FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22723

FusionGeneSummary for MTCH2_FHIT

check button Fusion gene summary
Fusion gene informationFusion gene name: MTCH2_FHIT
Fusion gene ID: 22723
HgeneTgene
Gene symbol

MTCH2

FHIT

Gene ID

23788

2272

Gene namemitochondrial carrier 2fragile histidine triad
SynonymsHSPC032|MIMP|SLC25A50AP3Aase|FRA3B
Cytomap

11p11.2

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial carrier homolog 22310034D24Rikmet-induced mitochondrial proteinsolute carrier family 25, member 50bis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase
Modification date2018052320180519
UniProtAcc

Q9Y6C9

P49789

Ensembl transtripts involved in fusion geneENST00000302503, ENST00000542981, 
ENST00000534074, 
ENST00000476844, 
ENST00000492590, ENST00000466788, 
ENST00000468189, ENST00000341848, 
Fusion gene scores* DoF score6 X 4 X 4=9617 X 7 X 10=1190
# samples 620
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/1190*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTCH2 [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFHIT

GO:0006163

purine nucleotide metabolic process

9323207


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-23-2077-01AMTCH2chr11

47660251

-FHITchr3

59738047

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000302503ENST00000476844MTCH2chr11

47660251

-FHITchr3

59738047

-
In-frameENST00000302503ENST00000492590MTCH2chr11

47660251

-FHITchr3

59738047

-
5CDS-5UTRENST00000302503ENST00000466788MTCH2chr11

47660251

-FHITchr3

59738047

-
5CDS-5UTRENST00000302503ENST00000468189MTCH2chr11

47660251

-FHITchr3

59738047

-
5CDS-5UTRENST00000302503ENST00000341848MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-3CDSENST00000542981ENST00000476844MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-3CDSENST00000542981ENST00000492590MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-5UTRENST00000542981ENST00000466788MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-5UTRENST00000542981ENST00000468189MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-5UTRENST00000542981ENST00000341848MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-3CDSENST00000534074ENST00000476844MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-3CDSENST00000534074ENST00000492590MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-5UTRENST00000534074ENST00000466788MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-5UTRENST00000534074ENST00000468189MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-5UTRENST00000534074ENST00000341848MTCH2chr11

47660251

-FHITchr3

59738047

-

Top

FusionProtFeatures for MTCH2_FHIT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTCH2

Q9Y6C9

FHIT

P49789

The substrate transported is not yet known. Inducesmitochondrial depolarization. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A)to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activitywith ATP. Modulates transcriptional activation by CTNNB1 andthereby contributes to regulate the expression of genes essentialfor cell proliferation and survival, such as CCND1 and BIRC5.Plays a role in the induction of apoptosis via SRC and AKT1signaling pathways. Inhibits MDM2-mediated proteasomal degradationof p53/TP53 and thereby plays a role in p53/TP53-mediatedapoptosis. Induction of apoptosis depends on the ability of FHITto bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or relatedcompounds, but does not require its catalytic activity, it may inpart come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calciumuptake. Functions as tumor suppressor.{ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915,ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326,ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:8794732,ECO:0000269|PubMed:9323207}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-3138_2893304TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-313118_20693304RepeatNote=Solcar 2
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-3132_9893304RepeatNote=Solcar 1
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-313175_19593304TransmembraneHelical
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-313224_24493304TransmembraneHelical
TgeneFHITchr11:47660251chr3:59738047ENST00000341848-352_109116148DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST00000468189-792_109116148DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST00000476844-7102_109116214DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST00000492590-7102_109116205DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST00000341848-3594_98116148MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST00000468189-7994_98116148MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST00000476844-71094_98116214MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST00000492590-71094_98116205MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST00000341848-3589_92116148Nucleotide bindingSubstrate
TgeneFHITchr11:47660251chr3:59738047ENST00000468189-7989_92116148Nucleotide bindingSubstrate
TgeneFHITchr11:47660251chr3:59738047ENST00000476844-71089_92116214Nucleotide bindingSubstrate
TgeneFHITchr11:47660251chr3:59738047ENST00000492590-71089_92116205Nucleotide bindingSubstrate


Top

FusionGeneSequence for MTCH2_FHIT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MTCH2_ENST00000302503_chr11_47660251_-_FHIT_ENST00000476844_chr3_59738047_-_125aa
MADAASQVLLGSGLTILSQPLMYVKVLIQVGTEPLPPTIGRNIFGRQVCQLPGLFSTAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGK

>In-frame_MTCH2_ENST00000302503_chr11_47660251_-_FHIT_ENST00000492590_chr3_59738047_-_125aa
MADAASQVLLGSGLTILSQPLMYVKVLIQVGTEPLPPTIGRNIFGRQVCQLPGLFSTAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MTCH2_ENST00000302503_chr11_47660251_-_FHIT_ENST00000476844_chr3_59738047_-_375nt
ATGGCGGACGCGGCCAGTCAGGTGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTG
GGATATGAGCCTCTTCCTCCAACAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGTCTCTTTAGTTATGCTCAGCAC
ATTGCCAGTATCGATGGGAGGCGCGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAA
GTTTTACAGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGG

