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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22704

FusionGeneSummary for MTA2_PTMA

check button Fusion gene summary
Fusion gene informationFusion gene name: MTA2_PTMA
Fusion gene ID: 22704
HgeneTgene
Gene symbol

MTA2

PTMA

Gene ID

9219

5757

Gene namemetastasis associated 1 family member 2prothymosin alpha
SynonymsMTA1L1|PIDTMSA
Cytomap

11q12.3

2q37.1

Type of geneprotein-codingprotein-coding
Descriptionmetastasis-associated protein MTA2MTA1-L1 proteinmetastasis -associated gene 1-like 1metastasis associated gene family, member 2metastasis-associated 1-like 1metastasis-associated protein 2p53 target protein in deacetylase complexprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
Modification date2018052320180522
UniProtAcc

O94776

P06454

Ensembl transtripts involved in fusion geneENST00000278823, ENST00000524902, 
ENST00000527204, 
ENST00000466801, 
ENST00000409321, ENST00000409115, 
ENST00000341369, ENST00000409683, 
ENST00000410064, 
Fusion gene scores* DoF score6 X 6 X 4=14417 X 17 X 2=578
# samples 618
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/578*10)=-1.683072586171
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTA2 [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF541543MTA2chr11

62361236

-PTMAchr2

232576100

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000278823ENST00000466801MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000278823ENST00000409321MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000278823ENST00000409115MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000278823ENST00000341369MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000278823ENST00000409683MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000278823ENST00000410064MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000524902ENST00000466801MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000524902ENST00000409321MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000524902ENST00000409115MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000524902ENST00000341369MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000524902ENST00000409683MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000524902ENST00000410064MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000527204ENST00000466801MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000527204ENST00000409321MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000527204ENST00000409115MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000527204ENST00000341369MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000527204ENST00000409683MTA2chr11

62361236

-PTMAchr2

232576100

+
intron-3UTRENST00000527204ENST00000410064MTA2chr11

62361236

-PTMAchr2

232576100

+

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FusionProtFeatures for MTA2_PTMA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTA2

O94776

PTMA

P06454

May be involved in the regulation of gene expression asrepressor and activator. The repression might be related tocovalent modification of histone proteins. Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MTA2_PTMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MTA2_PTMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MTA2_PTMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MTA2_PTMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTA2C0014175Endometriosis1CTD_human
TgenePTMAC0001430Adenoma1CTD_human
TgenePTMAC0015695Fatty Liver1CTD_human
TgenePTMAC0024121Lung Neoplasms1CTD_human
TgenePTMAC0035412Rhabdomyosarcoma1CTD_human