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Fusion gene ID: 22711 |
FusionGeneSummary for MTAP_EEF1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTAP_EEF1A2 | Fusion gene ID: 22711 | Hgene | Tgene | Gene symbol | MTAP | EEF1A2 | Gene ID | 4507 | 1917 |
| Gene name | methylthioadenosine phosphorylase | eukaryotic translation elongation factor 1 alpha 2 | |
| Synonyms | BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus | EEF1AL|EF-1-alpha-2|EF1A|EIEE33|HS1|MRD38|STN|STNL | |
| Cytomap | 9p21.3 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249 | elongation factor 1-alpha 2eukaryotic elongation factor 1 A-2statin-S1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13126 | Q05639 | |
| Ensembl transtripts involved in fusion gene | ENST00000580900, ENST00000380172, ENST00000460874, ENST00000427788, | ENST00000298049, ENST00000217182, | |
| Fusion gene scores | * DoF score | 7 X 6 X 7=294 | 3 X 3 X 3=27 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MTAP [Title/Abstract] AND EEF1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTAP | GO:0006738 | nicotinamide riboside catabolic process | 19001417 |
| Tgene | EEF1A2 | GO:0090218 | positive regulation of lipid kinase activity | 17088255 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-63-A5MM-01A | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000580900 | ENST00000298049 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| In-frame | ENST00000580900 | ENST00000217182 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| In-frame | ENST00000380172 | ENST00000298049 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| In-frame | ENST00000380172 | ENST00000217182 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| 5UTR-3CDS | ENST00000460874 | ENST00000298049 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| 5UTR-3CDS | ENST00000460874 | ENST00000217182 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| intron-3CDS | ENST00000427788 | ENST00000298049 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
| intron-3CDS | ENST00000427788 | ENST00000217182 | MTAP | chr9 | 21802780 | + | EEF1A2 | chr20 | 62127388 | - |
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FusionProtFeatures for MTAP_EEF1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTAP | EEF1A2 |
| This protein promotes the GTP-dependent binding ofaminoacyl-tRNA to the A-site of ribosomes during proteinbiosynthesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 91_95 | 48 | 464 | Nucleotide binding | GTP |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 91_95 | 48 | 464 | Nucleotide binding | GTP |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 153_156 | 48 | 464 | Region | G4 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 194_196 | 48 | 464 | Region | G5 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 70_74 | 48 | 464 | Region | G2 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 91_94 | 48 | 464 | Region | G3 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 153_156 | 48 | 464 | Region | G4 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 194_196 | 48 | 464 | Region | G5 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 70_74 | 48 | 464 | Region | G2 |
| Tgene | >EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 91_94 | 48 | 464 | Region | G3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MTAP | chr9:21802780 | chr20:62127388 | ENST00000380172 | + | 1 | 8 | 220_222 | 11 | 284 | Region | Note=Substrate binding |
| Hgene | >MTAP | chr9:21802780 | chr20:62127388 | ENST00000380172 | + | 1 | 8 | 60_61 | 11 | 284 | Region | Note=Phosphate binding |
| Hgene | >MTAP | chr9:21802780 | chr20:62127388 | ENST00000380172 | + | 1 | 8 | 93_94 | 11 | 284 | Region | Note=Phosphate binding |
| Hgene | >MTAP | chr9:21802780 | chr20:62127388 | ENST00000580900 | + | 1 | 8 | 220_222 | 11 | 335 | Region | Note=Substrate binding |
| Hgene | >MTAP | chr9:21802780 | chr20:62127388 | ENST00000580900 | + | 1 | 8 | 60_61 | 11 | 335 | Region | Note=Phosphate binding |
| Hgene | >MTAP | chr9:21802780 | chr20:62127388 | ENST00000580900 | + | 1 | 8 | 93_94 | 11 | 335 | Region | Note=Phosphate binding |
| Tgene | EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 5_242 | 48 | 464 | Domain | Note=tr-type G |
| Tgene | EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 5_242 | 48 | 464 | Domain | Note=tr-type G |
| Tgene | EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000217182 | - | 1 | 8 | 14_21 | 48 | 464 | Region | G1 |
| Tgene | EEF1A2 | chr9:21802780 | chr20:62127388 | ENST00000298049 | - | 0 | 7 | 14_21 | 48 | 464 | Region | G1 |
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FusionGeneSequence for MTAP_EEF1A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MTAP_ENST00000580900_chr9_21802780_+_EEF1A2_ENST00000298049_chr20_62127388_-_427aa MASGTTTTAVKMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGI SKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVE RKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDN VGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSG >In-frame_MTAP_ENST00000580900_chr9_21802780_+_EEF1A2_ENST00000217182_chr20_62127388_-_427aa MASGTTTTAVKMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGI SKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVE RKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDN VGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSG >In-frame_MTAP_ENST00000380172_chr9_21802780_+_EEF1A2_ENST00000298049_chr20_62127388_-_427aa MASGTTTTAVKMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGI SKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVE RKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDN VGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSG >In-frame_MTAP_ENST00000380172_chr9_21802780_+_EEF1A2_ENST00000217182_chr20_62127388_-_427aa MASGTTTTAVKMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGI SKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVE RKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDN VGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MTAP_ENST00000580900_chr9_21802780_+_EEF1A2_ENST00000298049_chr20_62127388_-_1281nt ATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAAGGCGGAGCGT GAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGGCCACCGCGAC TTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGAGGCGGGCATC TCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAAAATGGACTCC ACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAACCCGGCCACC GTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTGGAAGGTGGAG CGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAAGCCCCTGCGC CTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCCGGGCATGGTG GTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCCCGGCGACAAC GTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCCGCAGGAGGCT GCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCACACAGCCCAC ATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCTGAAGTCTGGA GACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTTCGCCGTGCGC GACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTCGGCGCAGAAG >In-frame_MTAP_ENST00000580900_chr9_21802780_+_EEF1A2_ENST00000217182_chr20_62127388_-_1281nt ATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAAGGCGGAGCGT GAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGGCCACCGCGAC TTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGAGGCGGGCATC TCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAAAATGGACTCC ACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAACCCGGCCACC GTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTGGAAGGTGGAG CGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAAGCCCCTGCGC CTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCCGGGCATGGTG GTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCCCGGCGACAAC GTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCCGCAGGAGGCT GCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCACACAGCCCAC ATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCTGAAGTCTGGA GACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTTCGCCGTGCGC GACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTCGGCGCAGAAG >In-frame_MTAP_ENST00000380172_chr9_21802780_+_EEF1A2_ENST00000298049_chr20_62127388_-_1281nt ATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAAGGCGGAGCGT GAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGGCCACCGCGAC TTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGAGGCGGGCATC TCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAAAATGGACTCC ACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAACCCGGCCACC GTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTGGAAGGTGGAG CGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAAGCCCCTGCGC CTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCCGGGCATGGTG GTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCCCGGCGACAAC GTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCCGCAGGAGGCT GCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCACACAGCCCAC ATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCTGAAGTCTGGA GACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTTCGCCGTGCGC GACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTCGGCGCAGAAG >In-frame_MTAP_ENST00000380172_chr9_21802780_+_EEF1A2_ENST00000217182_chr20_62127388_-_1281nt ATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAAGGCGGAGCGT GAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGGCCACCGCGAC TTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGAGGCGGGCATC TCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAAAATGGACTCC ACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAACCCGGCCACC GTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTGGAAGGTGGAG CGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAAGCCCCTGCGC CTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCCGGGCATGGTG GTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCCCGGCGACAAC GTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCCGCAGGAGGCT GCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCACACAGCCCAC ATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCTGAAGTCTGGA GACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTTCGCCGTGCGC GACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTCGGCGCAGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MTAP_ENST00000580900_chr9_21802780_+_EEF1A2_ENST00000298049_chr20_62127388_-_1666nt ACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCCACTGCAGATTCCTTTC CCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAA GGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGG CCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGA GGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAA AATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAA CCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTG GAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAA GCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCC GGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCC CGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCC GCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCA CACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCT GAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTT CGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTC GGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCGCTCCGAACCCCGGGCCC GGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCTCCGCTTGCCAGAGGCCC TCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAGGCTTCCGCGCCCAGCGC >In-frame_MTAP_ENST00000580900_chr9_21802780_+_EEF1A2_ENST00000217182_chr20_62127388_-_1666nt ACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCCACTGCAGATTCCTTTC CCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAA GGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGG CCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGA GGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAA AATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAA CCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTG GAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAA GCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCC GGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCC CGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCC GCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCA CACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCT GAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTT CGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTC GGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCGCTCCGAACCCCGGGCCC GGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCTCCGCTTGCCAGAGGCCC TCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAGGCTTCCGCGCCCAGCGC >In-frame_MTAP_ENST00000380172_chr9_21802780_+_EEF1A2_ENST00000298049_chr20_62127388_-_1772nt GATTTGGGGAAGGGGTGGCGGGGGAGATCCCACACAAGCAGCCAATCCAGCTGTCCCGGGGAGGAAGAGGAGGAGTCAAGGCCCGCCCCT GGTCTCCGCACTGCTCACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCC ACTGCAGATTCCTTTCCCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGG TGCTGGACAAGCTGAAGGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCA TCATCGATGCCCCCGGCCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGG GCGTGGGCGAGTTCGAGGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCA TCGTGGGCGTGAACAAAATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCA AGAAGATCGGCTACAACCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGC CGTGGTTCAAGGGCTGGAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCA CGCGCCCCACGGACAAGCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGA CCGGCATCCTGCGGCCGGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTC TGAGCGAAGCTCTGCCCGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACA GCAAGTCTGACCCGCCGCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCC CGGTCATCGACTGCCACACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGG ACAACCCCAAGTCCCTGAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACC CGCCTCTCGGCCGCTTCGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCG GCAAGGTCACCAAGTCGGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCGC TCCGAACCCCGGGCCCGGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCTC CGCTTGCCAGAGGCCCTCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAGG >In-frame_MTAP_ENST00000380172_chr9_21802780_+_EEF1A2_ENST00000217182_chr20_62127388_-_1772nt GATTTGGGGAAGGGGTGGCGGGGGAGATCCCACACAAGCAGCCAATCCAGCTGTCCCGGGGAGGAAGAGGAGGAGTCAAGGCCCGCCCCT GGTCTCCGCACTGCTCACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCC ACTGCAGATTCCTTTCCCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATGGGGAAGGGATCCTTCAAGTATGCCTGGG TGCTGGACAAGCTGAAGGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCA TCATCGATGCCCCCGGCCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGG GCGTGGGCGAGTTCGAGGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCA TCGTGGGCGTGAACAAAATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCA AGAAGATCGGCTACAACCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGC CGTGGTTCAAGGGCTGGAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCA CGCGCCCCACGGACAAGCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGA CCGGCATCCTGCGGCCGGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTC TGAGCGAAGCTCTGCCCGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACA GCAAGTCTGACCCGCCGCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCC CGGTCATCGACTGCCACACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGG ACAACCCCAAGTCCCTGAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACC CGCCTCTCGGCCGCTTCGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCG GCAAGGTCACCAAGTCGGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCGC TCCGAACCCCGGGCCCGGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCTC CGCTTGCCAGAGGCCCTCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAGG |
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FusionGenePPI for MTAP_EEF1A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MTAP | ELAVL1, FOLH1, CDC25A, RELB, LYRM1, ANXA6, ATP6V1A, CUTA, CFL1, GOT1, UBE2H, CHRAC1, GMPS, HPRT1, PNP, UROD, MTPN, PDIA3, RAB1A, FUS, CENPH, ARF4, ASS1, CARKD, CSE1L, EIF2B1, FAM49B, GLRX, GNPDA2, HINT1, LYPLA2, CNN2, DAZAP1, PCMT1, PPIL3, RBM12, SNX12, SNX3, SUMO3, SUMO4, TAGLN2, TAGLN3, TALDO1, UBE2D2, UFM1, CEP170, SCLT1, MCM2, TRIM25 | EEF1A2 | VARS, EEF1D, EEF1B2, MGMT, SRRM2, PTEN, MAPK6, ARRB1, ARRB2, TCF3, ISG15, FBXO25, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, UBXN6, TTLL12, YWHAE, BTK, CD81, IGSF8, CDK3, PARK2, AHCY, SHFM1, RPA3, RPA2, RPA1, ERG, TRIM25, LGR4, UBC, AURKA, CEP57, HAUS2, CEP76, TUBG1, VCP, ABTB1, PBDC1, NXPH2, NUFIP1, DGUOK, C4orf19, HEXIM1, HOMER1, TMEM25, WDR53, DCP2, DDHD2, GJA1, RNF26, EEF1G, FAM177A1, PLK2, CDK7, ACTB, ACTG1, POLR1A, EEF2, EFTUD2, GMPPB, GORASP2, PABPC1, PABPC3, PKLR, PKM, POLR2A, PSMD1, RPL12, RPL30, RPL4, RPSA, STK11, ID2, CRY2, MCM2, MCM5, ESRRB, CDC37, CDC73, DPF3, WWP2, EEF1A1, N6AMT2, CARS, PSG1, IL36A, FGB, SNRNP27, PITHD1, RAB1A, GTF2E2, CTAGE5, ZNF490, GYPA, LRRC56, MLLT6, FUOM, CKS1B, TPT1, NCSTN, HSPB8, GJB7, SLC38A7, SLC13A5, SREK1IP1, TBXAS1, BTNL3, RPS11, PPIAL4G, DHX57, ST6GALNAC1, USP47, TLE3, DBF4, FLT4, CYLD, MTF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTAP_EEF1A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTAP_EEF1A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MTAP | C0025202 | melanoma | 1 | CTD_human |
| Hgene | MTAP | C0027960 | Nevus | 1 | CTD_human |
| Hgene | MTAP | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | EEF1A2 | C4225337 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 33 | 2 | UNIPROT |
| Tgene | EEF1A2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | EEF1A2 | C4225343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 38 | 1 | UNIPROT |
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