>In-frame_MTCH2_ENST00000302503_chr11_47660251_-_FHIT_ENST00000492590_chr3_59738047_-_375nt
ATGGCGGACGCGGCCAGTCAGGTGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTG
GGATATGAGCCTCTTCCTCCAACAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGTCTCTTTAGTTATGCTCAGCAC
ATTGCCAGTATCGATGGGAGGCGCGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAA
GTTTTACAGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MTCH2_ENST00000302503_chr11_47660251_-_FHIT_ENST00000476844_chr3_59738047_-_797nt
GGGGCGGGGACTGGGCGGAGAGGCGCGTGCTGCTGCGTGCGTGCGCGCGCGCCGCGGGCGGGCCAGTGAAACCGGCGGCCCTGGCACGTG
ACCTAGGACCGGCTCACCGGGTCGCTTGGTGGCTCCGTCTGTCTGTCCGTCCGCCCGCGGGTGCCATCATGGCGGACGCGGCCAGTCAGG
TGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTGGGATATGAGCCTCTTCCTCCAA
CAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGTCTCTTTAGTTATGCTCAGCACATTGCCAGTATCGATGGGAGGC
GCGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAAGTTTTACAGCTCCAGAAACATG
ACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGAT
CCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCA
GTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGC

>In-frame_MTCH2_ENST00000302503_chr11_47660251_-_FHIT_ENST00000492590_chr3_59738047_-_808nt
GGGGCGGGGACTGGGCGGAGAGGCGCGTGCTGCTGCGTGCGTGCGCGCGCGCCGCGGGCGGGCCAGTGAAACCGGCGGCCCTGGCACGTG
ACCTAGGACCGGCTCACCGGGTCGCTTGGTGGCTCCGTCTGTCTGTCCGTCCGCCCGCGGGTGCCATCATGGCGGACGCGGCCAGTCAGG
TGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTGGGATATGAGCCTCTTCCTCCAA
CAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGTCTCTTTAGTTATGCTCAGCACATTGCCAGTATCGATGGGAGGC
GCGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAAGTTTTACAGCTCCAGAAACATG
ACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGAT
GTTTTTCAGATCCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGC
ATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAG


Top

FusionGenePPI for MTCH2_FHIT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MTCH2UBC, ESR1, HNRNPU, FMNL1, XRN1, FBXO6, RNF2, RIC3, HCCS, CACNG2, SUCNR1, LYPD3, PLIN3, WNT4, SLC38A6, FAM219B, NTRK1, ALDH3A2, ATP1A1, ATP2A2, ATP5C1, ATP6V0D1, CLTC, GNAI2, MRPL37, ATP1B1, ATP1B3, ATP5A1, ATP5B, ATP5F1, ATP5L, ATP5O, LMAN1, NDUFB5, SLC25A3, TOMM40, NDUFA12, NDUFA2, NDUFA6, NDUFB8, NDUFB9, NDUFS1, NDUFS2, NDUFS3, PHB, PHB2, RAB1A, RPN1, SDHB, SDHC, SGPL1, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, OFD1, MCM2, UBXN8, COQ9, NDUFA4, CHCHD10, C15orf48, OCIAD1, PTPMT1, OPA3, ADCK1, APOOL, GLP1R, DUSP21, DUSP22, DUSP23, DUSP4, SLC7A1, IMPDH1, CD97, CD44, PVR, TMEM206, VAC14, SPPL2B, BCAM, SLC1A5, PTPN5, PDHA1FHITFHIT, UBE2I, CTNNB1, LEF1, TRIM23, RAB40B, MDM2, REL, TP53, ARHGAP19, MTMR6, RABL2A, CHEK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MTCH2_FHIT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFHITP49789DB04173FructoseBis(5'-adenosyl)-triphosphatasesmall moleculeapproved|experimental

Top

RelatedDiseases for MTCH2_FHIT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTCH2C0028754Obesity1CTD_human
TgeneFHITC0024121Lung Neoplasms2CTD_human
TgeneFHITC0025500Mesothelioma2CTD_human
TgeneFHITC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneFHITC0023903Liver neoplasms1CTD_human
TgeneFHITC0033578Prostatic Neoplasms1CTD_human
TgeneFHITC0036341Schizophrenia1PSYGENET
TgeneFHITC0038356Stomach Neoplasms1CTD_human
TgeneFHITC0042076Urologic Neoplasms1CTD_human
TgeneFHITC0236733Amphetamine-Related Disorders1CTD_human
TgeneFHITC0236969Substance-Related Disorders1CTD_human