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Fusion gene ID: 22692 |
FusionGeneSummary for MSX1_MSX1 |
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Fusion gene information | Fusion gene name: MSX1_MSX1 | Fusion gene ID: 22692 | Hgene | Tgene | Gene symbol | MSX1 | MSX1 | Gene ID | 4487 | 4487 |
Gene name | msh homeobox 1 | msh homeobox 1 | |
Synonyms | ECTD3|HOX7|HYD1|STHAG1 | ECTD3|HOX7|HYD1|STHAG1 | |
Cytomap | 4p16.2 | 4p16.2 | |
Type of gene | protein-coding | protein-coding | |
Description | homeobox protein MSX-1homeobox 7homeobox protein Hox-7msh homeo box 1msh homeobox 1-like proteinmsh homeobox homolog 1 | homeobox protein MSX-1homeobox 7homeobox protein Hox-7msh homeo box 1msh homeobox 1-like proteinmsh homeobox homolog 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P28360 | P28360 | |
Ensembl transtripts involved in fusion gene | ENST00000382723, ENST00000468421, | ENST00000382723, ENST00000468421, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MSX1 [Title/Abstract] AND MSX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MSX1 | GO:0000902 | cell morphogenesis | 15705871 |
Hgene | MSX1 | GO:0030308 | negative regulation of cell growth | 15705871 |
Hgene | MSX1 | GO:0034504 | protein localization to nucleus | 15705871 |
Hgene | MSX1 | GO:0050821 | protein stabilization | 15705871 |
Hgene | MSX1 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 15705871 |
Tgene | MSX1 | GO:0000902 | cell morphogenesis | 15705871 |
Tgene | MSX1 | GO:0030308 | negative regulation of cell growth | 15705871 |
Tgene | MSX1 | GO:0034504 | protein localization to nucleus | 15705871 |
Tgene | MSX1 | GO:0050821 | protein stabilization | 15705871 |
Tgene | MSX1 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 15705871 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU624994 | MSX1 | chr4 | 4865416 | - | MSX1 | chr4 | 4865033 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000382723 | ENST00000382723 | MSX1 | chr4 | 4865416 | - | MSX1 | chr4 | 4865033 | + |
3UTR-intron | ENST00000382723 | ENST00000468421 | MSX1 | chr4 | 4865416 | - | MSX1 | chr4 | 4865033 | + |
intron-3UTR | ENST00000468421 | ENST00000382723 | MSX1 | chr4 | 4865416 | - | MSX1 | chr4 | 4865033 | + |
intron-intron | ENST00000468421 | ENST00000468421 | MSX1 | chr4 | 4865416 | - | MSX1 | chr4 | 4865033 | + |
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FusionProtFeatures for MSX1_MSX1 |
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Hgene | Tgene |
MSX1 | MSX1 |
Acts as a transcriptional repressor. May play a role inlimb-pattern formation. Acts in cranofacial development andspecifically in odontogenesis. Expression in the developing nailbed mesenchyme is important for nail plate thickness andintegrity. {ECO:0000269|PubMed:11369996,ECO:0000269|PubMed:12807959}. | Acts as a transcriptional repressor. May play a role inlimb-pattern formation. Acts in cranofacial development andspecifically in odontogenesis. Expression in the developing nailbed mesenchyme is important for nail plate thickness andintegrity. {ECO:0000269|PubMed:11369996,ECO:0000269|PubMed:12807959}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSX1_MSX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MSX1_MSX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSX1_MSX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSX1_MSX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MSX1 | C0376634 | Craniofacial Abnormalities | 4 | CTD_human |
Hgene | MSX1 | C0008925 | Cleft Palate | 3 | CTD_human;HPO |
Hgene | MSX1 | C1837210 | OROFACIAL CLEFT 5 | 2 | CTD_human;UNIPROT |
Hgene | MSX1 | C3489529 | Tooth Agenesis, Familial | 2 | UNIPROT |
Hgene | MSX1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | MSX1 | C0040427 | Tooth Abnormalities | 1 | CTD_human |
Hgene | MSX1 | C1956097 | Wolf-Hirschhorn Syndrome | 1 | CTD_human |
Tgene | MSX1 | C0376634 | Craniofacial Abnormalities | 4 | CTD_human |
Tgene | MSX1 | C0008925 | Cleft Palate | 3 | CTD_human;HPO |
Tgene | MSX1 | C1837210 | OROFACIAL CLEFT 5 | 2 | CTD_human;UNIPROT |
Tgene | MSX1 | C3489529 | Tooth Agenesis, Familial | 2 | UNIPROT |
Tgene | MSX1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | MSX1 | C0040427 | Tooth Abnormalities | 1 | CTD_human |
Tgene | MSX1 | C1956097 | Wolf-Hirschhorn Syndrome | 1 | CTD_human |