

CALB1

P05937

Downregulates SLC1A2/EAAT2 promoter activity whenexpressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independentgrowth of immortalized melanocytes and astrocytes which is a keycomponent in tumor cell expansion. Promotes lung metastasis andalso has an effect on bone and brain metastasis, possibly byenhancing the seeding of tumor cells to the target organendothelium. Induces chemoresistance.{ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207,ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. Buffers cytosolic calcium. May stimulate a membraneCa(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+1112441_451559583Compositional biasNote=Poly-Lys
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+111259_67559583Compositional biasNote=Poly-Leu
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+11121_71559583RegionNote=Activation of NF-kappa-B
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+1112381_443559583RegionLung-homing for mammary tumors
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+11121_48559583Topological domainLumenal
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+111249_69559583TransmembraneHelical
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-011111_12226262Calcium bindingNote=2
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-011155_16626262Calcium bindingNote=3
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-011199_21026262Calcium bindingNote=4
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-01124_3526262Calcium bindingNote=1
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-011142_17726262DomainEF-hand 4
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-011186_22126262DomainEF-hand 5
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-01153_8826262DomainEF-hand 2
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-01198_13326262DomainEF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+1112573_577559583Compositional biasNote=Poly-Lys
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+111270_582559583Topological domainCytoplasmic
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-01111_4626262DomainEF-hand 1


Top

FusionGeneSequence for MTDH_CALB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MTDH_ENST00000336273_chr8_98735263_+_CALB1_ENST00000265431_chr8_91094330_-_795aa
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKRE
EAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSS
RHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQ
VSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQST
TSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKK
KQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL
QETDKSKSNTKQNSVPPSQRSGYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQL
KSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMC

>In-frame_MTDH_ENST00000519934_chr8_98735263_+_CALB1_ENST00000265431_chr8_91094330_-_739aa
MLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEE
QKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQ
QRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKL
SSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIDGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQ
EPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNS
QPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQRSGYLEGKELQNLIQELQQARKKAGLELSPEMKTFVD
QYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKL
FDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMALSD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MTDH_ENST00000336273_chr8_98735263_+_CALB1_ENST00000265431_chr8_91094330_-_2385nt
ATGGCTGCACGGAGCTGGCAGGACGAGCTGGCCCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGC
TTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGG
CTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAG
GAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAG
AAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAG
CAGCCACCAGAGATTGACAAGAAAAATGAAAAGTCAAAGAAAAATAAGAAGAAATCAAAGTCAGATGCTAAAGCAGTGCAAAACAGTTCA
CGCCATGATGGAAAGGAAGTTGATGAAGGAGCCTGGGAAACTAAAATTAGTCACAGAGAGAAACGACAGCAGCGTAAACGTGATAAGGTG
CTGACTGATTCTGGTTCATTGGATTCAACTATCCCTGGGATAGAAAATACCATCACAGTTACCACCGAGCAACTTACAACCGCATCATTT
CCTGTTGGTTCCAAGAAGAATAAAGGTGATTCTCATCTAAATGTTCAAGTTAGCAACTTTAAATCTGGAAAAGGAGATTCTACACTTCAG
GTTTCTTCAGGATTGAATGAAAACCTCACTGTCAATGGAGGAGGCTGGAATGAAAAGTCTGTAAAACTCTCCTCACAGATCAGTGCAGGT
GAGGAGAAGTGGAACTCCGTTTCACCTGCTTCTGCAGGAAAGAGGAAAACTGAGCCATCTGCCTGGAGTCAAGACACTGGAGATGCTAAT
ACAAATGGAAAAGACTGGGGAAGGAGTTGGAGTGACCGTTCAATATTTTCTGGCATTGGGTCTACTGCTGAGCCAGTTTCTCAGTCTACC
ACTTCTGATTATCAGTGGGATGTTAGCCGTAATCAACCCTATATCGATGATGAATGGTCTGGGTTAAATGGTCTGTCTTCTGCTGATCCC
AACTCTGATTGGAATGCACCAGCAGAAGAGTGGGGCAATTGGGTAGACGAAGAAAGAGCTTCACTTCTAAAGTCCCAGGAACCAATTCCT
GATGATCAAAAGGTCTCAGATGATGATAAAGAAAAGGGAGAGGGAGCTCTTCCAACTGGGAAATCCAAAAAGAAAAAAAAGAAAAAGAAG
