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Fusion gene ID: 22704 |
FusionGeneSummary for MTA2_PTMA |
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Fusion gene information | Fusion gene name: MTA2_PTMA | Fusion gene ID: 22704 | Hgene | Tgene | Gene symbol | MTA2 | PTMA | Gene ID | 9219 | 5757 |
Gene name | metastasis associated 1 family member 2 | prothymosin alpha | |
Synonyms | MTA1L1|PID | TMSA | |
Cytomap | 11q12.3 | 2q37.1 | |
Type of gene | protein-coding | protein-coding | |
Description | metastasis-associated protein MTA2MTA1-L1 proteinmetastasis -associated gene 1-like 1metastasis associated gene family, member 2metastasis-associated 1-like 1metastasis-associated protein 2p53 target protein in deacetylase complex | prothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/- | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O94776 | P06454 | |
Ensembl transtripts involved in fusion gene | ENST00000278823, ENST00000524902, ENST00000527204, | ENST00000466801, ENST00000409321, ENST00000409115, ENST00000341369, ENST00000409683, ENST00000410064, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 17 X 17 X 2=578 |
# samples | 6 | 18 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/578*10)=-1.683072586171 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MTA2 [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF541543 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000278823 | ENST00000466801 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000278823 | ENST00000409321 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000278823 | ENST00000409115 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000278823 | ENST00000341369 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000278823 | ENST00000409683 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000278823 | ENST00000410064 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000524902 | ENST00000466801 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000524902 | ENST00000409321 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000524902 | ENST00000409115 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000524902 | ENST00000341369 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000524902 | ENST00000409683 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000524902 | ENST00000410064 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000527204 | ENST00000466801 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000527204 | ENST00000409321 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000527204 | ENST00000409115 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000527204 | ENST00000341369 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000527204 | ENST00000409683 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
intron-3UTR | ENST00000527204 | ENST00000410064 | MTA2 | chr11 | 62361236 | - | PTMA | chr2 | 232576100 | + |
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FusionProtFeatures for MTA2_PTMA |
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Hgene | Tgene |
MTA2 | PTMA |
May be involved in the regulation of gene expression asrepressor and activator. The repression might be related tocovalent modification of histone proteins. | Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MTA2_PTMA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MTA2_PTMA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MTA2_PTMA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTA2_PTMA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MTA2 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | PTMA | C0001430 | Adenoma | 1 | CTD_human |
Tgene | PTMA | C0015695 | Fatty Liver | 1 | CTD_human |
Tgene | PTMA | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | PTMA | C0035412 | Rhabdomyosarcoma | 1 | CTD_human |