	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 22709

FusionGeneSummary for MTA3_SEC31A

Fusion gene summary

Fusion gene information	Fusion gene name: MTA3_SEC31A
	Fusion gene ID: 22709
		Hgene	Tgene
	Gene symbol	MTA3	SEC31A
	Gene ID	57504	22872
	Gene name	metastasis associated 1 family member 3	SEC31 homolog A, COPII coat complex component
	Synonyms	-	ABP125\|ABP130\|HSPC275\|HSPC334\|SEC31L1
	Cytomap	2p21	4q21.22
	Type of gene	protein-coding	protein-coding
	Description	metastasis-associated protein MTA3metastasis associated gene family, member 3	protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
	Modification date	20180523	20180523
	UniProtAcc	Q9BTC8	O94979
	Ensembl transtripts involved in fusion gene	ENST00000405592, ENST00000406652, ENST00000407270, ENST00000406911, ENST00000405094, ENST00000472767,	ENST00000348405, ENST00000513858, ENST00000395310, ENST00000443462, ENST00000509142, ENST00000326950, ENST00000432794, ENST00000311785, ENST00000448323, ENST00000505472, ENST00000500777, ENST00000508502, ENST00000355196, ENST00000264405, ENST00000505984, ENST00000508479, ENST00000436790,
Fusion gene scores	* DoF score	3 X 3 X 2=18	8 X 8 X 4=256
	# samples	3	9
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(9/256*10)=-1.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTA3 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SEC31A	GO:0051592	response to calcium ion	17196169
Tgene	SEC31A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CA419101	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000405592	ENST00000348405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000513858	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000395310	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000443462	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000509142	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000326950	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000432794	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000311785	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000448323	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000505472	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000500777	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000508502	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000355196	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000264405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000505984	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000508479	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405592	ENST00000436790	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000348405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000513858	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000395310	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000443462	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000509142	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000326950	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000432794	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000311785	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000448323	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000505472	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000500777	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000508502	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000355196	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000264405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000505984	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000508479	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406652	ENST00000436790	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000348405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000513858	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000395310	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000443462	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000509142	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000326950	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000432794	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000311785	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000448323	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000505472	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000500777	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000508502	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000355196	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000264405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000505984	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000508479	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000407270	ENST00000436790	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000348405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000513858	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000395310	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000443462	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000509142	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000326950	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000432794	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000311785	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000448323	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000505472	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000500777	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000508502	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000355196	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000264405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000505984	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000508479	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000406911	ENST00000436790	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000348405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000513858	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000395310	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000443462	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000509142	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000326950	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000432794	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000311785	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000448323	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000505472	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000500777	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000508502	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000355196	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000264405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000505984	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000508479	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000405094	ENST00000436790	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000348405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000513858	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000395310	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000443462	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000509142	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000326950	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000432794	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000311785	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000448323	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000505472	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000500777	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000508502	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000355196	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000264405	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000505984	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000508479	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+
intron-intron	ENST00000472767	ENST00000436790	MTA3	chr2	42731318	-	SEC31A	chr4	83768137	+

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FusionProtFeatures for MTA3_SEC31A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTA3 Q9BTC8	SEC31A O94979
Plays a role in maintenance of the normal epithelialarchitecture through the repression of SNAI1 transcription in ahistone deacetylase-dependent manner, and thus the regulation ofE-cadherin levels. Contributes to transcriptional repression byBCL6. {ECO:0000269\|PubMed:12705869, ECO:0000269\|PubMed:15454082}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MTA3_SEC31A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTA3_SEC31A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MTA3_SEC31A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MTA3_SEC31A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SEC31A	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human

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Fusion gene ID: 22709

FusionGeneSummary for MTA3_SEC31A

FusionProtFeatures for MTA3_SEC31A

FusionGeneSequence for MTA3_SEC31A

FusionGenePPI for MTA3_SEC31A

RelatedDrugs for MTA3_SEC31A

RelatedDiseases for MTA3_SEC31A