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Fusion gene ID: 22688 |
FusionGeneSummary for MSS51_LAS1L |
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Fusion gene information | Fusion gene name: MSS51_LAS1L | Fusion gene ID: 22688 | Hgene | Tgene | Gene symbol | MSS51 | LAS1L | Gene ID | 118490 | 81887 |
Gene name | MSS51 mitochondrial translational activator | LAS1 like, ribosome biogenesis factor | |
Synonyms | ZMYND17 | Las1-like|WTS|dJ475B7.2 | |
Cytomap | 10q22.2 | Xq12 | |
Type of gene | protein-coding | protein-coding | |
Description | putative protein MSS51 homolog, mitochondrialMSS51 mitochondrial translational activator homologzinc finger MYND domain-containing protein 17zinc finger, MYND domain containing 17zinc finger, MYND-type containing 17 | ribosomal biogenesis protein LAS1Lprotein LAS1 homolog | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q4VC12 | Q9Y4W2 | |
Ensembl transtripts involved in fusion gene | ENST00000299432, ENST00000372912, | ENST00000374807, ENST00000374811, ENST00000374804, ENST00000312391, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: MSS51 [Title/Abstract] AND LAS1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK129496 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000299432 | ENST00000374807 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000299432 | ENST00000374811 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000299432 | ENST00000374804 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000299432 | ENST00000312391 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000372912 | ENST00000374807 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000372912 | ENST00000374811 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000372912 | ENST00000374804 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
intron-3CDS | ENST00000372912 | ENST00000312391 | MSS51 | chr10 | 75186863 | - | LAS1L | chrX | 64749630 | - |
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FusionProtFeatures for MSS51_LAS1L |
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Hgene | Tgene |
MSS51 | LAS1L |
Involved in the biogenesis of the 60S ribosomal subunit.Required for maturation of the 28S rRNA. Functions as a componentof the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMCcomplex is recruited to ZNF148 by methylated CHTOP, leading todesumoylation of ZNF148 and subsequent transactivation of ZNF148target genes. {ECO:0000269|PubMed:20647540,ECO:0000269|PubMed:22872859}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSS51_LAS1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MSS51_LAS1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSS51_LAS1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSS51_LAS1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MSS51 | C0036341 | Schizophrenia | 1 | PSYGENET |