AAGCAAGGTGAAGATAACTCTACTGCACAGGACACAGAAGAATTAGAAAAAGAGATTAGAGAAGACCTTCCAGTGAATACCTCTAAAACC
CGTCCAAAACAGGAAAAAGCTTTTTCCTTGAAGACCATAAGCACTAGTGATCCAGCCGAAGTACTCGTCAAAAATAGCCAGCCTATCAAG
ACTCTTCCACCTGCTACTTCTACCGAGCCATCTGTAATCTTATCAAAAAGTGATTCTGACAAGAGCTCTTCCCAAGTGCCGCCAATACTA
CAAGAGACAGATAAATCCAAGTCAAATACCAAGCAAAATAGTGTGCCTCCTTCACAGAGAAGTGGTTACCTGGAAGGAAAGGAGCTGCAG
AACTTGATCCAGGAGCTCCAGCAGGCGCGAAAGAAGGCTGGATTGGAGTTATCACCTGAAATGAAAACTTTTGTGGATCAGTATGGGCAA
AGAGATGATGGAAAAATAGGAATTGTAGAGTTGGCTCACGTATTACCCACAGAAGAGAATTTCCTGCTGCTCTTCCGATGCCAGCAGCTG
AAGTCCTGTGAGGAATTCATGAAGACATGGAGAAAATATGATACTGACCACAGTGGCTTCATAGAAACTGAGGAGCTTAAGAACTTTCTA
AAGGACCTGCTAGAAAAAGCAAACAAGACTGTTGATGACACAAAATTAGCCGAGTATACAGACCTAATGCTGAAACTATTTGATTCAAAT
AATGATGGGAAGCTGGAATTAACTGAGATGGCCAGGTTACTACCAGTGCAGGAGAATTTTCTTCTTAAATTCCAGGGAATCAAAATGTGT
GGGAAAGAGTTCAATAAGGCTTTTGAGCTGTATGATCAGGACGGCAATGGATACATAGATGAAAATGAACTGGATGCTTTACTGAAGGAT
CTGTGCGAGAAGAATAAACAGGATCTGGATATTAATAATATTACAACATACAAGAAGAACATAATGGCTTTGTCGGATGGAGGGAAGCTG

>In-frame_MTDH_ENST00000519934_chr8_98735263_+_CALB1_ENST00000265431_chr8_91094330_-_2217nt
ATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTG
GTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGG
AGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAA
CAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACA
CCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGTCAAAGAAAAATAAGAAGAAATCAAAGTCAGATGCT
AAAGCAGTGCAAAACAGTTCACGCCATGATGGAAAGGAAGTTGATGAAGGAGCCTGGGAAACTAAAATTAGTCACAGAGAGAAACGACAG
CAGCGTAAACGTGATAAGGTGCTGACTGATTCTGGTTCATTGGATTCAACTATCCCTGGGATAGAAAATACCATCACAGTTACCACCGAG
CAACTTACAACCGCATCATTTCCTGTTGGTTCCAAGAAGAATAAAGGTGATTCTCATCTAAATGTTCAAGTTAGCAACTTTAAATCTGGA
AAAGGAGATTCTACACTTCAGGTTTCTTCAGGATTGAATGAAAACCTCACTGTCAATGGAGGAGGCTGGAATGAAAAGTCTGTAAAACTC
TCCTCACAGATCAGTGCAGGTGAGGAGAAGTGGAACTCCGTTTCACCTGCTTCTGCAGGAAAGAGGAAAACTGAGCCATCTGCCTGGAGT
CAAGACACTGGAGATGCTAATACAAATGGAAAAGACTGGGGAAGGAGTTGGAGTGACCGTTCAATATTTTCTGGCATTGATGGTCTGTCT
TCTGCTGATCCCAACTCTGATTGGAATGCACCAGCAGAAGAGTGGGGCAATTGGGTAGACGAAGAAAGAGCTTCACTTCTAAAGTCCCAG
GAACCAATTCCTGATGATCAAAAGGTCTCAGATGATGATAAAGAAAAGGGAGAGGGAGCTCTTCCAACTGGGAAATCCAAAAAGAAAAAA
AAGAAAAAGAAGAAGCAAGGTGAAGATAACTCTACTGCACAGGACACAGAAGAATTAGAAAAAGAGATTAGAGAAGACCTTCCAGTGAAT
ACCTCTAAAACCCGTCCAAAACAGGAAAAAGCTTTTTCCTTGAAGACCATAAGCACTAGTGATCCAGCCGAAGTACTCGTCAAAAATAGC
CAGCCTATCAAGACTCTTCCACCTGCTACTTCTACCGAGCCATCTGTAATCTTATCAAAAAGTGATTCTGACAAGAGCTCTTCCCAAGTG
