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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22674

FusionGeneSummary for MSN_KAZN

check button Fusion gene summary
Fusion gene informationFusion gene name: MSN_KAZN
Fusion gene ID: 22674
HgeneTgene
Gene symbol

MSN

KAZN

Gene ID

4478

23254

Gene namemoesinkazrin, periplakin interacting protein
SynonymsHEL70|IMD50KAZ
Cytomap

Xq12

1p36.21

Type of geneprotein-codingprotein-coding
Descriptionmoesinepididymis luminal protein 70membrane-organizing extension spike proteinkazrin
Modification date2018052720180519
UniProtAcc

P26038

Q674X7

Ensembl transtripts involved in fusion geneENST00000609205, ENST00000360270, 
ENST00000376030, ENST00000503743, 
ENST00000422387, ENST00000361144, 
ENST00000400798, ENST00000400797, 
Fusion gene scores* DoF score7 X 7 X 3=1477 X 7 X 5=245
# samples 87
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSN [Title/Abstract] AND KAZN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSN

GO:0001771

immunological synapse formation

27405666

HgeneMSN

GO:0042098

T cell proliferation

27405666

HgeneMSN

GO:0070489

T cell aggregation

27405666

HgeneMSN

GO:0071394

cellular response to testosterone stimulus

24065547

HgeneMSN

GO:0072678

T cell migration

27405666


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW963054MSNchrX

64941655

+KAZNchr1

14937006

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000609205ENST00000376030MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000609205ENST00000503743MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000609205ENST00000422387MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000609205ENST00000361144MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000609205ENST00000400798MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000609205ENST00000400797MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000360270ENST00000376030MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000360270ENST00000503743MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000360270ENST00000422387MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000360270ENST00000361144MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000360270ENST00000400798MSNchrX

64941655

+KAZNchr1

14937006

+
intron-intronENST00000360270ENST00000400797MSNchrX

64941655

+KAZNchr1

14937006

+

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FusionProtFeatures for MSN_KAZN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSN

P26038

KAZN

Q674X7

Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSN_KAZN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSN_KAZN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSN_KAZN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSN_KAZN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMSNC0029408Degenerative polyarthritis1CTD_human
HgeneMSNC0151744Myocardial Ischemia1CTD_human
HgeneMSNC3495559Juvenile arthritis1CTD_human