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Fusion gene ID: 22673 |
FusionGeneSummary for MSN_HTR3D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSN_HTR3D | Fusion gene ID: 22673 | Hgene | Tgene | Gene symbol | MSN | HTR3D | Gene ID | 4478 | 200909 |
| Gene name | moesin | 5-hydroxytryptamine receptor 3D | |
| Synonyms | HEL70|IMD50 | 5HT3D | |
| Cytomap | Xq12 | 3q27.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | moesinepididymis luminal protein 70membrane-organizing extension spike protein | 5-hydroxytryptamine receptor 3D5-hydroxytryptamine (serotonin) receptor 3 family member D5-hydroxytryptamine (serotonin) receptor 3D, ionotropic5-hydroxytryptamine receptor 3 subunit Dserotonin 5-HT-3D receptorserotonin receptor 3D | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P26038 | Q70Z44 | |
| Ensembl transtripts involved in fusion gene | ENST00000609205, ENST00000360270, | ENST00000334128, ENST00000428798, ENST00000382489, ENST00000453435, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MSN [Title/Abstract] AND HTR3D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
| Hgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
| Hgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
| Hgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
| Hgene | MSN | GO:0072678 | T cell migration | 27405666 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-56-5898-01A | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000609205 | ENST00000334128 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| intron-3CDS | ENST00000609205 | ENST00000428798 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| intron-3CDS | ENST00000609205 | ENST00000382489 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| intron-3CDS | ENST00000609205 | ENST00000453435 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| In-frame | ENST00000360270 | ENST00000334128 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| In-frame | ENST00000360270 | ENST00000428798 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| In-frame | ENST00000360270 | ENST00000382489 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
| In-frame | ENST00000360270 | ENST00000453435 | MSN | chrX | 64887720 | + | HTR3D | chr3 | 183755809 | + |
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FusionProtFeatures for MSN_HTR3D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSN | HTR3D |
| Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}. | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functionsas a neurotransmitter, a hormone, and a mitogen. This receptor isa ligand-gated ion channel, which when activated causes fast,depolarizing responses. It is a cation-specific, but otherwiserelatively nonselective, ion channel. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSN_HTR3D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000334128_chr3_183755809_+_237aa MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAEL >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000428798_chr3_183755809_+_237aa MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAEL >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000382489_chr3_183755809_+_239aa MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPA GVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEA >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000453435_chr3_183755809_+_237aa MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAEL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000334128_chr3_183755809_+_711nt ATGCCCAAAACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATC GATGCCCTCAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTC ATGATGAATGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTC TACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCC CTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAG GGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTG ACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCG >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000428798_chr3_183755809_+_711nt ATGCCCAAAACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATC GATGCCCTCAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTC ATGATGAATGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTC TACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCC CTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAG GGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTG ACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCG >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000382489_chr3_183755809_+_717nt ATGCCCAAAACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATC GATGCCCTCAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTC ATGATGAATGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTGGCGCCTCTGGCCCTCATGCAGACCCCCTTGCCTGCA GGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACC CAGCCCCTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGA AATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCA GAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGC >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000453435_chr3_183755809_+_711nt ATGCCCAAAACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATC GATGCCCTCAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTC ATGATGAATGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTC TACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCC CTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAG GGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTG ACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000334128_chr3_183755809_+_1277nt GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTCGC CCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCT GCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGG TCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGG CTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGC CCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCA AACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCTCATTTT TAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCCATCAGC CCCACTCAGCCCTCCCATACCTCCCTGGCTCCTCAGGATTCAGGTTCCTAGGGTACGTCCTTGATTAAATCACCCCAATATGCCCCTTTG CAGAAAGTATTGGCTTTTCCCTGAATTCTGTTATGGTAAAAAAAATCTTGGGATTGAGAGTCTTCTTGCAGAAACTTCTCAGCCAAAGTA >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000428798_chr3_183755809_+_883nt GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTCGC CCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCT GCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGG TCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGG CTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGC >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000382489_chr3_183755809_+_1198nt GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTGGCGCCTCTGGCCCTCATGCAGACCCCCTTGCCTGCAGGTGTCTA CTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCT ACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGG CCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGAC AGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGAT GGACGCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCA CCTGCAAACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCT CATTTTTAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCC ATCAGCCCCACTCAGCCCTCCCATACCTCCCTGGCTCCTCAGGATTCAGGTTCCTAGGGTACGTCCTTGATTAAATCACCCCAATATGCC >In-frame_MSN_ENST00000360270_chrX_64887720_+_HTR3D_ENST00000453435_chr3_183755809_+_1108nt GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTCGC CCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCT GCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGG TCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGG CTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGC CCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCA AACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCTCATTTT TAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCCATCAGC |
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FusionGenePPI for MSN_HTR3D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MSN | TSC1, HLA-B, BID, TNFRSF10B, EZR, FADD, FASLG, MAPK8, FAS, RHOA, ARHGDIA, CASP10, CASP8, TNFRSF1A, MSN, ICAM3, NCF1, NCF4, VCAM1, SLC9A3R1, SELL, SPN, SPTAN1, CD46, ICAM2, CD44, SELPLG, H2AFX, ELAVL1, SIRT7, ISG15, TERF1, BRCA1, CDK2, HADHA, GTF3C4, SRCAP, S100A16, FN1, ITGA4, ICAM1, CD81, IGSF8, CDK11B, MAPK10, ASNS, CAPN2, DHX15, GINS3, GSS, HSPA5, AHCY, ATIC, DCPS, FH, NAE1, PDIA4, PFAS, PTMA, STK24, TATDN1, TUBB3, VCL, NSFL1C, PAFAH1B1, PAFAH1B2, PAPSS1, PDHA1, PPP1R2, RAP1GDS1, ABCE1, TSPAN33, VPS11, ACAA2, AKR1B1, CALR, CALU, CD2AP, CTNNB1, EIF5AL1, ENO1, ENO2, FABP5, FAXC, FKBP2, HNRNPA1, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, JUP, LCP1, DUT, GDI1, HSPB1, IMPA2, ME1, NOTCH2, P4HB, PGD, PGK1, PGK2, PLS1, PLS3, RCN1, STIP1, TAGLN2, TKT, UCHL3, WDR1, EWSR1, MYH9, PTPN1, MYO19, TRIM15, MCM2, U2AF2, SMURF1, CDC73, MISP, MRPL12 | HTR3D | LRFN4, RSPRY1, HSDL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSN_HTR3D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HTR3D | Q70Z44 | DB00898 | Ethanol | 5-hydroxytryptamine receptor 3D | small molecule | approved |
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RelatedDiseases for MSN_HTR3D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MSN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | MSN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | MSN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | MSN | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | HTR3D | C0036341 | Schizophrenia | 1 | PSYGENET |
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