CCGCCAATACTACAAGAGACAGATAAATCCAAGTCAAATACCAAGCAAAATAGTGTGCCTCCTTCACAGAGAAGTGGTTACCTGGAAGGA
AAGGAGCTGCAGAACTTGATCCAGGAGCTCCAGCAGGCGCGAAAGAAGGCTGGATTGGAGTTATCACCTGAAATGAAAACTTTTGTGGAT
CAGTATGGGCAAAGAGATGATGGAAAAATAGGAATTGTAGAGTTGGCTCACGTATTACCCACAGAAGAGAATTTCCTGCTGCTCTTCCGA
TGCCAGCAGCTGAAGTCCTGTGAGGAATTCATGAAGACATGGAGAAAATATGATACTGACCACAGTGGCTTCATAGAAACTGAGGAGCTT
AAGAACTTTCTAAAGGACCTGCTAGAAAAAGCAAACAAGACTGTTGATGACACAAAATTAGCCGAGTATACAGACCTAATGCTGAAACTA
TTTGATTCAAATAATGATGGGAAGCTGGAATTAACTGAGATGGCCAGGTTACTACCAGTGCAGGAGAATTTTCTTCTTAAATTCCAGGGA
ATCAAAATGTGTGGGAAAGAGTTCAATAAGGCTTTTGAGCTGTATGATCAGGACGGCAATGGATACATAGATGAAAATGAACTGGATGCT
TTACTGAAGGATCTGTGCGAGAAGAATAAACAGGATCTGGATATTAATAATATTACAACATACAAGAAGAACATAATGGCTTTGTCGGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MTDH_ENST00000336273_chr8_98735263_+_CALB1_ENST00000265431_chr8_91094330_-_4278nt
GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT
CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG
CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA
TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC
CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG
GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG
GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA
CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCG
GACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAA
GTCAAAGAAAAATAAGAAGAAATCAAAGTCAGATGCTAAAGCAGTGCAAAACAGTTCACGCCATGATGGAAAGGAAGTTGATGAAGGAGC
CTGGGAAACTAAAATTAGTCACAGAGAGAAACGACAGCAGCGTAAACGTGATAAGGTGCTGACTGATTCTGGTTCATTGGATTCAACTAT
CCCTGGGATAGAAAATACCATCACAGTTACCACCGAGCAACTTACAACCGCATCATTTCCTGTTGGTTCCAAGAAGAATAAAGGTGATTC
TCATCTAAATGTTCAAGTTAGCAACTTTAAATCTGGAAAAGGAGATTCTACACTTCAGGTTTCTTCAGGATTGAATGAAAACCTCACTGT
CAATGGAGGAGGCTGGAATGAAAAGTCTGTAAAACTCTCCTCACAGATCAGTGCAGGTGAGGAGAAGTGGAACTCCGTTTCACCTGCTTC
TGCAGGAAAGAGGAAAACTGAGCCATCTGCCTGGAGTCAAGACACTGGAGATGCTAATACAAATGGAAAAGACTGGGGAAGGAGTTGGAG
TGACCGTTCAATATTTTCTGGCATTGGGTCTACTGCTGAGCCAGTTTCTCAGTCTACCACTTCTGATTATCAGTGGGATGTTAGCCGTAA
TCAACCCTATATCGATGATGAATGGTCTGGGTTAAATGGTCTGTCTTCTGCTGATCCCAACTCTGATTGGAATGCACCAGCAGAAGAGTG
GGGCAATTGGGTAGACGAAGAAAGAGCTTCACTTCTAAAGTCCCAGGAACCAATTCCTGATGATCAAAAGGTCTCAGATGATGATAAAGA
AAAGGGAGAGGGAGCTCTTCCAACTGGGAAATCCAAAAAGAAAAAAAAGAAAAAGAAGAAGCAAGGTGAAGATAACTCTACTGCACAGGA
CACAGAAGAATTAGAAAAAGAGATTAGAGAAGACCTTCCAGTGAATACCTCTAAAACCCGTCCAAAACAGGAAAAAGCTTTTTCCTTGAA
