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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 22685

FusionGeneSummary for MSRB3_CCDC57

check button Fusion gene summary
Fusion gene informationFusion gene name: MSRB3_CCDC57
Fusion gene ID: 22685
HgeneTgene
Gene symbol

MSRB3

CCDC57

Gene ID

253827

284001

Gene namemethionine sulfoxide reductase B3coiled-coil domain containing 57
SynonymsDFNB74-
Cytomap

12q14.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionmethionine-R-sulfoxide reductase B3methionine-R-sulfoxide reductase B3, mitochondrialcoiled-coil domain-containing protein 57
Modification date2018052320180519
UniProtAcc

Q8IXL7

Q2TAC2

Ensembl transtripts involved in fusion geneENST00000355192, ENST00000308259, 
ENST00000540804, ENST00000535664, 
ENST00000538725, 		ENST00000392347, 
ENST00000389641, ENST00000392346, 
ENST00000327026, ENST00000392343, 
Fusion gene scores* DoF score5 X 4 X 3=609 X 6 X 9=486
# samples 411
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSRB3 [Title/Abstract] AND CCDC57 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSRB3

GO:0030091

protein repair

14699060


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3U6-01AMSRB3chr12

65847605

+CCDC57chr17

80059742

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355192ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000355192ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000355192ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000355192ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000355192ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000308259ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000308259ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000308259ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000308259ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000308259ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
Frame-shiftENST00000540804ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
Frame-shiftENST00000540804ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000540804ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000540804ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000540804ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000535664ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000535664ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000535664ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000535664ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000535664ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-3CDSENST00000538725ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-3CDSENST00000538725ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-intronENST00000538725ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-intronENST00000538725ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-intronENST00000538725ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-

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FusionProtFeatures for MSRB3_CCDC57


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSRB3

Q8IXL7

CCDC57

Q2TAC2

Catalyzes the reduction of free and protein-boundmethionine sulfoxide to methionine. Isoform 2 is essential forhearing. {ECO:0000269|PubMed:14699060,ECO:0000269|PubMed:21185009}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392343-01525_487-119752Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392343-015518_605-119752Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSRB3chr12:65847605chr17:80059742ENST00000308259+6747_169130186DomainMsrB
HgeneMSRB3chr12:65847605chr17:80059742ENST00000355192+5647_169137193DomainMsrB
HgeneMSRB3chr12:65847605chr17:80059742ENST00000535664+7847_169130186DomainMsrB
HgeneMSRB3chr12:65847605chr17:80059742ENST00000308259+67189_192130186MotifEndoplasmic reticulum retention signal
HgeneMSRB3chr12:65847605chr17:80059742ENST00000355192+56189_192137193MotifEndoplasmic reticulum retention signal
HgeneMSRB3chr12:65847605chr17:80059742ENST00000535664+78189_192130186MotifEndoplasmic reticulum retention signal
TgeneCCDC57chr12:65847605chr17:80059742ENST00000389641-161825_487855917Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000389641-1618518_605855917Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392347-151725_487855917Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392347-1517518_605855917Coiled coilOntology_term=ECO:0000255


Top

FusionGeneSequence for MSRB3_CCDC57


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MSRB3_ENST00000355192_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_198aa
MSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCG
TPLFKSETKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQSSQLLQQPTGGPSRCRQALPPQGXRQQPRQRPRPQEPPGLILQ

>In-frame_MSRB3_ENST00000355192_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_198aa
MSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCG
TPLFKSETKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQSSQLLQQPTGGPSRCRQALPPQGXRQQPRQRPRPQEPPGLILQ

>In-frame_MSRB3_ENST00000308259_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_191aa
MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSE
TKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQSSQLLQQPTGGPSRCRQALPPQGXRQQPRQRPRPQEPPGLILQKLKAARG

>In-frame_MSRB3_ENST00000308259_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_191aa
MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSE
TKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQSSQLLQQPTGGPSRCRQALPPQGXRQQPRQRPRPQEPPGLILQKLKAARG

>In-frame_MSRB3_ENST00000535664_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_191aa
MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSE
TKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQSSQLLQQPTGGPSRCRQALPPQGXRQQPRQRPRPQEPPGLILQKLKAARG

>In-frame_MSRB3_ENST00000535664_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_191aa
MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSE
TKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQSSQLLQQPTGGPSRCRQALPPQGXRQQPRQRPRPQEPPGLILQKLKAARG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MSRB3_ENST00000355192_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_596nt
ATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGCCTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCG
CAGTCCGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCAT
GTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGA
ACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTC
ACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCA
AGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAA

>In-frame_MSRB3_ENST00000355192_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_596nt
ATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGCCTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCG
CAGTCCGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCAT
GTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGA
ACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTC
ACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCA
AGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAA

>In-frame_MSRB3_ENST00000308259_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_575nt
ATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGAT
AAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACC
GAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAA
ACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGG
ATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCA
CCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGC

>In-frame_MSRB3_ENST00000308259_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_575nt
ATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGAT
AAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACC
GAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAA
ACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGG
ATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCA
CCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGC

>In-frame_MSRB3_ENST00000535664_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_575nt
ATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGAT
AAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACC
GAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAA
ACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGG
ATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCA
CCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGC

>In-frame_MSRB3_ENST00000535664_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_575nt
ATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGAT
AAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACC
GAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAA
ACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGG
ATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCA
CCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MSRB3_ENST00000355192_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_934nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAG
GAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAATACACACATCAC
AAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCA
TTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGC
TCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGG
CCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACAACATTATGGACT
GACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTG
GGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAGGCCTCCCTGAGC

>In-frame_MSRB3_ENST00000355192_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_934nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAG
GAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAATACACACATCAC
AAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCA
TTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGC
TCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGG
CCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACAACATTATGGACT
GACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTG
GGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAGGCCTCCCTGAGC

>In-frame_MSRB3_ENST00000308259_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_1061nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGCTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCAC
AGTGATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAG
GGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGG
GACCGAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTC
AGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTA
TGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATT
GCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAG
AGGCCCCCCAAGATCCGTAACTACAACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGG
TGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCT

>In-frame_MSRB3_ENST00000308259_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_1061nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGCTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCAC
AGTGATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAG
GGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGG
GACCGAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTC
AGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTA
TGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATT
GCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAG
AGGCCCCCCAAGATCCGTAACTACAACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGG
TGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCT

>In-frame_MSRB3_ENST00000535664_chr12_65847605_+_CCDC57_ENST00000392347_chr17_80059742_-_1126nt
CACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGCCTCTGCCTC
TGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGAGTGACATCACTGCCTCTCTTCCTGTGCGCTGGCTTTGACATAAGCCAGATGGCCA
CCGTGGTTGGTAGGCGCCCAGGCTGCCTGGTACAGGAGTTGATGAAACAGAATAGGAAGACGTTTTATGGTCAGCTGTGGAAGCACAGTG
AGACTGCAGCTTTGCTAACTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCACAGTGATGTCTGCATTCAACCTGCTG
CATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTC
TTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAA
TACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCA
GGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGC
TGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAG
CCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACA
ACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTG
TGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAG

>In-frame_MSRB3_ENST00000535664_chr12_65847605_+_CCDC57_ENST00000389641_chr17_80059742_-_1126nt
CACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGCCTCTGCCTC
TGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGAGTGACATCACTGCCTCTCTTCCTGTGCGCTGGCTTTGACATAAGCCAGATGGCCA
CCGTGGTTGGTAGGCGCCCAGGCTGCCTGGTACAGGAGTTGATGAAACAGAATAGGAAGACGTTTTATGGTCAGCTGTGGAAGCACAGTG
AGACTGCAGCTTTGCTAACTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCACAGTGATGTCTGCATTCAACCTGCTG
CATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTC
TTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAA
TACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCA
GGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGC
TGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAG
CCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACA
ACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTG
TGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAG


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FusionGenePPI for MSRB3_CCDC57


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSRB3GOLGA2, TCF4, TRIP6, PRDM4, MOV10, NXF1, AZIN1, GAPDH, MAPK8IP2, LNX2, KLHL7, RBP4, SPOP, DCUN1D4, C1QL1, BTBD9, STIM2, IFNA21CCDC57KIAA0368, NUMA1, HSFX1, PER1, AES, AQP1, HBA2, MFAP1, PTPN7, RAB3IL1, NELFE, USP2, UTP14C, SFI1, USP15, ARL4A, PRPF31, FAM50B, GPKOW, PPHLN1, FAM90A1, TMEM100, TBC1D22B, CBX8, ROBO3, LENG1, PRR3, PRAM1, FAM161A, ZGPAT, CCDC120, NAPRT, HAUS1, SIRPA, CWF19L2, LINC00526, ZNF417, ZMAT2, CDC20B, PPP1R18, ZFC3H1, TSGA10IP, CCDC57, CEP57L1, C17orf59, CCDC67, OFD1, XRCC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSRB3_CCDC57


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSRB3_CCDC57


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSRB3C1384666hearing impairment1CTD_human
HgeneMSRB3C2239351DEAFNESS, AUTOSOMAL RECESSIVE 741CTD_human;UNIPROT