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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22688

FusionGeneSummary for MSS51_LAS1L

check button Fusion gene summary
Fusion gene informationFusion gene name: MSS51_LAS1L
Fusion gene ID: 22688
HgeneTgene
Gene symbol

MSS51

LAS1L

Gene ID

118490

81887

Gene nameMSS51 mitochondrial translational activatorLAS1 like, ribosome biogenesis factor
SynonymsZMYND17Las1-like|WTS|dJ475B7.2
Cytomap

10q22.2

Xq12

Type of geneprotein-codingprotein-coding
Descriptionputative protein MSS51 homolog, mitochondrialMSS51 mitochondrial translational activator homologzinc finger MYND domain-containing protein 17zinc finger, MYND domain containing 17zinc finger, MYND-type containing 17ribosomal biogenesis protein LAS1Lprotein LAS1 homolog
Modification date2018052220180523
UniProtAcc

Q4VC12

Q9Y4W2

Ensembl transtripts involved in fusion geneENST00000299432, ENST00000372912, 
ENST00000374807, ENST00000374811, 
ENST00000374804, ENST00000312391, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: MSS51 [Title/Abstract] AND LAS1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK129496MSS51chr10

75186863

-LAS1LchrX

64749630

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000299432ENST00000374807MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000299432ENST00000374811MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000299432ENST00000374804MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000299432ENST00000312391MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000372912ENST00000374807MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000372912ENST00000374811MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000372912ENST00000374804MSS51chr10

75186863

-LAS1LchrX

64749630

-
intron-3CDSENST00000372912ENST00000312391MSS51chr10

75186863

-LAS1LchrX

64749630

-

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FusionProtFeatures for MSS51_LAS1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSS51

Q4VC12

LAS1L

Q9Y4W2

Involved in the biogenesis of the 60S ribosomal subunit.Required for maturation of the 28S rRNA. Functions as a componentof the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMCcomplex is recruited to ZNF148 by methylated CHTOP, leading todesumoylation of ZNF148 and subsequent transactivation of ZNF148target genes. {ECO:0000269|PubMed:20647540,ECO:0000269|PubMed:22872859}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSS51_LAS1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSS51_LAS1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSS51_LAS1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSS51_LAS1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSS51C0036341Schizophrenia1PSYGENET