GACCATAAGCACTAGTGATCCAGCCGAAGTACTCGTCAAAAATAGCCAGCCTATCAAGACTCTTCCACCTGCTACTTCTACCGAGCCATC
TGTAATCTTATCAAAAAGTGATTCTGACAAGAGCTCTTCCCAAGTGCCGCCAATACTACAAGAGACAGATAAATCCAAGTCAAATACCAA
GCAAAATAGTGTGCCTCCTTCACAGAGAAGTGGTTACCTGGAAGGAAAGGAGCTGCAGAACTTGATCCAGGAGCTCCAGCAGGCGCGAAA
GAAGGCTGGATTGGAGTTATCACCTGAAATGAAAACTTTTGTGGATCAGTATGGGCAAAGAGATGATGGAAAAATAGGAATTGTAGAGTT
GGCTCACGTATTACCCACAGAAGAGAATTTCCTGCTGCTCTTCCGATGCCAGCAGCTGAAGTCCTGTGAGGAATTCATGAAGACATGGAG
AAAATATGATACTGACCACAGTGGCTTCATAGAAACTGAGGAGCTTAAGAACTTTCTAAAGGACCTGCTAGAAAAAGCAAACAAGACTGT
TGATGACACAAAATTAGCCGAGTATACAGACCTAATGCTGAAACTATTTGATTCAAATAATGATGGGAAGCTGGAATTAACTGAGATGGC
CAGGTTACTACCAGTGCAGGAGAATTTTCTTCTTAAATTCCAGGGAATCAAAATGTGTGGGAAAGAGTTCAATAAGGCTTTTGAGCTGTA
TGATCAGGACGGCAATGGATACATAGATGAAAATGAACTGGATGCTTTACTGAAGGATCTGTGCGAGAAGAATAAACAGGATCTGGATAT
TAATAATATTACAACATACAAGAAGAACATAATGGCTTTGTCGGATGGAGGGAAGCTGTACCGAACGGATCTTGCTCTTATTCTCTGTGC
TGGGGATAACTAGAGTTGGTGGCCGCAACCACTTGCTAGTGATACACTGTATCTAAAAAATAACTGTGCACTATAAGGGAGTAGGCTGTA
TTTTCTTTTATATCTGTAAATTTAACTGCATATAGATAATTATCCAGGATGTGTGGCTCATTCTTTTCAGCTTGTTTCTATACTGTTTGT
AATATACAGTTTTTGTAACCATATGATTGAAAAGAAGAAAGTCTATGCTTAGGCCAGTCAGTACACCCAATTTTAAAAAATAACATATTC
TTGCTTTCACAAATATAGTTGAACAAGATTTCCCTAAAAATTCCACCAGGATTAATCTCTAAAATTCTAGTCTCTGATTTGCAAATGCAC
ATTTGTCACTGAATAATGGAATTATGTATAACAAGCCAAACATTCTTATTTTAGACAACCATAGAACTGTCCCACAAAATATTTCTAAGC
TTATTTCTAACTATTAGGAGGAATGTGCTTTTCCATCTAAAATACTCACCAAAATATAGTTAATTGTGGCTTTATGAAGTTAACAGTCTC
ATTACAGATTTAGTTTACCAATCAACAGCATGTCTACTGCTTGGATCCATACAAAACTATCGGTTCAAGTTGATGTGACAAGGGAAGGGA
GCACCAGATGACACATAAATCTGTCTGATTCTATGCCTGTATTTCCAACAAACTTACTGTCAGAGAATATGACCTAAATCCATTTTCTAA
ACTGTTTTCATGTGTTGCAAATTATTCTAGTCAACTGCTGTTTTATGTCATACTCTGTGTAATCTCTGATTAAATTTAATATACTGCATA
TCCTGGTGTCTAGTTTGCATACTTCCTGGATTTTCTTTCTATGTAGAACTGTTCATTTCCACCAAGGGTATCTGCTGCCTCTGAAAATAT
TTTTTTCTAGCTATAACAACTCTATTTTTTACTACATAATTAAATTTTAATGTAAAATTCATAGCATCCTGATTATTGAATGTTATATCA
TCAATACTTTTGTGTATTCTGTGGATTCTATATTTCATATTGAGATCAGCATTCAAAATAGTTCTATTTCTATCTGCAAATAGTTTCAAA
TGAGTTTAAAAAAATAACATCTGAAAAGAAATGCTAATGTAATCATTTATCTTATCTAGCAAGAAGATTCTAAAACATTCTTTAACATAC
ATCTAAGTCAGTTTCACATATTTGTAGCTAGAATATCCTATACTGGTTATAGTTGATATGTAACAGTTGGTGATTTTAGATTTCTTTGAT
TGTGAAACAGGGAGCTATGAGAGATGTGTCCATGTGAAATTTACAGTTACTGCCTAGGAGTTAATGATCGTTCTGGGTCAGCTTGAATGT
CCCCATTCTATAAATTCAACACTTATTTTCTGAATTCATAAAAATAACCAAAAAATGTGAGCTATAATGTTTCCCTCAAGAACAAACAGA
AACGAGATTTGCCAAAAACTAAAATTCAACAAATGATGTTGAGTGGGAGATTGGCTTTGCCTTTAGCGTGTAAATGGAAGCACTGCCATT

>In-frame_MTDH_ENST00000519934_chr8_98735263_+_CALB1_ENST00000265431_chr8_91094330_-_3812nt
GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG
CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG
GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG
GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTT
GAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGTCAAAG
AAAAATAAGAAGAAATCAAAGTCAGATGCTAAAGCAGTGCAAAACAGTTCACGCCATGATGGAAAGGAAGTTGATGAAGGAGCCTGGGAA
ACTAAAATTAGTCACAGAGAGAAACGACAGCAGCGTAAACGTGATAAGGTGCTGACTGATTCTGGTTCATTGGATTCAACTATCCCTGGG
ATAGAAAATACCATCACAGTTACCACCGAGCAACTTACAACCGCATCATTTCCTGTTGGTTCCAAGAAGAATAAAGGTGATTCTCATCTA
AATGTTCAAGTTAGCAACTTTAAATCTGGAAAAGGAGATTCTACACTTCAGGTTTCTTCAGGATTGAATGAAAACCTCACTGTCAATGGA
GGAGGCTGGAATGAAAAGTCTGTAAAACTCTCCTCACAGATCAGTGCAGGTGAGGAGAAGTGGAACTCCGTTTCACCTGCTTCTGCAGGA
AAGAGGAAAACTGAGCCATCTGCCTGGAGTCAAGACACTGGAGATGCTAATACAAATGGAAAAGACTGGGGAAGGAGTTGGAGTGACCGT
TCAATATTTTCTGGCATTGATGGTCTGTCTTCTGCTGATCCCAACTCTGATTGGAATGCACCAGCAGAAGAGTGGGGCAATTGGGTAGAC
GAAGAAAGAGCTTCACTTCTAAAGTCCCAGGAACCAATTCCTGATGATCAAAAGGTCTCAGATGATGATAAAGAAAAGGGAGAGGGAGCT
CTTCCAACTGGGAAATCCAAAAAGAAAAAAAAGAAAAAGAAGAAGCAAGGTGAAGATAACTCTACTGCACAGGACACAGAAGAATTAGAA
AAAGAGATTAGAGAAGACCTTCCAGTGAATACCTCTAAAACCCGTCCAAAACAGGAAAAAGCTTTTTCCTTGAAGACCATAAGCACTAGT
GATCCAGCCGAAGTACTCGTCAAAAATAGCCAGCCTATCAAGACTCTTCCACCTGCTACTTCTACCGAGCCATCTGTAATCTTATCAAAA
AGTGATTCTGACAAGAGCTCTTCCCAAGTGCCGCCAATACTACAAGAGACAGATAAATCCAAGTCAAATACCAAGCAAAATAGTGTGCCT
CCTTCACAGAGAAGTGGTTACCTGGAAGGAAAGGAGCTGCAGAACTTGATCCAGGAGCTCCAGCAGGCGCGAAAGAAGGCTGGATTGGAG
TTATCACCTGAAATGAAAACTTTTGTGGATCAGTATGGGCAAAGAGATGATGGAAAAATAGGAATTGTAGAGTTGGCTCACGTATTACCC
ACAGAAGAGAATTTCCTGCTGCTCTTCCGATGCCAGCAGCTGAAGTCCTGTGAGGAATTCATGAAGACATGGAGAAAATATGATACTGAC
CACAGTGGCTTCATAGAAACTGAGGAGCTTAAGAACTTTCTAAAGGACCTGCTAGAAAAAGCAAACAAGACTGTTGATGACACAAAATTA
GCCGAGTATACAGACCTAATGCTGAAACTATTTGATTCAAATAATGATGGGAAGCTGGAATTAACTGAGATGGCCAGGTTACTACCAGTG
CAGGAGAATTTTCTTCTTAAATTCCAGGGAATCAAAATGTGTGGGAAAGAGTTCAATAAGGCTTTTGAGCTGTATGATCAGGACGGCAAT
GGATACATAGATGAAAATGAACTGGATGCTTTACTGAAGGATCTGTGCGAGAAGAATAAACAGGATCTGGATATTAATAATATTACAACA
TACAAGAAGAACATAATGGCTTTGTCGGATGGAGGGAAGCTGTACCGAACGGATCTTGCTCTTATTCTCTGTGCTGGGGATAACTAGAGT
TGGTGGCCGCAACCACTTGCTAGTGATACACTGTATCTAAAAAATAACTGTGCACTATAAGGGAGTAGGCTGTATTTTCTTTTATATCTG
TAAATTTAACTGCATATAGATAATTATCCAGGATGTGTGGCTCATTCTTTTCAGCTTGTTTCTATACTGTTTGTAATATACAGTTTTTGT
AACCATATGATTGAAAAGAAGAAAGTCTATGCTTAGGCCAGTCAGTACACCCAATTTTAAAAAATAACATATTCTTGCTTTCACAAATAT
AGTTGAACAAGATTTCCCTAAAAATTCCACCAGGATTAATCTCTAAAATTCTAGTCTCTGATTTGCAAATGCACATTTGTCACTGAATAA
TGGAATTATGTATAACAAGCCAAACATTCTTATTTTAGACAACCATAGAACTGTCCCACAAAATATTTCTAAGCTTATTTCTAACTATTA
GGAGGAATGTGCTTTTCCATCTAAAATACTCACCAAAATATAGTTAATTGTGGCTTTATGAAGTTAACAGTCTCATTACAGATTTAGTTT
ACCAATCAACAGCATGTCTACTGCTTGGATCCATACAAAACTATCGGTTCAAGTTGATGTGACAAGGGAAGGGAGCACCAGATGACACAT
AAATCTGTCTGATTCTATGCCTGTATTTCCAACAAACTTACTGTCAGAGAATATGACCTAAATCCATTTTCTAAACTGTTTTCATGTGTT
GCAAATTATTCTAGTCAACTGCTGTTTTATGTCATACTCTGTGTAATCTCTGATTAAATTTAATATACTGCATATCCTGGTGTCTAGTTT
GCATACTTCCTGGATTTTCTTTCTATGTAGAACTGTTCATTTCCACCAAGGGTATCTGCTGCCTCTGAAAATATTTTTTTCTAGCTATAA
CAACTCTATTTTTTACTACATAATTAAATTTTAATGTAAAATTCATAGCATCCTGATTATTGAATGTTATATCATCAATACTTTTGTGTA
TTCTGTGGATTCTATATTTCATATTGAGATCAGCATTCAAAATAGTTCTATTTCTATCTGCAAATAGTTTCAAATGAGTTTAAAAAAATA
ACATCTGAAAAGAAATGCTAATGTAATCATTTATCTTATCTAGCAAGAAGATTCTAAAACATTCTTTAACATACATCTAAGTCAGTTTCA
CATATTTGTAGCTAGAATATCCTATACTGGTTATAGTTGATATGTAACAGTTGGTGATTTTAGATTTCTTTGATTGTGAAACAGGGAGCT
ATGAGAGATGTGTCCATGTGAAATTTACAGTTACTGCCTAGGAGTTAATGATCGTTCTGGGTCAGCTTGAATGTCCCCATTCTATAAATT
CAACACTTATTTTCTGAATTCATAAAAATAACCAAAAAATGTGAGCTATAATGTTTCCCTCAAGAACAAACAGAAACGAGATTTGCCAAA
AACTAAAATTCAACAAATGATGTTGAGTGGGAGATTGGCTTTGCCTTTAGCGTGTAAATGGAAGCACTGCCATTAGACTGAATTTAACTA


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FusionGenePPI for MTDH_CALB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTDHOTUD6B, MME, CUL3, ZBTB16, PLEC, ESR1, RELA, CREBBP, CSNK2A1, LMNA, TARDBP, TOPORS, CCDC8, RNF2, SIRT2, NR2E1, ACTL6A, NTRK1, TMEM237, TMEM216, EXOSC4, BTRC, SNN, SND1, MTUS2, ZYG11B, JUN, EP300CALB1RANBP9, IMPA1, IKBKG, CACNA1D, IQCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+111272_169559583BCCIP
HgeneMTDHchr8:98735263chr8:91094330ENST00000336273+1112101_205559583RELA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCALB1chr8:98735263chr8:91094330ENST00000265431-0112_726262RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTDH_CALB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTDH_CALB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTDHC0027627Neoplasm Metastasis1CTD_human
HgeneMTDHC1458155Mammary Neoplasms1CTD_human
TgeneCALB1C0005586Bipolar Disorder2PSYGENET
TgeneCALB1C0022658Kidney Diseases2CTD_human
TgeneCALB1C0036341Schizophrenia2PSYGENET